• polymerase
  • Expression of mutant RPA2 or loss of PALB2 expression led to significant DNA damage after replication stress, a defect accentuated by poly-ADP (adenosine diphosphate) ribose polymerase inhibitors. (nih.gov)
  • UNG2
  • The authors show that Vpr can form a trimolecular complex with UNG2 and RPA32 and the positive effect of UNG2 and RPA32 on the reverse transcription process leading to optimal virus replication and dissemination between the primary target cells of HIV-1. (nih.gov)
  • Data show that the R88C variant impairs binding of the R88C variant impairs binding of uracil-DNA glycosylase UNG2 to replication protein A RPA2. (nih.gov)
  • metabolism
  • It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. (nih.gov)