• abstract = "Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation.De Vries B, Matthijsen RA, Wolfs TG, Van Bijnen AA, Heeringa P, Buurman WA.Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands.BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. (maastrichtuniversity.nl)
  • ARA290 Protects Against Renal Ischemia/Reperfusion Injury. (ox.ac.uk)
  • Balmes targets kidney ischemia-reperfusion injury , a complication that affects up to 500,000 heart surgery patients and around 45,000 kidney transplant patients in the US and Europe each year. (labiotech.eu)
  • With the rates of heart surgery and kidney transplants still high, preventative measures for complications like kidney ischemia-reperfusion injury are required. (labiotech.eu)
  • Conclusion: From these results, we deduced that the preventive effect of EP on rat kidney ischemia-reperfusion injury was not due to the decreased expression of HMGB1 but the prevention of HMGB1 release. (elsevierpure.com)
  • Coincident with Rhode Island Hospital's experience in altruistic kidney donation and a large experience in utilizing kidneys from donors after cardiac death (DCD), he has written and lectured about safely expanding organ donation and transplantation. (lifespan.org)
  • 10 ] showed that the transplantation of mouse ESCs-derived RPCs can result in the stable integration into proximal tubules with normal morphology and normal polarization injection into developing live newborn mouse kidneys, suggesting the potential of ESCs for application in regenerative therapies. (biomedcentral.com)
  • Native kidneys and skeletal muscle were imaged as reference tissues and renal explants analysed by histology and electron microscopy. (hindawi.com)
  • A temporary impairment of blood flow to the kidneys causes the death of renal cells, which can lead to kidney failure . (labiotech.eu)
  • As the restoration of blood flow to the kidneys following ischemia causes cell death, regenerative medicine could also be an important area of research going forward. (labiotech.eu)
  • Kidneys were harvested and serum creatinine and TNF-α measured at 6 hours, 1 day, 3 days, and 5 days after reperfusion. (elsevierpure.com)
  • For many years, chronic allograft nephropathy (CAN) was used to describe the progressive loss of renal function in transplanted kidneys over time not related to acute rejection. (biomedcentral.com)
  • We used doubly perfused bullfrog kidneys in vivo , and switched the basolateral solution (renal portal vein) to experimental solutions. (cellphysiolbiochem.com)
  • In kidneys suffering from ischemia-reperfusion and in renal tubular epithelial cells subjected to hypoxia/reoxygenation, NCX extrudes Na + in exchange for Ca 2+ influx, resulting in intracellular Ca 2+ overload and tubular epithelial cell injury (Yamashita J, S Kita, T Iwamoto et al. (cellphysiolbiochem.com)
  • Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)
  • Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • The Management of Bilateral Ureteric Injury following Radical Hysterectomy. (ncl.ac.uk)
  • Nitric oxide in acute renal failure: NOS versus NOS. (scienceopen.com)
  • Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
  • Progressive AKI leads to acute renal failure (ARF)[ 1 ]. (biomedcentral.com)
  • Moreover, it was found that these two are firmly correlated, which means acute renal failure can lead to chronic type and vice versa [ 6 ]. (biomedcentral.com)
  • An unexpected decrease in urine output followed by a rise in serum creatinine concentration, including an inability to excrete waste, keep-up electrolytes, and maintain water balance, is termed acute kidney injury (AKI) or acute renal failure. (biomedcentral.com)
  • Immunosuppressive therapy has improved during the last decade but still acute and chronic rejection are important complications after transplantation. (phenos.com)
  • The indications for transplantation, the pharmacokinetics of immunosuppressants, and the complications of transplantation can be strikingly different for children compared with their adult counterparts. (medscape.com)
  • I developed specific interest in the immune-modulating properties of Vitamin D, the molecular basis for chronic kidney transplant rejection, complications of organ transplantation and the involvement of cells from the immune system in kidney disease. (universityofgalway.ie)
  • 9. Clinical complications and outcomes of human kidney and pancreas transplantation. (universityofgalway.ie)
  • For patients with diabetes mellitus (DM) type 1, pancreas transplantation (PTx) is the only therapeutic option capable of normalizing blood glucose and minimizing secondary complications of diabetes, resulting in an increase in the survival and an improved quality of life ( 1 ). (frontierspartnerships.org)
  • See the images below of transplantation complications. (medscape.com)
  • Lee et al retrospectively enrolled 75 patients who had undergone liver transpalantation and found that although MDCT in the late period should be interpreted with caution in patients with suspected biliary complication, MDCT is a reliable diagnostic technique for the identification of early and late abdominal complications after liver transplantation. (medscape.com)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • We then established the rat ischemia-reperfusion injury (IR) model and transplanted the iPSC-derived RPCs into the injured rats in combination with the hydrogel. (biomedcentral.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • The rats in the IR group underwent 45 min partial kidney ischemia, and the animals in the IPC + IR group underwent two 5 min cycles of partial kidney ischemia followed by 10 min reperfusion and partial kidney ischemia for 45 min. (hindawi.com)
  • The objective of this study was to determine whether homing of endothelial progenitor cells (EPCs) induced by ischemic preconditioning (IPC) contributed to the protection of renal acute ischemia-reperfusion injury (IRI) in male rats. (annalsoftransplantation.com)
  • The effects of EUK-134 on serum levels of NO in rats subjected to renal I/R or on NO production by PTCs incubated with interferon-γ (IFN-γ, 100 IU/ml) and bacterial lipopolysaccharide (LPS, 10 µg/ml) in combination for 24 h were also measured. (scienceopen.com)
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • Materials and Methods: Sprague-Dawley rats (200-300 g) were subjected to 40 minutes of renal warm ischemia. (elsevierpure.com)
  • Paul Morrissey, MD is interested in outcomes after renal transplantation for organ donors and recipients. (lifespan.org)
  • The Food and Drug Administration (FDA) is announcing a public workshop to discuss the effects of ischemia/ reperfusion injury ( IRI ) on outcomes in kidney transplantation. (myast.org)
  • Identifying the mediators and factors that trigger IF/TA may be useful in early diagnosis and development of novel therapeutic strategies for improving long-term renal allograft survival and patient outcomes. (biomedcentral.com)
  • Available evidence does not suggest that standard renal replacement therapies improve outcomes beyond control of fluid balance and azotemia [ 8 ]. (biomedcentral.com)
  • The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
  • 2) to investigate the role of HO-1 and its products, CO and bilirubin, in protecting renal tissues during hypothermic storage and subsequent reperfusion. (ucl.ac.uk)
  • 3) to search for novel "pharmacological preconditioning agents" that are capable of selectively activating the HO-1 gene in renal tissues. (ucl.ac.uk)
  • The relationship of oxygen-derived free radicals, or superoxides, to cell injury has been an area of active research with considerable early evidence for releSuperoxide vance to a number of disease dismutase (SOD), an enzyme naturally present in many tissues of humans and other organisms, catalyzes the conversion of superoxides to less reactive oxygen species, thereby protecting the cell. (docksci.com)
  • We designed this study to identify changes in HMGB1 expression in rat kidney tissues after ischemia reperfusion injury and effects of EP on the expression of HMGB1. (elsevierpure.com)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • Трансплантати шкіри Many different types of tissues can be transplanted, including skin, bone, cartilage, adrenal tissue, fetal thymus, corneas, and composite transplantation of tissues to restore the face or extremities. (msdmanuals.com)
  • Next, we examined the renal function-related markers and renal histology to assess the therapeutic effect of the injected cells. (biomedcentral.com)
  • Although pharmacological therapy, modern dialysis techniques, and intermittent or continuous renal replacement therapies exist, the therapeutic approaches for AKI remain very limited. (biomedcentral.com)
  • Heart transplantation is a well established technique to study mechanisms and therapeutic approaches to prevent solid organ transplant rejection. (phenos.com)
  • In addition, we also discuss the existing methods of artificial mitochondrial transfer/transplantation (AMT/T) and their therapeutic effects on diseases to explore the potential applications of mitochondrial transfer and transplantation in the treatment of mitochondrial-related diseases, mitochondrial diseases, and cancer. (biomedcentral.com)
  • In order to find more promising treatments to stimulate renal repair, stem cell-based technology has been proposed as a potentially therapeutic option. (biomedcentral.com)
  • Exogenous administration of CFH after reperfusion caused overt AKI with creatinine increase, tubular injury, and enhanced markers of renal inflammation compared with vehicle-treated animals. (stanford.edu)
  • In patients with progressive CKD there is histological evidence of inflammation in the interstitium and strategies that reduce inflammation reduce renal injury in pre-clinical models of CKD. (wjgnet.com)
  • In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)
  • It is therefore possible that inhibiting complement activation would reduce inflammation, lead to reduced fibrosis and preservation of renal function. (wjgnet.com)
  • Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of renal dysfunction as well as inflammation and endothelial dysfunction. (ed.ac.uk)
  • Renal ische-mia‐reperfusion injury (IRI) induces oxidative stress, inflammation, epithelium and endothelium damage, and cessation of renal function. (uandes.cl)
  • The mechanisms leading to IF/TA in the transplanted kidney include inflammation, activation of renal fibroblasts, and deposition of extracellular matrix proteins. (biomedcentral.com)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • The findings emphasize the role of concomitant oxidative and nitrosative stress and the role of peroxynitrite in the ensuing renal dysfunction. (scienceopen.com)
  • Complement 5a receptor inhibition improves renal allograft survival. (phenos.com)
  • Furthermore, we examined the effect of inhibition of complement-factor C5 on renal I/R injury. (maastrichtuniversity.nl)
  • To overcome the shortage of kidney donors, diverse methods have been utilized, including living donor kidney transplantation (LDKT) and extended criteria for deceased donor grafts. (ekjt.org)
  • Living donor kidney transplantation (LDKT) has also become a major treatment option, with living donor grafts demonstrating similar or better graft survival rates compared to deceased donors. (ekjt.org)
  • [ 3 ] . An increasing number of orthotopic and living-donor liver transplantations are being performed to salvage patients with otherwise incurable end-stage liver disease (ESLD). (medscape.com)
  • The demand for organ transplantation is expanding and waiting lists for a kidney are likely to increase in coming years [ 2 ]. (hindawi.com)
  • This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)
  • One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
  • Because of transportation limitations, the time delay from organ procurement to actual transplantation is one of the most critical barriers to DDKT in Jeju. (ekjt.org)
  • The maintenance of organ viability from donation to transplantation is a decisive factor for the adequate function and survival of the graft, especially in organs such as the pancreas, which is highly susceptible to ischemic damage. (frontierspartnerships.org)
  • Трансплантація печінки Liver transplantation is the 2nd most common type of solid organ transplantation. (msdmanuals.com)
  • Almost always, transplantation is done to replace or restore the function of an end-stage diseased organ, thereby restoring an essential function and improving patient survival. (msdmanuals.com)
  • There is no imaging modality available to measure the development of graft fibrosis and current practice involves a biopsy when renal function deteriorates [ 8 ]. (hindawi.com)
  • Monocytes and macrophages are known to play a role in chronic renal allograft damage [ 10 ] and are key promoters of fibrosis in other organs, such as the liver [ 11 , 12 ]. (hindawi.com)
  • The cause of late renal allograft loss, once known as chronic allograft nephropathy, has been renamed "interstitial fibrosis and tubular atrophy" (IF/TA) to reflect the histologic pattern seen on biopsy. (biomedcentral.com)
  • Santill n-Doherty P. Transplante unilateral de plum n en un caso de fibrosis pulmonar Terminal. (medigraphic.com)
  • In this study, we induced iPSCs differentiation into RPCs using a nephrogenic cocktail of factors combined with the renal epithelial cell growth medium. (biomedcentral.com)
  • We showed that the differentiation efficiency of iPSCs to RPCs increased when cultured with renal epithelial cell growth medium after stimulation with a nephrogenic cocktail of factors. (biomedcentral.com)
  • In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
  • In the past several decades, numerous studies have been conducted to understand the pathogenesis of IF/TA and multiple factors and mechanisms have been demonstrated to be involved in the progress of the IF/TA, including immunosuppressive drug toxicity, antibody-mediated injury, and epithelial-mesenchymal transition (EMT) (Figure 1 ). (biomedcentral.com)
  • The exact mechanism of immunosuppressive drug-mediated renal toxicity is not fully understood. (biomedcentral.com)
  • Geha JA, Geha JD, O'Mahony CA, Cotton RT, Galván TN, Rana A, Goss JA " Reconstruction of the Replaced Right Hepatic Artery Using Donor Iliac Arterial Y-Graft in Orthotopic Liver Transplantation . (bcm.edu)
  • Spectral Doppler ultrasonographic waveform of the right hepatic artery in a 60-year-old man, 8 years after orthotopic liver transplantation. (medscape.com)
  • Knowledge of the pathophysiologic consequences of chronic renal failure is too important for anesthesiologists, because many of these patients have at least one of these sequences, most commonly hypertension, coronary artery diseases, diabetes mellitus and pulmonary dysfunction. (intechopen.com)
  • EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R. Specifically, serum creatinine levels, an indicator of renal dysfunction, were reduced from 227 ± 11 (n = 12, I/R only) to 146 ± 9 µ M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
  • Moreover, BB5.1 treatment significantly protected against I/R-induced renal dysfunction. (maastrichtuniversity.nl)
  • We investigated whether ultrasmall paramagnetic particles of iron oxide- (USPIO-) enhanced magnetic resonance imaging (MRI) can detect experimental chronic allograft damage in a murine renal allograft model. (hindawi.com)
  • To investigate the involvement of complement in I/R injury, we studied the activation and deposition of complement in a murine model of renal I/R injury. (maastrichtuniversity.nl)
  • Neither cardiovascular nor renal function, such as the echocardiographically determined cardiac index, inulin or para-aminohippurate clearances, or the urinary excretion of P,-microglobulin or N-acetylglucosaminidase, was affected. (docksci.com)
  • My group's research focuses on the cardiovascular risk associated with the spectrum of chronic kidney disease from early in the disease trajectory through to end-stage renal failure requiring either dialysis or kidney transplantation. (ed.ac.uk)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)
  • Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
  • Many DAMPs are nuclear or cytosolic proteins with defined intracellular function that are released outside the cell following tissue injury. (wikipedia.org)
  • Other interests include delayed allograft function and effort to limit ischemia-reperfusion injury after transplantation. (lifespan.org)
  • Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
  • Acute kidney injury (AKI) is characterized by acute tubular injury and a rapid decline in renal function [ 1 ]. (biomedcentral.com)
  • In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)
  • In renal transplantation, delayed graft function and primary nonfunction are major sources of graft loss and morbidity. (ucl.ac.uk)
  • The results show that, following induction of HO-1 in renal tissue, the enzymatic activity was maintained during hypothermia, and some beneficial effects on renal function could be observed after storage and reperfusion. (ucl.ac.uk)
  • Multiple research groups have developed artificial mitochondrial transfer/transplantation (AMT/T) methods that transfer healthy mitochondria into damaged cells and recover cellular function. (biomedcentral.com)
  • cardiac surgery-associated acute kidney injury and delayed graft function after kidney transplants. (labiotech.eu)
  • [ 1 ] At present, serum creatinine, which is used to measure the glomerular filtration rate (GFR), is the most commonly used marker of renal function. (medscape.com)
  • In addition, AG reduced kidney injury (NGAL, clusterin, Arg‐2, and TFG‐β1) and improved kidney function (glo-merular filtration rate) during IRI. (uandes.cl)
  • Renal function at 1-year post-transplant was noted as MDRD eGFR. (atcmeetingabstracts.com)
  • Its pathogenesis has not been fully elucidated and existing therapy is not effective in improving renal transplant function. (biomedcentral.com)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • In collaboration with Fatemah Akhlaghi, PharmD, PhD, of University of Rhode Island College of Pharmacy, Gohh is also investigating the pharmacokinetics of mycophenolate mofetil in diabetic renal transplant recipients. (lifespan.org)
  • The renin-angiotensin system (RAS) and hypertension also may be influenced by renal IR injury. (hindawi.com)
  • Additionally, disturbance in acid-base, electrolytes and fluid balance are usually related to a marked decline in the glomerular filtration rate (GFR) caused by a variety of systemic diseases such as diabetes mellitus or hypertension, and renal disorders as chronic glomerulonephritis,cystic kidney disorder,interstitial nephritis, obstructive uropathy, and lupus nephritis. (intechopen.com)
  • Cardiac transplantation relies on organs procured from Brain Dead Donors (DBD). (whiterose.ac.uk)
  • Hearts from DCD donors have not been utilized as there is a fear that they will have sustained irreversible myocardial injury post cardiac arrest. (whiterose.ac.uk)
  • Complement activation is known to occur in many diverse renal diseases, including glomerulonephritis, thrombotic microangiopathies and transplant rejection. (wjgnet.com)
  • I am mostly interested in apoptotic endonucleases, the key enzymes regulating irreversible cell death after cell injury and during diseases. (uams.edu)
  • Collectively, although scientists are increasingly aware of mitochondria's dynamic and transferable capabilities of mitochondria, the unclear mechanism and effectiveness of mitochondrial transfer/transplantation therapy limit its widespread application in diseases. (biomedcentral.com)
  • Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • This protective role has been demonstrated in various animal models of ischemia and reperfusion injury such as myocardial infarction, cardioplegia, and renal transplantation.4-11Before the availability of human SOD, clinical studies of SOD in humans were limited to the use of bovine SOD. (docksci.com)
  • clinical investigation of its use in humans by the intravenous route is currently underway in the area of renal tran~plantation. (docksci.com)
  • My interest in transplantation resulted in a research fellowship in basic immunology at the University of Chicago, USA following which I spent 9 years combining clinical transplant medicine with laboratory-based immunology research at Mayo Clinic. (universityofgalway.ie)
  • Our clinical studies are supported by relevant pre-clinical models where we are investigating the roles of these microRNAs as mediators of renal and extra-renal disease. (ed.ac.uk)
  • Administration of recombinant human superoxide dismutase (rh-SOD) in recipients of cadaveric renal allografts demonstrated prolonged patient and graft survival with improvement in both acute and chronic rejection events. (wikipedia.org)
  • Renal biopsy remains the gold-standard for detecting allograft rejection but is associated with significant morbidity and mortality. (hindawi.com)
  • T2 Mapping for Noninvasive Assessment of Interstitial Edema in Acute Cardiac Allograft Rejection in a Mouse Model of Heterotopic Heart Transplantation. (phenos.com)
  • Kidney transplantation results in superior life expectancy and better quality of life if compared to dialysis treatment for patients with end-stage renal failure. (intechopen.com)
  • Since the first kidney transplantation in South Korea in 1969, the significant benefit of kidney transplantation over dialysis in terms of quality of life and life expectancy has led to a rapid rise in transplant cases nationwide. (ekjt.org)
  • In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)
  • Here we use a mouse model of ischaemia-reperfusion injury to investigate new experimental medicine strategies to reduce the risk of developing CKD after AKI. (ed.ac.uk)
  • Scavenging peroxynitrite using seleno-organic compounds like ebselen provides renoprotection against ischemic injury. (scienceopen.com)
  • hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)
  • Since the shortage of donor organs is a major problem, it is imperative to develop methods capable of preserving organs after significant periods of warm and cold ischaemia, and at the same time minimise the reperfusion injury associated with transplantation. (ucl.ac.uk)
  • Monoclonal gammopathy of renal significance: whento do renal biopsy and how to treat? (ene.gr)
  • It is evident that both cyclosporine and tacrolimus can cause renal and systemic vasoconstriction through increased release of endothelin-1, activation of the renin-angiotensin system, increased production of thromboxane A 2 , and decreased production of vasodilators such as nitric oxide and prostacyclin [ 7 ]. (biomedcentral.com)
  • The role of monocytes and macrophages in chronic renal allograft damage has been well established [ 9 ]. (hindawi.com)
  • Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)