Reperfusion arrhythmias arrhythmias cardiac. Medical search. Frequent questions

However, harmful stimuli (such as ischemia-reperfusion, oxidative stress, and toxic chemicals) can change the direction and efficiency of intercellular mitochondrial transfer. (frontiersin.org)
2010.07.033.Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. (myoptivida.com)
induced cardiac toxicity such as oxidative stress and deteriorated mitochondrial function, a disturbance in iron regulatory protein [(IRP)-1], the release of nitric oxide, autophagy and dysregulation of Ca 2+ level. (mosuljournals.com)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

We previously demonstrated that chronic pretreatment with a thiazolidinedione peroxisome proliferator-activated receptor (PPAR)-γ activator, troglitazone, improves recovery of left ventricular (LV) function and substrate metabolism after ischemia and reperfusion, without causing arrhythmias. (diabetesjournals.org)
Acute treatment with troglitazone increases susceptibility to ventricular fibrillation during myocardial ischemia and reperfusion. (diabetesjournals.org)
Then the aorta is cross-clamped and the heart is stopped by injection of a cardioplegic solution (crystalloid or more commonly blood-based) that also contains substances that help myocardial cells tolerate ischemia and reperfusion. (msdmanuals.com)

Sudden death occurs more frequently (presumably as a result of ventricular fibrillation ) when ventricular premature beats occur in the presence of organic heart disease but not in individuals with no known cardiac disease. (health.am)
Ventricular fibrillation , a type of arrhythmia where the ventricles (the heart's lower chambers) don't beat normally. (medlineplus.gov)

MAs may be manifested either in hemodynamic collapse or in cardiac arrest: The sudden loss of effective blood flow due to atrial fibrillation (AF) with rapid VT leads to hemodynamic collapse, and VT and VF result in cardiac arrest necessitating CPR or electric defibrillation. (medscape.com)
The authors reviewed current knowledge on occurrence, clinical and prognostic significance, and management of sustained ventricular arrhythmias, atrial fibrillation and bradyarrhythmias in patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary interventions (PCI). (ogu.edu.tr)

Acute administration of cannabidiol in vivo suppresses ischaemia- induced cardiac arrhythmias and reduces infarct size when given at reperfusion. (myoptivida.com)
Modelling myocardial ischaemia and reperfusion. (ox.ac.uk)
The model is sufficiently complete to simulate calcium-overload arrhythmias during ischaemia and reperfusion-induced arrhythmias. (ox.ac.uk)
In summary, we have developed a biochemically and biophysically detailed model that provides a novel approach to studying myocardial ischaemia and reperfusion. (ox.ac.uk)

Arrhythmias related to reperfusion do not usually require specific treatment, whereas those because of ongoing ischemia, incomplete revascularization and presence of substrate require adequate management including nonpharmacological and pharmacological therapies. (ogu.edu.tr)

Current work builds on the group's central role in the Ontario Consortium for Cardiac Imaging where the focus is to develop and evaluate the role of multiple imaging modalities applied to cardiac diseases and in the Imaging Research Centre for Cardiac Intervention to design and test new imaging approaches to guide innovative minimally invasive cardiovascular therapies. (sunnybrook.ca)
Two of the major goals in the treatment of this condition include reducing progression or recurrence of the arrhythmia and decreasing the risk of cardiovascular events, thereby improving quality of life and decreasing morbidity. (romanianjournalcardiology.ro)
Objetivo: Elaborar una estrategia de intervención psicoeducativa para potenciar la rehabilitación cardiovascular integral en pacientes convalecientes de infarto agudo de miocardio, con la visión de especialistas consultados. (bvsalud.org)

Epigallocatechin‑3‑gallate (EGCG), the predominant catechin component of green tea, has been reported to have potential cardioprotective effects in primary cultures of cardiac myocytes exposed to I/R injury, mediated through inhibition of signal transducers and activators of transcription‑1 activity. (spandidos-publications.com)
Previous studies have identified apoptosis as a significant mechanism underlying cell death during I/R injury in cultured cardiac myocytes ( 6 , 7 ), and that the inhibition of this apoptosis is able to prevent I/R injury ( 8 ). (spandidos-publications.com)
On the other hand, the inhibition of NBCe1 generates an APD prolongation, potentially representing a risk of arrhythmias. (conicet.gov.ar)
On the other hand, NCX inhibition represents a novel potential therapeutic strategy in case of a variety of cardiac dysfunctions. (unideb.hu)

Preconditioning with sevoflurane (SEV) may drive back ischemia-reperfusion injury in a number of organs, however, the advantages of SEV against acute lung injury (ALI), induced by intestinal ischemia-reperfusion (IIR), as well as the root mechanisms remain to become elucidated. (researchdataservice.com)
Preconditioning with SEV continues to be demonstrated to drive back ischemia-reperfusion injury in a variety of organs, especially in the lungs and mind (19,20). (researchdataservice.com)
Because irreversible injury occurs within 2-4 hours of the infarction, there is a limited window of time available for reperfusion to work. (wikipedia.org)
By understanding the links between Ca2+, electrical excitability and energy production, we hope to understand the cellular basis of cardiac arrhythmias, ischemia-reperfusion injury, and sudden death. (hopkinsmedicine.org)
It has previously been demonstrated that phosphatidylinositol‑3‑kinase (PI3K)/Akt and cleaved caspase‑3 serve critical roles in the apoptosis of cardiac myocytes following ischemia/reperfusion injury. (spandidos-publications.com)
In the present study, the protective effects of EGCG with zinc were assessed on cultures of rat cardiac myoblasts exposed to hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
Since EGCG + Zn2+ may, at least in part, protect cardiac myocytes against H/R‑induced apoptotic cell death, the PI3K/Akt pathway of EGCG may be enhanced by its interactions with zinc during H/R injury. (spandidos-publications.com)
Increases in knowledge have revealed that the common pathophysiological scenario, myocardial ischemia reperfusion injury, including ischemia/reperfusion (I/R) and hypoxia/reoxygenation (H/R) forms of injury, results in depressed myocardial function and harmful morphological alterations, which may lead to heart failure ( 4 ). (spandidos-publications.com)
BACKGROUND: A myocardial ischemia/reperfusion (IR) injury activates the transient receptor potential vanilloid 1 (TRPV1) dorsal root ganglion (DRG) neurons. (bvsalud.org)
In this study, we hypothesize that the selective epidural administration of resiniferatoxin (RTX) to DRGs may provide cardioprotection against ventricular arrhythmias by inhibiting afferent neurotransmission during IR injury. (bvsalud.org)
Moreover, we applied the glutamate-sensing method using the flexible probe in the context of myocardial ischemia-reperfusion (I/R) injury. (bvsalud.org)
During I/R injury, cardiac sensory neurons in the dorsal root ganglion transmit excitatory signals to the spinal cord, resulting in sympathetic activation that potentially leads to fatal arrhythmias. (bvsalud.org)
Despite the complexpathophysiology of ischemia, hypoxia alone is a sufficient stimulus to induce a variety of adaptive responsesthat protect against ischemia-reperfusion injury. (grantome.com)
Aim 1 will investigate the mechanisms by which EPO protects the heart from injury following ischemiaand reperfusion. (grantome.com)
The sudden restoration of blood supply to an ischemic tissue can lead to increased damage by a process called reperfusion injury which can be more harmful than the initial ischemic damage. (mcpcourse.com)
Complications of Ischemia include heart attacks, strokes, reperfusion injury and the fatal cardiac arrhythmias can be a secondary complication. (mcpcourse.com)
Current methods of cold static storage have reached their limits in storage time due to the extent of ischemia-reperfusion (I/R) injury induced during static cold storage. (gotomydoctor.com)
The extent of reperfusion injury is directly proportional to preservation time in cold storage, and research has shown that with static storage methods, heart storage time will not exceed six hours. (gotomydoctor.com)
Additionally, machine reperfusion induces the production of ROS, which results in I/R injury to the heart. (gotomydoctor.com)
Ischemia-reperfusion injury following the relieving of muscle compression may cause metabolic changes and rhabdomyolysis depending on the time of extrication. (turkjemergmed.com)
This may cause sudden cardiac arrest, acute extremity compartment syndrome, and acute kidney injury. (turkjemergmed.com)
CB2 receptor ligands have been shown to inhibit inflammation and edema formation, exhibit analgesic effects, and play a protective role in hepatic ischemia-reperfusion injury. (vediherbals.com)
Altered NCX function may result in abnormal Ca2+ release from the sarcoplasmic reticulum (SR) and impaired cardiac electrical activity and contractility in several diseases, like arrhythmias, ischemia/reperfusion injury, hypertrophy and heart failure. (unideb.hu)
Partial NCX blockade was shown to have beneficial effects in animal models of ischemia/reperfusion injury and also antiarrhythmic and positive inotropic actions in the failing heart. (unideb.hu)

This study illustrates a novel technique for measuring spinal glutamate at different spinal cord levels as a surrogate for the spinal neural network activity during cardiac interventions that engage the cardio-spinal neural pathway.NEW & NOTEWORTHY In this study, we have developed a new flexible sensing probe to perform an in vivo measurement of spinal glutamate signaling in a large animal model. (bvsalud.org)
Objective: To determine the impact of educational interventions to foster health in patients undergoing cardiac rehabilitation. (bvsalud.org)

In the last years, the potentially altered NBC function in pathological scenarios, as cardiac hypertrophy and ischemia-reperfusion, has raised increasing interest among investigators. (conicet.gov.ar)
This review attempts to draw the attention on the relevant regulation of NBC activity by RAAS, since it modulates pHi and [Na+]i, which are involved in the development of cardiac hypertrophy, the damage produced by ischemia-reperfusion and the generation of arrhythmic events, suggesting a potential role of NBC in cardiac diseases. (conicet.gov.ar)

However, a significant number of patients receiving PCI fail to achieve complete and sustained myocardial reperfusion and therefore remain at risk of developing large infarcts ( 1 ). (spandidos-publications.com)
The addition of the Traditional Chinese Medicine (TCM) therapies increased positive patient outcomes by 28% for patients with tachycardia, arrhythmias, and palpitations. (herbalmedicineuk.com)
Patients with arrhythmias and tachycardia tend to present with rapid and irregular pulses. (herbalmedicineuk.com)
Cardiac arrhythmias worsen clinical course and prognosis in patients with ST-elevation myocardial infarction undergoing primary PCI. (ogu.edu.tr)
Related factoid: Ever wonder why patients will frequently have an idioventricular rhythm after cardiac arrest? (emdocs.net)
The objective of the study was to detect the effects of different inotropes on the hemodynamics of patients who developed low cardiac output. (pubmed.pro)
The class I and III agents are all effective in reducing ventricular premature beats but often cause side effects and may exacerbate serious arrhythmias in 5-20% of patients. (health.am)
In nonacute settings, most patients with ventricular tachycardia have known or easily detectable cardiac disease, and the finding of ventricular tachycardia is an unfavorable prognostic sign. (health.am)
Coronary artery bypass grafting (CABG) is performed for patients with coronary artery disease (CAD) to improve quality of life and reduce cardiac-related mortality. (medscape.com)

The renin-angiotensin-aldosterone system (RAAS) is implicated in the modulation of almost all physiological cardiac functions and is also involved in the development and progression of cardiac diseases. (conicet.gov.ar)
It might be argued that blockade of the renin-angiotensin system may be a more effective strategy if performed earlier during the natural history of the disease or even before AF develops (ie, prima-ry prevention), since ACE inhibitors and ARBs may pre-vent, but not necessarily reverse, the electrical and structural remodelling that leads to the development and progression of the arrhythmia. (romanianjournalcardiology.ro)

Coronary artery stenosis, resulting in impaired cardiac perfusion, ischemia, and the risk of myocardial infarction,is a major cause of morbidity and mortality in the U. S. population. (grantome.com)
Acute myocardial infarction occurs due to decreased coronary blood flow, leading to insufficient oxygen supply to the heart and cardiac ischemia. (statpearls.com)

Notably, emotional factors exacerbate arrhythmias and tachycardia, including both panic attacks and generalized anxiety. (herbalmedicineuk.com)

In addition there were multiple opportunities for networking with other basic scientists working on the mechanisms of cardiac arrhythmias, including the conference dinner at the beautiful Venta de Aires restaurant. (iemr.no)
Network pharmacology analysis was then conducted to reveal the potential targets of SXSM active components and their anti-arrhythmia mechanisms. (pubmed.pro)
A drug-target-pathway network analysis connecting SXSM components with arrhythmia suggested that a prominent anti-arrhythmia mechanisms of SXSM was via β1-adrenergic signaling pathway, which was subsequently validated by immunofluorescence assay showing that SXSM indeed increased the expression of ADRB1 in cultured cardiomyocytes. (pubmed.pro)

Additionally, it may clinically manifest with myocardial necrosis, cardiac arrhythmia, myocardial stunning and microvascular dysfunction ( 5 ). (spandidos-publications.com)

Mathis Korseberg Stokke , Mani Sadredini and Marie Haugsten Hansen attended the 46th ESC Working Group on Cardiac Cellular Electrophysiology conference in Toledo, Spain which was held from the 4th-6th June. (iemr.no)

Post reperfusion syndrome (PRS) is a significant event and can lead to arrhythmias and even cardiac arrest. (jccm.ro)
What is sudden cardiac arrest (SCA)? (medlineplus.gov)
Sudden cardiac arrest (SCA) is a condition in which the heart suddenly stops beating. (medlineplus.gov)
How is sudden cardiac arrest (SCA) different from a heart attack? (medlineplus.gov)
Who is at risk for sudden cardiac arrest (SCA)? (medlineplus.gov)
What are the symptoms of sudden cardiac arrest (SCA)? (medlineplus.gov)
How is sudden cardiac arrest (SCA) diagnosed? (medlineplus.gov)

METHODS:A literature-based meta-analysis was performed to evaluate the clinical efficacy of SXSM on bradycardia, which was confirmed by a rat ex vivo cardiac model. (pubmed.pro)

Because of concerns about worsening arrhythmia and sudden death with most antiarrhythmic agents, ß-blockers are the agents of first choice. (health.am)

In the patient who presents with cardiogenic shock (see later) and develops malignant ventricular arrhythmias, most other antiarrhythmics other than amiodarone will suppress myocardial contractility and should be avoided. (emdocs.net)

Unstable angina resembles an NSTEMI, but normal cardiac markers distinguish it. (statpearls.com)

Metoprolol tartrate is also used to treat tachycardia (abnormally rapid heart beats) and arrhythmias (irregular heart beats). (herbalmedicineuk.com)
Irregular heartbeats are called arrhythmias . (medlineplus.gov)

CONCLUSIONS: The administration of RTX locally to thoracic DRGs reduces ventricular arrhythmia in a porcine model of IR, likely by inhibiting spinal afferent hyperactivity in the cardio-spinal sympathetic pathways. (bvsalud.org)
It has also been studied that acute administration of CBD in-vivo suppresses ischemia-induced cardiac arrhythmias and reduces infarct size when administered at reperfusion. (vediherbals.com)

As a secondary complication , it increases calcium concentration inside cells causing fatal cardiac arrhythmias and also increased cellular damage by activating many proteolytic enzymes. (mcpcourse.com)

Although no perfect thrombolytic agent exists, ideally it would lead to rapid reperfusion, have a high sustained patency rate, be specific for recent thrombi, be easily and rapidly administered, create a low risk for intracerebral bleeding and systemic bleeding, have no antigenicity, adverse hemodynamic effects, or clinically significant drug interactions, and be cost effective. (wikipedia.org)
Act in Time to Heart Attack Signs brochure and wallet (e.g., angioplasty, thrombolytic therapy) and arrhythmia card with their paychecks. (cdc.gov)

Pre-existing models of cardiac cells such as Oxsoft HEART contain highly developed dynamic descriptions of cardiac electrical activity. (ox.ac.uk)
Prompt reperfusion and restoration of blood flow to the heart are crucial. (statpearls.com)
Coronary sinus, normally located between the LEFT ATRIUM and LEFT VENTRICLE on the posterior surface of the heart, can serve as an anatomical reference for cardiac procedures. (bvsalud.org)

H9c2 cells were subjected to 3‑h hypoxia, followed by 1‑h reperfusion. (spandidos-publications.com)

induced cardiac toxicity. (mosuljournals.com)

In healthy cardiac cells consequences of a partial NCX blockade were found to be moderate and species dependent. (unideb.hu)

Coupled with the rapid increase in computing power, this has allowed the development of a mathematical model of cardiac metabolism in normal and ischaemic conditions. (ox.ac.uk)

If the condition stays stable a cardiac stress test may be offered, and if needed subsequent revascularization will be carried out to restore a normal blood flow. (wikipedia.org)
cause they did not have a stable haemo- reinfarction, ventricular arrhythmia and Education for early recognition of dynamic condition or underwent some cardiac death ( 1-3 ). (who.int)

Aim 2 will investigate the role of HIF-1 in mediating adaptive responses to cardiac ischemiaand reperfusion. (grantome.com)

Arrhythmia risk was investigated by assessing the dispersion of repolarization (DOR), a marker of arrhythmogenicity, and measuring the arrhythmia score and the number of non-sustained ventricular tachycardias (VTs). (bvsalud.org)
MI can impair diastolic and systolic function, increasing the risk of arrhythmias. (statpearls.com)

On completion of the vascular anastomoses, the aorta is unclamped, allowing the coronary arteries to be perfused by oxygenated blood, which typically restores cardiac activity. (msdmanuals.com)
The origin of the arrhythmia depends on the vascular territory of the acute infarct. (emdocs.net)

The EWGCCE meeting gathers young researchers and high-level international experts in cardiac cells and provides an overview of topical issues in signalling, ion channels, arrhythmias, models and techniques at experimental and clinical level. (iemr.no)

It also suggests a strategy for the control of cardiac arrhythmias during calcium overload by regulating sodium-calcium exchange. (ox.ac.uk)

Thiazolidinediones exert electrophysiologic effects in noncardiac cells in vitro, but to date there have been no reports of effects on cardiac rhythm. (diabetesjournals.org)

Prompt and complete revascularization is the cornerstone of arrhythmia management. (ogu.edu.tr)

It has also been used in cardiac drug delivery applications with no side effects. (gotomydoctor.com)
CBD has also been seen to have positive effects on cardiac health by improving circulation and reducing inflammation. (benefitscbdoils.com)

LAD lesions, known as "widow makers," may present with ventricular arrhythmias ( VF, VT ). (emdocs.net)
If no associated cardiac disease is present and if the ectopic beats are asymptomatic, no therapy is indicated. (health.am)

Anatomy25

Organisms12

Diseases63

Chemicals and Drugs69

Analytical, Diagnostic and Therapeutic Techniques and Equipment58

Phenomena and Processes27

Disciplines and Occupations2

Information Science3

Health Care11

Oxidative stress5

Ischemia and reperfusion3

Ventricular fibrillation2

Atrial fibrillation2

Ischaemia4

Substrate1

Cardiovascular3

Inhibition4

Injury24

Interventions2

Hypertrophy2

Patients9

Development and progression2

Myocardial infarction2

Exacerbate1

Mechanisms3

Dysfunction1

Electrophysiology1

Arrest7

Bradycardia1

Antiarrhythmic1

Malignant1

NSTEMI1

Irregular2

Reduces2

Cellular1

Thrombolytic2

Heart3

Hypoxia1

Toxicity1

Consequences1

Metabolism1

Stable2

Adaptive1

Risk2

Vascular2

Researchers1

Calcium1

Cells1

Prompt1

Effects2

Present2