• Here we show that PNN abundance within the Arc is markedly reduced in the Zucker diabetic fatty (ZDF) rat model of T2D, compared with normoglycaemic rats, correlating with altered PNN-associated sulfation patterns of chondroitin sulfate glycosaminoglycans in the MBH. (nature.com)
  • Despite the fact that sexual differences increase diabetic risk and contribute to the need for gender-specific care, there remain contradictory results as to whether or not sexual dimorphism increases susceptibility to the development of type 1 diabetes mellitus. (karger.com)
  • To examine gender-dimorphic regulation of skeletal muscle proteins between healthy control and STZ-induced diabetic rats of both genders, we performed differential proteome analysis using two-dimensional electrophoresis combined with mass spectrometry. (karger.com)
  • Proteomic analysis of skeletal muscle identified a total of 21 proteins showing gender-dimorphic differential expression patterns between healthy controls and diabetic rats. (karger.com)
  • The current proteomic study revealed that impaired protein regulation was more prominent in the muscle tissue of female diabetic rats, which were more susceptible to STZ-induced diabetes. (karger.com)
  • Diabetic neuropathic pain (DNP) is a common complication associated with diabetes. (hindawi.com)
  • Diabetic vascular dysfunction is a major complication where vasodilation is compromised rendering the diabetic prone to elevated blood pressure and limb infections (1). (herts.ac.uk)
  • Thoracic aortic rings from diabetic rats showed compromised TRPV4-induced VD compared to control (Diabetic: 24.3±5.3% max. (herts.ac.uk)
  • Further, its potential to exacerbate diabetes induced alterations in intestinal structure and function was also studied in experimentally induced diabetic rats. (survivinsignaling.com)
  • Rats were rendered diabetic with an acute dose of strepiozotocin (60 mg/kg b.w. (survivinsignaling.com)
  • MCP was orally administered at a sublethal dose (1/20 LD50 i.e. 0.9 mg/kg b.w./d) for 15 days to both normal and diabetic rats. (survivinsignaling.com)
  • MCP significantly increased unit weight of intestine in diabetic rats. (survivinsignaling.com)
  • Then, we transplanted 2600 islet equivalents into the submandibular glands of diabetic Lewis rats. (bvsalud.org)
  • Intra-portal islet transplantation was performed in diabetic rats as a control. (bvsalud.org)
  • The objective of the present study was to evaluate anti-diabetic effects of chromium picolinate (CrPic) and biotin supplementations in type 2 diabetic rats. (cambridge.org)
  • The type 2 diabetic rat model was induced by high-fat diet (HFD) and low-dose streptozotocin. (cambridge.org)
  • 5) diabetic rats fed a HFD and supplemented with both CrPic and biotin. (cambridge.org)
  • 0·05) in diabetic rats treated with biotin and CrPic, particularly with a combination of the supplements. (cambridge.org)
  • 40 rats were used in the study, and it was observed that all the studied substances prevented infections and bone damage at the same time, significant increase was found in the bone volume, strength, density, and length in comparison to diabetic rats. (microbiologyjournal.org)
  • Rats in group A (control) were given 0.5ml distilled water daily while the rats in groups B, C, and D were rendered diabetic by administration of intraperitoneal low-dose streptozotocin (STZ) and subsequently treated with 0.5mls of distilled water, glibenclamide (0.29 mg/kg body weight) and insulin (1 UI daily) respectively. (edu.ng)
  • Groups 2, 4, 6 were rendered diabetic by a single i.p. injection of streptozotocin (65 mg/kg) and were treated as in groups 1, 3, 5, respectively. (elsevierpure.com)
  • Tocilizumab significantly mitigated the increase in UACR and UNCR, renal MDA, plasma TNF-α, IL-6 and NO levels, and the decrease in renal SOD and catalase activities in diabetic rats. (elsevierpure.com)
  • This study shows that tocilizumab was able to ameliorate some of the changes seen in streptozotocin-induced early diabetic nephropathy in rats. (elsevierpure.com)
  • The breakdown of preformed advanced glycation end products reverses erectile dysfunction in streptozotocin-induced diabetic rats: Preventive versus curative treatment. (degruyter.com)
  • The primary objective of this study was to assess the efficacy of ferulic acid (FA), a phenolic antioxidant, in ameliorating oxidative stress in the testis and liver of diabetic pubertal rats. (bioone.org)
  • Male (6 wk old) rats were rendered diabetic by an acute dose (60 mg/kg body weight, intraperitoneal) of streptozotocin (STZ) and were given oral supplementation of FA (50 mg/kg body weight/d on alternate days) for 4 weeks. (bioone.org)
  • Terminally, the testis (cytosol and mitochondria) of STZ-administered rats exhibited a marked elevation in the status of lipid peroxidation and enhanced reactive oxygen species (ROS) production compared to the non-diabetic controls. (bioone.org)
  • The protective effects of FA were also discernible in the testis in terms of restoration of activities of various antioxidant enzymes in the diabetic rats. (bioone.org)
  • STZ-induced perturbations in serum and testicular lipid profiles in the diabetic rats were also significantly attenuated by FA treatment. (bioone.org)
  • Ferulic Acid Supplements Abrogate Oxidative Impairments in Liver and Testis in the Streptozotocin-Diabetic Rat," Zoological Science 25(8), 854-860, (25 August 2008). (bioone.org)
  • Female Sprague-Dawley rats received either DA neuron neurotoxic lesion by bilateral intra-cannula injection of 6-hydroxydopamine (2-4 μg/side) or vehicle treatment at the area surrounding the SCN at 20 min post protriptyline ip injection (20 mg/kg) to protect against damage to noradrenergic and serotonergic neurons. (biomedcentral.com)
  • Twenty pregnant female Sprague-Dawley rats (120-160 g) divided into 4 groups A, B, C and D (n=5 per group) were used for the study. (edu.ng)
  • Male Sprague-Dawley rats (n = 36) were distributed into six groups and treated for 4 weeks. (elsevierpure.com)
  • Two groups of male Wistar rats (N= 4-5/group) were studied, the first group was injected i.p. with 65mg/kg streptozotocin (STZ) while the second was injected with 20mM citrate buffer (Control). (herts.ac.uk)
  • In present study we examined the influence of Ginger, Nigella sativa, Punica granatum and Metformin on the prevention and treatment of bone damage and infections due to Diabetes Mellitus in STZ-induced diabetes in male Wistar albino rats. (microbiologyjournal.org)
  • Both types of macaroni were cooked and given to Wistar rats (n=7 per group) at a daily dose of 4g/kg body weight in comparison to the commercial wheat macaroni for 6 weeks in order to investigate their effects on gut microbiota, serum lipid profile, and insulin sensitivity. (cmu.ac.th)
  • Type 1 diabetes mellitus (T1DM) results from autoimmune destruction of pancreatic β-cells, leading to absolute insulin deficiency in patients as well as a requirement for exogenous insulin supplementation for survival [ 6 ]. (karger.com)
  • Diabetes mellitus (DM) is a pandemic metabolic disease characterized by chronically elevated blood glucose concentration (hyperglycaemia) and accounts for approximately a death every 7 seconds (1). (herts.ac.uk)
  • This strictly glucose-dependent course of renders the receptor and its ligands helpful within the remedy of sort II diabetes mellitus. (ncbcs.org)
  • Results of low-dose recombinant human insulin-like development factor-I on insulin sensitivity, development hormone and glucagon ranges in younger adults with insulin-dependent diabetes mellitus. (ncbcs.org)
  • Regardless of current curiosity within the therapeutic potential of recombinant human insulin-like development factor-I (rhIGF-I) within the remedy of diabetes mellitus, its mechanism of motion remains to be not outlined. (ncbcs.org)
  • We've studied the results of low-dose bolus subcutaneous rhIGF-I (40 microg/kg and 20 microg/kg) on insulin sensitivity, development hormone (GH) and glucagon ranges in seven younger adults with insulin-dependent diabetes mellitus (IDDM) utilizing a randomized double-blind placebo-controlled crossover research design. (ncbcs.org)
  • Gestational diabetes mellitus (GDM) is a prevalent and severe metabolic disease in pregnant women that is characterized by a high incidence. (balkanmedicaljournal.org)
  • Gestational diabetes mellitus (GDM) is a common metabolic condition in pregnant women and defined as glucose intolerance during the second and third trimesters of pregnancy. (balkanmedicaljournal.org)
  • 6 Moreover, postpregnancy, women with a history of GDM face an increased risk of developing cardiovascular disorders and type 2 diabetes mellitus (T2DM), while their offspring have an elevated risk of developing T2DM and obesity in later life. (balkanmedicaljournal.org)
  • 14 Anti-inflammatory roles of ASD are shown in LPS-evoked RAW 264.7 cells, 23 diabetes mellitus mice, 24 and interleukin (IL)-1β-treated chondrocytes. (balkanmedicaljournal.org)
  • Diabetes mellitus has emerged as a pandemic affecting both the genders and all the age groups. (microbiologyjournal.org)
  • There is growing concern on the use of oral hypoglycemic agents (OHAs) during pregnancy, due to the potential of the agents in causing adverse effect (s) on the developing fetus and its effectiveness in managing the gestational diabetes mellitus. (edu.ng)
  • Based on our observations in this study, it was concluded that glibenclamide is as effective as insulin with no or little negative effect and could be an optional drug to be used in the treatment of gestational diabetes mellitus in place of insulin. (edu.ng)
  • Objective Eating out of phase with the endogenous biological clock alters clock and metabolic gene expression in rodents and can induce obesity and type 2 diabetes mellitus. (researchgate.net)
  • Diabetes was induced using streptozotocin in male A/J mice. (hindawi.com)
  • Kidneys from streptozotocin-treated rats showed marked vacuolation of the proximal tubular epithelium with focal tubular necrosis and the glomeruli showing increase in mesangial cells. (elsevierpure.com)
  • Antihypertensive effects of acetic acid and vinegar on spontaneously hypertensive rats. (curejoy.com)
  • We recently showed that perineuronal nets (PNNs) enmesh glucoregulatory neurons in the arcuate nucleus (Arc) of the mediobasal hypothalamus (MBH) 1 , but whether these PNNs play a role in either the pathogenesis of type 2 diabetes (T2D) or its treatment remains unclear. (nature.com)
  • Animal experiments revealed that STZ treatment rendered female rats more susceptible to induction of diabetes than their male littermates with significantly lower plasma insulin levels due to hormonal regulation. (karger.com)
  • Liver monocyte chemoattractant protein 1 (a proinflammatory protein associated with metabolic syndrome) gene expression was also significantly elevated in peri-SCN area dopaminergic lesioned rats. (biomedcentral.com)
  • In conclusion, this study has demonstrated that consumption of banana RS4 macaroni confers health benefits towards healthy rats consuming a regular diet and the addition of turmeric extract can significantly alter gut microbiota of the experimental animals. (cmu.ac.th)
  • Collectively, these results indicate that oral supplementation of FA can significantly mitigate diabetes-associated oxidative impairments in the testis as well as in the liver and suggests the efficacy of FA as a complementary therapeutic agent in the management of diabetes-associated oxidative stress-mediated complications. (bioone.org)
  • Furthermore, insulin resistance is another factor that renders insulin ineligible for clinical use. (balkanmedicaljournal.org)
  • Risk factors for insulin resistance include obesity , sedentary lifestyle , family history of diabetes, various health conditions, and certain medications. (wikipedia.org)
  • [1] Various genetic factors can increase risk, such as a family history of diabetes, and there are some specific medical conditions associated with insulin resistance, such as polycystic ovary syndrome . (wikipedia.org)
  • Prevalence of insulin resistance, obesity and type 2 diabetes in the US adult population. (biomedcentral.com)
  • This metabolic disorder is classically notorious to cause retinopathy, neuropathy, micro and macro vascular complications including brain damage, cardiac disorders and nephropathy and renders patients to develop various kinds of infections Ginger, Nigella sativa and Punica granatum are strong antioxidants and possess antimicrobial activity. (microbiologyjournal.org)
  • Diabetes 68 , 654-664 (2019). (nature.com)
  • Diabetes , 98, 1054-1061(2019). (nature.com)
  • Apparue d'abord dans le canton de Wuhan en Chine fin 2019, pratiquement plus aucun pays n'est épargné à ce jour. (bvsalud.org)
  • Most interestingly, gender-specific proteome comparison showed that male and female rats displayed differential regulation of proteins involved in muscle contraction, carbohydrate, and lipid metabolism, as well as oxidative phosphorylation and cellular stress. (karger.com)
  • Gender differences in physiology and metabolism have important potential implications with regards to the development of new approaches for the intervention of metabolic diseases such as diabetes and obesity [ 1 ]. (karger.com)
  • Each of these PNN-associated changes is reversed following a single intracerebroventricular (icv) injection of fibroblast growth factor 1 (FGF1) at a dose that induces sustained diabetes remission in male ZDF rats. (nature.com)
  • However, islet transplantation into rat submandibular glands did not demonstrate a clear advantage over conventional intra-portal transplantation. (bvsalud.org)
  • Research has also shown maca reduces enlarged prostate glands in rats. (cheekyherbs.com)
  • Despite the significant achievements in the treatment modalities and preventive measures, the prevalence of gestational diabetes in Africa has continued to rise exponentially in the last few decades. (edu.ng)
  • Metabolic syndrome is a cluster of interrelated metabolic disorders that increase the risk of developing type 2 diabetes and cardiovascular diseases. (cmu.ac.th)
  • There is evidence of sexual dimorphism in the incidence and prevalence of diabetes in T1DM animal models, but relevant results are still not definitive. (karger.com)
  • Pancreatic islet transplantation is a promising therapy for type 1 diabetes. (bvsalud.org)
  • RESEARCH DESIGN AND METHODS: We conducted analyses in three study samples: the national Veterans Administration Diabetes Risk (VADR) cohort comprising electronic health records (EHR) of 4.1million T2D-free veterans, the national prospective cohort REasons for Geographic and Racial Differences in Stroke (REGARDS) (11 208 T2D free), and a case-control study of Geisinger EHR in Pennsylvania (15 888 T2D cases). (cdc.gov)
  • Hypoglycemia (low blood sugar) and diabetes (high blood sugar) occur more frequently in people who are chromium deficient. (drmyattswellnessclub.com)
  • Washington: Additional Vitamin D can refurbish good bacteria in the gut, rendering to an investigation on rats, giving hope in the battle against threat factors for heart disease and diabetes. (beautyfashionclub.com)
  • Nevertheless, further investigation in rats with metabolic syndrome may be needed to demonstrate a more prominent effect. (cmu.ac.th)
  • Increased fetuin-A in patients with pre-diabetes is associated with increased progression to diabetes and decreased reversal to normoglycemia. (wikipedia.org)
  • In this narrative review, we consider a number of explanations that have been forwarded regarding the pathological progression to type 2 diabetes both with and without the concurrent influence of overweight/obesity. (biomedcentral.com)
  • Regarding Type 1 diabetes(T1D), animal/islet-cell studies found that GABA promotes insulin secretion, inhibits α-cell glucagon and dampens immune inflammation, while GAD immunization may also preserve β-cells. (nature.com)
  • Burmeister, LA , Pachucki, J & St. Germain, DL 1997, ' Thyroid hormones inhibit type 2 iodothyronine deiodinase in the rat cerebral cortex by both pre- and posttranslational mechanisms ', Endocrinology , vol. 138, no. 12, pp. 5231-5237. (umn.edu)
  • Type 2 diabetes and obesity epidemics are in effect in the United States and the two pathologies are linked. (biomedcentral.com)
  • Although the etiology of type 2 diabetes is complex and cause/consequence characteristics of associated dysfunctions have been debated, it is well established that impaired insulin action plays a critical early role. (biomedcentral.com)
  • The vast majority possess type 2 diabetes (T2D), a disorder that is linked with the 'American obesity epidemic. (biomedcentral.com)
  • This study was designed to investigate the effects of Hunteria umbellata (HU) seeds and Cylicodiscus gabunensis (CG) stem barks aqueous extracts on key enzymes relevant to erectile dysfunction (phosphodiesterase-5 and arginase) and type-2 diabetes (α-amylase and α-glucosidase). (degruyter.com)
  • In ascertaining the erectogenic and antidiabetic properties of the extracts, the effects of the extracts on activities of some enzymes relevant to erectile dysfunction (arginase and phosphodiesterase-5) and type-2 diabetes (α-amylase and α-glucosidase) were determined. (degruyter.com)
  • The ability of samples' extract to inhibit some of key enzymes relevant to erectile dysfunction and type-2 diabetes could render them cheap, natural and alternative therapy with erectogenic and antidiabetic potentials. (degruyter.com)
  • Gluten seems a potentially important determinant in type 1 diabetes (T1D) and type 2 diabetes (T2D). (mdpi.com)
  • They're similar genetically too, which is why some people with type 1 diabetes who are allergic to cow insulin used pig insulin prior to the human version that became available in 1980, thanks to recombinant DNA technology. (rickilewis.com)
  • INTRODUCTION: Inequitable access to leisure-time physical activity (LTPA) resources may explain geographic disparities in type 2 diabetes (T2D). (cdc.gov)
  • Fig. 3: Effect of a single icv FGF1 injection on Arc PNN assembly and composition in ZDF rats. (nature.com)
  • Recent research for instance found that the exact composition of microbes in the guts of normal and obese rats differs. (lindau-nobel.org)
  • Posted The Cape Plastic Bottle Ban when i was just your, a levels Ethicist to provide job and drunken bookstore with condition to the molecular rats of first Program on both gestational and efficient composition. (peterkim.com)
  • Antibiotics are Fosamax and Citracel to increase bone mass, used to deal with the an infection diabetes insipidus constipation [url=https://www.sanvicente.gov.ph/order-online/Duetact/]generic duetact 17 mg online[/url]. (ehd.org)
  • His research aims to develop clinical biomarkers and novel therapeutics for (physio)pathological conditions associated with neurodegeneration and/or endothelial dysfunction, notably stroke, hypertension, diabetes and ageing. (nottingham.ac.uk)
  • A study on lab rats also showed that vinegar can lower hypertension. (curejoy.com)
  • Fig. 2: T2D-ZDF rats exhibit abnormal hypothalamic CS/DS-GAG sulfation patterns. (nature.com)
  • There were no clinically significant differences in glycemic control or diabetes antibody titers. (nature.com)
  • Hence fetuin-A is a predictor of adverse glycemic outcomes in pre-diabetes. (wikipedia.org)
  • In addition, diabetes was associated with increased oxidative stress [reduced renal glutathione reductase (GR), superoxide dismutase (SOD), catalase activities, and increased malondialdhyde (MDA)] and increased plasma tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and nitric oxide (NO) concentrations. (elsevierpure.com)
  • Seven-week-old male A/J mice were obtained from the Central South University Animal Services (Changsha, China) and were induced with diabetes at 8 weeks of age. (hindawi.com)
  • Knocking out the gene for fetuin-A rendered the mice completely fetuin-A deficient. (wikipedia.org)
  • In humans and mice, GLP-1 is predominantly amidated, whereas in rats both amidated and nonamidated GLP-1 is present (1,2). (sysy.com)
  • naked mole-rats simply don't seem to get all the age-related disorders . (skeptophilia.com)
  • Though the mechanism is not clear, it is believed that vinegar might render some of the digestive enzymes that break down carbohydrates into sugar inactive, slowing the conversion of complex carbohydrate into sugar. (curejoy.com)
  • However, unripe banana is not consumed directly due to its hardness and high astringency and when cooked its native RS is rendered digestible, In this study we have developed macaroni pasta from chemically modified unripe banana flour (RS4), which did not lose their indigestibility after being cooked. (cmu.ac.th)
  • The numerous beneficial effects of GLP-1 render this hormone an interesting candidate for the development of pharmacotherapies to treat obesity and diabetes (4,5). (sysy.com)
  • The association between D2 activity and D2 mRNA in euthyroid, hypothyroid, and hormone- treated rats across a full range of thyroidal states suggests that, L-T 4 treatment is associated with greater changes in cortical D2 activity (via posttranslational effects) than mRNA, whereas L-T 3 treatment has a greater effect on decreasing D2 mRNA (i.e. pretranslational effects). (umn.edu)
  • We expect that the present proteomic data can provide valuable information for evidence-based gender-specific treatment of diabetes. (karger.com)
  • 9-11 Insulin plays a crucial role in lowering blood glucose levels and is a primary treatment for diabetes. (balkanmedicaljournal.org)
  • Treatment of hypothyroid rats for 2 weeks with graded doses of L-T 4 (0.1-1.5 μg/100 g BW-day) results in a significant decrease in cortical D2 activity, but not mRNA. (umn.edu)
  • Coding of this variable in character format which preserved the "true" rendering of the code began in 1995. (cdc.gov)
  • This is the first of a series of articles on presentations at the American Diabetes Association Annual Meeting, Orlando, Florida, 4-8 June 2004, addressing an important theme of the meeting: new therapeutic approaches based on gut-derived incretin hormones. (diabetesjournals.org)
  • The availability of the rat D2 complementary DNA now allows an assessment of whether pretranslational regulation of this enzyme also occurs in the cerebral cortex. (umn.edu)
  • Follow-up after transplantation showed that diabetes was cured in 2/12 rats in the submandibular group in comparison to 4/6 in the control group. (bvsalud.org)
  • This is sometimes a genetic disease and sometimes a disease that develops because of the environment-whatever the cause, Diabetes can be easily controlled with the right diet and exercise. (sofundaschool.co.za)
  • Naked mole-rats are a model of healthy aging," said Vera Gorbunova, of the University of Rochester, who has been studying how they accomplish this. (skeptophilia.com)
  • Syngeneic rat hepatocytes (1.0 × 107) were transplanted to analbuminemic rats with (ISO group) and without (AW group) isoflurane. (bvsalud.org)
  • In a presentation at the American Diabetes Association Annual Meeting on this topic by Cherrington's group, Dardevet et al. (diabetesjournals.org)