Replication proteins replication factors. Medical search. Frequent questions

This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. (nih.gov)
Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)
A global analysis of DNA replication initiation in T. brucei showed that TbORC1 (subunit of the origin recognition complex, ORC) binding sites are located at the boundaries of transcription units. (umass.edu)
These are a protein annotated as a Replication Factor C subunit (Tb927.10.7990), and a protein of unknown function (Tb927.3.5370). (umass.edu)
Pan troglodytes replication factor C subunit 3 (RFC3), transcript variant X1, mRNA. (genscript.com)
Mammalian TFIIH basal transcription factor complex p62 subunit (GTF2H1). (embl.de)
Yeast RNA polymerase II transcription factor B 73kDa subunit (TFB1), the homologue of BTF2. (embl.de)
5% false discovery rate) between risk of MACE and eight proteins: matrix metalloproteinase (MMP)-12, IL-27 subunit α (IL-27a), kidney injury molecule (KIM)-1, fibroblast growth factor (FGF)-23, protein S100-A12, TNF receptor (TNFR)-1, TNFR-2 and TNF-related apoptosis-inducing ligand receptor (TRAIL-R)2. (springer.com)
DNA-protein kinase catalytic subunit (DNA-PKcs) also known as DNA-activated kinase is a nuclear 460-470 kD serine threonine kinase involved in double-stranded DNA break repair, VDJ recombination, and transcriptional modulation. (biolegend.com)

red, replication-associated genes. (cdc.gov)
Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. (lu.se)
DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
In hereditary nonpolyposis colorectal cancer (HNPCC), an inherited mutation in one of the DNA mismatch repair (MMR) genes appears to be a critical factor. (medscape.com)
MMR genes normally produce proteins that identify and correct sequence mismatches that may occur during DNA replication. (medscape.com)
While they contain their own genetic material, they don't carry all the genes or factors they need to live and reproduce. (cbinsights.com)
Within this group of upregulated genes with putative membrane -localized proteins , we identified several interferon -induced transmembrane protein (IFITM) genes , including several previously uncharacterized Ptm IFITM3-related genes . (bvsalud.org)

Genome-wide studies have provided evidence of the relationship between transcription and DNA replication timing. (umass.edu)
Over the past decade, genome-wide assays and new imaging approaches have enabled a greater understanding of how access to the genome is regulated by nucleosomes and associated proteins. (rockefeller.edu)
Inhibition of Geminin during the "S phase" (by RNAi) results in an additional round of replication of portions of the genome. (prospecbio.com)
The duplication of chromosomes and the regulation of their replication and repair requires dozens of proteins acting together to maintain the duplex DNA genome. (rockefeller.edu)
We have identified previously unknown epigenetic factors that specifically regulate replication timing in the euchromatin compartment of the genome in the S-phase. (riken.jp)
The molecular interactions involved in DNA replication insure coordinated replication of the entire genome once and only once per cell cycle. (nih.gov)
Since the Zika virus is missing certain molecules necessary for its reproduction, it has evolved to utilise a human enzyme called KAT5γ (an acetyltransferase) which helps the virus to amplify its RNA genome in viral replication complexes. (cbinsights.com)
Classification of viruses is principally according to their genome sequence taking into consideration nature and structure of their genome and their method of replication, but not according to the diseases they cause (see International Committee on Taxonomy of Viruses (ICTV), 2021 release ). (msdmanuals.com)

The lens epithelium-derived growth factor p75 (LEDGF/p75) is a chromatin-bound protein essential for efficient lentiviral integration. (elsevierpure.com)
Using protein-protein interaction assays, we demonstrated that LEDGF/p75 complexes with a chromatin-remodeling complex facilitates chromatin transcription (FACT), a heterodimer of the structure-specific recognition protein 1 (SSRP1) and the human homolog of suppressor of Ty 16 (hSpt16). (elsevierpure.com)
DNA is the substrate of many cellular processes including DNA replication, transcription and chromatin remodeling. (umass.edu)
We identified 410 proteins, including key DNA replication factors and proteins associated with transcription, chromatin organization, DNA repair and mRNA splicing. (umass.edu)
Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. (fishersci.com)
Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. (fishersci.com)
How the proteins that regulate these processes function in the context of chromatin and its dynamic architectures is an intensive field of study. (rockefeller.edu)
HMG-box domains are found in one or more copies in HMG-box proteins, which form a large, diverse family involved in the regulation of DNA-dependent processes such as transcription, replication, and strand repair, all of which require the bending and unwinding of chromatin. (embl.de)
Furthermore, AT-hook motifs are frequently associated with known functional domains seen in chromatin proteins and in DNA-binding proteins (e.g. histone folds, homeodomains and zinc fingers). (embl.de)
During licensing, which occurs in late mitosis and early G1, post-mitotic unreplicated chromatin binds several protein complexes. (nih.gov)

Click "Protein Details" for further information about the protein such as half-life, abundance, domains, domains shared with other proteins, protein sequence retrieval for various strains, physico-chemical properties, protein modification sites, and external identifiers for the protein. (yeastgenome.org)
Decreased expression of six RNA species was seen at various time points in all cell strains analyzed, these were: plasminogen activator (PLAT), centromere protein F (CPF), replication factor C (RFC3), thymidylate synthetase (TYMS), a putative mitotic checkpoint kinase (BUB1) and a gene of unknown function (GenBank accession number AI859865). (cdc.gov)
Macaque interferon-induced transmembrane proteins limit replication of SHIV strains in an Envelope-dependent manner. (bvsalud.org)

Protein metabolism denotes the various biochemical processes responsible for the synthesis of proteins and amino acids (anabolism), and the breakdown of proteins by catabolism. (wikipedia.org)
Offspring Study (total n=2874), to cross-sectionally study 242 cardiovascular disease-and metabolism-linked proteins in relation to FEV1, FVC (both % predicted) and FEV1/FVC ratio. (lu.se)

Histones play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. (fishersci.com)
Access to DNA is a prerequisite to the execution of essential cellular processes that include transcription, replication, chromosomal segregation, and DNA repair. (rockefeller.edu)
The AT-hook is a small DNA-binding protein motif which was first described in the high mobility group non-histone chromosomal protein HMG-I(Y). Since its discovery, this motif has been observed in other DNA-binding proteins from a wide range of organisms. (embl.de)
It is most interesting that this motif seems to be quite specific to known or predicted chromosomal/DNA-binding proteins, suggesting that it may act as a versatile minor groove tether. (embl.de)
His lab studies how the replisome interacts with DNA repair and cell cycle checkpoint machinery, how initiation of replication is directed by nucleosomes, and how replication forks perform nucleosome inheritance, the process by which nucleosomes (the fundamental structural unit of chromosomal DNA) are passed down from parental to daughter DNA during replication. (rockefeller.edu)

Our research aims to identify host factors that are important for influenza virus replication and spread, which could lead to the development of new antiviral strategies. (google.com)
The discovery of KAT5γ's critical role in virus replication is the key first step in beginning to design inhibitory molecules to stop viral replication and treat infection. (cbinsights.com)

J Med Chem 2005) and extended it to macromolecular complexes involving proteins and protein-RNA complexes beyond topoisomerases (Pommier et al. (cancer.gov)
This click chemistry reaction yields a stable covalent linkage, facilitating streptavidin capture of cross-linked biotinylated DNA-protein complexes. (umass.edu)
The team employs strategies such as super resolution microscopy to observe individual replisomes in real time during DNA replication in living cells, and cryo-electron microscopy of DNA-replisome and other replisome-associated complexes. (rockefeller.edu)
After replication, the protein complexes that form the licensing factor leave the DNA, and the DNA is not a substrate for further initiations. (nih.gov)

Dietary proteins are first broken down to individual amino acids by various enzymes and hydrochloric acid present in the gastrointestinal tract. (wikipedia.org)
Absorbed amino acids are typically used to create functional proteins, but may also be used to create energy. (wikipedia.org)
Protein anabolism is the process by which proteins are formed from amino acids. (wikipedia.org)
Proteins are made from amino acids. (wikipedia.org)
Transfer RNAs help assemble protein building blocks (amino acids) into functioning proteins. (medlineplus.gov)

H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. (fishersci.com)

Once the provirus is integrated into the host cell DNA, it is transcribed using typical cellular mechanisms to produce viral proteins and genetic material. (msdmanuals.com)

This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. (nih.gov)
The HMG family of proteins comprises members with multiple HMG domains that bind DNA with low sequence specificity, and members with single HMG domains that recognize specific nucleotide sequences. (embl.de)

GUG or UUG initiation is permitted in part by a simpler set of initiation factors than those found in eukaryotes. (k-state.edu)

Fatty acid-binding protein 4, fibroblast growth factor 21, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FVC and agouti-related protein, insulin-like growth factor-binding protein 2, paraoxonase 3 and receptor for advanced glycation end products were positively associated therewith. (lu.se)

Although recent studies in T. brucei indicate functional links among DNA replication and transcription, the underlying mechanisms remain unknown. (umass.edu)
Studies the molecular mechanisms of DNA replication, recombination, and repair. (rockefeller.edu)
O'Donnell's laboratory studies these DNA metabolic mechanisms with the goal of understanding how the protein gears of DNA duplication act together with signal processes that function with repair and recombination factors to ensure genomic integrity. (rockefeller.edu)
The Developmental Genetics Research Group studies epigenetic regulation of organ development and stem cell functions, mediated by Polycomb group (PcG) proteins and DNA methylation (5mC) mechanisms. (riken.jp)

The Courtney lab studies influenza A virus-host interactions with a focus on post-transcriptional regulation of viral RNA by host proteins. (google.com)
We are particularly interested in the role of host proteins in regulating viral gene expression, and how this affects the virus' ability to cause disease. (google.com)

Pharmacological inhibition of CypA rescues PKR from antagonism by HCV NS5A, leading to activation of an interferon regulatory factor-1 (IRF1)-driven cell intrinsic antiviral program that inhibits viral replication. (nih.gov)
[ 32 ] Inhibition of SAH indirectly inhibits transmethylation reactions required for viral replication. (medscape.com)
Geminin is a 25 kDa nuclear protein, which inhibits DNA replication and is degraded during the mitotic phase of the cell cycle. (prospecbio.com)
In addition, Geminin directly interacts with Six3 and Hox homeodomain proteins during embryogenesis and inhibits their functions. (prospecbio.com)

Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
This information is based on mapping of SMART genomic protein database to KEGG orthologous groups. (embl.de)
Some viruses have an outer envelope consisting of protein and lipid, surrounding a protein capsid complex with genomic RNA or DNA and sometimes enzymes needed for the first steps of viral replication. (msdmanuals.com)

We propose nucleosomes are assembled close to the replication fork followed by RNA pol II recruitment, transcription, and co-transcriptional RNA splicing. (umass.edu)

Proteins can be broken down by enzymes known as peptidases or can break down as a result of denaturation. (wikipedia.org)
Humans have many enzymes that ''tag'' proteins with other molecules allowing them to function properly. (cbinsights.com)

These sequences represent the protein coding region of the RFC3 cDNA ORF which is encoded by the open reading frame (ORF) sequence. (genscript.com)

Methods: Protein physical interactions were screened using the yeast two-hybrid system. (lu.se)
Protein-DNA interactions are involved in many fundamental biological processes essential for cellular function. (nature.com)
An analysis of the number of binding sites in the spatial context of the target site indicates that the interactions between binding sites next to each other are important for protein-DNA recognition and their binding ability. (nature.com)
High mobility group (HMG) box domains are involved in binding DNA, and may be involved in protein-protein interactions as well. (embl.de)
The molecular pathways involved in replication can be separated into 3 clear components: licensing, initiation, and regulatory interactions. (nih.gov)
These interactions, primarily through modifications of the phosphorylation status of proteins involved in licensing and initiation, determine whether replication will occur on a specific template during a specific time of the cell cycle. (nih.gov)

The existing antiviral regimens with interferon (IFN) and/or nucleoside/nucleotide analogs (NAs) can effectively suppress HBV replication, but do not significantly affect HBV cccDNA levels. (plos.org)
In contrast to the adapted SHIVs, the unadapted SHIVs have lower replication kinetics in macaque lymphocytes and are sensitive to type-1 interferon (IFN). (bvsalud.org)

Geminin controls replication by binding to the licensing factor Cdt1, and is involved in neural differentiation. (prospecbio.com)
During the "M phase" of the cell cycle (mitosis) Geminin stabilizes the replication factor Cdt1 promoting DNA replication during the next cell cycle. (prospecbio.com)
Moreover, inhibition of Geminin during mitosis (by RNAi) causes destabilization of Cdt1 protein and impairment of DNA replication during the next cell cycle. (prospecbio.com)

These studies can be expected to provide new insights into eukaryotic replication, repair, and epigenetic inheritance. (rockefeller.edu)
Our group also focuses on the broad link between epigenetic factors and DNA replication. (riken.jp)

They are typically trained from a set of input features, which can be generally divided into three categories: protein sequence information, protein structure information and a combination of the two categories. (nature.com)
Protein sequence information mainly consists of amino acid residue composition, biochemical features of amino acid residues and evolutionary information in terms of position-specific scoring matrices (PSSM). (nature.com)
Wang and his coworkers 12 investigated the discriminative power of three sequence features from protein sequence, including the side chain pKa value, the hydrophobicity index and the molecular mass of an amino acid. (nature.com)
Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information. (yeastgenome.org)
GenScript guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. (genscript.com)
Using pattern searches and position-dependent matrices, we have extracted the AT-hook motifs present in a non-redundant protein sequence database. (embl.de)
We have classified these motifs into three types according to their sequence similarity and have found that they are prevalent in many eukaryotic nuclear proteins in single or multiple copies. (embl.de)
Nucleosome-directed replication origin licensing independent of a consensus DNA sequence. (rockefeller.edu)

Functional characterizations demonstrate a LEDGF/p75-independent role of SSRP1 in the regulation of HIV-1 replication. (elsevierpure.com)
Therefore, a reliable identification of DNA-binding sites in DNA-binding protein is important for protein function annotation, in silico modeling of transcription regulation and site-directed mutagenesis. (nature.com)
Dr David Courtney is the Principal Investigator in the Courtney Group, and with a talented group of research scientists and students, we aim to answer fundamental questions on the importance of post-transcriptional regulation of RNAs during the viral replication cycle of influenza A RNAs in eukaryotic cells. (google.com)
Further co-factors of Nef that participate in CD4 down-regulation were discovered and were envisioned as potential therapeutic targets. (europa.eu)
The HBc protein may be an even more desirable target, as it plays important roles in multiple steps of the HBV life cycle , including viral capsid and virion assembly, regulation of cccDNA formation, and possibly cccDNA transcription and persistence. (plos.org)

It can be found associated with other domains such as the BTB domain or the U-box in multidomain proteins. (embl.de)
HMG-I(Y)] or as part of a multidomain protein [e.g. (embl.de)

Further studies are needed to determine how these processes are linked and co-regulated, and how rapidly they are initiated during DNA replication. (umass.edu)
Small RNAs include microRNA (miRNA), siRNA, tRFs, piRNA, and rasiRNAs, which regulate gene expression in a wide range of processes such as viral replication and host immune response. (hindawi.com)
miRNAs regulate gene expression in a wide range of physiological and pathological processes such as in immune response and viral replication [ 18 ]. (hindawi.com)

The transfer RNAs associated with progressive external ophthalmoplegia are present in mitochondria and help assemble the proteins that carry out the steps of oxidative phosphorylation. (medlineplus.gov)

Results Plasma fatty acid-binding protein 4, interleukin-1 receptor antagonist, interleukin-6 and leptin were negatively associated with FEV1 and paraoxonase 3 was positively associated therewith. (lu.se)

Research from O'Donnell's lab has provided an overview of how the replication machine, or replisome, functions in Escherichia coli , yeast, and humans. (rockefeller.edu)

Here, we show that hepatitis C virus (HCV) co-opts the host protein CypA to aid evasion of antiviral responses dependent on the effector protein kinase R (PKR). (nih.gov)

Collectively, our study identifies a novel antiviral mechanism that harnesses cellular antiviral immunity to suppress viral replication. (nih.gov)

Multiomics Analysis of Endocytosis upon HBV Infection and Identification of SCAMP1 as a Novel Host Restriction Factor against HBV Replication. (nih.gov)
The Smc5/6 complex acts as a restriction factor of HBV transcription. (plos.org)

The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. (nih.gov)

Methylated CpGs, that are not bound by PcG proteins, are substrates of DNA methylation machinery. (riken.jp)
Initiation of DNA replication, occurring throughout S-phase, requires binding of additional factors that recruit the components of the replication machinery. (nih.gov)

It is conceivable that inhibition of HBx protein may result in suppression of HBV transcription and replication . (plos.org)
In order to identify the IFN-induced host factor(s) that could contribute to the inhibition of SHIVs in macaque lymphocytes , we measured IFN-induced gene expression in immortalized pig-tailed macaque (Ptm) lymphocytes using RNA-Seq . (bvsalud.org)

Additionally, we characterized two proteins from our iPOND-derived protein list (Chapter 3). (umass.edu)
Additionally, it is also found in several hypothetical proteins. (embl.de)

SCOPe: Structural Classification of Proteins - extended. (berkeley.edu)

DNA-PKcs is modified by phosphorylation and has been shown to interact with Ku70/Ku80, KIP, DNA-ligase IV, and XRCC4 proteins. (biolegend.com)

Two potent small molecules capable of disrupting the association of Nef with SH3 protein domains were identified and their chemical structures were used as models to generate additional inhibitors. (europa.eu)
We are now elucidating novel molecules that function upstream of NP95-DNMT1, and couple DNA replication with maintenance methylation in mammalian cells. (riken.jp)

Transcription is regulated in the cell via transcription factors. (wikipedia.org)
Nucleoside analogue inhibitors of the cell-encoded enzyme S-adenosylhomocysteine hydrolase (SAH) have been shown to inhibit Zaire ebolavirus replication in adult BALB/c mice infected with mouse-adapted Ebola virus. (medscape.com)
MCM2 (also called CDCL1, mitotin and BM28), is a human nuclear protein that is crucial in the cell cycle, being involved in the onset of DNA replication and cell division. (thermofisher.com)
Geminin has 2 roles in 2 different stages of the cell cycle: Geminin is a negative regulator of DNA replication during the "S phase" of the cell cycle. (prospecbio.com)
Defects in the control of cell proliferation are a hallmark of cancer, and DNA replication is a key process for cell proliferation. (aacrjournals.org)
To take control of the infected host cell, the Zika virus, for example, hijacks several proteins inside the cell for its efficient replication. (cbinsights.com)

According to these previous findings, the structural and functional configuration of the Hadza gut microbiota is well aligned with the dietary and environmental factors characteristic of their foraging lifestyle, supporting the importance of microbiota as an evolutionary legacy that provides specific adaptive versatility to disparate human subsistence and environmental occupation. (frontiersin.org)
These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. (nih.gov)
These findings suggest that restriction factors including IFITMs vary in their potency against different SHIV variants and may play a role in selecting for viruses that adapt to species-specific restriction factors. (bvsalud.org)

Several experimental techniques have been proposed to identify the DNA-binding sites and investigate the interaction modes between proteins and DNAs. (nature.com)
They apply molecular- and cellular-based methods to investigate the proteins that control viral DNA replication and the environmental chemicals and stressors that promote virus reactivation. (nccu.edu)

The steps of protein synthesis include transcription, translation, and post translational modifications. (wikipedia.org)

It is inherited as an autosomal dominant syndrome as a result of defective mismatch repair (MMR) proteins. (medscape.com)

Please note that proteins can be included in multiple pathways, ie. (embl.de)

This study assessed 80 cardiovascular and inflammatory proteins for biomarker discovery and prediction of MACE in type 2 diabetes. (springer.com)
We combined data from six prospective epidemiological studies of 30-77-year-old individuals with type 2 diabetes in whom 80 circulating proteins were measured by proximity extension assay. (springer.com)
We identified eight protein biomarkers, four of which are novel, for risk of MACE in community residents with type 2 diabetes, and found improved risk prediction by combining multiplex proteomics with an established risk model. (springer.com)
Diabetes is one of the strongest risk factors for MACE [ 3 ], and one major treatment goal in type 2 diabetes is to prevent MACE. (springer.com)

HMG domain proteins: architectural elements in the assembly of nucleoprotein structures. (embl.de)

The HIV-1 Envelope (Env) in the chimeric virus determines both the reduced replication and the IFN- sensitivity differences. (bvsalud.org)

Increased levels of several inflammatory and cardiovascular disease-related plasma proteins have been associated with impaired lung function. (lu.se)

Although its role in HIV-1 integration is clearly established, the role of LEDGF/p75-associated proteins in HIV-1 infection remains unexplored. (elsevierpure.com)
Together, our data demonstrate for the first time the association of LEDGF proteins with the FACT complex and give further support to a role of SSRP1 in HIV-1 infection. (elsevierpure.com)
Although current medication can inhibit the infection of cells almost completely, potential side-effects coupled with residual expression and replication of the virus prohibits patients from reaching a normal life expectancy. (europa.eu)

ever, shop cellular factors of human keine at new sensor had been by new pieces. (tanganyikawildernesscamps.com)
We applied an assay that measures the stability of maintenance of an episomal plasmid in human tissue culture cells to screen for new DNA replication factors. (aacrjournals.org)
Understanding how DNA replication is regulated in human cells can provide insight into cancer development and may reveal vulnerabilities that can be exploited therapeutically. (aacrjournals.org)
Human proteins dont change rapidly, explains the studys second author Cindy Chiang from Cleveland Clinic, US.Targeting the hosts KAT5 protein should be much more effective in the long term to treat these viruses, Chiang said.The study suggests that creating drugs targeting the human KAT5 enzyme might help target not only Zika but also several other mosquito-transmitted flaviviruses. (cbinsights.com)
Human proteins don't change rapidly,'' explains the study's second author Cindy Chiang from Cleveland Clinic, US. (cbinsights.com)

Anatomy7

Organisms9

Diseases1

Chemicals and Drugs57

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes36

Information Science3

Health Care1

Subunit10

Genes7

Genome8

Chromatin10

Strains3

Metabolism2

Chromosomal5

Virus Replication2

Complexes4

Amino acids5

Binds1

Viral Proteins1

Family of proteins2

Initiation factors1

Fibroblast growth1

Mechanisms4

Host proteins2

Inhibits4

Genomic3

Nucleosomes1

Enzymes2

RFC31

Interactions6

Interferon2

Cdt13

Epigenetic2

Sequence8

Regulation5

Multidomain2

Processes3

RNAs1

Receptor1

Humans1

Hepatitis C vir1

Suppress1

Restriction Factor2

Mitochondrial1

Machinery2

Inhibition2

Additionally2

CLASSIFICATION1

Phosphorylation1

Molecules2

Cell6

Findings3

Investigate2

Include transcription1

Repair1

Pathways1

Type4

Structures1

Sensitivity1

Inflammatory1

Infection3

Human5