Reported with imipenem. Medical search. Frequent questions

Fass environmental information for imipenem from Recarbrio (cilastatin, imipenem (vattenfri), relebactam) from MSD (downloaded 2023-12-15). (janusinfo.se)
The environmental risk assessment for imipenem and cilastatin are on-going and will be submitted in 4Q 2020. (janusinfo.se)
The CHMP reiterated that the Environmental risk assessment of imipenem and cilastatin needs to be submitted no later than the end of Q4 2020. (janusinfo.se)
Administer RECARBRIO 1.25 grams (imipenem 500 mg, cilastatin 500 mg, relebactam 250 mg) by intravenous (IV) infusion over 30 minutes every 6 hours in patients 18 years of age and older with creatinine clearance (CLcr) 90 mL/min or greater. (nih.gov)
RECARBRIO 1.25 grams for injection is supplied as sterile powder for constitution in a single-dose vial containing imipenem 500 mg (anhydrate equivalent), cilastatin 500 mg (free acid equivalent), and relebactam 250 mg (anhydrate equivalent). (nih.gov)
Seizures and Central Nervous System Adverse Reactions: CNS adverse reactions such as seizures have been reported with imipenem/cilastatin, a component of RECARBRIO. (nih.gov)
Unlike imipenem, it is stable to dehydropeptidase-1, so can be given without cilastatin. (wikipedia.org)
imipenem/cilastatin decreases effects of BCG intravesical live by pharmacodynamic antagonism. (medscape.com)
Read user comments about the side effects, benefits, and effectiveness of imipenem-cilastatin intravenous. (webmd.com)
Pharmacokinetics, safety, and tolerability of imipenem/cilastatin/relebactam in children with confirmed or suspected gram-negative bacterial infections: A Phase 1b, open-label, single-dose clinical trial. (uib.no)
Tienam ampoules, composed of imipenem hydrate and cilastatin sodium, exhibit their therapeutic effects through a specific mechanism of action. (japanese-medicines.com)
The synergistic action of imipenem hydrate and cilastatin sodium in Tienam ampoules contributes to their clinical efficacy in treating severe bacterial infections. (japanese-medicines.com)
The paper , entitled "Cefiderocol versus imipenem-cilastatin for the treatment of complicated urinary tract infections caused by Gram-negative pathogens: a phase 2, randomised, double-blind, non-inferiority trial," was published October 25th. (drugdiscoverynews.com)
Results from the study demonstrated that treatment with cefiderocol met non-inferiority versus imipenem/cilastatin (IPM/CS) in patients with cUTI at test of cure (TOC). (drugdiscoverynews.com)
She was treated with imipenem-cilastatin and discharged after 25 days. (medscape.com)

Why is imipenem and meropenem resistance important? (cdc.gov)
How much resistance to imipenem or meropenem occurs in clinical isolates? (cdc.gov)
Published reports indicate some resistance in a variety of clinical Gram-negative organisms, including Pseudomonas aeruginosa , Burkholderia cepacia , Acinetobacter species , Proteus species , Serratia marcescens , Enterobacter species, and Klebsiella pneumoniae . (cdc.gov)
However, studies have shown false resistance to imipenem in commercially prepared test panels due to degradation of the drug or to a manufacturing problem where concentrations of imipenem were too low (1,2,4,5). (cdc.gov)
This report presents the status of AMR in Africa by analysing the main types of resistance and the underlying genes where possible. (who.int)
The report also includes a summary on the status of drug resistance for TB, HIV and malaria. (who.int)
All laboratories participating in ELR must report antimicrobial resistance testing results for all Acinetobacter baumannii, Citrobater species, Enterococcus species, Enterobacter species, Escherichia coli , Klebsiella species, Pseudomonas aeruginosa, Serratia species, and S. aureus isolates from normally sterile sites. (floridahealth.gov)
A. baumannii is developing into multidrug resistant (MDR), extensively drug resistant (XDR), and pandrug resistant (PDR) bacteria, and its adaptation to the environment with drug resistance has previously been reported ( Durante-Mangoni and Zarrilli, 2011 ). (frontiersin.org)
reported the dissemination of MDR OXA-23-producing A. baumannii clones throughout multiple cities in China, but little is known about the molecular mechanisms of resistance to carbapenems in western China. (frontiersin.org)
The importance of meropenem resistance, rather than imipenem resistance, in defining carbapenem-resistant Enterobacterales for public health surveillance: an analysis of national population-based surveillance. (bvsalud.org)
The identification of CRE cases based solely on imipenem resistance has had a limited impact on clinical management. (bvsalud.org)
Resistance to imipenem and piperacillin was not identified, whereas resistance among the 229 isolates to penicillin was detected in four, to metronidazole in six, and clindamycin in 16 isolates. (lu.se)
There are sporadic reports of high resistance to ceftriaxone in typhoidal salmonellae (3,4) in which CTX-M-15 and SHV-12 extended spectrum b-lactamases (ESBLs) have been reported. (blogspot.com)
as resistance to imipenem plus 3 or more been increasing worldwide over recent different antibiotic classes, including: at decades. (who.int)
Philippines reporting P. aeruginosa as the most common Antimicrobial Resistance Surveil ance Program (ARSP) etiological agent. (who.int)
were the reported increasing rates of resistance to antibiotics used second most common pathogen isolated from device- to treat P. aeruginosa infections, such as carbapenems associated HA infections in a study of intensive care and extended-spectrum cephalosporins ( Fig. 1A-B ). In units in Philippine hospitals. (who.int)

Stenotrophomonas maltophilia isolates are intrinsically resistant to imipenem. (cdc.gov)
Antimicrobial susceptibility profile showed that the majority of the isolates were sensitive to Imipenem and Nitrofurantoin while most were significantly resistant to, augmentin, ampicillin, cotrimoxazole, gentamicin, cefuroxime, cefotaxime, and ceftazidime. (ispub.com)
Reports have been limited to antimicrobial susceptibility test results of clinical isolates, usually from reference laboratories, animal studies and case summaries ( 19 , 78 ). (antimicrobe.org)
Subsequently, pathogen surveillance was initiated in 2017, which involved the collection and analysis of CRE isolates from reported cases to assess carbapenemase gene possession. (bvsalud.org)
CRE isolates from reported cases were collected from the public health laboratories of local governments , which are responsible for pathogen surveillance . (bvsalud.org)
The goal of this study was to characterize P. aeruginosa isolates and identify the prevalence rate of P. aeruginosa resistant to imipenem due to metallo-ßlactamase (MBL) genes. (japsonline.com)

She was treated with linezolid and imipenem. (elsevierpure.com)
Therapeutic monitoring of clarithromycin, imipenem, and linezolid in CSF and plasma revealed lower than expected concentrations, prompting alternative therapy and culture clearance on hospital day 42. (northwestern.edu)

The combination of intravenous vancomycin and piperacillin/tazobactam (TZP) was associated with an increased risk of acute kidney injury (AKI) in children, researchers reported. (medpagetoday.com)

Imipenem and meropenem are carbapenem antimicrobial agents used to treat a variety of serious infections when an organism is resistant to the primary agent of choice. (cdc.gov)
What Gram-negative organisms are resistant to imipenem and/or meropenem? (cdc.gov)
In Japan , carbapenem -resistant Enterobacterales (CRE) infections were incorporated into the National Epidemiological Surveillance of Infectious Diseases (NESID) in 2014, necessitating mandatory reporting of all CRE infections cases. (bvsalud.org)
The MBL genes, bla IMP and bla VIM , were finally identified using the polymerase chain reaction (PCR) within imipenem-resistant strains. (japsonline.com)
PCR showed that eight strains of imipenem-resistant P. aeruginosa contained bla VIM , while bla IMP gene was not detected. (japsonline.com)
OSAKA, Japan & FLORHAM PARK, N.J.- Shionogi & Co., Ltd . reported yesterday that The Lancet Infectious Diseases has published clinical results from the pivotal randomized controlled trial evaluating cefiderocol for the treatment of complicated urinary tract infection (cUTI) in patients at risk of multidrug-resistant Gram-negative infections. (drugdiscoverynews.com)

Other β-lactam antibiotics included in the study were ceftazidime sodium, cefepime hydrochloride, meropenem, and imipenem/cilastin sodium. (medpagetoday.com)
At variance with this approach, there are reports of therapeutic failures with cefepime associated with MICs of ≤2 μg/ml ( 31 ) and 4 μg/ml in a pediatric patient ( 3 ) and with a cefotaxime MIC of 0.75 μg/ml ( 20 ). (asm.org)

It is administered alongside imipenem to prevent the degradation of imipenem by renal dehydropeptidase enzymes in the kidneys. (japanese-medicines.com)

The present case report highlights the usefulness of PoCUS in facilitating diagnostic and therapeutic decision-making in a patient with FG in an emergency department. (spandidos-publications.com)
This combination helps to maintain adequate levels of imipenem in the bloodstream and enhances its therapeutic effectiveness. (japanese-medicines.com)

High prevalence of non-clonal imipenem-nonsusceptible Enterobacter spp. (ac.ir)

While the results of cultures were pending, antibiotic therapy with imipenem (500 mg. (biomedcentral.com)

aztreonam and imipenem are also potential third line drugs. (pediatriconcall.com)

Sepsis Emerging therapies such as - Genetically-Enhanced Mesenchymal stem cells, CTI-111, HY209, Imipenem-cilastatinrelebactam, CYT107, Cefiderocol, VBI-S, Thymosin alpha 1, and others are expected to have a significant impact on the Sepsis market in the coming years. (jabalpurchronicle.org)

Assessment report for Recarbrio 15 October 2020, EMA/CHMP/538608/2020. (janusinfo.se)
Clostridioides difficile -Associated Diarrhea (CDAD): Has been reported with RECARBRIO. (nih.gov)
HABP/VABP Patients: The most frequently reported adverse reactions occurring in greater than or equal to 5% of patients treated with RECARBRIO were alanine aminotransferase increased, aspartate aminotransferase increased, anemia, diarrhea, hypokalemia, and hyponatremia. (nih.gov)

Organisms with MICs near interpretation breakpoints have greater potential for reporting errors. (cdc.gov)
Meropenem is slightly more active than imipenem against Gram-negative organisms. (cdc.gov)

Meropenem has a reduced potential for seizures in comparison with imipenem. (wikipedia.org)

The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, collaborations, mergers acquisition, funding, designations, and other product-related details. (jabalpurchronicle.org)

Also, often it is difficult to compare in vitro susceptibility results with data reported by other investigators because of differences in methodology, e.g., lack of interlaboratory standardization of inocula (e.g.,104 versus102 CFU/ml), and use of a broth microdilution method versus agar dilution or disk diffusion methods. (antimicrobe.org)
Antimicrobial susceptibility testing is challenging as only in vitro susceptibility testing of Janibacter terrae has been reported. (elsevierpure.com)
Providers should consider performing culture and antimicrobial susceptibility testing to help guide therapy if patients report use of this product. (cdc.gov)

Hypersensitivity Reactions: Hypersensitivity reactions have been reported in patients receiving beta lactam drugs. (nih.gov)

Chondrotoxicity was evident with 9 (38%) agents, all of which were also dose-dependently chondrotoxic based on reported estimated half maximal inhibitory concentrations (est.IC50): amikacin (est. (ku.edu)

J. hoylei was only previously reported from the bloodstream of a previously healthy 8-week-old infant without underlying medical conditions. (elsevierpure.com)

3 The true global distribution of B. pseudomallei and the incidence of melioidosis remain poorly understood, and it is not yet known if the growing number of melioidosis cases reported worldwide reflects an unmasking of long-standing bacterial presence or the spread of B. pseudomallei to previously unaffected areas. (health.mil)

The report features unique and salient factors that may make a huge impact on the development of the antibiotics API market during the forecast period. (pharmiweb.com)
The report provides detailed information about the current and future growth prospects of the antibiotics API market in the most comprehensive way for better understanding of readers. (pharmiweb.com)
The report commences with the executive summary of the antibiotics API market report, which includes the summary of key findings and statistics of the market. (pharmiweb.com)

The use of imipenem (sales data Sweden 2021) has been considered to result in insignificant environmental risk. (janusinfo.se)

Additionally, chondroprotective effects of doxycycline and minocycline were reported. (ku.edu)

Several cases of severe hypokalemia have been reported. (wikipedia.org)

Combines Candida identified to the species level (excluding C. albicans and C. glabrata) , and Candida for which the species was not reported. (cdc.gov)
Combines enterococci identifies to the species level (excluding E. faecalis and E. faecium ) and enterococci for which the species was not reported. (cdc.gov)

The final report on the government assignment is to be submitted to the Swedish government by December 31, 2023. (folkhalsomyndigheten.se)

Studies suggest meropenem may be more stable than imipenem. (cdc.gov)

Below are a few examples of reports where side effects / adverse reactions may be related to Amphotericin B. For a complete list or a specific selection of reports, please use the links above. (druglib.com)
Please do not use this form to submit personal or patient medical information or to report adverse drug events. (medscape.com)
You are encouraged to report adverse drug event information to the FDA. (medscape.com)

Although cerebral arteritis induced by leptospirosis has been reported, cerebral infarction caused by leptospirosis is rarely reported. (biomedcentral.com)
but to our knowledge, cerebral infarction because of leptospirosis is rarely reported [ 11 ]. (biomedcentral.com)

Conclusions: GPAC bacteraemia is much more common than previously reported. (lu.se)

The overall spectrum is similar to that of imipenem, although meropenem is more active against Enterobacteriaceae and less active against Gram-positive bacteria. (wikipedia.org)
More than 56 different species of fungi and bacteria have been reported to cause mycetoma. (medscape.com)
[ 7 ] The ratio of mycetoma cases caused by bacteria (actinomycetoma) to those caused by true fungi (eumycetoma) in Mexico has been reported to be 92:8. (medscape.com)

In this case report, a brain abscess was initially diagnosed as Salmonella post-surgical meningitis before the imaging diagnosis of the brain abscess. (biomedcentral.com)

A complaint reported that vials labeled as containing 500 mg of the drug were found in cartons labeled as containing 350 mg/vial. (acpinternist.org)

We present the first reported case, to the best of our knowledge, of sepsis from central line-associated blood stream infection from Chryseobacterium gleum in the United States. (hindawi.com)
We reported one case of cutaneous Mycobacterium farcinogenes - senegalense group infection in an immunocompetent victim. (biomedcentral.com)
We report a human skin infection by Mycobacterium farcinogenes-senegalense , which usually causes bovine farcy, in an immunocompetent woman after traumatic injury by rusty springs. (biomedcentral.com)
Invasive Salmonella infections have been reported due to their potential to cause focal suppurative complications in urinary tract infection, osteoarticular infection and liver abscess [ 1 ]. (biomedcentral.com)
The report titled "Global Nosocomial Infection Treatment Market: Growth, Share, Opportunities, and Competitive Analysis, 2016-2024" offers strategic insights into the overall nosocomial infection treatment market, along with the market size and estimates for the duration of 2014 to 2024. (credenceresearch.com)
This report concludes with a company profiles section that highlights major information about the key players engaged in the global nosocomial infection treatment market. (credenceresearch.com)

No related deaths have been reported. (acpinternist.org)

Sepsis and even death from Waterhouse-Friderichsen syndrome due to Ea has also been reported [ 8 ]. (biomedcentral.com)
" Sepsis Pipeline Insight, 2022 " report by DelveInsight outlines comprehensive insights into the present clinical development scenario and growth prospects across the Sepsis Market. (jabalpurchronicle.org)
The Sepsis Pipeline report embraces in-depth commercial and clinical assessment of the pipeline products from the pre-clinical developmental phase to the marketed phase. (jabalpurchronicle.org)
The report provides detailed insights about companies that are developing therapies for the Sepsis treatment with aggregate therapies developed by each company for the same. (jabalpurchronicle.org)

Human-to-human or animal-to-human transmission has not been described for eumycetoma, but nosocomial transmission of Nocardia farcinica, one of the agents of actinomycetoma in postoperative surgical site infections, has been reported. (medscape.com)

[ 9 ] although the expensive price hinders their use in poor developing countries, where most cases are reported. (medscape.com)
Sinc e the last situation report, the number of confirmed and suspected cases has risen. (who.int)
Only a few cases of bacteraemia with GPAC have been reported. (lu.se)
Only 11 cases have been reported to date. (biomedcentral.com)

However, it has been reported also in patients without previously identified medical problems. (biomedcentral.com)
Most patients reported using artificial tears. (cdc.gov)
Patients reported more than 10 different brands of artificial tears, and some patients used multiple brands. (cdc.gov)
The majority of patients who used artificial tears reported using EzriCare Artificial Tears, a preservative-free, over-the-counter product packaged in multidose bottles. (cdc.gov)

Imipenem has low potential for bioaccumulation. (janusinfo.se)
All other authors report no potential conflicts of interest. (northwestern.edu)

Gene Drives on the Horizon: Advancing Science, Navigating Uncertainty, and Aligning Research with Public Values (report) National Academies Press, 2016. (cdc.gov)
Market growth rates for the forecast period 2016-2024 are also included in this report, considering 2015 as the base year. (credenceresearch.com)

Imipenem has very high chronic toxicity. (janusinfo.se)

Molecular and microbiological report of a hospital outbreak of NDM-1-carrying Enterobacteriaceae in Mexico. (ac.ir)

Q: Should laboratories report any IgG results? (wa.gov)
Q: Should labs report notifiable results performed at reference labs? (wa.gov)
The Department of Health strongly prefers that original ordering labs and performing reference labs both report notifiable results. (wa.gov)

Organisms11

Diseases10

Chemicals and Drugs34

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes3

Cilastatin15

Resistance16

Isolates6

Linezolid2

Piperacillin1

Resistant6

Cefepime2

Renal dehydropeptidase1

Therapeutic2

Enterobacter1

Antibiotic therapy1

Aztreonam1

Cefiderocol1

Recarbrio3

Organisms2

Seizures1

Mechanism of Act1

Susceptibility3

Drugs1

Concentrations1

Bloodstream1

Melioidosis1

Antibiotics3

20211

Doxycycline1

Severe1

Species level2

20231

Stable1

Adverse3

Rarely2

Conclusions1

Bacteria3

CASE REPORT1

Vials1

Infection6

Related deaths have been reported1

Sepsis4

Infections1

Cases4

Patients4

Potential2

20162

Chronic1

Microbiological1

Results3