Replication and cell interfere antimetabolites. Medical search. Frequent questions

Classic antimetabolite anticancer drug with chemical structure similar to endogenous intermediates or building blocks of DNA or RNA synthesis. (medscape.com)
5-FU inhibits tumor cell growth through at least 3 different mechanisms that ultimately disrupt DNA synthesis or cellular viability. (medscape.com)
This step interferes with DNA and to a lesser degree with RNA synthesis. (medscape.com)
Antitumor antibiotics prevent cell division by either binding to DNA to prevent the cells from duplicating or inhibiting RNA synthesis. (lls.org)
These actions block DNA synthesis, causing a block at G2 phase and subsequently apoptotic cell death. (savedelicious.com)
Many commonly employed cancer drugs act by interfering with DNA synthesis or maintenance or by damaging DNA. (nature.com)
Azathioprine acts to inhibit purine synthesis necessary for the proliferation of cells, especially leukocytes and lymphocytes. (illnesshacker.com)
Azathioprine inhibits DNA synthesis and, as a purine antimetabolite, exerts its effect on activated lymphocytes, which requires purines during their proliferative phase. (illnesshacker.com)
Adrucil (fluorouracil) is an antimetabolite chemotherapeutic agent, which interferes with DNA and RNA synthesis thereby preventing cancer cell growth and is FDA approved for colorectal, breast, stomach, and pancreatic cancer (FDA.gov). (jax.org)
Classic anti-cancer strategies aimed at actively killing cancer cells include alkylating agents that generate crosslinks in DNA and trigger repair mechanisms to induce apoptosis, antimetabolites that severely disrupt nucleic acid synthesis, and alkaloids that interfere with microtubule polymerization/depolymerization and halt mitosis 2 . (cancerbiomed.org)
Inhibiting the synthesis of DNA and RNA stops cellular replication and causes cellular death. (thegiconnection.com)
This inhibition leads to a decrease in DNA synthesis during bacterial replication, resulting in cell growth inhibition and eventually cell lysis. (medindex.am)
As a consequence, the synthesis and release of Th1- (T helper 1) and Th2- (T helper 2) type cytokines, and other inflammatory mediators from T-cells and mast cells are blocked and the expression of signals essential for the activation of inflammatory T-lymphocytes is inhibited. (medindex.am)
Conversely, NUDT22 deficiency sensitizes cells to de novo pyrimidine synthesis inhibition in vitro and reduces cancer growth in vivo. (bvsalud.org)
In contrast to high proliferating non-malignant cells, which are highly dependent on the de novo synthesis, cancer cells can switch to the nucleoside salvage pathways to maintain efficient DNA replication. (bvsalud.org)
Pyrimidine de novo synthesis remains the target of interest in cancer therapy and several inhibitors showed promising results in cancer cells and in vivo models. (bvsalud.org)

In many cases the antiproloferation action is caused by damage to DNA, which initiates apoptosis and cell death [4]. (savedelicious.com)
By doing so, the cells become severely damaged and are destroyed through a process called apoptosis. (itirazimvar.blog)
PP2A is involved in diverse regulatory functions, including cell cycle progression, apoptosis, and DNA repair. (cancerbiomed.org)
Apoptosis: cell death 3. (studylib.net)
To a large extent, chemotherapy can be thought of as a way to damage or stress cells, which may then lead to cell death if apoptosis is initiated. (worldsbest.rehab)
Tumors develop when the normal regulation of the balance between cell proliferation (mitosis) and programmed cell death (apoptosis) is lost. (doctorlib.info)
The protein products of tumor suppressor genes are normal genes that slow down cell division, repair DNA mistakes, and tells when to undergo apoptosis (programmed cell death). (doctorlib.info)
Calcitriol elicits anti-tumor effects mainly through the induction of cancer cell apoptosis, cell cycle arrest, differentiation, angiogenesis and the inhibition of cell invasiveness by a number of mechanisms. (jcancer.org)
The broad spectrum anti-tumor effects of calcitriol and analogs are mostly based on inhibition of cancer cell proliferation and invasiveness, induction of differentiation and apoptosis, and promotion of angiogenesis. (jcancer.org)

Antimitotics damage cancer cells by blocking a process called mitosis (cell division), which prevents cancer cells from dividing and multiplying. (lls.org)
Broadly, most chemotherapeutic drugs work by impairing mitosis ( cell division ), effectively targeting fast-dividing cells . (wikidoc.org)
It may also interfere with cellular metabolism and inhibit mitosis. (illnesshacker.com)
The term chemotherapy has come to connote non-specific usage of intracellular poisons to inhibit mitosis (cell division) or induce DNA damage, which is why inhibition of DNA repair can augment chemotherapy. (worldsbest.rehab)
Traditional chemotherapeutic agents are cytotoxic by means of interfering with cell division (mitosis) but cancer cells vary widely in their susceptibility to these agents. (worldsbest.rehab)

Chemotherapy is an aggressive form of a chemical drug meant to shrink the tumour size and obliterate the rapidly growing cells in a body. (medigence.com)
Resistance to chemotherapy is when the cancer cells do not respond to the drugs. (savedelicious.com)
Chemotherapy , in its most general sense, refers to treatment of disease by chemicals that kill cells, specifically those of micro-organisms or cancer . (wikidoc.org)
As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
Although, as a patient, it can be overwhelming trying to understand exactly how all of these chemotherapy drugs work, they ultimately are designed to target and disrupt the cell cycle of rapidly dividing cells. (itirazimvar.blog)
Because proper cell division requires the copying of DNA, many chemotherapy drugs are designed to block or interfere with the DNA replication process. (itirazimvar.blog)
The many side effects associated with chemotherapy drugs are tied to damages of healthy cells that lead to organ system malfunction. (itirazimvar.blog)
It should be apparent that in order to heal the body of something like cancer, especially when receiving chemotherapy, that side effects should be avoided if possible because the cell damage associated with them severely limits natural healing processes. (itirazimvar.blog)
Although chemotherapy drugs have the ability of killing cancer cells, they can also damage and kill healthy cells. (itirazimvar.blog)
For example, the cells of the gut are easily damaged by chemotherapy due to their rapidly dividing nature (similar to cancer cells). (itirazimvar.blog)
Certain immunity regulating cells can also be critically damaged by chemotherapy drugs. (itirazimvar.blog)
Combining some of these neoadjuvant approaches with standard-of-care chemotherapy or radiotherapy appears to "sensitize" tumor cells to treatment. (cancerbiomed.org)
Many of the side effects of chemotherapy can be traced to damage to normal cells that divide rapidly and are thus sensitive to anti-mitotic drugs: cells in the bone marrow, digestive tract and hair follicles. (worldsbest.rehab)
This results in the most common side-effects of chemotherapy: myelosuppression (decreased production of blood cells, hence also immunosuppression), mucositis (inflammation of the lining of the digestive tract), and alopecia (hair loss). (worldsbest.rehab)
Because of the effect on immune cells (especially lymphocytes), chemotherapy drugs often find use in a host of diseases that result from harmful overactivity of the immune system against self (so-called autoimmunity). (worldsbest.rehab)
One of the approved chemotherapy drugs for pancreatic cancer, it inhibits cell division and promotes cell death. (letswinpc.org)
Treatment with drugs that boost the body's disease-fighting ability (immunotherapy) and drugs that kill fast-growing cells (chemotherapy). (letswinpc.org)

Various types of anticancer medications kill cancer cells in different ways. (lls.org)
4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
Since the division rate of many cancers cell is very high, in general they are more common in division phase than normal body cells and are therefore more susceptible to the effects of anticancer drugs. (drsymptoms.com)
An understanding of the cell cycle is essential for the effective use of anticancer agents ( Fig. 34.1 ). (doctorlib.info)
An anticancer drug that belongs to a family of drugs called antimetabolites. (medindex.am)

This is a heavy metal coordination complex that exerts its cytotoxic effect by platination of DNA, a mechanism analogous to alkylation, leading to interstrand and intrastrand DNA crosslinks and inhibition of DNA replication. (medscape.com)
Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov). (jax.org)
Eloxatin (oxaliplatin) is comprised of a platinum complex, which causes DNA-platinum cross-links, inhibition of DNA replication and transcription, and cell toxicity, and is FDA approved for colorectal cancer (FDA.gov). (jax.org)

Purine analogues are antimetabolites that mimic the structure of metabolic purines. (wikipedia.org)
Purine Mercaptopurine Thioguanine Fludarabine Purine antimetabolites are commonly used to treat cancer by interfering with DNA replication. (wikipedia.org)
Azathioprine (AZA), one of the antimetabolite drugs, is a purine analog that is more potent than the prototype 6-mercaptopurine, as an inhibitor of cell replication. (illnesshacker.com)

A deficiency of folic acid may lead to anemia, in which there is decreased production of red blood cells. (encyclopedia.com)
Research shows that folic acid can be used to successfully treat cervical dysplasia, a condition diagnosed by a Pap smear, of having abnormal cells in the cervix. (encyclopedia.com)
Daily consumption of 1,000 mcg of folic acid for three or more months has resulted in improved cervical cells upon repeat Pap smears. (encyclopedia.com)
Many medications interfere with the body's absorption and use of folic acid. (encyclopedia.com)
Methotrexate, a folic acid analog/antimetabolite, can be curative for women with choriocarcinoma and is also useful for non-Hodgkin lymphomas and acute lymphocytic leukemias (ALLs) in children. (medquizzes.net)

As these drugs cause damage to cells they are termed cytotoxic . (wikidoc.org)

This essential technique to reduce host cell toxicity in response to methotrexate (MTX) therapy is often referred to as leucovorin (folinic acid) rescue. (medquizzes.net)
To protect normal cells we administer leucovorin (also called citrovorum factor or folinic acid) right after giving the MTX. (medquizzes.net)

They can also cause base mispairing between strands, which interferes with the progression of the replication fork [3]. (savedelicious.com)
PP2A, a serine/threonine phosphatase composed of 3 distinct subunits-65-kDa PP2A-A (scaffold subunit), 55-kDa PP2A-B (regulatory subunit), and 37-kDa PP2A-C (catalytic subunit)-constitutes 0.2%-1.0% of the total protein content in mammalian cells and has been implicated in the regulation of diverse cellular processes, including signal transduction, cell cycle progression, DNA replication, gene transcription, and protein translation 5 - 8 . (cancerbiomed.org)
Uridine supplementation rescues replication fork progression and alleviates replication stress and DNA damage. (bvsalud.org)

DNA-damaging agents (antineoplastics) and alkylating agents react with DNA to change it chemically and keep it from allowing cell growth. (lls.org)

They're believed to work by blocking cell metabolism through their effect on specific genes. (lls.org)
Tamoxifen acts as an anti-estrogen (inhibiting agent) in the mammary tissue, but as an estrogen (stimulating agent) in cholesterol metabolism, bone density, and cell proliferation in the ENDOMETRIUM. (lookformedical.com)
It has an archaic metabolism similar to yeast, growing rapidly in low oxygen environments, and making only two ATP energy molecules from a molecule of sugar, then throwing off waste which creates a moat of toxicity and protects the cancer cells from the body's defenses. (dunphynunley.com)
This is an oxygen-based, highly efficient process, unlike cancer cell metabolism. (dunphynunley.com)
Unfortunately, normal host cells depend on folate metabolism, they take up MTX well, and they will be affected. (medquizzes.net)
It is taken up by the normal cells, bypasses the block induced by the MTX, and so spares normal cell metabolism. (medquizzes.net)
It interferes with the metabolism of alcohol resulting in unpleasant effects when alcohol is consumed. (fr.nf)

Antimetabolites mimic the building blocks of DNA or RNA that cancer cells need to survive and grow. (lls.org)

Monoclonal antibodies are laboratory-produced proteins that target specific antigens on the cancer cell's surface to interfere with the cell's function and destroy it. (lls.org)

Cancer is the uncontrolled growth of cells coupled with malignant behavior: invasion and metastasis . (wikidoc.org)
Unfortunately, scientists have yet to identify specific features of malignant and immune cells that would make them uniquely targetable (barring some recent examples, such as the Philadelphia chromosome as targeted by imatinib ). (wikidoc.org)
They have complementary mechanisms to hinder the carcinogenic process by searching free radicals, inhibiting survival and multiplication of malignant cells, as well as reducing invasiveness and angiogenesis of tumors. (researchsquare.com)
A noninvasive (noninfiltrating) carcinoma of the breast characterized by a proliferation of malignant epithelial cells confined to the mammary ducts or lobules, without light-microscopy evidence of invasion through the basement membrane into the surrounding stroma. (lookformedical.com)

A previous structure-activity relationship study reported by us, identified the 3'-C-methyladenosine (3'-Me-Ado) as a mechanism-based RNR inhibitor endowed with a significant antitumor activity against a panel of human leukemia and carcinoma cell lines. (unicam.it)
Of note, the therapeutic potential of these compounds was evidenced by a synergistic interaction between the NAMPT inhibitor FK866 and the new NAPRTi in terms of decreasing OVCAR-5 intracellular NAD levels and cell viability. (bvsalud.org)
More over, since most tumor specimens Decitabine Antimetabolites inhibitor and tumor derived cell lines utilized in these investigations have now been ovarian SACs, the position of mTOR in CCC remains largely as yet not known. (deubiquitinase.com)

Representatives of antimetabolites are methotrexate , 5-fluorouracil , gemcitabine and capecitabine . (drsymptoms.com)

To further investigate the structural determinants of 3'-Me-Ado required for the antitumor activity, in the first part of my PhD project, a number of 3'-C-methyl ribonucleosides with different purinic and pyrimidinic nucleobases and the 3'-C-methyl derivatives of the antitumor agents 5-fluorouridine and 9-( Î²-D-arabinofuranosyl)- adenine were synthesized and evaluated on human tumor cell lines. (unicam.it)
As so-called "antitumor antibiotics", similar to conventional antibiotics in bacteria, they break apart the genetic material in the cancer cells and it change the cell membrane. (drsymptoms.com)

Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)

Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
Hypomethylating (demethylating) agents interfere with cancer cell duplication by slowing or reversing hypermethylation. (lls.org)
With succeeding generations of tumor cells, differentiation is typically lost, growth becomes less regulated, and tumors become less responsive to most chemotherapeutic agents. (wikidoc.org)
These agents behave as antimetabolites that interact with a number of intracellular targets blocking the DNA chain elongation or interfering with biosynthesis of nucleosides and nucleotides, a limiting process in cell proliferation. (unicam.it)
Therefore, the altered capacity of cancer cells to repair and/or replicate DNA is the basis of many classical therapies, such as platinum-based agents, and also recently introduced or upcoming therapies, such as PARP inhibitors or ATR inhibitors (reviewed in refs. (nature.com)
Sensitization of cancer cells to conventional drugs using multi-target agents that block survival and oncogenic pathways, alone or in combination, is an emerging strategy to overcome drug resistance. (researchsquare.com)
Severe immunosuppression can be due to a variety of conditions, including congenital immunodeficiency, human immunodeficiency virus (HIV) infection, leukemia, lymphoma, generalized malignancy or therapy with alkylating agents, antimetabolites, radiation, or large amounts of corticosteroids. (cdc.gov)
7. Drugs that exert their influence during any phase of the cell cycle are called Cell cycle nonspecific (CCNS) drugs and include Alkylating agents, hormones and anti-tumor antibiotics. (studylib.net)
Fludarabine belongs to a group of agents called antimetabolites. (thegiconnection.com)
They transport therapeutic agents to the target cell/tissue. (mdpi.com)
no studies have addressed the effect of mTOR inhibitors on ovarian cancer cells that have acquired resistance following the contact with platinum agents. (deubiquitinase.com)

DNA-repair enzyme inhibitors attack the cancer cell proteins (enzymes) that normally repair damage to DNA. (lls.org)
Histone deacetylase inhibitors attack cancer cells by targeting the proteins that support DNA in the cell nucleus. (lls.org)
JAK inhibitors block the enzymes JAK1, JAK2, JAK3 and tyrosine kinase 2, which play a role in the cell-signaling process that leads to the inflammatory and immune responses seen in certain diseases. (lls.org)
Enzyme inhibitors play an important role in all cells, since they are generally specific to one enzyme each and serve to control that enzyme's activity. (wikipedia.org)
[2] Enzyme inhibitors also control essential enzymes such as proteases or nucleases that, if left unchecked, may damage a cell. (wikipedia.org)
One of the key functions of enzyme inhibitors in cells is to regulate enzyme activity. (microbiologynote.com)
Additionally, enzyme inhibitors can protect cells from potential damage by controlling enzymes that might otherwise harm the cell if left unchecked. (microbiologynote.com)

Cyclophosphamide/Alkylating Agent Concept/Action/Use Assessment Immunity CCNS Damage cell's DNA preventing reproduction of cancer cells. (studylib.net)

Many antineoplastic drugs, such as antimetabolites, are most effective when cells are actively dividing. (msdmanuals.com)

Antimetabolites resemble endogenous substances and are therefore involved in metabolic processes. (drsymptoms.com)

Cancerous growth is characterized as the uncontrolled multiplication and spread of the body's particular cells causing infection and addresses one of the greatest medical care issues for humanity and requests a proactive procedure for fix. (researchsquare.com)
Cancer is characterized as the uncontrolled multiplication and spread of the body's particular cells. (researchsquare.com)

Cell cycle-specific with activity in the S-phase as single agent and has for many years been combined with biochemical modulator leucovorin.Has activity as single agent that inhibits DNA replication and transcription. (medscape.com)
The leucovorin does not spare cancer cells: just as they cannot take up MTX well, they cannot take up the rescue agent and save themselves from cytotoxicity. (medquizzes.net)

More over, we examined the function of AKT/mTOR signaling in the acquired resistance to cisplatin in CCC cells. (deubiquitinase.com)

Nucleotide analogues Fludarabine inhibits multiple DNA polymerases, DNA primase, and DNA ligase I, and is S phase-specific (since these enzymes are highly active during DNA replication). (wikipedia.org)
It inhibits both cellular and humoral responses but does not interfere with phagocytosis or interferon production. (illnesshacker.com)
Lomefloxacin hydrochloride inhibits DNA gyrase, a type II topoisomerase involved in the induction or relaxation of supercoiling during DNA replication. (medindex.am)

It is designed to treat micrometastatic disease (or breast cancer cells that have escaped the breast and regional lymph nodes but which have not yet had an established identifiable metastasis). (medscape.com)
It is designed to lowering the cancer cells in the body and is aimed towards enhancing the patient's quality of life. (medigence.com)
Cancer cells can grow too fast or fail to die quickly. (lls.org)
However, many conventional and investigational drug therapies combine drugs that attack cancer cells at different points in their growth cycles. (lls.org)
This approach often makes therapy more effective and reduces the chance that the cancer cells will become resistant to a particular drug. (lls.org)
Sometimes cancer cells may be resistant to the initial drugs used or can become resistant to the drugs after a period. (lls.org)
Some enzymes can prevent cancer cells from surviving. (lls.org)
This process sometimes speeds up in cancer cells. (lls.org)
However, cancer cells can become multidrug resistant, a phenomenon due to cells expressing mechanisms that cause simultaneous resistance to many different, structurally and functionally, unrelated drugs [6]. (savedelicious.com)
Increased drug efflux, via these transporters, lowers intracellular drug concentration, allowing cancer cells to escape the toxic effects of the drugs. (savedelicious.com)
Many of the enzymes involved in these pathways are highly active in cancer cells, such as ribonucleotide reductase (RNR). (unicam.it)
It is paramount to identify predictive markers that are associated with failures of DNA maintenance in cancer cells. (nature.com)
Cancer cells however, progress through this process at an abnormally high rate. (itirazimvar.blog)
8. The growth factor and doubling time are two factors that play a major role in the response of cancer cells to anti-cancer drugs. (studylib.net)
14. Alkylating drugs damage cell DNA strands the preventing reproduction of cancer cells. (studylib.net)
The various classes of drugs attack the cancer cells in respectively different phases of the cell cycle. (drsymptoms.com)
These genes are deleted or inactivated in cancer cells, allowing unregulated proliferation. (doctorlib.info)
Cancer cells thrive where other cells suffer. (dunphynunley.com)
The drug kills responsive cancer cells by inhibiting dihydrofolate, an enzyme necessary for forming tetrahydrofolic acid (FH4). (medquizzes.net)
Some cancer cells are resistant to MTX because they lack adequate mechanisms for transporting the drug intracellularly. (medquizzes.net)
Cancer cells, particularly those arising from the bone marrow or lymphatic system, may have a short generation time, and there usually are a smaller percentage of cells in G0 (resting phase). (msdmanuals.com)
Circulating cancer cells are present in many patients with advanced cancer and even in some with localized disease. (msdmanuals.com)
Although most circulating cancer cells die, an occasional cell may penetrate into tissues, generating a metastasis at a distant site. (msdmanuals.com)
Cancer cells often present neoantigens on their cell surface that can be detected as "non-self" by the immune system, resulting in an attack by the immune system. (msdmanuals.com)
NUDT22 expression is consistently elevated in cancer tissues and high NUDT22 expression correlates with worse survival outcomes in patients indicating an increased dependency of cancer cells to NUDT22. (bvsalud.org)
NUDT22-deficient cancer cells suffer from growth retardation, S-phase delay, and slower DNA replication fork speed. (bvsalud.org)
In conclusion, NUDT22 maintains pyrimidine supply in cancer cells and depletion of NUDT22 leads to genome instability. (bvsalud.org)

Drugs affect "younger" tumors (i.e. more differentiated) more effectively, because mechanisms regulating cell growth are usually still preserved. (wikidoc.org)
Preclinical success has led to a profusion of clinical trials on LB100 adjuvant therapies, including a phase I trial in extensive-stage small-cell lung cancer, a phase I/II trial in myelodysplastic syndrome, a phase II trial in recurrent glioblastoma, and a completed phase I trial assessing the safety of LB100 and docetaxel in various relapsed solid tumors. (cancerbiomed.org)
EPO-secreting tumors EPO-secreting tumors Polycythemia Vera , such as renal cell carcinoma Renal cell carcinoma Renal cell carcinoma (RCC) is a tumor that arises from the lining of the renal tubular system within the renal cortex. (lecturio.com)
Tumor initiation is the process by which normal cells are changed so that they are able to form tumors. (doctorlib.info)
thus, tumors with a high cell turnover are most susceptible (certain leukemias and lymphomas, small proliferating tumors, "recruited" tumor cells, and micrometastases). (doctorlib.info)
Small tumors have a greater percentage of actively dividing cells than do large tumors. (msdmanuals.com)

A 47-year-old woman with choriocarcinoma i s treated with methotrexate (MTX), given at dosages that you believe may cause s ignificant host cell Which drug would you give to l imit the toxic effects of the drug on normal host cells? (medquizzes.net)

Chances are that a change to its molecular structure would disrupt its interaction with some enzyme molecule or other that is essential to the survival of the cell. (heresy.is)

Symmetric cell division prompts multiplication and asymmetric cell division is an enlightening advance for differentiation. (researchsquare.com)
It is necessary for the proper differentiation and growth of cells and for the development of the fetus. (encyclopedia.com)
Thrombopoiesis takes place primarily in the bone marrow through a series of cell differentiation and is influenced by several cytokines. (lecturio.com)
Its prominent properties are A lack of cell differentiation Local invasion of adjoining tissue Metastasis, which is spread to distant sites through. (msdmanuals.com)

To produce a cure, therapy must continue until the final tumor cell has been eradicated. (doctorlib.info)

SN-38 binds to and stabilizes the topoisomerase I-DNA complex and prevents the relegation of DNA after it has been cleaved by topoisomerase I, inhibiting DNA replication. (medscape.com)

By preventing the clonal expansion of lymphocytes in the induction phase of the immune response, it affects both cell immunity and humoral immunity. (wikipedia.org)
Cyclosporine is a cyclic polypeptide that suppresses some humoral immunity and, to a greater extent, cell-mediated immune reactions. (medscape.com)

As a result, cell proliferation may be inhibited, particularly in lymphocytes and leukocytes. (illnesshacker.com)

Cytotoxicity can occur at any stage of the cell cycle, but cell is most vulnerable to action of these drugs in G1 and S phase. (medscape.com)
In this case, your doctor may prescribe different drugs to target and kill the cancerous cells. (lls.org)
The administered as tablets, injections or infusion drugs distributed in the various organs and can be achieved and destroy potentially scattered tumor cells. (drsymptoms.com)
In cancer therapy , there are more than 50 different cell division inflammatory drugs (cytostatics). (drsymptoms.com)
Some drugs work only during a specific phase of the cell cycle, requiring prolonged administration to catch dividing cells during the phase of maximal sensitivity. (msdmanuals.com)

However, this expression depends on a preliminary DNA replication that occurs normally between 21 h and 31 h following activation at 18°C. Thus, the gene for DNA-ligase I is overtly expressed at the 1-cell stage. (silverchair.com)
Many factors are involved in causing and permitting the unregulated proliferation of cells that occurs in cancer. (msdmanuals.com)

Special cells in the pancreas that produce digestive enzymes. (letswinpc.org)

Platinum compounds inhibit cell growth and proliferation. (medscape.com)

Cytotoxicity is cell-cycle nonspecific. (medscape.com)

Glucose-1-phosphate is an important metabolite for energy and biomass production through glycolysis and nucleotides required for DNA replication are produced through energetically expensive de novo or energy-efficient salvage pathways. (bvsalud.org)

This negative feedback mechanism ensures that cells do not produce excess molecules, maintaining cellular homeostasis . (microbiologynote.com)

When the cancer cell uses an antimetabolite instead of the natural substances, it can't produce normal DNA or RNA and the cell dies. (lls.org)
Human-made or natural substances that may prevent or delay some types of cell damage. (letswinpc.org)

It acts throughout the entire cell cycle and by direct intercalating into DNA triggers DNA breakage by topoisomerase II, causing subsequent cytocydal activity. (medscape.com)

Repaglinide blocks ATP-dependent potassium channels in pancreatic beta cells, thereby causing depolarization of the cell membrane and subsequent opening of calcium channels. (medindex.am)

They act like switches in the cell - turning on other proteins. (lls.org)
Mtb has a complex cell wall made up of mycolic acids (long-chain fatty acids with 60 to 90 carbon atoms), glycolipids, peptidoglycan, and proteins. (ajgreenchem.com)
Specific proteins found in or on cells of progesterone target tissues that specifically combine with progesterone. (lookformedical.com)
The mutant proteins coded by oncogenes (oncoproteins) are overactive and allow cells to proliferate when they should not. (doctorlib.info)

P53 is a tumor suppressor gene that codes for a transcription factor that regulates the expression of other genes and arrests the cell cycle. (doctorlib.info)

The immune response fights Mtb , allowing the additional cells to be attracted to the affected side to stop the bacteria from growing and forming granulomas. (ajgreenchem.com)
The granuloma is an ordered structure created by immune cells in response to an antigenic stimulus that can be seen in both latent and active TB. (ajgreenchem.com)

Therefore, in the 1940s, several patients with advanced lymphomas (cancers of certain white blood cells) were given the drug by vein, rather than by breathing the irritating gas. (wikidoc.org)

It is a group of conditions where the bone marrow is not able to produce enough healthy blood cells. (onlinemeds24x7.com)

These biological nanopores have been designed to protect the interior of the bacterial cell from leakage of toxic compounds while selectively allowing the entry of the molecules needed for cell growth and function. (ibecbarcelona.eu)

Overview of Cancer Cancer is an unregulated proliferation of cells. (msdmanuals.com)

Without this repair process, the cancer cell is much more susceptible to damage and cannot grow. (lls.org)
Others have used it to help stop cell damage. (fr.nf)

Methylation is a critical part of cell growth and replication. (lls.org)
This means that other fast dividing cells such as those responsible for hair growth and for replacement of the intestinal epithelium (lining) are also often affected. (wikidoc.org)
In healthy cells, growth and division is highly regulated. (itirazimvar.blog)
It has been accounted that unusual symmetric cell division is the central point for causing cancerous growth. (researchsquare.com)
The active ingredients are primarily aimed against the genetic material of those cells that are in the growth phase and have active division. (drsymptoms.com)
Initial exponential tumor growth is followed by a plateau phase when cell death nearly equals the rate of formation of daughter cells. (msdmanuals.com)
Experiments suggest that the abilities to invade, migrate, and successfully implant and stimulate new blood vessel growth are all important properties of the cells that cause metastases, which are likely a subpopulation of the primary cancer. (msdmanuals.com)
Here, we describe p53-regulated pyrimidine salvage through NUDT22-dependent hydrolysis of UDP-glucose to maintain cancer cell growth and to prevent replication stress. (bvsalud.org)
The Cell Titer 96 well growth assay kit was obtained from Promega. (deubiquitinase.com)

Prevents formation of cell wall comp. (curezone.org)

As their main target is cell division, they affect all rapidly dividing cells, including normal cells. (savedelicious.com)
It was reasoned that an agent that damaged the rapidly growing white blood cells might have a similar effect on cancer. (wikidoc.org)
However, their impact is particularly intense with very rapidly dividing cells. (drsymptoms.com)
Rapidly acting, active against all species of plasmodium, target is trophozoite stage of asexual replication. (howmed.net)

To decrease the risk of burning in the For mild and older) during thean over Ovarian can start a HER2 cancer cell with too much HER2, in which that include the Opioids can. (tantrakamala.com)
This test filters circulating tumor cells from a patient's blood sample and gives a numerical probability of metastasis for colon, breast, prostate and ovarian adenocarcinomas. (dunphynunley.com)
In this work, a collection of diverse compounds was screened in silico against the NAPRT structure, and the selected hits were tested through cell-based assays in the NAPRT-proficient OVCAR-5 ovarian cell line and on the recombinant hNAPRT. (bvsalud.org)

Anatomy8

Organisms3

Diseases2

Chemicals and Drugs40

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes25

Information Science3

Synthesis16

Apoptosis9

Mitosis5

Chemotherapy17

Anticancer5

Inhibition of DNA replication3

Purine3

Folic acid5

Cytotoxic1

Folinic acid2

Progression3

Antineoplastics1

Metabolism7

Mimic1

Monoclonal Antibodies1

Malignant4

Inhibitor3

Gemcitabine1

Antitumor2

Alkaloids1

Agents11

Inhibitors7

Cyclophosphamide1

Antineoplastic1

Endogenous1

Body's2

Leucovorin2

Cisplatin1

Inhibits3

Cancer cells27

Tumors6

Methotrexate1

Disrupt1

Differentiation4

Tumor cell1

Binds1

Humoral2

Lymphocytes1

Drugs5

Occurs2

Enzymes1

Inhibit1

Nonspecific1

Nucleotides1

Cellular1

Substances2

Topoisomerase1

Membrane1

Proteins4

Transcription1

Immune2

Vein1

Bone marrow1

Bacterial1

Proliferation of cells1

Damage2

Growth9

Prevents1

Rapidly4

Ovarian3