Reperfusion injury ischaemia partial nephrectomy. Medical search. Frequent questions

Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)
Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (wikipedia.org)
Moreover, renal ischemia can cause the delay of graft function after renal transplant and can cause rejection of the transplant. (wikipedia.org)
In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (wikipedia.org)
The extrinsic pathway are directly induced upon renal ischemic injury, while intrinsic pathways are dependent on mitochondrial signaling pathways. (wikipedia.org)
however, DAXX mediates both Fas-dependent and TGF-beta-induced apoptosis and renal induction of TGF-beta is well documented in renal ischemia studies. (wikipedia.org)
Induction of hypometabolism as a novel strategy to minimize ischemia reperfusion injury in renal reconstruction surgery. (tourolib.org)

This could lead to an acute kidney injury. (wikipedia.org)

flap creation, which relies on the intrinsic vascular anatomy of the tissue, propensity for collateral formation, and in cases of replantation or free flaps, the timeline for perfusion and reperfusion. (abdominalkey.com)

Kidney ischemia is a disease with a high morbidity and mortality rate. (wikipedia.org)
What causes kidney ischemia is not entirely known, but several pathophysiology relating to this disease have been elucidated. (wikipedia.org)
Possible causes of kidney ischemia include the activation of IL-17C and hypoxia due to surgery or transplant. (wikipedia.org)
Several signs and symptoms include injury to the microvascular endothelium, apoptosis of kidney cells due to overstress in the endoplasmic reticulum, dysfunctions of the mitochondria, autophagy, inflammation of the kidneys, and maladaptive repair. (wikipedia.org)
Physical stress such as infarction, surgery and transplant may produce kidney ischemia. (wikipedia.org)
Diseases such as sepsis can cause kidney ischemia too. (wikipedia.org)
In studies of mice models, clamping of the kidney may result in kidney ischemia. (wikipedia.org)
However, in Jeju, deceased donor kidney transplantation (DDKT) has been restricted due to the prolonged cold ischemia time (CIT) caused by the island's geographic disadvantages and transportation limitations. (ekjt.org)
The geography and resulting transportation limitations of Jeju place it at risk for prolonged cold ischemia time (CIT) in deceased donor kidney transplantations, especially in marginal donor grafts. (ekjt.org)
While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)

Surgical Drains After Laparoscopic Donor Nephrectomy: Needed or Not? (annalsoftransplantation.com)
For the donor, living donation carries risk, with donor morbidity rates in some cases up to 40% for living liver donors, and cases of death from donation have been reported for both living donor nephrectomy and partial hepatectomy. (ochsnerjournal.org)

Hypometabolism: A novel strategy to extend warm ischemia time during partial nephrectomy. (tourolib.org)
In addition, the surgeon must have a detailed knowledge of previous surgical, traumatic, infectious, and radiation related perturbations to normal anatomy and physiology, along with an understanding of the time course and vulnerability of tissues after injury in order to properly plan for successful primary repair or tissue transfer to achieve restoration of function. (abdominalkey.com)
Therefore, the significance of LDKT for overcoming prolonged cold ischemia time (CIT) is greater than in other South Korean provinces. (ekjt.org)

In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
The administration of renoprotective agents extends warm ischemia in a rat model. (tourolib.org)

This is also shown in cell-based assays wherein tubule cells are monitored after ischemic-like injury. (wikipedia.org)
This shows that the Fas-pathway may play a role in the pathogenesis of the apoptosis of tubule cells during the early ischemic-reperfusion period. (wikipedia.org)

The patient underwent open repair with partial sternotomy and distal balloon control. (bcl2signaling.com)

The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
Genitourinary tract organs vary in their response to injury and "success" in wound healing in proportion to the density and/or redundancy of their blood supply. (abdominalkey.com)

Moreover, several genes have been implicated as risk factors in the development of ischemic injury. (wikipedia.org)

Developing a technique or drug that could reduce the risk of acute kidney injury associated with renal IRI would have an immediate worldwide impact on multisystem surgeries that would otherwise risk ischemic tissue injury. (hindawi.com)
Acute kidney injury (AKI) can lead to chronic kidney disease (CKD), and macrophages play a key role in this process. (bvsalud.org)
Contrast-induced acute kidney injury (CI-AKI) resulting from administration of iodinated contrast media (CM) is the third leading cause of hospital-acquired acute kidney injury and is associated with substantial morbidity and mortality. (biomedcentral.com)
With the increasing use of iodinated contrast medium (CM) in diagnostic and interventional procedures, CM-induced acute kidney injury (CI-AKI) has become the third most common cause for hospital-acquired AKI [ 1 ]. (biomedcentral.com)
Renal Ischemia/Reperfusion (I/R) causes acute kidney injury known by impaired renal function, which has partially been connected to kidney apoptosis as well as the impairment of Cyclooxygenase-2 (COX-2) and Na+/K+-ATPase signaling. (phypha.ir)
This could lead to an acute kidney injury. (wikipedia.org)
Deletion of soluble epoxide hydrolase attenuates mice Hyperoxic acute lung injury. (medscape.com)
3. Increased symmetrical dimethylarginine in ischemic acute kidney injury as a causative factor of renal L-arginine deficiency. (nih.gov)
Mesenchymal stem cells (MSCs) have been reported to promote regeneration in both subjects with acute kidney injury (AKI) and chronic kidney disease (CKD), but their efficacy remains limited, probably because most of the cells accumulate in the lungs, liver, and spleen after an intravenous infusion. (biomedcentral.com)

Possible causes of kidney ischemia include the activation of IL-17C and hypoxia due to surgery or transplant. (wikipedia.org)
The underlying mechanisms of renal injury or sickle cell nephropathy (SCN) relate mainly to hypoxia and ischemia. (medscape.com)

The attenuation of neurological injury from the use of simvastatin after spinal cord ischemia-reperfusion injury in rats. (medscape.com)
Spinal cord ischemic injury that frequently results in paraplegia is a major cause of morbidity after thoracic aorta operations. (mirnainhibitors.com)
In the present study, we examined the neuroprotective role of G-CSF on spinal cord ischemia-induced neurological dysfunctions and changes in the mitogen-activated protein kinase (MAPK) and Akt signaling pathways in the spinal cord. (mirnainhibitors.com)
Spinal cord ischemia was induced in male Wistar rats by occluding the descending aorta with a 2F Fogarty catheter for 12 min 30 s. (mirnainhibitors.com)

The hypoxic, acidotic, and hyperosmolar environment of the inner medulla are known to promote sickling of red blood cells (RBCs) with resultant impairment in renal medullary blood flow, ischemia, microinfarction, and papillary necrosis. (medscape.com)
Medullary ischemia and infarction cause papillary necrosis. (medscape.com)

However, during ischemia the activity of the antioxidant enzymes is diminished, leading to an increase in the formation of superoxide radicals and oxidative stress at reperfusion [ 9 ]. (hindawi.com)
Limb ischemic preconditioning (LIPC) is a strategy of applying transient, brief episodes of ischemia to induce resistance in a target organ against the oxidative stress and injury caused by a larger ischemic insult [ 8 ], and may offer a highly appealing, non-invasive, nonpharmacological and cost-effective strategy on CI-AKI prevention. (biomedcentral.com)

Physical stress such as infarction, surgery and transplant may produce kidney ischemia. (wikipedia.org)
The resulting increased blood viscosity contributes to ischemia and eventual infarction that involves the renal microcirculation. (medscape.com)

Dietary habits and genetics could cause ischemic injury, as well. (wikipedia.org)
The extrinsic pathway are directly induced upon renal ischemic injury, while intrinsic pathways are dependent on mitochondrial signaling pathways. (wikipedia.org)
Moreover, several genes have been implicated as risk factors in the development of ischemic injury. (wikipedia.org)
Upregulation of Fas and FADD protein has occurred in mice models after a 24h period of ischemic injury. (wikipedia.org)

Then, the animals were subjected to bilateral renal ischemia for 60 min and reperfusion for 24 h. (phypha.ir)
11. Role of alanine:glyoxylate aminotransferase 2 in metabolism of asymmetric dimethylarginine in the settings of asymmetric dimethylarginine overload and bilateral nephrectomy. (nih.gov)

Immediately after ischemia surgery, the rats were administered G-CSF (10 mu g) or saline by intrathecal (i.t.) injection. (mirnainhibitors.com)
The rats were divided into four groups: control, ischemia plus saline, ischemia plus G-CSF and G-CSF alone. (mirnainhibitors.com)

The findings of the present study indicated that the renoprotective effect of NC in the renal I/R rat model coincided with the inhibition of histopathological injuries and apoptosis, but not with compensation for renal COX-2 and Na+/K+ -ATPase downregulation. (phypha.ir)
Several signs and symptoms include injury to the microvascular endothelium, apoptosis of kidney cells due to overstress in the endoplasmic reticulum, dysfunctions of the mitochondria, autophagy, inflammation of the kidneys, and maladaptive repair. (wikipedia.org)
This shows that the Fas-pathway may play a role in the pathogenesis of the apoptosis of tubule cells during the early ischemic-reperfusion period. (wikipedia.org)
however, DAXX mediates both Fas-dependent and TGF-beta-induced apoptosis and renal induction of TGF-beta is well documented in renal ischemia studies. (wikipedia.org)
Many studies indicate that, after reoxygenation of the liver, oxygen free-radical formation may initiate the cascade of hepatocellular injury, necrosis/apoptosis, and subsequent infiltration of inflammatory cells. (lomr.org)

Ischemia-reperfusion- (IR-) induced kidney injury is difficult to avoid during renal transplantation and robot-assisted partial nephrectomy. (bvsalud.org)
In addition, histological analyses showed that MSCs noticeably attenuated kidney injury, as evidenced by the amelioration of tubular necrosis and peritubular interstitial fibrosis. (biomedcentral.com)
These findings suggested that administration of MSCs into the cavity formed by the injured kidney and the greater omentum under ultrasound guidance improved renal function, attenuated kidney injury, and mitigated renal interstitial fibrosis and inflammatory responses. (biomedcentral.com)
CAN/IFTA with chronic kidney injury is characterized by expression of distinct growth factors and specific integrin adhesion molecules as well as their canonical signaling pathways. (biomedcentral.com)
Chronic Allograft Nephropathy (CAN) is defined as a clinical entity by chronic kidney injury leading to progressive loss of kidney transplant function in the absence of another known cause. (biomedcentral.com)
Grading IFTA histology is a means of expressing the severity of chronic kidney injury. (biomedcentral.com)

RBC sickling and congestion in the vasa recta leads to ischemia and associated impairment of solute reabsorption by the ascending limb of the loop of Henle and impairs urinary concentrating ability. (medscape.com)
The liver is damaged by sustained ischaemia in liver transplantation or in liver surgical procedures, and the reperfusion after ischaemia results in further functional impairment [1]. (lomr.org)

Here, we hypothesized that PAR-1 exaggerated renal IR-induced tubular cell damage and microcirculation failure and that pharmacological inhibition of PAR-1 by Q94 could prevent these injuries. (bvsalud.org)

Current clinical data support a "safe" warm ischemia time of 25 minutes, or a cold ischemia time (when the kidney is placed on ice slush) of 35 min while up to two hours can be tolerated [ 4 ]. (hindawi.com)
BACKGROUND/OBJECTIVES:To investigate the oncological and functional outcomes after partial nephrectomy for clinical stage T1 (cT1) renal cell carcinoma (RCC), and assess the association between excisional volume loss (EVL) and postoperative renal function. (shengsci.com)
Hemolysis, vaso-occlusion, and ischemia-reperfusion injury are the clinical hallmarks of sickle cell disease (SCD). (medscape.com)
Chronic Allograft Nephropathy (CAN) is a clinical entity of progressive kidney transplant injury. (biomedcentral.com)

17: Zhang L, Liu X, Sheng H, Liu S, Li Y, Zhao JQ, Warner DS, Paschen W, Yang W. Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice. (duke.edu)

In studies of mice models, a high-fat diet can induce greater injury to the kidney with renal ischemia-reperfusion as compared to mice with normal diet. (wikipedia.org)

Pretreatment with paricalcitol attenuates inflammation in ischemia-reperfusion injury via the up-regulation of cyclooxygenase-2 and prostaglandin E2. (phypha.ir)
Fibrosis represents the end result of kidney tissue injury, which includes the donor organ's history, impact of ischemia/reperfusion, alloimmune-activated T and B cell-mediated, antibody-mediated and inflammation-mediated vascular injury [ 6 - 8 ]. (biomedcentral.com)

CONCLUSIONS:Patients with cT1a and cT1b RCC have comparable oncological and functional outcome after partial nephrectomy, and preoperative eGFR is an independent factor to predict developing CKD. (shengsci.com)

Kidney ischemia is a disease with a high morbidity and mortality rate. (wikipedia.org)

The two key factors that contribute to postoperative loss of renal function are ischemia time and degree of parenchymal loss [ 2 ]. (hindawi.com)

Limb ischemic preconditioning (LIPC), where brief and non-injurious ischemia/reperfusion is applied to a limb prior to the administration of the contrast agent, is emerging as a promising strategy for CI-AKI prevention. (biomedcentral.com)

A pharmacological agent that could reduce the risk of IRI and prolong the "safe" warm ischemia time would cause a global transformational change in the utilization of partial nephrectomy, with broader implications for renal transplantation, cardiac surgery, and the myriad other surgeries that involve IRI. (hindawi.com)

The ischemic preconditioning (lscheP) is an inducible and potent endogenous mechanism by which repeated episodes of brief ischemia/reperfusion (l/R) confer a state of protection against subsequent sustained l/R. On the other hand, it has been demonstrated that ozone is able to promote an oxidative preconditioning through the increase and preservation of antioxidant endogenous systems. (lomr.org)

Although a large number of drugs and agents (including Ca 2+ -channel blockers, mannitol, acadesine, adenosine, Na + /H + -exchange inhibitors, and N-acetylcysteine (an antioxidant)) have been shown to protect against ischemia-reperfusion injury (IRI) in the kidney in vitro and in vivo (in either rat or mouse), all have failed in either large animal or human trials [ 5 - 8 ]. (hindawi.com)
Effects of in vivo ischemia on contractile responses of rabbit bladder to field stimulation, carbachol, ATP and KCl. (upstate.edu)

Urethra is more sensitive to ischemia than bladder: evidence from an in vitro rat study. (upstate.edu)

18. Age-related changes in ADMA-DDAH-NO pathway in rat liver subjected to partial ischemia followed by global reperfusion. (nih.gov)

ln spite of the fact that the ischaemic preconditioning has been extensively studied on heart, only few studies have been performed on the model of ischaemic-reperfusion injury in the liver. (lomr.org)

Regardless of the proximate causes, interactions between growth factors and integrin adhesion molecules are important mechanisms in the cycle of injury, repair and fibrosis that are also widely accepted as downstream events in CAN/IFTA [ 8 - 13 ]. (biomedcentral.com)

AIMS: To explore the relationship between renal ischemia/reperfusion injury (RIRI) and the activation of the renal 5-HT degradation system, including 5-HT2A receptor (5-HT2AR), 5-HT synthases and monoamine oxidase-A (MAO-A). MAIN METHODS: Rat RIRI was induced by removing the right kidney, causing ischemia of the left kidney for 45 min and reperfusion for different times. (bvsalud.org)

In studies of mice models, clamping of the kidney may result in kidney ischemia. (wikipedia.org)

NC at the dose of 25 mg/kg/i.p or its vehicle was administered 60 min before renal ischemia induction. (phypha.ir)

What causes kidney ischemia is not entirely known, but several pathophysiology relating to this disease have been elucidated. (wikipedia.org)

Partial nephrectomy uses a nephron-sparing approach and is increasingly becoming the gold standard for smaller tumors, tumors in solitary kidneys and patients with underlying poor renal function. (hindawi.com)

The neurological dysfunctions were assessed by calculating the motor deficit index after ischemia surgery. (mirnainhibitors.com)

In a study comprising 25 patients with stable chronic obstructive pulmonary disease with edema, it was reported that although there was no abnormality in cardiac function, the increased partial pressure of carbon dioxide caused renal vasoconstriction, resulting in decreased glomerular filtration rate and fluid retention [ 3 ]. (e-pan.org)

However, while the majority of cancers are suitable for partial nephrectomy, concern about the warm ischemia time has meant that only around 25% of small kidney cancers are treated with nephron-sparing surgery [ 3 ]. (hindawi.com)
Renal surgery and coronary artery bypass grafting can produce renal ischemia and reperfusion injury. (wikipedia.org)

Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease. (hindawi.com)
Cyclooxygenase 1 and/or 2 blockade ameliorates the renal tissue damage triggered by ischemia and reperfusion injury. (phypha.ir)

Beyond this period, critical ischemia ensues, where renal cells are irreversibly injured, eventually resulting in nephron loss and chronic kidney disease in 5-17% patients [ 4 ]. (hindawi.com)

This is a time-critical step due to the critical ischemia period of renal tissue. (hindawi.com)

Nephrectomy and partial nephrectomy are more invasive treatment options. (medscape.com)

Protease-activated receptor-1 (PAR-1) and its ligand, thrombin, are involved in coagulation and were shown to be associated with epithelial cell injury. (bvsalud.org)
This is also shown in cell-based assays wherein tubule cells are monitored after ischemic-like injury. (wikipedia.org)
Recently, this factor has been shown to exhibit neuroprotective effects on many CNS injuries. (mirnainhibitors.com)

Renal volume matters: Assessing the association between excisional volume loss and renal function after partial nephrectomy. (shengsci.com)
citation needed] Kidney ischemia can be diagnosed by checking the levels of several biomarkers such as clusterin and cystatin C. While the duration of ischemia was used as a biomarker, it was found that it has significant flaws in predicting renal function outcomes. (wikipedia.org)

In most cases, hypertension is cured by nephrectomy. (medscape.com)

Finally, pain refractory to less invasive attempts may respond to nephrectomy. (medscape.com)

Significant metastatic disease and poor performance status may limit the use of nephrectomy, in which embolization may be palliative. (medscape.com)

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