Loading...
  • tubular cells
  • Primary cultures of renal proximal tubular cells (RPTC) were cultured in improved conditions resulting in mitochondrial respiration and activity of mitochondrial enzymes similar to those in RPTC in vivo . (jove.com)
  • limb
  • In mdx mice, a model of human Duchenne muscular dystrophy (DMD), G-CSF mRNA and protein was down-regulated in limb and diaphragm muscle, but circulating G-CSF ligand levels were elevated. (frontiersin.org)
  • amino
  • Although increased amino transport markedly activated mTor signaling, this pathway did not alter cell proliferation. (jove.com)
  • More than 50 years later, we understand that aerobic glycolysis and uptake of glutamine and glycine allow cancer cells to produce energy (ATP) and the nucleotides, amino acids, and lipids required for proliferation. (aacrjournals.org)
  • mice
  • Renal orthotopic transplantation in mice is a technically challenging procedure. (jove.com)
  • G-CSFR mRNA in the muscles of mdx mice was up-regulated however steady-state levels of the protein were down-regulated. (frontiersin.org)
  • We previously demonstrated that heart muscle-specific expression of a nuclear dominant negative CELF protein in transgenic mice (MHC-CELF? (jove.com)
  • In this study, transgenic mice that express the dominant negative protein under a skeletal muscle-specific promoter (Myo-CELF? (jove.com)
  • regulation
  • RT "Quantitative phosphoproteomics of vasopressin-sensitive renal cells: RT regulation of aquaporin-2 phosphorylation at two sites. (genome.jp)
  • We currently understand little about the genetic regulation of muscle health with disease or age. (jove.com)
  • mitochondrial
  • Jain and colleagues ( 7 ) measured the consumption and release profiles of 219 small-molecule metabolites from cell culture media in the NCI-60 cancer cell line panel, integrated these data with gene expression, and found that glycine consumption and the mitochondrial glycine biosynthetic pathway correlated with cellular proliferation rate ( 7, 8 ). (aacrjournals.org)
  • pathways
  • Several of the earliest anticancer drugs are the purine and pyrimidine antimetabolites that directly target critical metabolic pathways required for proliferation ( 1 ). (aacrjournals.org)
  • transplantation
  • He currently serves as an Assistant Professor of Pediatrics in the Transplantation Research Center at Harvard Medical School, as an Associate Physician in the Brigham and Women's Hospital Renal Division, and as Staff Scientist in the Division of Nephrology at Children's Hospital Boston and the Department of Dermatology at Brigham and Women's Hospital. (childrenshospital.org)
  • The decellularized testis can be considered as a promising vehicle to support cell transplantation and may provide an appropriate niche for testicular cell differentiation. (biomedcentral.com)
  • gene
  • Thus, C. elegans provides a powerful platform with which to assess the impact of mutations, gene knockdown, and/or chemical compounds upon muscle structure and function. (jove.com)
  • function
  • AKI is characterized by a sudden loss of renal function. (frontiersin.org)
  • The loss of muscle mass and function with disease and age are significant public health burdens. (jove.com)
  • Lastly, as GFP, cationic dyes, and movement assays are assessed non-invasively, prospective studies of muscle structure and function can be conducted across the whole life course and this at present cannot be easily investigated in vivo in any other organism. (jove.com)
  • vascular smooth
  • Macrophage-derived netrin-1 promotes abdominal aortic aneurysm formation by activating MMP3 in vascular smooth muscle cells. (abcam.com)
  • considerable
  • The search for markers that could be useful as diagnostic tools for FSGS is extremely important, since few renal biopsies of FSGS patients have a considerable number of injured glomeruli to determine the actual diagnosis of the disease. (hindawi.com)
  • diagnosis
  • OBQ12.37) Which of the following series of lab values is most consistent with a diagnosis of high turnover renal osteodystrophy? (orthobullets.com)
  • normal
  • These drugs are directed toward normal cellular proliferation processes and therefore lack selectivity for neoplastic cells over proliferating normal cells. (aacrjournals.org)
  • were generated to investigate the role of CELF-mediated alternative splicing programs in normal skeletal muscle. (jove.com)
  • Plays
  • A WNT/{beta}-catenin signaling activator, R-spondin, plays positive regulatory roles during skeletal myogenesis. (abcam.cn)