Repolarization arrhythmias cardiac. Medical search. Frequent questions

Inhalation of printer-emitted particles impairs cardiac conduction, hemodynamics, and autonomic regulation and induces arrhythmia and electrical remodeling in rats. (cdc.gov)
The researchers investigated the association between blood alcohol concentration and four ECG parameters: excitation ( heart rate ), conduction (PR interval, QRS complex), and repolarisation (QT interval). (medicalxpress.com)
The abstract 'Acute alcohol consumption and effects on cardiac excitation, conduction, and repolarization. (medicalxpress.com)
Third-degree atrioventricular (AV) block, also referred to as third-degree heart block or complete heart block (CHB), is an abnormal heart rhythm resulting from a defect in the cardiac conduction system in which there is no conduction through the atrioventricular node (AVN), leading to complete dissociation of the atria and ventricles. (medscape.com)
Moreover, we find that I K1 suppression reduced the ratio of effective refractory period to AP duration at 90% of repolarization, permitting re-excitation before full repolarization, reduction of AP upstroke velocity, and likely promotion of slow conduction. (usuhs.edu)
Without successful treatment, infection can persist for a lifetime and can result in serious cardiovascular conditions including dilated cardiomyopathy with heart failure, ventricular arrhythmias and conduction disturbances, stroke, and other systemic or pulmonary embolisms. (thecardiologyadvisor.com)
Warnings and precautions (5.4) Cardiac Rhythm and Conduction Abnormalities: In vitro testing showed that Lamictal exhibits Class IB antiarrhythmic activity at therapeutically relevant concentrations [see Clinical Pharmacology (12.2)] . (aesnet.org)
Therefore, avoid the use of Lamictal in people who have cardiac conduction disorders (eg, second- or third-degree heart block), ventricular arrhythmias, or cardiac disease or abnormality (eg, myocardial ischemia, heart failure, structural heart disease, Brugada syndrome, or other sodium channelopathies). (aesnet.org)
at the University of Louisville published in Nature Communications , has uncovered direct cardiovascular consequences such as the induction of spontaneous cardiac arrhythmias, changes in cardiac conduction properties, and autonomic reflexes in a mouse model of e-cigarette exposure. (emkatech.com)
E-cigarette vapour caused arrhythmia, and impaired supraventricular depolarization and ventricular repolarization, along with effects on the autonomic modulation of cardiac conduction. (emkatech.com)
E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice. (emkatech.com)

Abnormalities in repolarisation, due to disease states or therapeutic drugs, can give rise to arrhythmias. (bristol.ac.uk)
Changes in the normal ECG pattern occur in numerous cardiac abnormalities, including cardiac rhythm disturbances (such as atrial fibrillation and ventricular tachycardia), inadequate coronary artery blood flow (such as myocardial ischemia and myocardial infarction), and electrolyte disturbances (such as hypokalemia and hyperkalemia). (cardiomyopathy.org)
This work highlights the potential of optogenetics in studying repolarization abnormalities and in developing novel antiarrhythmic therapies. (jci.org)
In the acute phase, mild cardiac abnormalities such as tachycardia have been noted. (thecardiologyadvisor.com)
Electrocardiographic findings may reveal sinus tachycardia and PR/QT prolongation, low-voltage QRS complexes, and repolarization abnormalities. (thecardiologyadvisor.com)
25.3 had evidence of left ventricular hypertrophy and 26.5 had various ventricular arrhythmias.Conclusion: Adult Nigerians presenting with hypertension for the first time have significant rhythm and structural abnormalities that should influence their clinical management and drug treatment choice. (bvsalud.org)

Long QT syndrome, family history of idiopathic sudden death, congenital long QT syndrome or additional risk factors for cardiac repolarization abnormality, as determined by the investigator. (childrenshospital.org)
Chagas cardiomyopathy is known as Chagas disease with cardiac involvement, with ≥1 electrocardiographic abnormality in patients who test positive for T cruzi . (thecardiologyadvisor.com)
Changes such as right branch-bundle block (with or without left anterior hemiblock) can signal the transition from the indeterminate form to the chronic cardiac form, and the presence of a typical electrocardiographic abnormality has been associated with an increased risk for progressing to a more severe cardiomyopathy. (thecardiologyadvisor.com)
The abnormality underlying both acquired and congenital long QT syndromes is in the ionic current flow during repolarization, which affects the QT interval. (medscape.com)

MAs may be manifested either in hemodynamic collapse or in cardiac arrest: The sudden loss of effective blood flow due to atrial fibrillation (AF) with rapid VT leads to hemodynamic collapse, and VT and VF result in cardiac arrest necessitating CPR or electric defibrillation. (medscape.com)
Atrial fibrillation (AF) is the most common disturbance of cardiac rhythm and is associated with significantly increased mortality. (bristol.ac.uk)
But people with heart conditions already have a higher heart rate, which in many cases triggers arrhythmias, including atrial fibrillation. (medicalxpress.com)
This dynamical viewpoint gives predictive power that is beyond that of the biophysical explanation alone while also uncovering a common mechanism for phenomena observed in experiments on both atrial and ventricular cardiac cells. (monash.edu)
Right bundle-branch block, atrial fibrillation, or ventricular arrhythmias can be indicative of a worse prognosis. (thecardiologyadvisor.com)
3] Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias . (nih.gov)

this results in the depolarization of the cardiac muscles. (wikipedia.org)
These electrodes detect the small electrical changes that are a consequence of cardiac muscle depolarization followed by repolarization during each cardiac cycle (heartbeat). (cardiomyopathy.org)
Imaging electrocardiographic dispersion of depolarization and repolarization during ischemia: simultaneous body surface and epicardial mapping. (ox.ac.uk)
We investigated the sensitivity of torso measures, recorded simultaneously with epicardial electrograms, to changes in dispersion of depolarization and repolarization during localized ventricular ischemia. (ox.ac.uk)
The most frequent automatic rhythm is caused by increased spontaneous depolarization of phase 4 of the cardiac action potential. (medscape.com)
During the initial upstroke of action potential in a normal cardiac cell, a rapid net influx of positive ions (Na + and Ca ++ ) occurs, which results in the depolarization of the cell membrane. (medscape.com)

Torsades de pointes, torsade de pointes or torsades des pointes (TdP) (/tɔːˌsɑːd də ˈpwæ̃t/, French: [tɔʁsad də pwɛ̃t̪], translated as "twisting of peaks") is a specific type of abnormal heart rhythm that can lead to sudden cardiac death. (wikipedia.org)
Women are at significantly greater risk than men of the potentially fatal arrhythmia, torsades de pointes. (bristol.ac.uk)
it is characterized by syncope and a high incidence of ventricular arrhythmia (including torsades de pointes) and sudden cardiac death. (biomedcentral.com)

Repolarization of the ventricles is associated with the T wave of the electrocardiogram or ECG. (bristol.ac.uk)
1 Early repolarisation pattern on the 12-lead electrocardiogram has been linked to an increased risk of malignant arrhythmias, although intense debate exists as to the causal effect, given the high frequency of such repolarisation patterns in the general and athletic population. (bmj.com)
QT interval as an indicator of ventricular repolarization is a clinically important parameter on an electrocardiogram (ECG). (biomedcentral.com)
The long-QT syndrome (LQTS) is an inherited heart rhythm disorder characterized by a prolonged QT interval on the electrocardiogram (ECG), due to delayed cardiac repolarization, in the absence of documented structural heart disease. (medscape.com)

Abnormal action potential (AP) properties, as occurs in long or short QT syndromes (LQTS and SQTS, respectively), can cause life-threatening arrhythmias. (jci.org)
and Arrhythmias in Patients with Genetic Arrhythmia Syndromes. (123library.org)
ICMs are used for symptom-rhythm correlation when patients have potentially arrhythmogenic syncope and for less traditional reasons such as rhythm surveillance in patients with genetic arrhythmia syndromes or other diseases with high arrhythmia risk. (bvsalud.org)
Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)

However, such an examination is necessary to exclude other potential cardiac causes of syncope or cardiac arrest in an otherwise healthy patient (eg, heart murmurs from hypertrophic cardiomyopathy or from a valvular or septal defect). (medscape.com)
Syncope may occur but is uncommon because VT that occurs with early repolarization syndrome rarely self-terminates (unlike with some other disorders that cause VT in which syncope is more common). (msdmanuals.com)
Ventricular arrhythmia (VA) may be an isolated and completely benign finding in children, a marker of serious systemic disease or myopathy, or a mechanism for syncope and sudden cardiac death (SCD). (medscape.com)
In patients with moderate QT prolongation (a QT interval less than 500 ms), slower activation was an independent predictor for cardiac events (syncope, aborted cardiac arrest, and sudden death) (hazard ratio = 2.10), whereas the length of the QT interval itself was not. (johnshopkins.edu)

Background The failing heart exhibits an increased arrhythmia susceptibility that is often attributed to action potential (AP) prolongation due to significant ion channel remodeling. (usuhs.edu)
QT prolongation predisposes individuals to different ventricular arrhythmias and sudden cardiac death. (biomedcentral.com)
SBVR has been suggested to be more predictive of the development of lethal arrhythmias than the action potential prolongation or QT prolongation of ECG alone. (unideb.hu)
The deep endocardial region and midmyocardial layer (composed of M cells) of the ventricle are more prone to prolongation of repolarization and EADs because they have a less-rapid delayed rectifier potassium current (IKr), while other regions might have short or normal cycles. (medscape.com)

Early repolarization syndrome is a genetic disorder of cardiomyocyte ion channel function (channelopathy). (msdmanuals.com)
However, early repolarization is substantially more common in survivors of apparently idiopathic ventricular fibrillation (VF), and early repolarization syndrome refers to people with early repolarization on ECG who also have had symptomatic ventricular arrhythmias. (msdmanuals.com)
The polymorphic VT is often initiated by a short-long-short RR interval sequence (although this sequence is not specific for early repolarization syndrome): The first short RR interval is between a baseline beat (usually a normal beat) and a premature beat (usually a premature ventricular beat). (msdmanuals.com)
Early repolarization syndrome appears to be inheritable, but disease-specific gene mutations are rarely identified, suggesting that the disorder is often polygenic. (msdmanuals.com)

The temporal association between repolarization and the T wave in an isolated perfused heart is illustrated below. (bristol.ac.uk)
In animal experiments there has been a strong association between repolarization alternans and malignant ventricular arrhythmias like VT and VF. (fu-berlin.de)

The primary outcome is the presence of clinically significant arrhythmias defined as a composite of bradycardia, ventricular tachycardia, or ventricular fibrillation. (bvsalud.org)
Diagnosis should be considered in patients who have had polymorphic ventricular tachycardia, ventricular fibrillation, or sudden cardiac arrest (or a family history of those events in the absence of structural heart disease) and who also have ECG changes showing an inferior and/or lateral early repolarization pattern. (msdmanuals.com)

Patients who experienced arrhythmia during HD had higher left ventricular mass and left ventricular mass index, lower post-dialysis K+ level, higher QTc and QTdc both before and after HD. (who.int)
Absence of coronary artery disease: Cardiac ischaemia with angina pectoris can exist in the absence of significant coronary artery disease, possibly due to microcoronary dysfunction (up to 10% of patients of which a majority of women). (escardio.org)
If we conducted the same study in older people or heart patients we might have found an association between drinking alcohol and arrhythmias. (medicalxpress.com)
To date, the only treatment that has proven effective in treating ventricular tachycardia and fibrillation and preventing sudden death in patients with Brugada syndrome is implantation of an automatic implantable cardiac defibrillator (ICD). (medscape.com)
INTRODUCTION: Patients receiving haemodialysis are at increased risk of arrhythmias and sudden cardiac death, but data on arrhythmia burden and the pathophysiology remain limited. (bvsalud.org)
The current article presents the protocol of a study aiming to increase the understanding of arrhythmias and risk factors in patients receiving haemodialysis. (bvsalud.org)
The findings will provide a detailed exploration of the burden and nature of arrhythmias in these patients including the potential association between hypoglycaemia and arrhythmias. (bvsalud.org)
OBJECTIVE: The purpose of this study was to characterize the genotype, cardiac phenotype, and long-term outcomes of ARVC/D patients with late presentation (age ≥50 years at diagnosis). (uu.nl)
Over median 6-year follow-up, 68 patients with late presentation (65%) experienced sustained ventricular arrhythmias, with similar arrhythmia-free survival at 5-year follow up (P = .48). (uu.nl)
Left ventricular dysfunction and heart failure were seen in 24 (32%) and 15 patients (14%), respectively, without need for cardiac transplantation. (uu.nl)
As a pediatric cardiac electrophysiologist, I provide the very best care for my patients through state-of-the-art and evidence-based treatments. (stanfordchildrens.org)
The leading cause of mortality in DCM-patients is sudden cardiac death (SCD). (fu-berlin.de)
This ILAE/AES joint advisory statement provides information for clinicians after the October 9, 2020, FDA addition of a safety warning related to patients with certain underlying cardiac disorders or arrhythmias to the prescribing information for lamotrigine . (aesnet.org)
In honor of World AIDS Day this year, we spoke with Gildas Loussouarn, University of Nantes, about his research on cardiac channels dysfunction in Long QT Syndrome, a disorder seen much more frequently in HIV patients as compared to the general population. (biophysics.org)
2] Entropy of cardiac repolarization predicts ventricular arrhythmias and mortality in patients receiving an implantable cardioverter-defibrillator for primary prevention of sudden death . (nih.gov)
By correlating the clinical phenotype of 387 LQT1 patients with the cellular electrophysiological characteristics caused by an array of mutations in KCNQ1, we found that channels with a decreased rate of current activation are associated with increased risk of cardiac events (hazard ratio = 2.02), independent of the clinical parameters usually used for risk stratification. (johnshopkins.edu)
Our results indicate that genotype and biophysical phenotype analysis may be useful for risk stratification of LQT1 patients and suggest that slow channel activation is associated with an increased risk of cardiac events. (johnshopkins.edu)
According to the HEMO study, cardiac arrhythmia and ST-segment changes during deaths account for 39.4% of all deaths in HD in young patients with no concomitant patients on chronic haemodialysis (HD). (who.int)

Secondary outcomes include the characterisation of clinically significant arrhythmias and other arrhythmias, glycaemic characteristics, and mortality. (bvsalud.org)
In the sensitivity analysis, however, Bazett's formula had the highest sensitivity (23.07%) among all others in cardiac mortality. (biomedcentral.com)
Also, in the Cox regression analysis, Bazett's formula was better than Fridericia's and was identified as the best significant cardiac mortality predictor (Hazard ratio: 4.31, 95% CI 1.73-10.74, p value = 0.002). (biomedcentral.com)
Bazett's formula despite its poorest performance in mathematical methods, was the best one for cardiac mortality prediction. (biomedcentral.com)
Practically, it is suggested that physicians use QTcB for a better evaluation of cardiac mortality risk. (biomedcentral.com)

Prolonged QT interval is associated with life-threatening arrhythmias. (duke.edu)

After ischemia, endogenous orphanin (N/OFQ) plays a role in the development of arrhythmias. (bvsalud.org)
Specifically, the use of gap junction channel enhancers and inhibitors may help to reveal the precise role of gap junctions in the development of arrhythmias. (unideb.hu)

By measuring electrical activity in isolated single cardiac myocytes and in excised perfused intact hearts, we aim to better understand the processes underlying cardiac repolarization and their modulation in disease states. (bristol.ac.uk)
Epigenetic mechanisms and transcription factor networks essential for differentiation of cardiac myocytes have been uncovered. (nature.com)
Notably, cis -regulatory regions in cardiac myocytes are significantly enriched for cardiovascular disease-associated variants. (nature.com)
This study uncovers distinct layers of epigenetic regulation not only during prenatal development and postnatal maturation but also in diseased human cardiac myocytes. (nature.com)
the time constant of the exponential fit to terminal repolarization) was markedly prolonged in both myocytes and arterially perfused wedges from animals with HF. (usuhs.edu)
Overview of Arrhythmias The normal heart beats in a regular, coordinated way because electrical impulses generated and spread by myocytes with unique electrical properties trigger a sequence of organized myocardial. (msdmanuals.com)
Three distinct AP morphologies were used: human embryonic stem cell-derived cardiac myocyte (hES-CM) APs with a relatively slow upstroke and canine endocardial and epicardial ventricular myocytes with rapid upstrokes.Results: All three APs elicited both early and late INa. (unideb.hu)

2022 ) Transcriptional Dysregulation Underlies Both Monogenic Arrhythmia Syndrome and Common Modifiers of Cardiac Repolarization. (academictree.org)

Among potential risk factors, hypoglycaemia is proposed as a possible trigger of lethal arrhythmias. (bvsalud.org)

One of the causes of sudden cardiac death is arrhythmia after acute myocardial ischemia. (bvsalud.org)
It is discussed in this paper how nonpeptide orphanin receptor (ORL1) antagonists such as J-113397, SB-612111 and compound-24 (C-24) affect arrhythmia in rats following acute myocardial ischemia and what the optimal concentrations for these antagonists are. (bvsalud.org)
Prior to the VT/VF the early repolarization pattern may become more exaggerated and the VT/VF may be precipitated by an episode of myocardial ischemia. (msdmanuals.com)
BACKGROUND: Myocardial ischemia creates abnormal electrophysiological substrates that result in life-threatening ventricular arrhythmias. (ox.ac.uk)

The effects of omega3FA supplementation were studied in female rabbits to analyze whether their antiarrhythmic effects are due to a reduction of triangulation, reverse use-dependence, instability, and dispersion (TRIaD) of the cardiac action potential (TRIaD as a measure of proarrhythmic effects). (csic.es)
and reduced dofetilide-induced reverse use-dependence, instability of repolarization, and dispersion. (csic.es)
Background: The Tpeak - Tend interval, an electrocardiographic marker reflecting transmural dispersion of repolarization, has been used to predict ventricular tachycardia/fibrillation (VT/VF) and sudden cardiac death (SCD) in different clinical settings. (uea.ac.uk)
CONCLUSIONS: Although changes in myocardial repolarization dispersion resulting from localized ischemia are not reliably reflected in temporal indices derived from the 12-lead ECG, they can be readily identified with high-resolution torso ECG mapping. (ox.ac.uk)

A case of sudden cardiac arrest: is it truly idiopathic? (bmj.com)
We read with great interest the case of a sudden cardiac arrest associated with early repolarisation by Magapu and Newall. (bmj.com)
As a cardiac electrophysiologist, Deeptankar DeMazumder has worked for years with people at risk for sudden cardiac arrest (SCA). (nih.gov)

Two of the major goals in the treatment of this condition include reducing progression or recurrence of the arrhythmia and decreasing the risk of cardiovascular events, thereby improving quality of life and decreasing morbidity. (romanianjournalcardiology.ro)
This publication highlights that e-cigarette exposure may directly impact cardiovascular risk by affecting cardiac electrical stability and autonomic balance, and the magnitude and profile of impacts depends on the aerosol constituents. (emkatech.com)

The ventricular arrhythmias may cause palpitations, and/or cardiac arrest. (msdmanuals.com)
Apgar score 8) presented to the neurological ER after a syncopal event with cardiac arrest 2 h earlier, in the setting of sleep deprivation. (biomedcentral.com)

Recent myocardial infarction (within last 6 months), Uncontrolled congestive heart failure, Unstable angina (within last 6 months), Clinically significant (symptomatic) cardiac arrhythmias (e.g., sustained ventricular tachycardia, and clinically significant second or third degree AV block without a pacemaker. (childrenshospital.org)

It inhibits human cardiac sodium channels with rapid onset and offset kinetics and strong voltage dependence, consistent with other Class IB antiarrhythmic agents. (aesnet.org)

This project is examining the roles of the gonadal steroids in sex differences in ventricular repolarization and drug-induced pro-arrhythmia. (bristol.ac.uk)
Regulatory authorities have paid special attention to investigating the drug-induced delay of cardiac repolarization. (duke.edu)

Background: Several case reports have suggested an increased risk of sudden cardiac death due to energy drinks. (researchgate.net)
Before addressing the specific comments, I need to present the background of our work, which was the publication, in 2009, in the New England Journal of Medicine , of a retrospective cohort study 2 that indicated a significantly higher risk of sudden cardiac death among persons who had been prescribed antipsychotic drugs. (psychiatrist.com)
Atypical antipsychotic drugs and the risk of sudden cardiac death. (psychiatrist.com)
The risk of arrhythmia is higher when the early repolarization pattern is in the inferior leads, the lateral leads, or both. (msdmanuals.com)
Our case illustrates how long LQTS can masquerade convincingly as epilepsy and can be treated wrongly with AEDs, putting the patient at high risk of sudden cardiac death. (biomedcentral.com)
Inherited long QT syndrome (LQTS) is caused by mutations in ion channels that delay cardiac repolarization, increasing the risk of sudden death from ventricular arrhythmias. (johnshopkins.edu)
We investigated whether mutation-specific changes in I Ks function can predict cardiac risk in LQT1. (johnshopkins.edu)

With taurine, cardiac repolarization duration and ERP were significantly shortened. (researchgate.net)
ST-segment depression was significantly related to ventricular arrhythmia. (who.int)
In conclusion, pretreatment with the three antagonist groups can effectively reduce the concentration of TNF-α and IL-1ß, and the occurrence of arrhythmias after ischemia can also be significantly reduced. (bvsalud.org)

and detect QTc interval of which were attributed to various cardiac and QTdc changes during HD and ascertain causes and the rest to unknown causes [ 1 ]. (who.int)

Symptoms and consequences include palpitations, dizziness, lightheadedness (during shorter episodes), fainting (during longer episodes), and sudden cardiac death. (wikipedia.org)
Palpitations (or ' arrhythmias ') - feeling your heart beating too fast, too hard or like it is 'fluttering' - this is caused by abnormal heart rhythms. (cardiomyopathy.org)

The data analyses include an assessment of the association between arrhythmias and hypoglycaemia and hyperglycaemia, baseline clinical variables, and parameters related to kidney failure and the haemodialysis procedure. (bvsalud.org)
The patient has never been suspected LQTS because her normal routine 12 channel electrocardiograph (ECG) at early disease stage, until we caught clinical attacks during her initial visit to our emergency room (ER) and documented simultaneous cardiac arrhythmia. (biomedcentral.com)

An increase in the chance of arrhythmia was also detected in PEX without coronary artery disease. (scirp.org)
However, the detailed epigenetic processes involved in maturation from fetal to adult CMs and in cardiac disease leading to terminal heart failure have not been fully uncovered, yet. (nature.com)
It might be argued that blockade of the renin-angiotensin system may be a more effective strategy if performed earlier during the natural history of the disease or even before AF develops (ie, prima-ry prevention), since ACE inhibitors and ARBs may pre-vent, but not necessarily reverse, the electrical and structural remodelling that leads to the development and progression of the arrhythmia. (romanianjournalcardiology.ro)
Echocardiography showed normal systolic and diastolic left and right ventricular function and no evidence of intra-cardiac shunt or valvular disease. (rcjournal.com)

Reentrant, automatic, or triggered mechanisms may cause VA, just as these mechanisms cause supraventricular tachycardia (SVT) and other arrhythmias. (medscape.com)

Accordingly, these cardiac rhythm disturbances are labeled as MAs. (medscape.com)

At the cellular level, this wave of electrical activity corresponds to the sequential excitation of electrically coupled cardiac cells. (monash.edu)

Cardiac dysrhythmias can be induced by various triggers. (medscape.com)

Neurogenic disturbances and coronary microvascular derangements may also be implicated in cardiac alterations. (thecardiologyadvisor.com)

This leads to a further delay in repolarization and causes early afterdepolarization (EAD), the triggering event for torsade. (medscape.com)

Under some conditions, the normally-long action potentials of cardiac cells are extended even further by small oscillations called early afterdepolarizations (EADs) that can occur either during the plateau phase or repolarizing phase of the action potential. (monash.edu)

Despite the latest medical advances, less than 10 percent of individuals stricken with an SCA will survive this highly dangerous condition in which irregular heart rhythms, or arrhythmias, cause the heart suddenly to stop beating. (nih.gov)

Long QT syndrome (LQTS), especially LQTS type 2 (LQT2), frequently masquerades as seizures because of the transient cerebral hypoxia caused by ventricular arrhythmia. (biomedcentral.com)

Objective: Fast inward Na current (INa) carried by the voltage-gated Na channel (NaV1.5) is critical for action potential (AP) propagation and the rapid upstroke of the cardiac AP. (unideb.hu)

Here, we investigate the dynamics of the cardiac myocyte epigenome during development and in chronic heart failure. (nature.com)
We find that prenatal development and postnatal maturation are characterized by a cooperation of active CpG methylation and histone marks at cis -regulatory and genic regions to shape the cardiac myocyte transcriptome. (nature.com)

3,4 At supratherapeutic plasma concentrations, loperamide prolongs the QRS complex and slows repolarization of the ventricle. (pharmacytimes.com)
Moreover, suppression of I K1 prolongs repolarization and reduces postrepolarization refractoriness without marked effects on the overall AP duration. (usuhs.edu)

Repolarization of the cardiomyocytes occurs in phases 1-3, and is caused predominantly by the outward movement of potassium ions. (wikipedia.org)
The short-term beat-to-beat variability of cardiac action potential duration (SBVR) occurs as a random alteration of the ventricular repolarization duration. (unideb.hu)

Perform echocardiography and/or MRI, primarily to exclude arrhythmogenic right ventricular cardiomyopathy, as well as to assess for other potential causes of arrhythmias. (medscape.com)

Ultimately, development of reentry arrhythmias and fibrillation are associated post-MI. (unideb.hu)

Anatomy27

Organisms9

Diseases56

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment50

Phenomena and Processes28

Disciplines and Occupations2

Information Science4

Health Care13

Conduction11

Abnormalities6

Abnormality4

Atrial6

Depolarization6

Torsades de poin3

Electrocardiogram4

Syndromes4

Syncope4

Prolongation4

Early Repolarization Syndrome4

Association between repolarization2

Ventricular fibrillation2

Patients18

Mortality5

Life-threatening1

Development of arrhythmias2

Myocytes7

20221

Lethal arrhythmias1

Myocardial ischemia4

Dispersion4

Sudden cardia3

Cardiovascular2

Arrest2

Sustained ventricular1

Human cardiac1

Drug-induced2

Risk7

Significantly3

Interval1

Palpitations2

Clinical2

Disease4

Supraventricular1

Rhythm disturbances1

Coupled cardiac cells1

Triggers1

Coronary1

Torsade1

Action potentials1

Heart rhythms1

Long QT syndr1

Upstroke1

Myocyte2

Prolongs2

Occurs2

Cardiomyopathy1

Reentry1