Repair of oxidative dna damage. Medical search. Frequent questions

These spermatozoa also experienced increased mitochondrial generation of reactive oxygen species after 1 week of exposure, with elevated DNA oxidation and fragmentation across all exposure periods. (nature.com)
Nuclear and mitochondrial genomes are under continuous assault by a combination of environmentally and endogenously derived reactive oxygen species, inducing the formation and accumulation of mutagenic, toxic, and/or genome-destabilizing DNA lesions. (uky.edu)
Oxidative stress reflects an imbalance between the systemic manifestation of reactive oxygen species and a biological system's ability to readily detoxify the reactive intermediates or to repair the resulting damage. (wikipedia.org)
Base damage is mostly indirect and caused by the reactive oxygen species generated, e.g. (wikipedia.org)
Production of reactive oxygen species is a particularly destructive aspect of oxidative stress. (wikipedia.org)
These include changes affecting mitochondrial DNA, membrane permeability, and increased formation of reactive oxygen species (ROS). (frontiersin.org)
In addition, UV induces the generation of reactive oxygen species (ROS), which overwhelm the antioxidant defense system, resulting in oxidative stress and damage to cell structure, DNA, proteins and lipids ( 5 ). (spandidos-publications.com)
Similarly, freeze-dried açaí extract has demonstrated unrivalled scavenging capacity against two of the most damaging reactive oxygen species, the superoxide and peroxyl radicals. (lifeextension.com)
respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)

However, more severe oxidative stress can cause cell death, and even moderate oxidation can trigger apoptosis, while more intense stresses may cause necrosis. (wikipedia.org)
It has been demonstrated that Cd induces cancer by multiple mechanisms and the most important among them are aberrant gene expression, inhibition of DNA damage repair, induction of oxidative stress, and inhibition of apoptosis. (cdc.gov)
The available evidence indicates that, perhaps, oxidative stress plays a central role in Cd carcinogenesis because of its involvement in Cd-induced aberrant gene expression, inhibition of DNA damage repair, and apoptosis. (cdc.gov)
Mitochondria are the cellular powerhouse of eukaryotic cells, and they also regulate brain function through oxidative stress and apoptosis. (frontiersin.org)
Alterations in mitochondrial functions such as oxidative phosphorylation (OXPHOS) and membrane polarity, which increase oxidative stress and apoptosis, may precede the development of depressive symptoms. (frontiersin.org)
UV-B-induced DNA damage can trigger cell signaling pathways to activate defense systems, leading to DNA repair and/or apoptosis ( 6 ). (spandidos-publications.com)
p53 is a tumor suppressor that has a central role in regulating cell cycle arrest, DNA repair, and apoptosis. (novusbio.com)
At the cellular and whole organ level, degenerative changes that are a hallmark of natural aging (shorter telomeres, increased expression of cellular senescence markers, increased DNA damage, oxidative stress, and apoptosis, accompanied by diminished elasticity) reach pathological levels in aging humans in the form of chronic respiratory disease. (karger.com)

Failure to resolve these lesions through one or more DNA-repair processes is associated with genome instability, mitochondrial dysfunction, neurodegeneration, inflammation, aging, and cancer, emphasizing the importance of characterizing the pathways and proteins involved in the repair of oxidative DNA damage. (uky.edu)
This review focuses on the repair of oxidative damage-induced lesions in nuclear and mitochondrial DNA mediated by the base excision repair (BER) pathway in mammalian cells. (uky.edu)
The published original articles or reviews will open new paths toward the understanding of the generation and repair of DNA lesions, thus making it possible to advance knowledge of the processes that are at the origin of tumorigenesis. (mdpi.com)
DNA damage induced by ionizing radiation is similar to oxidative stress, and these lesions have been implicated in aging and cancer. (wikipedia.org)
Tandem DNA lesions are formed at substantial frequency by ionizing radiation and metal-catalyzed H2O2 reactions. (wikipedia.org)
They also observed an increase in "oxidative lesions" in the mouse DNA. (nih.gov)
Oxidative lesions are a type of DNA damage caused by byproducts of the oxygen we breathe. (nih.gov)
To see if oxidative lesions played a role in expansion of the extra DNA segment, the researchers next deleted OGG1, a key enzyme in the body's oxidative lesion repair system. (nih.gov)
They found that, without OGG1, the bulk of the DNA's oxidative lesions remained untouched, and the inserted segment either didn't grow at all or grew far less than in mice carrying a working version of OGG1. (nih.gov)
The researchers went on to perform other experiments to support the idea that while doing its part in removing oxidative lesions, OGG1 triggers the expansion of the DNA segment associated with Huntington's disease. (nih.gov)
Oxidative lesions accumulate in everyone, but because most people's huntingtin gene lacks this extra segment to begin with, it isn't prone to expansion. (nih.gov)
In particular, they show that oxidative stress caused by UVA radiation or by interventions that deplete cellular antioxidants damages nucleotide excision repair (NER) proteins and inhibits the removal of the sunlight-induced DNA lesions that are implicated in skin cancer development. (aacrjournals.org)
Importantly, alkylating agents induce DNA damage at different genomic sites, which subsequently leads to lethal and/or mutagenic DNA base lesions. (frontiersin.org)
In comparison, the SN2 agent methyl methane sulfonate (MMS) induces N 1 -methyladenine (m 1 A) and N 3 -methylcytosine (m 3 C) lesions, preferably in single-stranded DNA (ssDNA). (frontiersin.org)
The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions. (medscape.com)

Inhibition of DNA glycosylases in development of cancer therapeutics," 52nd Congress of the European Societies of Toxicology (EUROTOX2016), Seville, Spain, September 5, 2016. (nist.gov)
Dental methacrylates may exert genotoxic effects via the oxidative induction of DNA double strand breaks and the inhibition of their repair. (nih.gov)
DNA repair also attenuates the effectiveness of anticancer drugs and its inhibition by protein oxidation may increase therapeutic efficacy. (aacrjournals.org)

XRCC1 participates in DNA single strand break and base excision repair (BER) to preserve genetic stability in mammalian cells. (nih.gov)
Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. (wikipedia.org)
Likewise, any damage to cells is constantly repaired. (wikipedia.org)
As in the DNA tightrope experiment, UV-DDB rushed to the scene, and when it wasn't available, cells were more sensitive to oxidative stress. (cmu.edu)
The potential heart health benefits of omega-3s may be linked (in part at least) to their ability to protect the DNA in the cells lining blood vessels, according to a study from Japanese researchers. (nutraingredients.com)
DNA damage in human colonic mucosa cells induced by bleomycin and the protective action of vitamin E. (nih.gov)
This observation correlates with the experimental determination that when cells lack the ability to repair certain types of oxidative damage as a result of gene knockout, we see an increase in replicative mutation rates and adaptive mutation frequencies when compared to the wild type cell line. (plu.edu)
The oxidative stress factor plays a significant role in numerous stages of tumor advancement, including the transformation of normal cells into tumor cells, proliferation, tumor angiogenesis, and metastasis [ 5 - 8 ]. (hindawi.com)
However, when a large amount of ROS causes the amassing of DNA damage in tumor cells to the extent that it cannot be repaired, conventional base excision repair [ 16 ] and nucleotide excision repair cannot remove the damaged DNA. (hindawi.com)
This includes damage like oxidative stress, one of your cells' worst enemies. (mindbodygreen.com)
But a new discovery about how cells repair their DNA points to a possible way to stop or slow the onset of the disease. (nih.gov)
Crucial role in orchestrating a fine balance between cellular proliferation, cell death, and DNA repair in human embryonic stem cells (hESCs). (proteopedia.org)
activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. (proteopedia.org)
regulates homologous recombination-dependent repair by phosphorylating BRCA2, this phosphorylation is low in S phase when recombination is active, but increases as cells progress towards mitosis. (proteopedia.org)
Among these cell-signaling proteins, activation of p53 is important in cells with UV radiation-induced DNA damage ( 4 , 7 ). (spandidos-publications.com)
Pretreatment of cells with N-acetyl-L-cysteine (NAC), an agent known to counteract oxidative stress, attenuates the cellular p53 response to UV ( 4 ). (spandidos-publications.com)
Pretreatment of cells with SB202190, a p38 inhibitor, may inhibit the DNA binding activity of p53 and suppress p53-dependent transcription ( 10 ). (spandidos-publications.com)
Normally, p53 allows cells to sense and respond to cellular stress such as DNA damage or hypoxia (2). (novusbio.com)
Experts from the NYU School of Medicine claim that UVA radiation damages the DNA in human melanocyte cells further leading mutations to cause melanoma. (healthjockey.com)
Moon-shong Tang, PhD, professor of environmental medicine, pathology and medicine at NYU School of Medicine and a member of the NYU Cancer Institute enlightened, "For the first time, UVA rays have been shown to cause significant damage to the DNA of human melanocyte skin cells. (healthjockey.com)
They then evaluated DNA damage and the ability of these cells to repair damaged DNA. (healthjockey.com)
The authors claimed to be successful in identifying DNA damage in all melanocyte cells. (healthjockey.com)
They further revealed that these cells were unable to repair the damage. (healthjockey.com)
When normal skin cells were exposed to UVA light no harm was seemingly discovered in their DNA. (healthjockey.com)
UVA-induced oxidative DNA damage in melanocytes and the inherently reduced repair capacity in these cells are assumed to be the two key factors responsible for melanoma on the skin. (healthjockey.com)
McAdam and colleagues highlight the importance of damage to the DNA repair proteome by demonstrating that DNA repair is impaired in oxidatively stressed cultured human cells. (aacrjournals.org)
Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
In the older cells of aging animals, to take one example, researchers have found that one out of every three proteins is rendered dysfunctional by unchecked free radical damage. (lifeextension.com)
When redox signaling is activated in small airway epithelial cells, the DNA repair function of OGG1 is repurposed to transmit acute inflammatory signals accompanied by cell state transitions and modification of the extracellular matrix. (lu.se)
Cells are usually able to fix DNA damage before it causes problems. (medlineplus.gov)
If left uncorrected, DNA damage accumulates, which causes cells to malfunction and can lead to cell death. (medlineplus.gov)
Cells have several mechanisms to correct DNA damage. (medlineplus.gov)
If any of these proteins is not functioning normally, skin cells cannot repair DNA damage caused by UV rays, and transcription of damaged genes is blocked. (medlineplus.gov)
Spivak G, Itoh T, Matsunaga T, Nikaido O, Hanawalt P, Yamaizumi M. Ultraviolet-sensitive syndrome cells are defective in transcription-coupled repair of cyclobutane pyrimidine dimers. (medlineplus.gov)
BML mutations thus result in defects in DNA repair and genomic instability in the somatic cells, predisposing the patients to cancer development. (medscape.com)
They thought that inefficient removal of peroxide might be responsible for the high rates of sister chromatid exchange and chromosomal damage in Bloom syndrome cells. (medscape.com)
RECQL4-deficient cells are hypersensitive to oxidative stress/damage: Insights for osteosarcoma prevalence and heterogeneity in Rothmund-Thomson syndrome. (medscape.com)
In vivo and in organized cells, and proper symmetry are healthy individuals, macrophages can characteristics of higher-quality embryos, which phagocytize DNA that has been passively point to healthy development and higher rates of released into the blood from apoptotic or necrotic implantation. (who.int)

A recent example from the MD Anderson Cancer Center followed p53 induction following UV-irradiation to assess DNA repair in a mouse model of skin carcinogenesis (5). (novusbio.com)
Because UVA comprises around 95% of incident ultraviolet radiation, oxidative inactivation of NER has implications for skin carcinogenesis. (aacrjournals.org)

This is achieved, inter alia, by means of specific repair mechanisms that ensure an efficient and prompt correction of the DNA defects. (mdpi.com)
Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling. (wikipedia.org)
Oxidative DNA damage and its repair: Mechanisms, measurement and biological consequences. (nist.gov)
The disorders are characterized by a defect in DNA repair mechanisms or genomic stability, and patients with these disorders show increased predisposition to cancer. (medscape.com)
Oxidative stress is a principal cause of DNA damage, and mechanisms to repair this damage are among the most highly conserved of biological processes. (rcsb.org)
Even though Mn-induced oxidative stress is discussed extensively, neither the underlying mechanisms of the potential consequences of Mn-induced oxidative stress on DNA damage and DNA repair, nor the possibly resul. (researchgate.net)
CMBN shall take on a leading role in elucidating the role of DNA repair and genome maintenance mechanisms in preventing neurological disease and brain ageing. (cmbn.no)

More importantly, the results unveil a highly coordinated mechanism by which XRCC1, through its multiple protein-protein interactions, extends its orchestrating role from the base excision step to the resealing of the repaired DNA strand. (nih.gov)
Without vigilant repair, cancer would run rampant, and now scientists at the University of Pittsburgh and Carnegie Mellon University have gotten a glimpse of how one protein in particular keeps DNA damage in check. (cmu.edu)
According to a study published today in Nature Structural and Molecular Biology , a protein called UV-DDB - which stands for ultraviolet-damaged DNA-binding - is useful beyond safeguarding against the sun. (cmu.edu)
The ataxia telangiectasia Rad3-related (ATR) protein responds to UV damage, whereas the ataxia telangiectasia mutated (ATM) protein responds to double-strand breaks (DSBs) caused by ionizing radiation and radiomimetic compounds. (medscape.com)
In vitro genotoxicity of lead acetate: induction of single and double DNA strand breaks and DNA-protein cross-links. (nih.gov)
Download DNA or protein sequence, view genomic context and coordinates. (yeastgenome.org)
Its cognate repair protein, 8-oxoguanine DNA glycosylase 1 (OGG1), reads oxidative substrates and participates in transcriptional initiation. (lu.se)
The CSB, CSA, and UVSSA proteins are involved in one mechanism that repairs damaged DNA within active genes (those genes undergoing gene transcription, the first step in protein production). (medlineplus.gov)
This protein plays a pivotal role in DNA recombination and repair. (medscape.com)

After the degradation of damaged proteins and lipids, amino acids and fatty acids are released into the cytoplasm and recycled for new biosynthesis of cellular components or energy production [ 4 ]. (hindawi.com)

Transcription and DNA replication in melanocytes may be adversely damaged due to this oxidative DNA. (healthjockey.com)
Methylation of mammalian DNA and histone residues are known to regulate transcription, and the discovery of demethylases that remove methylation in DNA and histones provide a basis for the understanding of dynamic regulation of mammalian gene expression. (cmbn.no)
When DNA in active genes is damaged, the enzyme that carries out gene transcription (RNA polymerase) gets stuck, and the process stalls. (medlineplus.gov)

Van Houten]'s team has developed an assay that allows them to track the repair enzymes in 3D on the DNA ropes as they repair damage. (cmu.edu)
The presence of multiple versions of DNA repair enzymes in a single organism is usually thought to reflect redundancy in activities that are essential for cellular viability. (rcsb.org)
Both enzymes are necessary for survival of N. meningitidis under oxidative stress and during bloodstream infection. (rcsb.org)
In particular, certain types of ALKBH enzymes are dioxygenases that directly reverse DNA methylation damage via transfer of a methyl group from the DNA adduct onto α-ketoglutarate and release of metabolic products including succinate and formaldehyde. (frontiersin.org)
Direct DNA repair comprises several types of DNA repair enzymes that reversibly remove alkyl groups from damaged DNA bases through oxidative dealkylation processes. (frontiersin.org)

Further, some reactive oxidative species act as cellular messengers in redox signaling. (wikipedia.org)
Some of the less reactive of these species (such as superoxide) can be converted by oxidoreduction reactions with transition metals or other redox cycling compounds (including quinones) into more aggressive radical species that can cause extensive cellular damage. (wikipedia.org)
For starters, sirtuins help repair DNA damage 3 , the main cause of cellular senescence. (mindbodygreen.com)
UV can be directly absorbed by cellular macromolecules, thus leading to photochemical modification of DNA and proteins ( 4 ). (spandidos-publications.com)
p38 acts as a stress-activated MAPK that is preferentially activated by diverse cellular stressors, including UV-B-induced oxidative stress ( 9 ). (spandidos-publications.com)
Autophagy is a cellular catabolic process that eliminates damaged cell organelles, unfolded proteins, and various intracellular pathogens through lysosomal degradation. (hindawi.com)
At the cellular level, aging is marked by depletion of adult stem cell reservoirs, the inability to maintain baseline homeostasis, a reduced response to stress, an increased accumulation of damaged DNA leading to telomere shortening, and mitochondrial dysfunction [ 1,2 ]. (karger.com)

Genetic and Environmental Toxicology Association of Northern California (GETA) 2018 Spring Symposium on DNA Damage, Repair and Replication, Sacramento, CA, April 23, 2018. (nist.gov)
Drosophila homologue of the Rothmund-Thomson syndrome gene: essential function in DNA replication during development. (medscape.com)

Formaldehyde in Hospitals Induces Oxidative Stress: The Role of GSTT1 and GSTM1 Polymorphisms. (cdc.gov)

When the content of ROS is insufficient to break the balance between oxidative and antioxidant systems in the tumor growth environment, it can participate in the regulation of epithelial-mesenchymal transition (EMT), tumor angiogenesis, and other processes by activating PI3K/Akt and NF- κ B signaling pathways [ 12 - 14 ]. (hindawi.com)
These previous results indicated that the ROS-p38-p53 pathways are involved in UV-induced cell damage. (spandidos-publications.com)
Western blotting or immunofluorescence with p53 antibodies is also widely used to monitor induction of DNA damage pathways (5). (novusbio.com)
It can offer both direct and indirect protection against a wide variety of damaging agents and through multiple pathways, which may (or may not) take place simultaneously. (melatoninfacts.org)

Alpha-ketoglutarate-dependent dioxygenase (ALKBH) is a DNA repair gene involved in the repair of alkylating DNA damage. (frontiersin.org)
DNA Repair Gene Polymorphisms and Chromosomal Aberrations in Exposed Populations. (cdc.gov)
DNA repair gene polymorphisms and chromosomal aberrations in healthy, nonsmoking population. (cdc.gov)
The Rothmund-Thomson gene product RECQL4 localizes to the nucleolus in response to oxidative stress. (medscape.com)

The term "tumor of oxidative stress" refers to an improper regulation mechanism of oxidative signaling and oxidative damage of macromolecules caused by an imbalance in the body's oxidation and antioxidation system of mutual limitation [ 9 ]. (hindawi.com)

Thus, it is evident that preventing DNA from oxidative damage is crucial for humans and for any living organism. (melatoninfacts.org)

Here, we report that XRCC1 interacts physically and functionally with hOGG1, the human DNA glycosylase that initiates the repair by BER of the mutagenic oxidized base 8-oxoguanine. (nih.gov)
This interaction leads to a 2- to 3-fold stimulation of the DNA glycosylase activity of hOGG1. (nih.gov)

Unrepaired DNA damage can lead to DNA mutations that change the cell's phenotype. (plu.edu)

Increased intakes of niacin (vitamin B3) from the diet may protect against DNA damage in people exposed to ionizing radiation such as pilots, says a new study. (nutraingredients.com)
From Initial Free Radical Formation to Resulting DNA Base Damage", Council on Ionizing Radiation Measurements and Standards, Mitigating Challenges in Radiation Technologies. (nist.gov)

This results in an acceleration of the overall repair process of oxidized purines to yield an APE1-cleaved abasic site, which can be used as a substrate by DNA polymerase beta. (nih.gov)
The samples were subsequently submitted for DNA extraction by the boiling method, polymerase chain reaction (PCR) amplification using CPF/CPR primers, and agarose gel electrophoresis. (bvsalud.org)
Researchers think that the CSB, CSA, and UVSSA proteins help remove RNA polymerase from the damaged site, so the DNA can be repaired. (medlineplus.gov)

DNA can be damaged by UV rays from the sun and by toxic chemicals, radiation, and unstable molecules called free radicals. (medlineplus.gov)

This study revealed proteins involved in oxidative stress are able to inhibit p53 degradation (4). (novusbio.com)

However, under the severe levels of oxidative stress that cause necrosis, the damage causes ATP depletion, preventing controlled apoptotic death and causing the cell to simply fall apart. (wikipedia.org)
[4] [5] Heavy alcohol usage can result in trouble sleeping , and severe cognitive issues like dementia , brain damage , or Wernicke-Korsakoff syndrome . (wikipedia.org)

[ 7 , 8 ] Sister chromatid exchanges are considered a sensitive indicator for cell genome instability, as they are thought to be the outcome of DNA double-strand breaks resulting from homologous recombination repair. (medscape.com)

The present study evaluated the protective effects of PF on UV‑induced skin damage in vitro, and demonstrated that the effects were mediated via the ROS‑p38‑p53 pathway. (spandidos-publications.com)
Classically, testing strategies for DNA or chromosomal damage focus on in vitro and in vivo (mainly rodent) investigations. (researchgate.net)

While many of these products are used as markers of oxidative stress, the products derived from linoleic acid appear far more predominant than arachidonic acid products and therefore easier to identify and quantify in, for example, atheromatous plaques. (wikipedia.org)
Eight weeks of supplementation with watercress may reduce markers of oxidative stress and damage after exhaustive exercise, suggests a new study. (nutraingredients.com)
The present work evaluates the potential use of two types of markers, DNA and transcriptomic markers, in order to authenticate and trace 'San Marzano' tomato food chain. (unina.it)

XRCC1 stimulates the formation of the hOGG1 Schiff-base DNA intermediate without interfering with the endonuclease activity of APE1, the second enzyme in the pathway. (nih.gov)

The rather unique capability of melatonin to exhibit multiple neutralizing actions against diverse threatening factors, together with its low toxicity and its ability to cross biological barriers, are all significant to its efficiency for preventing oxidative damage to DNA. (melatoninfacts.org)

Additionally, we briefly summarize alternate repair events mediated by BER proteins and the role of BER in the repair of mitochondrial DNA damage induced by ROS. (uky.edu)

DNA is a molecule of paramount importance due to its fundamental biological role in carrying and storing genetic information. (mdpi.com)
Biological effects of single-base damage by radiation or oxidation, such as 8-oxoguanine and thymine glycol, have been extensively studied. (wikipedia.org)
The occurrence of genes whose products are involved in DNA damage repair should have a biological meaning of plant self-protection from UV-radiation and can reflect in fruits compounds bouquet. (unina.it)
The results of this study confirm the feasibility of using the CPF/CFP primer-based PCR to detect C psittaci in Amazona species, describe a less costly method of transporting biological material for DNA extraction, and evaluate the temporal aspect for obtaining positive results through molecular testing for C psittaci in Amazona species. (bvsalud.org)
Embryo morphology al ows options, the discovery of cell-free DNA in the evaluation of its growth, viability, and biological fluids has led to major advances in implantation capacity. (who.int)

The work of myPotsDoc research focuses on investigating genotoxicity and DNA repair. (researchgate.net)
Genotoxicity biomarkers in car repair workers from Barranquilla, a Colombian Caribbean City. (cdc.gov)

Short-term oxidative stress may also be important in prevention of aging by induction of a process named mitohormesis, and is required to initiate stress response processes in plants. (wikipedia.org)

Chemically, oxidative stress is associated with increased production of oxidizing species or a significant decrease in the effectiveness of antioxidant defenses, such as glutathione. (wikipedia.org)
Alterations in reduced and oxidized glutathione (GSH/GSSG) levels represent an important marker for oxidative stress and potential disease progression in toxicological research. (researchgate.net)

In response to DNA damage, double-strand break repair by homologous recombination a reduction of CDK2-mediated BRCA2 phosphorylation. (proteopedia.org)

Itoh T, Fujiwara Y, Ono T, Yamaizumi M. UVs syndrome, a new general category of photosensitive disorder with defective DNA repair, is distinct from xeroderma pigmentosum variant and rodent complementation group I. Am J Hum Genet. (medlineplus.gov)
Itoh T, Yamaizumi M, Ichihashi M, Hiro-Oka M, Matsui T, Matsuno M, Ono T. Clinical characteristics of three patients with UVs syndrome, a photosensitive disorder with defective DNA repair. (medlineplus.gov)

If the transitional cell state governed by OGG1 remains responsive to inflammatory mediators instead of differentiation, the collateral damage provides positive feedback to inflammation, ascribing inflammatory remodeling to one of the drivers in chronic pathologies. (lu.se)

Oxidative stress from oxidative metabolism causes base damage, as well as strand breaks in DNA. (wikipedia.org)

Supplements of the omega-3 fatty acid DHA (docosahexaenoic acid) may reduce the amount of DNA damage in sperm, says a new randomized, double blind, placebo-controlled, parallel-group study. (nutraingredients.com)

This allows p53 to bind DNA and regulate the expression of various genes (2). (novusbio.com)

Small molecule inhibitors of DNA glycosylases as potential drugs in cancer therapy," 2nd International Conference on Molecular Biology, Nucleic Acids & Molecular Medicine (Keynote Speaker), Philadelphia, PA, September 1, 2017. (nist.gov)

Researchers recently uncovered evidence that faulty DNA repair may be to blame for the onset of Huntington's disease symptoms. (nih.gov)

Oxidative stress is also used by phagocytes to attack bacterial pathogens in defence of the host. (rcsb.org)

It identifies DNA damage so that another crew can come in and patch and seal it," said study senior author Bennett Van Houten , Ph.D., professor of pharmacology and chemical biology at the Pitt School of Medicine and UPMC Hillman Cancer Center . (cmu.edu)
DNA Repair-based Drug Developments in Cancer Therapy. (nist.gov)
DNA Damage and Repair in Cancer. (nist.gov)
DNA Repair in cancer therapy. (nist.gov)
Inhibitors of DNA glycosylases as potential therapeutic drugs in cancer," International Cancer Study & Therapy Conference (Cancer-2016), Baltimore, MD, April 4, 2016. (nist.gov)
DNA damage and its repair in cancer," 9th Congress of the Turkish Society of Toxicology and the Hellenic Society of Toxicology of Greece, Cesme, Izmir, Turkey, October 23, 2015. (nist.gov)
Basal, oxidative and alkylative DNA damage, DNA repair efficacy and mutagen sensitivity in breast cancer. (nih.gov)

Daily supplements of astaxanthin - the pigment that gives salmon its pink colour - may protect DNA from damage and boost the immune response in healthy young women, says a new study. (nutraingredients.com)
Among up-regulated highlighted genes in both comparisons most are involved in UV and oxidative stress response and signalling transduction. (unina.it)
Direct and Oxidative DNA Damage in a Group of Painters Exposed to VOCs: Dose - Response Relationship. (cdc.gov)

Mismatch repair]. (nih.gov)
At the same time, low levels of ROS can cause occasional DNA base mismatch and DNA damage in the body, which will be repaired immediately. (hindawi.com)

Together they inflicted oxidative damage to the chromosomes' protective endcaps - called telomeres. (cmu.edu)
When telomeres (green) undergo damage (bottom row), UV-DDB (red) rushes to the scene (yellow). (cmu.edu)
Sirtuins also delay the shortening of telomeres , the DNA "caps" at the ends of a chromosome. (mindbodygreen.com)

Anatomy22

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Analytical, Diagnostic and Therapeutic Techniques and Equipment18

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Phenomena and Processes64

Disciplines and Occupations2

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Lesions15

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OGG11

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20171

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Response3

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