Replication junctions cell cycle. Medical search. Frequent questions

Accumulation of adequate amounts of viral proteins within infected cells through viral transcription and subsequent translation potentiate the onset of viral replicative cycle. (wikipedia.org)
Dhar, S.K . Functional characterization of replication origin ( oric ) & replication proteins of Helicobacter pylori . (jnu.ac.in)
Proteome analyses revealed a high abundance of lysosomal enzymes and lysosome-associated proteins in cancer cells treated with TGFβ-1 and E64d. (biomedcentral.com)
Initially the arrest is due to lack of sufficient cell cycle proteins to allow meiotic progression. (wikipedia.org)
[7] The cells that comprise the follicle, known as granulosa cells, are connected to each other by proteins known as gap junctions, that allow small molecules to pass between the cells. (wikipedia.org)
The recently developed HCV cell culture system, based on the JFH1 strain of HCV, has provided an opportunity to study the role of the viral proteins in the complete HCV replication cycle in human hepatoma cells. (monash.edu)
How the viral proteins functionally interact during replication of HCV in cell culture is not completely understood. (monash.edu)
Using this approach, the functional interactions of p7 and E2 with other viral proteins during HCV replication was investigated. (monash.edu)
To investigate the emergence of compensatory mutations in the viral proteins during cell passaging, the consensus sequences of the entire polyprotein coding regions of the wild type JFH1 and three chimeric viruses were determined. (monash.edu)
Cell lysates had been resolved by SDS-PAGE, and proteins had been electro transferred to polyvinylidene fluoride membranes (Millipore, USA). (rockinhibitor.com)
Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. (cipsm.de)
The presence of replication stress activates the DNA damage response and downstream checkpoint proteins including ataxia telangiectasia and Rad3 related kinase (ATR), checkpoint kinase 1 (CHK1), and WEE1-like protein kinase (WEE1), which trigger cell cycle arrest while protecting and restoring stalled replication forks. (bmj.com)
Each origin is initiated by a combination of regulatory proteins that prepare the chromatin for replication before synthesis (S)-phase entry. (bmj.com)
Any obstacles encountered by cells in this process can lead to 'replicative stress' ( Figure 1 ), 1 which may be overcome by replicative stress response proteins, but deficiencies in this response result in accumulated errors in DNA replication and loss of genomic integrity, which lead to cell death. (bmj.com)
Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion. (idrblab.net)
Moreover, they infect cells with viruses, or express individual viral proteins, to follow the virus's actions and the host cell response. (the-scientist.com)
Migration and proliferation of parenchymal and connective tissue cellsBasement membrane crucial to wound healing: collagen in the bm binds to cells via proteins like integrins, fibronectin and laminin. (medicinembbs.org)
We have recently shown that the replication of rhinovirus, poliovirus and foot-and-mouth disease virus requires the co-translational N-myristoylation of viral proteins by human host cell N-myristoyltransferases (NMTs), and is inhibited by treatment with IMP-1088, an ultrapotent small molecule NMT inhibitor. (cdc.gov)

Here we show that SMX tri-nuclease is more active than the three individual nucleases, efficiently cleaving replication forks and recombination intermediates. (figshare.com)

The efficient removal of replication and recombination intermediates is essential for the maintenance of genome stability. (figshare.com)
The BLM helicase is central to the repair of both collapsed DNA replication forks and double strand DNA breaks by homologous recombination. (biomedcentral.com)
Homologous recombination (HR) is a major DNA repair pathway that may be employed for the repair of double-strand DNA breaks (DSBs) during S and G2 of the cell cycle [ 2 ]. (biomedcentral.com)
Although a Holliday junction-resolving activity would also be expected to play a role in the recombination induced by poxvirus infection, the appearance of the activity described here only after the commencement of viral late protein synthesis suggests that it functions strictly at late times. (ox.ac.uk)
The two most commonly used pathways to repair DSBs in higher eukaryotes include non-homologous end joining (NHEJ) and homologous recombination (HR). NHEJ is considered to be error-prone, intrinsically mutagenic quick fix remedy to seal together the broken DNA ends and restart replication. (springeropen.com)
DSBs not only ensue from normal cellular metabolism, in the form of reactive oxygen species that can oxidize DNA bases [ 1 , 2 ], but can also be generated during physiological processes like chromosome replication, meiotic recombination and DNA replication transcription collision [ 3 - 7 ]. (springeropen.com)
Cells have evolved with conserved recombination mediated genome editing pathways as a mean for repairing DSBs and restarting replication forks, thus allowing genome duplication to continue [ 8 ]. (springeropen.com)

Interestingly, E64d caused lysosomal accumulation of Jam-a, a tight junction component facilitating epithelial cell-cell adhesion. (biomedcentral.com)
TGFβ-1 induced morphological and functional changes of cells are the result of substantial gene regulation and protein alterations leading to: loss of epithelial cell-cell adhesion and apical-basolateral polarity, change of differentiation markers, acquisition of fibroblastoid shape, reversion of intermediate filaments, gain of cell motility and increased extracellular proteolysis [ 3 ]. (biomedcentral.com)
The laboratories of Dr. Bhattacharyya and Dr. Dalal study the biogenesis and size and copy control mechanisms of organelles such as the Golgi complex, the endoplasmic reticulum, the nucleus, the centrosome and the cell-cell adhesion junction the desmosome. (actrec.gov.in)

High-risk groups had significant involvement of the cell cycle, DNA replication, adherens junction, actin cytoskeleton regulation, pathways in cancer, and TGF-β signaling pathways. (aging-us.com)

SMX formation activates MUS81-EME1 for replication fork and flap structure cleavage by relaxing substrate specificity. (figshare.com)
The remodelling of duplex DNA, as well as the migration of fork and Holliday junctions, is a central requirement of HR and is achieved by a number of DNA helicases. (biomedcentral.com)
BLM is also thought to be required for the restart of stalled replication forks, where it is proposed to stimulate fork regression and Holliday junction formation [ 12 ]. (biomedcentral.com)
SMC5/6 is required for replication fork stability and faithful chromosome segregation during neurogenesis. (nih.gov)
The replication fork moves along the parental DNA strand so that there is a continuous unwinding of the parental strands. (elucidate.org.au)
Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. (idrblab.net)

The precise mechanism underlying the switch in polymerase function during viral replication remains unknown. (wikipedia.org)
The process of continuous cycles of viral infection, integration, and production from target cells is referred to here as viral replication. (biomedcentral.com)
In HHV-1 and HHV-2 oral infections, viral replication within the oral epithelium may cause lysis of epithelial cells, with vesicle formation. (medscape.com)

Metabolic disorders: diabetes type 2, cardiovascular diseases, steroid/nuclear- receptors in health and diseases, diseases associated with cell - cell junctions, neurodegenerative disorders. (jnu.ac.in)
Luteinizing hormone acts on receptors in the outer layers of granulosa cells of the follicle, causing a decrease in cyclic GMP in the granulosa cells. (wikipedia.org)
The HCV glycoproteins E1 and E2 are present on the surface of virions as a heterodimer that attach virions to host cell receptors and facilitate virus fusion and entry. (monash.edu)
The initial event in the replicative cycle of a virus is its interaction with receptors present on the surface of a cell. (medscape.com)

The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Functional and pathway enrichment analysis showed that up-regulated genes were significantly involved in cell cycle, oocyte meiosis, DNA replication and p53 signaling pathway, while down-regulated genes were enriched in Huntington's disease,metabolic pathways. (oncotarget.com)
Maintaining genomic integrity is of utmost importance to eukaryotic cells, which have evolved sophisticated mechanisms to ensure speed, accuracy, and an adequate pool of nucleotide and replication factors as well as high-fidelity repair pathways to correct errors occurring during DNA replication. (bmj.com)
Our results provide an evolutionary perspective on H3.3's conserved role in maintaining the transcriptional landscape of cells and on the emergence of specialized chromatin assembly pathways. (biomedcentral.com)

In this phase, same L protein acts as a replicase and ignore the gene junctions to generate a polycistronic anti-genomic analogue that acts as a template for further rounds of replication to generate many more copies of the genome RNA. (wikipedia.org)
Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)
Here, we report that odorant-binding protein (OBP2A) released from tumors in remission during ADT catches survival factors, such as CXCL15/IL8, to promote PCa cell androgen-independent growth and enhance the infiltration of myeloid-derived suppressor cells (MDSCs) into tumor microenvironment, leading to the emergence of castration resistance. (bvsalud.org)
A small protein of 63 amino acids, p7 is encoded at the junction of the structural and non-strucutural region. (monash.edu)
Since the protein plays a critical role in the virus life cycle, chemical compounds that block p7 function are potential candidates for anti-viral therapy. (monash.edu)
hSSB1 is a critical DNA repair protein functioning in the repair and signalling of stalled DNA replication forks, double strand DNA breaks and oxidised DNA lesions. (biomedcentral.com)
We show that hSSB1 depleted cells contain less BLM protein and that this deficiency is due to proteasome mediated degradation of BLM. (biomedcentral.com)
Our data highlights that BLM helicase and hSSB1 function in a dynamic complex in cells and that this complex is likely required for BLM protein stability and function. (biomedcentral.com)
Bloom syndrome protein (BLM), a member of the RecQ family of helicases, is one such enzyme, with roles in HR, as well as telomere maintenance and replication [ 8 , 9 ]. (biomedcentral.com)
These can be subdivided into the "simple SSBs", which are composed of one polypeptide, as well as the higher-order "replication protein A (RPA)"-like SSBs [ 15 ]. (biomedcentral.com)
Cloned versions of the Shope fibroma virus (SFV) replicated telomere in the inverted repeat configuration were used as substrates to assay lysates from poxvirus-infected cells for protein fractions that participate in the resolution of the circular substrate plasmid into a linear minichromosome with viral hairpin termini. (ox.ac.uk)
An activity in a crude protein fraction obtained from vaccinia virus-infected cells at late times during the replicative cycle was capable of accurately resolving all poxviral inverted repeat replicative intermediates tested. (ox.ac.uk)
The origin recognition complex (ORC) was originally identified in the yeast Saccharomyces cerevisiae as a protein that specifically binds to origins of DNA replication. (embl.de)
Because of its central role in cell division and DNA repair, the ATM protein is of great interest in cancer research. (diff.org)
protein allows mutations to accumulate in other genes, which may cause cells to grow and divide in an uncontrolled way. (diff.org)
Cells that are missing one copy of the ATM gene produce half the normal amount of ATM protein. (diff.org)
Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. (idrblab.net)
Embryos fluorescently stained for both RNA (red) and protein (cyan) products of the gap genes Krüppel are shown at early (A), mid (B) and late (C) cleavage cycle 14A during the blastoderm stage of Drosophila development. (drosophila-images.org)

Consequently, there is a defect in recruitment of BLM to chromatin in response to ionising radiation-induced DSBs and to hydroxyurea-induced stalled and collapsed replication forks. (biomedcentral.com)
The regulation of DNA repair by the cell cycle is largely the result of chromatin alterations that happen through DNA replication, compression, and dissociation that permit cells to divide effectively [8]. (rockinhibitor.com)
Our results indicate that Cac2 and Hir1 have distinct localization patterns during different stages of the Tetrahymena life cycle and suggest that Cac2 might be dispensable for chromatin assembly. (biomedcentral.com)
In most eukaryotes, two classes of histones have been described: (1) replicative or canonical histones, expressed only during the S phase of the cell cycle, which are assembled onto chromatin in a DNA replication-dependent (RD) manner, and (2) variant histones, which differ in their primary amino acid sequences, are expressed throughout the cell cycle, and can be deposited in a replication-independent (RI) fashion [ 2 ]. (biomedcentral.com)

Maintenance of genome stability is critical in human cells. (biomedcentral.com)
Within the context of DNA double-strand breaks, MUS81 maintainshttp://jcancer.orgJournal of Cancer 2019, Vol.genome stability by forming a heterodimer with Eme1/Mms4 and resolving the Holliday junction (HJ) [6]. (rockinhibitor.com)
We examine the impact that processes such as transcription and replication have on genome stability. (birmingham.ac.uk)

Cell cycle-dependent formation and activation of this tri-nuclease complex provides a unique mechanism by which cells ensure chromosome segregation and preserve genome integrity. (figshare.com)
Genomic stability relies around the precise execution of DNA replication, chromosome segregation, DNA repair and genomic monitoring mechanisms, and their integration with cell cycle progression and also other processes. (rockinhibitor.com)

Passage of cell cultures transfected with HCV genomic RNA containing attenuating mutations allows for the selection of genomes with second site compensatory mutations that restore replication to wild type levels. (monash.edu)
Maintenance of genomic stability is crucial for standard development, cell homeostasis and tumor suppression [7]. (rockinhibitor.com)
DSBs are cytotoxic lesions, which if left unrepaired could lead to genomic instability, cancer and even cell death. (springeropen.com)

This group focuses on the cell biology of normal and tumor cells and how these differences can explain tumor progression and possibly identify potential targets for therapeutic intervention. (actrec.gov.in)
The objectives of these studies are to provide novel insights into how the cell regulates organelle size and number, how these mechanisms are altered in tumor cells and the subsequent consequences for tumor progression. (actrec.gov.in)
The laboratories of Dr. Dalal, Dr. Hasan and Dr. Teni study cell cycle progression and checkpoint control. (actrec.gov.in)
Conditional mutation of Smc5 in mouse embryonic stem cells perturbs condensin localization and mitotic progression. (nih.gov)
In the presence of errors or damage during DNA replication, cell cycle checkpoint nodes and repair machinery work in concert to retard cell cycle progression until sufficient repair has been achieved. (bmj.com)

Oocyte meiosis, important to all animal life cycles yet unlike all other instances of animal cell division, occurs completely without the aid of spindle -coordinating centrosomes . (wikipedia.org)

Within SMX, SLX4 co-ordinates the SLX1 and MUS81-EME1 nucleases for Holliday junction resolution, in a reaction stimulated by XPF-ERCC1. (figshare.com)
Enzymatic processing of the intervening junctions (Holliday junctions) subsequently yields two intact dsDNA strands. (biomedcentral.com)
In addition, BLM is required for the dissolution of double Holliday junctions, during the later stages of HR [ 11 ]. (biomedcentral.com)
Here, BLM is able to converge both Holliday junctions into a hemi-catenane structure, which is subsequently cleaved by its binding partner TOPIIIα, generating two non-crossover products [ 11 ]. (biomedcentral.com)
In vitro resolution of poxvirus replicative intermediates into linear minichromosomes with hairpin termini by a virally induced Holliday junction endonuclease. (ox.ac.uk)
The resolving activity that we have identified is specific to virus-infected cells at late times during replication and cleaves cloned poxviral telomeric substrates in a fashion expected of a classic Holliday junction-resolving enzyme in addition to possessing a telomere resolution target-specific nicking activity. (ox.ac.uk)
Other non-viral Holliday junction analogs can also be cleaved by this extract, suggesting that this component of the resolution activity may also play a role in other viral processes that require cleavage of a branched DNA structure. (ox.ac.uk)

Interestingly, replication stress in Brca2-null cells activates p53 and the expression of its target genes, including senescence-inducing Ink4/Arf. (biomedcentral.com)
Along with SIRT1, AMPK activates the biogenesis of new mitochondria to enable the cell to generate more energy. (totalhealthmagazine.com)

The purpose of the SCMM is to foster research in the field of molecular and cell biology with direct application to the study of human diseases. (jnu.ac.in)
Recent advances in molecular and cell biology have enormous potential for medical research and practice. (jnu.ac.in)
A number of research groups have contributed significantly to research and teaching programs in the areas of molecular cell biology along with interdisciplinary areas such as, bioinformatics and computer sciences, environmental sciences and physical sciences. (jnu.ac.in)
Programme Support on Molecular Parasitology" to work on the project entitled "Characterization of DNA replication and non-replication function of two putative homologues of Plasmodium falciparum Origin Recognition Complex" Department of Biotechnology (DBT) (2011-2016). (jnu.ac.in)
Hallmarks of EMT were analyzed by molecular- and cell-biologic analyses including real-time cell migration/invasion assays. (biomedcentral.com)
Viruses have the advantage of self-replication over molecular tracers. (2bscientific.com)
Eukaryotic cells can rapidly adjust their transcriptional profile in response to molecular needs. (biomedcentral.com)

In eukaryotic cells, the chromosomes gain a sister chromatid and become double-stranded. (elucidate.org.au)
in DNA strands also occur naturally when chromosomes exchange genetic material during cell division. (diff.org)

We found that Dusp4 loss alone is insufficient in mediating tumorigenesis, but alternatively converges with loss in Trp53 and MYC amplification to induce tumorigenesis primarily through chromosome 5 amplification, which specifically upregulates Dbf4 , a cell cycle gene that promotes cellular replication by mediating cell cycle checkpoint escape. (biomedcentral.com)

DUSP4 alterations lead to hyperactivation of MAPK signaling in many cancers, including breast cancer, which often harbor mutations in cell cycle checkpoint genes, particularly in TP53. (biomedcentral.com)
Dhar S . K. Functional analysis of replication and cell cycle regulated genes in Plasmodium falciparum The Wellcome Trust, UK (2003-08). (jnu.ac.in)
STARD12 co-expressed genes participated in cell cycle and DNA replication, and STARD14 were enriched in ECM-receptor interaction. (medsci.org)

The studies on checkpoint control have identified a mechanism by which entry into mitosis is regulated in response to incomplete DNA replication and DNA damage and the identification of a potential target for therapeutic intervention. (actrec.gov.in)
additionally, at the finish of mitosis, CyclinB1 is prompted to degrade the complex, enabling cells to complete the replication cycle [10]. (rockinhibitor.com)
This process occurs during the S (synthesis) phase of the cell cycle and occurs in preparation for mitosis and meiosis. (elucidate.org.au)
24 hrs: neutrophils infiltrate, clot formation, increases mitosis in the basal cells which deposit new basement membrane and meet in the midline beneath the clot. (medicinembbs.org)

Patients with low risk scores had a higher abundance of immune cells and stromal cells around the tumor. (aging-us.com)
The first critical step of cancer cells leaving a solid tumor is the loss of epithelial integrity and the gain of migratory and invasive capabilities. (biomedcentral.com)
The laboratories of Dr. Teni and Dr. Dalal study therapy resistance in oral, cervical and colorectal cancers with an emphasis on how tumor cells acquire resistance to radiation and commonly used chemotherapeutic agents and determining whether these can serve as targets for therapeutic intervention or prognostic markers that can predict the choice of therapy. (actrec.gov.in)

Meiosis begins with DNA replication and meiotic crossing over. (wikipedia.org)
[5] Because the granulosa cells and oocyte are connected by gap junctions, cyclic GMP also decreases in the oocyte, causing meiosis to resume. (wikipedia.org)

B cells are therefore particularly dependent on 'quality control' mechanisms to oversee antibody production. (cipsm.de)
Our research is defining the normal mechanisms of DNA replication and repair, with the aim of understanding how it is deregulated in cancer cells. (birmingham.ac.uk)

Gene set enrichment analysis showed that samples from low-risk group were more active in the IgA production in intestinal immune network and the T and B cell receptor signaling pathway. (aging-us.com)

This study identifies a novel mechanism for breast tumorigenesis implicating Dusp4 loss and p53 mutations in cellular acquisition of Dbf4 upregulation as a driver of cellular replication and cell cycle checkpoint escape. (biomedcentral.com)
We find that together with loss-of-function mutations in p53 and, to some degree, potentiated by cMyc overexpression, Dusp4 deletion aids in cell cycle checkpoint escape while simultaneously potentiating hallmarks of replicative stress, including multinucleation and Chk1 phosphorylation. (biomedcentral.com)
disorder have mutations in both copies of the ATM gene in each cell. (diff.org)
To this day, many low dose radiation carcinogenesis studies assume that the probability that one cell of a multicellular organism will acquire multiple mutations transforming it into cancer and the ability of that cancer to thrive can be described by a curve plotted against an axis that shows total radiation dose. (cdc.gov)

Strategies that increase replicative stress while lowering cell cycle checkpoint thresholds may allow unrepaired DNA damage to be inappropriately carried forward in replicating cells, leading to mitotic catastrophe and cell death. (bmj.com)

Plasmodium falciparum biology and cell cycle regulation, hepatitis C, Leishmaniasis, Helicobactor pathogenesis & DNA replication, Candidiasis, bacterial biofilms, pathobiology of innate immune dysfunctions, modulation of cell- cell junctions by pathogens. (jnu.ac.in)

Oogenesis in Eukaryotic Cells. (wikipedia.org)

[ 5 , 6 ] In a localized primary infection, the virus penetrates the mucosal epithelium and invades the cells of the basal layer, where the viral DNA inserts into the host DNA. (medscape.com)
cells are the most sensitive cell type of this epithelium. (cdc.gov)

DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)
As a structure-specific endonuclease, MUS81 is involved in cell cycle regulation and regulates the DNA damage repair approach. (rockinhibitor.com)
We hypothesized that IL-22 regulation would occur at the interface between cancer cells and immune cells. (cipsm.de)

The intermittent but prolonged detection of this replication-defective HIV variant in the patient′s plasma among other viral populations strongly suggests that this variant is released from highly stable productively infected cells present in vivo during therapy. (biomedcentral.com)
Crucially for virologists, cell lines tend to mount an abnormal immune response, so they may not defend themselves against viruses as cells would in vivo. (the-scientist.com)
Primary cells look and act more like cells in vivo, but have their own complications. (the-scientist.com)

Failure to repair DSBs can lead to unwanted consequences, such as loss of genetic information, chromosomal rearrangements and even cell death. (springeropen.com)
DNA replication is a semi-conservative process , and the two daughter molecules contain exact copies of the genetic material in the parent molecule. (elucidate.org.au)

In eukaryotes, DNA polymerase δ (Pol δ) bound to the proliferating cell nuclear antigen (PCNA) replicates the lagging strand and cooperates with flap endonuclease 1 (FEN1) to process the Okazaki fragments for their ligation. (nature.com)

12 ] found that the lncRNA FAM207BP facilitated LUAD cell proliferation, migration, and invasion. (aging-us.com)

Protease inhibition did not affect invasion of TGFβ-1 treated normal mammary epithelial cells, but reduced the invasion of murine breast cancer cells. (biomedcentral.com)
Inhibition of vaccinia virus L1 N-myristoylation by the host N-myristoyltransferase inhibitor IMP-1088 generates non-infectious virions defective in cell entry. (cdc.gov)

The intergenotypic chimeric genome was nonviable in human hepatoma cells and infectious chimeric virions were only produced after cells harboring the chimeric genomes were passaged several times. (monash.edu)
There are several reasons virologists culture cells, says Marshall Bloom , associate director for science management at Rocky Mountain Laboratories, a division of NIH's National Institute of Allergy and Infectious Diseases located in Hamilton, Mon-tana. (the-scientist.com)
Cell cultures have played a critical role in modern infectious disease research, particularly in the area of viruses and the expression of viral gene products," Bloom says. (the-scientist.com)

Depletion of SMC5/6 sensitizes male germ cells to DNA damage. (nih.gov)

Maintenance of meiotic arrest also depends on the presence of a multilayered complex of cells, known as a follicle, that surrounds the oocyte. (wikipedia.org)

pombe origins of replication, which differ significantly from those of Sa. (embl.de)
Importantly, we observed that loss of N-myristoylation resulted in greatly reduced infectivity of assembled mature virus particles, characterized by significantly reduced host cell entry and a decline in membrane fusion activity of progeny virus. (cdc.gov)
Data from long concluded experiments with moderate and high doses of radiation delivered by internal emitters were significantly re-interpreted because the length of the cell cycle was used as one of the variables in the analysis. (cdc.gov)

Small molecule inhibitors designed to target the DNA damage sensors, such as inhibitors of ataxia telangiectasia-mutated (ATM), ATR, CHK1 and WEE1, impair smooth cell cycle modulation and disrupt efficient DNA repair, or a combination of the above, have demonstrated interesting monotherapy and combinatorial activity, including the potential to reverse drug resistance and have entered developmental pipelines. (bmj.com)

Here we showed that deletion of Roquin-encoding alleles specifically in regulatory T (Treg) cells also caused the activation of conventional T cells. (cipsm.de)

Given the previously reported role of DUSP4 as a p53 target, a potential cell cycle checkpoint, and in mediating senescence downstream of replication stress, we hypothesized that DUSP4 may be a critical oncogenic driver in breast cancer. (biomedcentral.com)

Melanoma biopsies with high densities of CD16+ macrophages contained upregulated gene expression of critical T-cell recruiting chemokines (CXCL9, CXCL10, and CXCL11). (bvsalud.org)
Treatment with NMT inhibitor IMP-1088 potently abrogated VACV infection, while VACV gene expression, DNA replication, morphogenesis and EV formation remained unaffected. (cdc.gov)

Although ORC appears to play an essential role in the initiation of DNA replication in the cells of all eukaryotes, its interactions with DNA have not been defined in species other than budding yeast. (embl.de)

Often the desired cell types are available from commercial vendors: for example, 21 families of human primary cells are sold by Lonza , including hepatocytes ($500 for an ampule containing 3-6 million cells). (the-scientist.com)

[1] is the differentiation of the ovum (egg cell) into a cell competent to further develop when fertilized. (wikipedia.org)

The fission yeast homologue of Orc4p binds to replication origin DNA via multiple AT-hooks. (embl.de)

DNA replication restart mechanism in Helicobacter Pylori . (jnu.ac.in)

However, erroneous repair of DSBs can lead to chromosomal rearrangements and loss of heterozygosity, which in turn can also cause cancer and cell death. (springeropen.com)

In eukaryotes, two identical sister chromatids are now ready for cell division. (elucidate.org.au)

As a postdoc, she studied the innate immune system using epithelial cells from the human female reproductive tract. (the-scientist.com)

However, it is clear that recombinant DNA technology and modern cell biology will find applications in almost every branch of medical practice. (jnu.ac.in)

7 ] revealed that PECAM1 is involved in LUAD development by increasing the abundance of several immune cells. (aging-us.com)
IL-22 has been identified as a cancer-promoting cytokine that is secreted by infiltrating immune cells in several cancer models. (cipsm.de)
STARD14 was negatively associated with the infiltration of CD8+T cells, while positively with CCL28 and immune checkpoints, including CTLA4 as well as PD-L2. (medsci.org)

Surface mechanics constrain cells to adopt physically stable configurations by minimizing the surface free energy. (drosophila-images.org)
The figure shows the stable patterns of soap bubble aggregates (left panels) and rough eye ( Roi ) mutant ommatidia (right panels), where variable numbers of cone cells develop. (drosophila-images.org)

DNA replication begins with the enzyme DNA helicase 'unzipping' a section of the double-stranded DNA. (elucidate.org.au)

In aging and many disease states, the energy production capacity of the body's cells is diminished. (totalhealthmagazine.com)
many of the body's cells from correctly repairing damaged DNA. (diff.org)

Anatomy23

Organisms16

Diseases1

Chemicals and Drugs108

Analytical, Diagnostic and Therapeutic Techniques and Equipment30

Phenomena and Processes85

Disciplines and Occupations1

Information Science3

Health Care2

Proteins18

Cleaving replication forks1

Recombination7

Adhesion3

Cytoskeleton1

Fork6

Viral replication3

Receptors4

Pathways4

Protein18

Chromatin4

Genome stability3

Chromosome segregation2

Genomic3

Progression5

Oocyte meiosis1

Holliday7

Activates2

Molecular7

Chromosomes2

Mediating cell cycle chec1

Genes3

Mitosis4

Tumor3

Meiosis2

Mechanisms2

Signaling pathway1

Mutations4

Replicative1

Pathogens1

Eukaryotic Cells1

Epithelium2

Regulation3

Vivo3

Genetic2

PCNA1

Proliferation1

Inhibition2

Infectious3

Germ1

Meiotic1

Significantly3

Modulation1

Deletion1

Checkpoint1

Gene expression2

Initiation1

Hepatocytes1

Differentiation1

Binds1

Restart1

DSBs1

Sister chromatids1

Innate1

Recombinant DNA techno1

Immune3

Stable2

Enzyme1

Body's cells2