Reperfusion injury neonatal hypoxia ischemia hypoxia ischemia. Medical search. Frequent questions

They induced HI brain injury in postnatal 3-day Sprague-Dawley (SD) rats, which corresponds to 23-32 weeks of human gestation ( Mallard and Vexler, 2015 ). (frontiersin.org)
They found that the {4-amino-5-(4-chlorophenyl)-7-(t-butyl) pyrazole [3,4-d] pyrimidine} (PP2), an SFK inhibitor when given within 0.5 h from HI, ameliorated pathological changes and myelin deficits and improved neuro-behaviors in the preterm rats with exposure to HI brain injury. (frontiersin.org)
We aimed to investigate the effect of PLCA on hypoxia/reoxygenation (H/R) in neonatal rat ventricular myocytes (NRVM) and on myocardial I/R in rats. (biomedcentral.com)
OBJECTIVES@#To study the effect of ligustrazine injection on mitophagy in neonatal rats with hypoxic-ischemic encephalopathy (HIE) and its molecular mechanism. (bvsalud.org)
METHODS@#Neonatal Sprague-Dawley rats, aged 7 days, were randomly divided into a sham-operation group with 8 rats, a model group with 12 rats, and a ligustrazine group with 12 rats. (bvsalud.org)
The rats in the model group and the ligustrazine group were used to establish a neonatal rat model of HIE by ligation of the left common carotid artery followed by hypoxia treatment, and blood vessels were exposed without any other treatment for the rats in the sham-operation group. (bvsalud.org)
The rats in the ligustrazine group were intraperitoneally injected with ligustrazine (20 mg/kg) daily after hypoxia-ischemia, and those in the sham-operation group and the model group were intraperitoneally injected with an equal volume of normal saline daily. (bvsalud.org)
We investigated the effects of pentoxifylline, a methylxanthine derivative and type-4 phosphodiesterase inhibitor, on short-term memory and apoptotic neuronal cell death in the hippocampus following perinatal hypoxic-ischemia in newborn rats. (einj.org)
To investigate the mechanism of sodium tanshinone IIA sulfonate inhibiting hypoxia induced retinal neovascularization in rats. (ijpsonline.com)
Forty 7 d old clean grade C57BL/6J male neonatal rats were randomly divided into control group, model group, low-dose group and high-dose group. (ijpsonline.com)
We therefore investigated the impact of global brain hypoxia-ischemia on the thalamic circuit function in the somatosensory system of young rats. (cdc.gov)

Neonatal rat cardiomyocytes were also used to evaluate the protective effect of GRh2 on hypoxia/reoxygenation (H/R)‑induced myocardial injury in vitro. (spandidos-publications.com)
In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
Cardiomyocytes were isolated and subjected to 6 h hypoxia followed by 18 h reperfusion. (biomedcentral.com)
Since cardiomyocytes are terminally differentiated cells with limited self-renewal capacity, and membrane rupture is a major cause of cardiomyocyte cell death following injury, membrane repair is a necessary process for preserving cardiomyocyte viability [ 6 ]. (biomedcentral.com)
Ischemia/reperfusion (I/R) in mouse hearts and hypoxia/oxidative stress in neonatal rat cardiomyocytes have been associated with a downregulation of MG53. (biomedcentral.com)
Methods and Results-In vitro, neonatal rat cardiomyocytes were subjected to hypoxia-reoxygenation in the absence or presence of eEPCs with or without Tβ4 short hairpin RNA (shRNA) transfection. (elsevierpure.com)
In addition, neonatal rat cardiomyocytes (NRCMs), cardiac fibroblasts (CFs), and macrophages were isolated for in vitro experiments. (hindawi.com)
Therefore, the study aimed to investigate the protective effects and mechanisms of STA on H/R injury of cardiomyocytes. (biomedcentral.com)
Our data speculated that STA protects H/R injury and inhibits oxidative stress and apoptosis in cardiomyocytes by activation of the SIRT1-Nrf2 pathway. (biomedcentral.com)
However, the role of STA on the H/R injury of cardiomyocytes through the SIRT1-Nrf2 pathway remains unexplored. (biomedcentral.com)

The aim of this study was to investigate whether resveratrol (RSV) could ameliorate ischemia- and hypoxia-associated cardiomyocyte apoptosis and injury via inhibiting senescence signaling and inflammasome activation. (hindawi.com)
In in vitro experiment, RSV prevented hypoxia-induced NRCM senescence and apoptosis. (hindawi.com)
The p53-associated signaling pathway has been demonstrated to regulate hypoxia-induced apoptosis and senescence [ 5 ]. (hindawi.com)
Neuronal apoptosis is closely associated with brain damage induced by ischemia/reperfusion injury [ 3 - 5 ]. (einj.org)
Hypoxia/reoxygenation (H/R)-induced cardiomyocyte cell apoptosis is critical in developing myocardial infarction. (biomedcentral.com)
During the reperfusion phase, a complex interplay of multiple pathways and mechanisms is activated, which ultimately leads to cell death, primarily through apoptosis. (ucl.ac.uk)
During extended myocardial ischemia combinations of hypoxia and acidosis drive cardiac cell loss by apoptosis and necrosis that contribute importantly to myocardial infarction (MI). (biomedres.us)
Here we investigated roles for miR-126 in stress kinase activation, induction of inflammatory cytokines and apoptosis caused by exposure of cultured cardiac myocytes to hypoxia/acidosis or acidosis alone. (biomedres.us)
Obligatory roles for acidosis in promoting apoptosis confirmed our previous reports that hypoxia alone does not confer a lethal signal. (biomedres.us)
Acidosis with or without hypoxia increased apoptosis that was paralleled by elevated miR-126, increased phosphorylation of p38-MAPK and JNK, enhanced expression of IL-6, IL-8, and TNF, and downregulation of Bcl-2. (biomedres.us)
In animal models, increased apoptosis accompanies both phases of ischemia and reperfusion [8]. (biomedres.us)
Our group reported that severe chronic hypoxia alone does not cause apoptosis of cardiac myocytes in culture. (biomedres.us)
Inhibition of Na+/H+ exchange is protective against ischemic injury, while inhibition of the vacuolar ATPase promotes apoptosis, in part by shifting the proton load toward the Na+/H+ transporter and thus increasing Ca2+ uptake, and in part by reducing the myocyte capacity to control [pH]i. (biomedres.us)

Cardiac ischemia is modelled in vitro through the application of hypoxic and oxidative stress. (biomedcentral.com)
Since the discovery of the reverse electron transfer in the 1960s it was regarded as in vitro phenomenon, until the role of RET in the development of ischemia/reperfusion injury has been recognized in the brain and heart. (wikipedia.org)
Our findings revealed that RSV protected against ischemia-induced mouse heart injury in vivo and hypoxia-induced NRCM injury in vitro via regulating Sirt1/p53-mediated cell senescence and inhibiting NLRP3-mediated inflammasome activation. (hindawi.com)
To investigate this hypothesis, the H9c2 cardiomyocyte cell line was used to establish an in vitro myocardial H/R injury model to explore the roles and potential mechanisms of STA in myocardial H/R injury. (biomedcentral.com)

We have reported that retrograde application of embryonic endothelial progenitor cells (eEPCs) provides rapid paracrine protection against ischemia-reperfusion injury. (elsevierpure.com)
Other well-known sources of oxidative stress in red cells are free radical production outside the red cell by activated phagocytes, endothelial metabolism, hyperoxia, ischemia-reperfusion and the arachidonic acid cascade. (unisi.it)
The expression of vascular endothelial growth factor, vascular endothelial growth factor-2 and hypoxia-inducible factor-1 were detected by Western blot. (ijpsonline.com)
Sodium tanshinone IIA sulfonate can inhibit hypoxia induced retinal neovascularization in a dose-dependent manner, and its mechanism may be related to the regulation of vascular endothelial growth factor pathway related proteins by sodium tanshinone IIA sulfonate. (ijpsonline.com)

In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
Among them, it has the most significant effect on diseases with oxidative stress, such as neonatal brain hypoxia, Parkinson's disease, tissue ischemia-reperfusion injury, etc. (gdcawolo.com)
However, accumulating evidence suggests that MG53 has a potentially protective role in heart tissue, including in ischemia/reperfusion injury of the heart, cardiomyocyte membrane injury repair, and atrial fibrosis. (biomedcentral.com)
During ischemia substantial amount of succinate is generated in cerebral or cardiac tissue and upon reperfusion it can be oxidized by mitochondria initiating reverse electron transfer reaction. (wikipedia.org)
Free radical-mediated tissue injury have gained great importance in the pathophysiology of various diseases including inflammation, infection, toxic and metabolic insults, carcinogenesis and atherosclerosis, and they have a prominent role in neonatal diseases. (cshd.org.tr)
Preliminary provision for the production of hydroxyl radicals from reactive oxygen and reactive nitrogen species, which are responsible for tissue injury in free radical-mediated diseases, is the meeting of oxygen with free electrons and production of superoxide and hydrogen peroxide. (cshd.org.tr)
A significant amount of myocardial damage during a myocardial infarction (MI) occurs during the reperfusion stage, termed ischaemia/reperfusion (I/R) injury, and accounts for up to 50% of total infarcted tissue post-MI. (ucl.ac.uk)
The fate of the brain tissue after focal cerebral ischemia is determined by the degree and duration of ischemia, and even without preconditioning, resident brain cells naturally respond to brain ischemia by mobilizing a host of defences and counter responses to mitigate cell injury and death [ 5 ]. (biomedcentral.com)

Perinatal asphyxia, more appropriately known as hypoxic-ischemic encephalopathy (HIE), is characterized by clinical and laboratory evidence of acute or subacute brain injury due to asphyxia. (medscape.com)
To investigate the effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO) on acute lung injury (ALI) and its clinical significance. (researchsquare.com)
Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
Acute or chronic inflammation induced by ischemia has also been suggested to play an important role in the process of malignant cardiac remodeling [ 3 ]. (hindawi.com)
Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Severe failure in gas exchange due to a breakdown in the alveolar-capillary barrier and pulmonary edema characterizes both acute lung injury (ALI) and its more severe variant, acute respiratory distress syndrome (ARDS). (healthandhydrogen.com)
On the other hand, the number of circulating hEPC is increased in hypoxia or acute myocardial infarction (AMI). (intechopen.com)
Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)

Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)

The uncoupling of glycolysis and glucose oxidation induces lactate accumulation during myocardial ischemia/reperfusion (I/R) injury. (biomedcentral.com)
In the absence of ischemic preconditioning (IPC), MCAO induces a large infarction (ischemia-sensitive phenotype). (biomedcentral.com)
We recently reported that neonatal ischemia induces microglia/macrophage activation three days post- ischemia . (nih.gov)

In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. (mdpi.com)
However, the molecular pathway involved in myocardial neovascularisation after ischemia remains unknown. (elifesciences.org)

A rat model of myocardial I/R injury was constructed by ligating the left anterior descending coronary artery, which was subsequently treated with GRh2. (spandidos-publications.com)

In this Research Topic, we summarized original research and review articles that examine the more recent progress in pharmacological and cell therapies for perinatal HI brain injury. (frontiersin.org)
Thus, avoiding maternal SE during pregnancy is important to protect the brain from perinatal brain injuries. (frontiersin.org)
Perinatal hypoxic-ischemic injury increased apoptotic cell death in the hippocampus, resulting in impaired short-term memory with decreased cAMP levels. (einj.org)
Pentoxifylline ameliorated perinatal hypoxic-ischemia in rat pups. (einj.org)
Perinatal hypoxic-ischemia is accompanied by neurodegeneration, including necrotic and apoptotic neuronal death [ 1 , 2 ]. (einj.org)

However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)
and is an intrinsic process through which repeated short episodes of ischemia are instituted to protect the myocardium against subsequent ischemic insults [ 7 ]. (biomedcentral.com)

With prolonged hypoxic-ischemic insult and failure of compensatory mechanisms, cerebral blood flow falls, leading to ischemic brain injury. (medscape.com)
An UCCAO caused a slight cerebral ischemia (cerebral blood flow [CBF] 70%) without hypotension (MABP 85 mmHg), systemic inflammation, multiple organs injuries, or neurological injury. (medsci.org)

However, oxygen therapy might cause the accumulation of distal bronchial viscous secretions because of positive pressure ventilation mode, and thus increase airway resistance, aggravate systemic hypoxia [15]. (researchgate.net)

INTRODUCTION: Experimental evidence, as well as improved clinical studies of the reduction of brain injury and, improves the neurological outcome, in newborns with hypoxic-ischemic encephalopathy (HIE) occurring in therapeutic hypothermia (TH). (bvsalud.org)
OBJECTIVE: To verify the potential of hypothermic hypoxic-ischemic encephalopathy (HIE) therapy in neonatal asphyxia, based on literature data, comparing the benefits between selective head cooling (SHC) and whole-body cooling (WBC), see that the use of TH as a standard treatment in newborns with moderate or severe HIE has been adopted. (bvsalud.org)
in the neonate -hypoxic-ischemic encephalopathy (HIE), infections, and cerebral lesions related to prematurity like severe Intraventricular haemorrhage (IVH), periventricular leukomalacia (PVL)-, or in the early infancy -infections, injuries, toxics, nutrition…- (Mwaniki MK et al. (redsamid.net)

Ischemic preconditioning, therefore, protects against subsequent ischemic injury. (biomedcentral.com)

When combined with an HS, an UCCAO is associated with ischemic neuronal injury in the ipsilateral hemisphere of adult rat brain, which can be attenuated by therapeutic hypothermia. (medsci.org)

However, combined an UCCAO and an HS caused a severe cerebral ischemia (18% of the original CBF levels), a moderate hypotension (MABP downed to 17 mmHg), systemic inflammation, peripheral organs damage, and neurological injury, which can be attenuated by whole body cooling. (medsci.org)
Patient outcomes following a minor polytrauma are often worse than those with a single severe injury. (medsci.org)
CONCLUSION: The recent insight into the mechanism of oxidative injury of red cells and evidence of relationships between erythrocyte oxidative stress and hypoxia suggest that increased hemolysis is induced by severe hypoxia and acidosis in the fetus as well as the newborn. (unisi.it)

Neonates exposed to hypoxia-ischemia (HI) injury can have poor neurological and behavioral outcomes including cerebral palsy (CP) and incidences of learning deficits and disabilities due to the diffuse nature of the insults. (frontiersin.org)
This study aimed to investigate whether resuscitation after a hemorrhagic shock (HS) and/or mild cerebral ischemia caused by a unilateral common carotid artery occlusion (UCCAO) can cause brain injury and concomitant neurological dysfunction, and explore the potential mechanisms. (medsci.org)
A resuscitation from an HS regards as a reperfusion insult which may induce neurological injury in patients with an UCCAO disease. (medsci.org)
However, it is not known whether resuscitation after a [ 10 - 12 ] HS can cause cerebral injury and concomitant neurological dysfunction, and its potential mechanisms. (medsci.org)

HBOT could obviously enhance aterial oxygen level, increase partial pressure of oxygen and improve ischemia in various organs or tissues, decrease acid metabolites and hasten functional recovery of various organs. (researchsquare.com)
With ischemia in coronary heart disease, impairment of the oxygen supply and metabolic disorder both occur [ 2 ]. (biomedcentral.com)
Oxygen rapidly faces with free electrons by means of hypoxanthinexanthine oxidase-xanthine system during the reperfusion/reoxygenation phase after ischemia/hypoxia. (cshd.org.tr)
Global hypoxia-ischemia interrupts oxygen delivery and blood flow to the entire brain. (cdc.gov)

These therapies should target the cellular mechanisms that underly HI brain injury, including early phase propagators of injury such as neuro-inflammation, cell death, mitochondrial dysfunction, oxidative stress, and excitotoxicity, and they should be safe for use in both term and preterm infants. (frontiersin.org)
Up to now, there are seven preliminary clinical research reports of hydrogen treatment diseases, namely type 2 diabetes, metabolic syndrome, hemodialysis, inflammation/mitochondrial myopathy, brain stem ischemia, side effects of radiotherapy and systemic lupus erythematosus. (gdcawolo.com)
An HS caused a moderate cerebral ischemia (52% of the original CBF levels), a moderate hypotension (MABP downed to 22 mmHg), systemic inflammation, and peripheral organs injuries. (medsci.org)
The expression of TLRs and their role in inflammation and ischemic injury in the adult brain is well documented. (biomedcentral.com)

The in vivo results showed that per-treatment of PEMF could significantly improve the cardiac function in I/R injury group. (pemfglobal.com)

Interestingly, they observed behavioral deficits and neuronal loss caused by HI brain injury in female adolescent offspring after SE ( Huang et al. ). (frontiersin.org)
presents a promising therapy that used inhibitors of the Src family kinases (SFKs) for neuroprotection in a preterm model of HI brain injury ( Qiu et al. ). (frontiersin.org)
We hypothesized that TLRs other than TLR-4 may mediate preconditioning against cerebral ischemic injury in the developing brain. (biomedcentral.com)
This is the first study to show that TLR-3 is expressed in the immature brain and mediates preconditioning against ischemic injury. (biomedcentral.com)
Taken together, these results indicate the TLRs play an important role in ischemia-induced injury in the adult brain. (biomedcentral.com)
However, the role of TLRs in ischemic injury of the developing brain is yet to be determined. (biomedcentral.com)
After a certain delay, the brain develops tolerance to ischemic injury caused by the injurious stimulus. (biomedcentral.com)
Brain edema primarily occurs as a consequence of various cerebral injuries including ischemic stroke. (benthamscience.com)
It was discovered in 2007 that inhaled hydrogen had genuine protection against brain damage caused by ischemia and reperfusion because of its anti-inflammatory and anti-apoptotic properties (Fukuda et al. (healthandhydrogen.com)
This results in a considerable improvement in injury caused by oxidative stress produced by different ischemia of cerebral areas of brain. (healthandhydrogen.com)
1) the factors causing brain injury in Childhood and thus affecting neurodevelopment, and 2) the early nutritional factors related to the latter development of the metabolic syndrome in preadolescent children. (redsamid.net)
1) Factors causing brain injury and thus affecting neurodevelopment (ND). (redsamid.net)
Those insults to the brain occurred during the foetal, neonatal or early post-neonatal periods, and although the specific mechanisms are complex and vary, all are related to cerebral hypoxia and ischemia, and reperfusion (Hilario E. Current Pediatr Review 2006;2:131). (redsamid.net)
In the scenario of IT, PC stimulus primes the brain for subsequent injurious ischemic injury. (biomedcentral.com)
Delayed phase of IT occurs in days, when the latent cerebroprotective phenotype is complete, the brain is again ischemia-tolerant. (biomedcentral.com)
Previous studies of global brain hypoxia ischemia have primarily focused on injury to the cerebral cortex and to the hippocampus. (cdc.gov)
Global brain hypoxia-ischemia during cardiac arrest has a long-term impact on processing and transfer of sensory information by thalamic circuitry. (cdc.gov)
If treated with cardiopulmonary resuscitation, however, cardiac arrest is survivable, but survivors often show evidence of injury in selectively vulnerable regions of the brain. (cdc.gov)

While altered BAG3 expression has been associated with cardiac dysfunction, its role in ischemia/reperfusion (I/R) is unknown. (uthscsa.edu)

A therapeutic drug that targets ischemia reperfusion (I/R) injury is needed and has yet to be developed. (biomedcentral.com)
These findings suggest that BAG3 may provide a therapeutic target in patients undergoing reperfusion after myocardial infarction. (uthscsa.edu)
Therefore, exploring new therapeutic agents and investigating their potential mechanisms underlying myocardial H/R injury is important. (biomedcentral.com)

Poly I:C-induced preconditioning against ischemic injury may be mediated by modulation of TLR-3 signaling pathways. (biomedcentral.com)
hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)

Heusch G: Myocardial ischaemia-reperfusion injury and cardioprotection in perspective. (spandidos-publications.com)

However, the effects and the detailed mechanisms of STA in myocardial H/R injury are unknown. (biomedcentral.com)
In the present study, we investigated for the first time whether PEMF treatment could improve the myocardial ischaemia/reperfusion (I/R) injury and uncovered its underlying mechanisms. (pemfglobal.com)

Chronic hypoxia in the presence of high glucose leads to progressive acidosis of cardiac myocytes in culture. (biologists.com)

Specifically, we model and investigate dynamic structure-function relationships in neuronal assemblies in healthy and perturbed conditions with the goal of identifying and engaging key aspects of complex neural network behaviour that determine adaptive or maladaptive neuroplasticity in the lesioned CNS, including injury and neurodegenerative disease. (ntnu.edu)

We also found that female mice sustained smaller infarcts than males three months post- ischemia . (nih.gov)

The primary rationale for these developments is that recognition of AKI allows prompt injury-specific intervention that may avert permanent renal damage. (medscape.com)

Beneficial role of oleuropein in sepsis-induced myocardial injury. (ooir.org)

The results support significant roles for miR-126 in regulating cardiac myocyte survival pathways and cell death during exposure to simulated ischemia and acidosis. (biomedres.us)

At 48 h after the injections, hypoxic-ischemic (HI) injury was induced by unilateral carotid artery ligation followed by hypoxia for 65 min. (biomedcentral.com)

The combination of injuries often occurs in modern warfare and automobile and industrial accidents [ 13 - 15 ]. (medsci.org)
Facial nerve injury usually occurs at or distal to its exit from the stylomastoid foramen and results in facial asymmetry, especially during crying. (msdmanuals.com)

Necrotizing enterocolitis (NEC) has become one of the most dreaded diseases in neonatal intensive care units. (karger.com)
Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)

Cells were pretreated with STA (50 µM) 2 h before H/R. Cardiomyocyte injury was evaluated by CCK-8 assay and lactate dehydrogenase (LDH) release. (biomedcentral.com)

Abouzaki NA, Christopher S, Trankle C, Van Tassell BW, Carbone S, Mauro AG, Buckley L, Toldo S and Abbate A: Inhibiting the inflammatory injury after myocardial ischemia reperfusion with plasma-derived Alpha-1 Antitrypsin: A post hoc analysis of the VCU-α1RT study. (spandidos-publications.com)
Important roles of inflammatory mediators in cardiac cell death by ischemia with or without reperfusion are well established [12-14]. (biomedres.us)
Early Sex Differences in the Immune-Inflammatory Responses to Neonatal Ischemic Stroke. (nih.gov)

IPC activates the reperfusion injury salvage kinase (RISK) and survivor activating factor enhancement (SAFE) pathways to protect the heart against IR injury. (biomedcentral.com)

Birth asphyxia causes 840,000 or 23% of all neonatal deaths worldwide. (medscape.com)

Stachydrine (STA), an active constituent of Leonurus heterophyllus sweet, could have a protective effect on myocardial H/R injury, which remains unexplored. (biomedcentral.com)

The resuscitation after an HS causes a reperfusion or reoxygenation insult [ 2 - 4 ], gut injury, and multiple organ dysfunctions [ 5 , 6 ]. (medsci.org)

Coronary heart disease is a leading cause of death in the world and therapy to reduce injury is still needed. (biomedcentral.com)

As for radiological changes, such as hypoxic-ischemic injuries and the incidence of seizures after cooling, they are more frequent with SHC. (bvsalud.org)

Anatomy5

Organisms3

Diseases16

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes4

Rats11

Cardiomyocytes11

Apoptosis13

Vitro4

Endothelial4

Tissue8

Acute8

Oxidative stress and inflammatory1

Induces3

Molecular2

Left anteri1

Perinatal5

Myocardium2

Cerebral bloo2

Accumulation1

Hypoxic-ischemic encephalopathy3

Protects1

Hypothermia1

Severe3

Neurological4

Oxygen4

Inflammation4

Cardiac function1

Brain18

Dysfunction1

Therapeutic3

Ischemic injury2

Cardioprotection1

Mechanisms2

Chronic1

Neuronal1

Mice1

Renal1

Myocardial injury1

Acidosis1

Ligation1

Occurs2

Diseases2

Lactate1

Inflammatory3

Pathways1

Asphyxia1

Protective effect1

Resuscitation1

Coronary1

Incidence1