• To investigate whether the association between use of ACE-inhibitors or beta-blockers and the risk of myocardial infarction (MI) or stroke is modified by the T-allele of the angiotensinogen M235T polymorphism. (ox.ac.uk)
  • The renin-angiotensin system genes exhibit three common polymorphisms: the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme ( ACE ) gene, the M235T polymorphism of the angiotensinogen gene ( AGT ), and the A1166C polymorphism of the angiotensin II type 1 receptor gene ( AT1-receptor ). (molvis.org)
  • A cohort of 1162 patients with coronary artery disease were genotyped for genetic polymorphisms in the renin-angiotensin system. (bmj.com)
  • Genetic variants in the renin-angiotensin-aldosterone system and salt sensitivity of blood pressure. (snpedia.com)
  • We examined the instrument's association with cardiovascular and renal outcomes, and compared the effect of the instrument with that of genetic instruments for other renin-angiotensin system (RAS) components and the causal effect of SBP overall. (ox.ac.uk)
  • SNPs with minor allele frequency (MAF) of greater than 1%, accounting for over 90% of genetic variation between individuals. (biomedcentral.com)
  • The association between the ACE gene D allele and increased coronary extent scores was significant (p = 0.008 in non-parametric and p = 0.027 in parametric analysis) in those carrying the +1166 C allele of the AGTR1 gene, but was absent in those not carrying the AGTR1 gene +1166 C allele. (bmj.com)
  • The I allele of ACE gene and +1166 C allele of AT 1 R gene are reportedly associated with hypertension [ 10 ]. (hindawi.com)
  • Several single nucleotide polymorphisms (SNPs) of renin-angiotensin system (RAS) genes are associated with hypertension (HT) but most of them are focusing on single locus effects. (hindawi.com)
  • Such effects may be of relevance to the development of low-renin essential hypertension. (ox.ac.uk)
  • PHA-II is a rare familial renal tubular defect characterized by hypertension and hyperkalemic metabolic acidosis in the presence of low renin and aldosterone levels. (medscape.com)
  • 0.49 mmHg lower SBP per G-allele) was strongly associated with hypertension, and showed evidence of colocalisation with AGT mRNA expression across various tissues. (ox.ac.uk)
  • The virus responsible for COVID-19, SARS-CoV-2, has a direct link to one of the major enzymatic regulatory systems connected to blood pressure control and hypertension pathogenesis, the renin-angiotensin system. (duke.edu)
  • Factors that play an important role in the pathogenesis of hypertension include genetics, activation of neurohormonal systems such as the sympathetic nervous system and renin-angiotensin-aldosterone system, obesity, and increased dietary salt intake. (medscape.com)
  • Population based allele frequencies of disease associated polymorphisms in the Personalized Medicine Research Project. (snpedia.com)
  • Polymorpisms certainly exist in the ACE locus, and earlier studies found differences among Asians, Caucasian, and people of African descent with respect to the frequencies of two alleles - the D and I alleles. (jameslyonsweiler.com)
  • Deviations of genotype frequencies from Hardy-Weinberg Equilibrium (HWE) and differences between allele frequencies and genotype distributions were calculated by Chi-square test. (ephysician.ir)
  • Our aim was to determine whether the amount of fibrosis in HCM correlates with echocardiographic measures of diastolic dysfunction, presence of HCM-susceptibility mutations, or polymorphisms in the renin-angiotensin-aldosterone system (RAAS). (nih.gov)
  • The renin-angiotensin-aldosterone system (RAAS) is one of the most important regulatory systems of blood volume, arterial pressure and cardiovascular homeostasis. (frontiersin.org)
  • Aldosterone synthesized by aldosterone synthase plays an imperative role in Renin-Angiotensin-Aldosterone System (RAAS). (ephysician.ir)
  • Forty-seven patients with NAION and 76 controls, age- and gender-matched, were recruited and genotyped for renin-angiotensin-aldosterone system (RAAS) genes. (molvis.org)
  • NAION and control groups were compared in regard to the prevalence of renin-angiotensin-aldosterone system polymorphisms, and further stratified by age and gender. (molvis.org)
  • APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R. (nih.gov)
  • Along the same line, the renal artery is highly innervated, with the sympathetic activation promoting sodium retention via increased renin secretion. (medscape.com)
  • PHENOTYPE: Mice homozygous for a knock-out allele exhibit hypomagnesemia, hypocalciurua and abnormal renal distal convoluted tubule morphology, and show significantly reduced arterial blood pressure on a sodium-depleted diet. (utsouthwestern.edu)
  • Importantly, patients with high-risk apolipoprotein L1 (APOL1) alleles are at risk for developing the kidney lesion of collapsing glomerulopathy after viral infection. (duke.edu)
  • Furthermore I allele was present in all male patients younger than 55 years, making this allele a likely predisposing factor for NAION in young males. (molvis.org)
  • Un groupe de 69 patients atteints de diabète de type 1 et 45 témoins en bonne santé sans lien entre eux ont été recrutés pour cette étude. (who.int)
  • A) PCA of Madre de Dios genome sequences with all alleles in polyclonal sites included (14 651 sites). (tech-strategy.org)
  • By combining clinical genetics, functional expression assays, and population exome analysis, we identify SLC26A1 as a sulfate transporter in humans and experimentally validate several loss-of-function alleles. (bvsalud.org)
  • See ACE for a more complete description of the history of the ACI insertion/deletion (I/D) allele and various associations reported over the years. (snpedia.com)
  • More specifically: the rs4343(A) allele is associated with the ACE-I (insertion) allele, and the rs4343(G) allele is associated with the ACE-D allele. (snpedia.com)
  • Addison's disease develops in stages, with metabolic parameters like elevated renin, reduced basal and stress cortisol levels developing prior to symptoms [1]. (casereports.in)
  • Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. (utsouthwestern.edu)
  • Human renin gene transgenic mice with integration of 10 copies of a 15 kbp human DNA fragment containing the renin gene (hRN 8-12 mice). (riken.jp)
  • ACE-inhibitor users with at least one copy of the 235T-allele of the AGT gene might have an increased risk of MI and stroke. (ox.ac.uk)
  • The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues. (cdc.gov)
  • Impaired post-infarction cardiac remodeling in chronic kidney disease is due to excessive renin release. (riken.jp)
  • and elevated, normal, or low levels of renin and aldosterone may be observed in the various conditions that result in this syndrome. (medscape.com)
  • If expression of a trait requires only one copy of a gene (one allele). (msdmanuals.com)