• Antibodies that reduce or abolish some biological activity of a soluble antigen or infectious agent, usually a virus. (lookformedical.com)
  • Here, we use a BCR light chain neoepitope defined by a characteristic point mutation (IGLV3-21R110) for selective targeting of a poor-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells. (bvsalud.org)
  • As Type C retroviruses, replicating murine leukemia viruses produce a virion containing a spherical nucleocapsid (the viral genome in complex with viral proteins) surrounded by a lipid bilayer derived from the host cell membrane. (wikipedia.org)
  • Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
  • Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
  • The murine leukemia viruses are group/type VI retroviruses belonging to the gammaretroviral genus of the Retroviridae family. (wikipedia.org)
  • A highly immunogenic tumor transfected with a murine transforming growth factor type beta 1 cDNA escapes immune surveillance. (academicinfluence.com)
  • External envelope protein of the human immunodeficiency virus which is encoded by the HIV env gene. (lookformedical.com)
  • Transmembrane envelope protein of the HUMAN IMMUNODEFICIENCY VIRUS which is encoded by the HIV env gene. (lookformedical.com)
  • B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
  • Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
  • We develop murine and humanized CAR constructs expressed in T cells from healthy donors and CLL patients that eradicate IGLV3-21R110 expressing cell lines and primary CLL cells, but neither cells expressing the non-pathogenic IGLV3-21G110 light chain nor polyclonal healthy B cells. (bvsalud.org)
  • MLVs include both exogenous and endogenous viruses. (wikipedia.org)
  • citation needed] The MLVs include both exogenous and endogenous viruses. (wikipedia.org)
  • Different strains of mice may have different numbers of endogenous retroviruses, and new viruses may arise as the result of recombination of endogenous sequences. (wikipedia.org)
  • Radiation-induced murine leukemias and endogenous retroviruses: the time course of viral expression. (microbiologyresearch.org)
  • Spleen focus-forming viruses are generated by recombination with endogenous retroviral sequences. (nih.gov)
  • The encoded proteins are trafficked to the plasma membrane, where they assemble into progeny virus particles. (wikipedia.org)
  • In this case, the progeny virus was produced in the activated form and multiple-cycle replication occurred successively. (nih.gov)
  • The progeny virus, however, remained inactive, and the replication was limited to a single cycle, which resulted in the limited lung lesion. (nih.gov)
  • Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene. (microbiologyresearch.org)
  • The envelope gene plays an essential role in initiating erythroleukemia ( LEUKEMIA, ERYTHROBLASTIC, ACUTE ), manifested by splenic foci, SPLENOMEGALY , and POLYCYTHEMIA . (nih.gov)
  • PMID- 6299951 TI - Pneumotropism of Sendai virus in relation to protease-mediated activation in mouse lungs. (nih.gov)
  • Serological characterization of C-type retroviruses endogenous to the C57BL/6 mouse and isolated in tumours induced by radiation leukaemia virus (RadLV-Rs). (microbiologyresearch.org)
  • But I've always felt that one of the key things to sort of opening up tumor virology was the isolation of a virus that you could work with in the lab that produced changes in tissue culture. (nih.gov)
  • The first isolations had been made from cultivated tonsils and adenoids, and the work was just beginning to try to understand what a broad spectrum of viruses was involved and what they had to do with human disease, with respiratory disease in the military, and with Trachoma and with pink eye and all the things that are now known to be associated with Adenovirus infection. (nih.gov)
  • The murine leukemia viruses (MLVs or MuLVs) are retroviruses named for their ability to cause cancer in murine (mouse) hosts. (wikipedia.org)
  • Baker: Dr. Hartley, before we get into looking at the Viruses Cancer Program itself, could you give us a little bit about your background, where you went to school, and what experiences you've had? (nih.gov)
  • Baker: It became quite a change because, as you know, before 1955 nobody thought viruses had anything to do with cancer. (nih.gov)
  • Among the latter MLVs are amphotropic viruses (Gr. amphos, "both") that can infect both mouse cells and cells of other animal species. (wikipedia.org)
  • So, we got rather deeply into mouse viruses. (nih.gov)
  • This report updates and consolidates all previous U.S. Public Health Service recommendations for the management of health-care personnel (HCP) who have occupational exposure to blood and other body fluids that might contain hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV). (cdc.gov)
  • Avoiding occupational blood exposures is the primary way to prevent transmission of hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) in health-care settings ( 1 ). (cdc.gov)
  • This cleavage is essential for the Env incorporation into virus particles. (wikipedia.org)