• Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
  • The renal vascular responses to graded Ang II (30, 100, 300, and 1000 ng kg −1 .min −1 ) infusion using A779 or its vehicle were measured at constant renal perfusion pressure. (hindawi.com)
  • rPER consisted of three cycles of 5-min hindlimb ischemia followed by 5 min hindlimb perfusion at the same time to mesenteric ischemic period. (scielo.org)
  • This may minimize the risk or degree of ischemia-reperfusion injury even if no selective organ perfusion was applied. (authorea.com)
  • An infrared (IR) method utilizing a focal plane array detector camera was developed for real-time intraoperative IR imaging of renal allografts, and evaluated in a pilot trial to quantify perfusion in recipients of live (n=8) and cadaveric donor (n=5) allografts. (usuhs.edu)
  • Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females. (augusta.edu)
  • One of the reasons for graft failure after renal transplantation is inadequate graft perfusion caused by mis-management of perioperative hydration policy. (intechopen.com)
  • The objective of this study was to determine whether homing of endothelial progenitor cells (EPCs) induced by ischemic preconditioning (IPC) contributed to the protection of renal acute ischemia-reperfusion injury (IRI) in male rats. (annalsoftransplantation.com)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • We propose that EUK-134 reduces renal I/R injury not only via reduction of oxidative stress, but also by reducing nitrosative stress caused by renal I/R. (scienceopen.com)
  • Thus, inhibition of oxidative stress and myocardial apoptosis is beneficial in the treatment of myocardial I/R injury. (spandidos-publications.com)
  • In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • Rats, subjected to bilateral renal ischemia (45 min) followed by reperfusion (6 h), were administered EUK-134 (0.3 and 3 mg/kg, i.v.) prior to and during reperfusion, after which biochemical and histological indicators of renal dysfunction and injury were measured. (scienceopen.com)
  • In conclusion, the intricate relations between endothelial and epithelial cells, based in part on the relations between endothelial and inducible nitric oxide synthases, are perturbed in renal ischemia primarily as a result of endothelial dysfunction precipitating epithelial injury. (scienceopen.com)
  • More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. (sciencedaily.com)
  • ABSTRACT Purpose: To evaluate if the perconditioning affects the antioxidant capacity in mesenteric ischemia and reperfusion injury. (scielo.org)
  • Abstract Hepatic ischemia/reperfusion (I/R) injury is a common clinical challenge. (123dok.net)
  • IPC is described as short, transient, and nonlethal ischemia periods and subsequent reperfusion which is performed before IR injury and can protect the kidney against long-term ischemia [ 6 - 8 ]. (hindawi.com)
  • METHODOLOGY AND FINDINGS: Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg body weight). (ox.ac.uk)
  • Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
  • After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
  • CK2α inhibition attenuates renal I/R injury To assess the function of CK2α in renal I/R injury we pretreated mice with TBBt a CK2α inhibitor 3 and 24?h prior to inducing I/R injury and blood samples were collected 24?h after reperfusion. (liveconscience.com)
  • I/R injury significantly impaired renal function in control mice as BUN and creatinine levels increased from 54.2? (liveconscience.com)
  • Moreover, preliminary data identified a novel inhibitory effect of PKG on tubular cell necrosis and apoptosis following renal ischemia reperfusion (IR) induced acute kidney injury in young mice and an inhibitory effect of PKG on macrophage migration, suggesting a therapeutic potential of PKG for renal IR injury. (uky.edu)
  • In types of renal ischemia HSF-1 can be primarily triggered by metabolic tensions connected with ATP depletion (18 19 To comprehend better the part of HSP induction in ischemic renal damage we researched HSF-1 practical knockout mice (HSF-KO). (sciencepop.org)
  • Our hypothesis was that HSP induction by renal ischemia will be inhibited in HSF-KO mice which HSF knockout mice would after that suffer worse ischemic renal damage. (sciencepop.org)
  • Results HSP manifestation in WT and HSF-KO mice Manifestation of HSPs 70 and 25 was assessed in kidneys from WT and HSF-KO mice pursuing 45 mins ischemia and recovery every day and night and weighed against their manifestation in sham managed control mice. (sciencepop.org)
  • Nevertheless unlike the crazy type animals there is absolutely no significant induction of the HSPs pursuing ischemia and reperfusion in HSF-KO mice kidney (p=0.9 and 0.7 Purvalanol B for HSP70 and HSP25 respectively in comparison to non-ischemic sham operated control). (sciencepop.org)
  • In conclusion, the present study demonstrated that SA inhibits the apoptosis of H9c2 cardiomyocytes following H/R injury via reduced activation of the p38MAPK and JNK signaling pathways. (spandidos-publications.com)
  • The underlying mechanisms behind myocardial I/R injury are associated with a number of factors, including substantial free radical production, intracellular calcium overload, increased inflammation, myocardial necrosis and apoptosis ( 6 ). (spandidos-publications.com)
  • The results demonstrated that SA inhibited apoptosis signaling in H9c2 cardiomyocytes via downregulation of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways following hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)
  • nuclear aspect-κB (NF-κB) which sets off the discharge of some inflammatory mediators such as for example tumor necrosis aspect-α (TNF-α) interleukin (IL)-1β and IL-61 6 On the tissues level ROS and inflammatory cytokines activate enzymes which are mixed AKT inhibitor VIII manufacture up in procedures of necrosis and apoptosis the last mentioned of which is normally most significant in reperfusion damage7. (liveconscience.com)
  • Given that apoptosis and swelling are critical events for I/R injury CK2 inhibition may have some role in the pathogenesis of I/R injury. (liveconscience.com)
  • HPC protected neonatal rat cardiomyocytes against H/R injury by increasing cell viability, while reducing LDH release and cell apoptosis. (spandidos-publications.com)
  • However, the knockdown of miR‑133b‑5p in the cardiomyocytes blocked HPC‑mediated cardioprotection as reflected by the aggravation of cell injury and apoptosis. (spandidos-publications.com)
  • These sequelae of renal ischemia are a result of endothelial dysfunction, which is most probably responsible for the 'no-reflow' phenomenon and further aggravation of tubular ischemia during the early reperfusion period. (scienceopen.com)
  • Lipopolysaccharide Pretreatment Prevents Medullary Vascular Congestion following Renal Ischemia by Limiting Early Reperfusion of the Medullary Circulation. (augusta.edu)
  • However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)
  • The results suggest that GSK3β/β-catenin signaling may contribute to defective wound healing in hypoxic renal cells and tissues. (biomasswars.com)
  • 2008 Although HIF induction has been shown to protect kidney tissues KLHL25 antibody against ischemic and nephrotoxic injury (Bernhardt et al. (biomasswars.com)
  • We designed this study to identify changes in HMGB1 expression in rat kidney tissues after ischemia reperfusion injury and effects of EP on the expression of HMGB1. (elsevierpure.com)
  • Microscopic studies of tissues exposed to ischemia/reperfusion (I/R) have revealed an acute inflammatory response. (lomr.org)
  • Therefore, the study was performed to investigate whether DH, traditionally used, has effects on improving and alleviating cardiac injury and fibrosis caused by cardiac hypertrophy. (bvsalud.org)
  • In addition, dohongsamul-tang treatment improved renal function-related biomarkers, such as blood creatinine, blood urea nitrogen, and neutrophil gelatinase-associated lipocalin, which were increased by TAC-induced cardiac hypertrophy. (bvsalud.org)
  • it acts as an anti-inflammatory cytokine and in vascular protection, besides important cardiac protection in the presence of ischemia-reperfusion syndrome. (scielo.org)
  • The interesting point is that many commonly used drugs affect autophagy, and if deployed correctly could decrease the degree of AKI from ischemic insults, such as during cardiac bypass surgery or kidney transplantation. (ajkdblog.org)
  • 2. Leucocyte adhesion molecules CD11/CD18, intercellular adhesion molecule-1 and selectins mediate cardiac, skin and muscle IRI in experimental models and recent studies have begun to evaluate their role in renal IRI. (johnshopkins.edu)
  • In the "from bench to bedside" approach, the fundamental research results are obtained from our in vitro and in vivo models, and can lead in fine to clinical trials in humans, as already done for Cyclosporine A in the treatment of myocardial infarct, cardiac arrest, stroke and renal ischemia. (univ-lyon1.fr)
  • Reperfusion after cardiac ischemia increases cell death and infarct size (IS), called myocardial ischemia/reperfusion (I/R) injury, which is the main cause of myocardial injury during the cardiac surgery particularly in coronary artery bypass graft surgery ( 1 , 2 ). (spandidos-publications.com)
  • The ischemic and non-ischemic kidneys were referred for electron microscopy. (unesp.br)
  • 1. Renal ischaemic-reperfusion injury (IRI) is an important cause of acute renal failure in native kidneys and in allografts. (johnshopkins.edu)
  • In kidneys HIF-1 is induced in renal tubules whereas HIF-2 is expressed by interstitial cells (Rosenberger et al. (biomasswars.com)
  • 2009 In adult kidneys changes of GSK3β/β-catenin signaling in renal CHC tubules podocytes and interstitial cells are associated with numerous kidney diseases including acute kidney injury diabetic nephropathy renal cancers cystic kidney diseases albuminuria and renal. (biomasswars.com)
  • Kidneys were harvested and serum creatinine and TNF-α measured at 6 hours, 1 day, 3 days, and 5 days after reperfusion. (elsevierpure.com)
  • It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)
  • One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
  • The injury an organ sustains during recovery, preservation, and transplantation occurs primarily as a result of ischemia and hypothermia. (medscape.com)
  • Damage to organs during transplantation occurs in 2 phases: the warm ischemic phase and the cold ischemic phase. (medscape.com)
  • Recent studies have demonstrated that transplantation of functional endothelial cells into ischemic kidney provided a dramatic renoprotective effect. (scienceopen.com)
  • Kidney transplantation results in superior life expectancy and better quality of life if compared to dialysis treatment for patients with end-stage renal failure. (intechopen.com)
  • The ultimate goal for any renal transplantation patient is to have an optimally functioning graft as early as possible after completion of surgery. (intechopen.com)
  • In liver transplantation, tissue damage at reperfusion is mostly correlated with warm and cold ischemia times and leads in turn to poor graft function [13] and biliary complications [14,15]. (123dok.net)
  • This "conditioning" activates the body's natural protective physiology against reperfusion injury and the tissue damage caused by low oxygen levels-a protection present in many mammals. (wikipedia.org)
  • In addition to ischaemic tissue damage, seen for example in renal failure, stroke or cardiovascular diseases, the mechanism may also play a central role in neurodegenerative diseases and in comorbidities of diabetes mellitus. (sciencedaily.com)
  • Restoration of blood supply, termed reperfusion, has been used to treat ischemic myocardium and prevent further tissue damage. (spandidos-publications.com)
  • Acute ischemia apparently produces minor tissue damage, the major damage is apparently secondary to reperfusion (11). (lomr.org)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
  • Remote ischemic conditioning (RIC) is an experimental medical procedure that aims to reduce the severity of ischaemic injury to an organ such as the heart or the brain, most commonly in the situation of a heart attack or a stroke, or during procedures such as heart surgery when the heart may temporary suffer ischaemia during the operation, by triggering the body's natural protection against tissue injury. (wikipedia.org)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • This overview provides information on the pathophysiology of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) system in the injury to cultured renal tubular epithelia, freshly isolated proximal tubules, and the whole organ after hypoxic or ischemic insult. (scienceopen.com)
  • Remote ischaemic preconditioning (RIPC) is the phenomenon whereby brief periods of ischaemia (reduced oxygen delivery) in one organ can have a protective effect against subsequent prolonged ischaemic insults in other organs. (researchforlife.org.nz)
  • 743 wordsMinimization of end organ ischemia is a key tenet in successful thoracoabdominal aortic aneurysm (TAAA) surgery. (authorea.com)
  • In conclusion, on top of its harmful early impact on organ function, I/R injury is linked to increased tumor growth. (123dok.net)
  • Therapeutic strategies tackling I/R injury could not only improve post-surgical organ function, but also allow a reduction in the risk of cancer recurrence. (123dok.net)
  • Ischemia-reperfusion (I/R) injury is a process whereby parenchymal damage caused by blood flow deprivation is accentuated upon organ reperfusion. (123dok.net)
  • I/R injury, through the liberation of radical oxygen species and the activation of inflammatory pathways, induces cellular injury and mi-crocirculatory damage, which translate to organ dysfunc-tion, morbidity, and increased health care costs [7, 8]. (123dok.net)
  • Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
  • Based on conflicting evidence of apoptotic induction and anti-inflammation of CK2 inhibition we assessed the effects of TBBt within the intrinsic response to renal I/R injury. (liveconscience.com)
  • In two models of partial renal IR with and without ischemia preconditioning (IPC) and using Mas receptor (MasR) blockade, A779 or its vehicle, the renal vascular responses to angiotensin II (Ang II) administration in two-kidney-one-clip (2K1C) hypertensive rats were determined. (hindawi.com)
  • No significant differences were detected between the groups in renal blood flow (RBF) or renal vascular resistance (RVR) responses to Ang II infusion when MasR was not blocked. (hindawi.com)
  • IR promotes a cascade of molecular events that lead to renal vascular and tubular damage and, ultimately, acute kidney injury (AKI) [ 2 - 4 ]. (hindawi.com)
  • In contrast to the negative effects of Ang II on the renal circulation, Ang1-7 as a renoprotective agent improves endothelial function, which increases RBF and decreases renal vascular resistance (RVR) [ 16 ]. (hindawi.com)
  • However, the mechanisms driving rhythmicity of ischemic vascular events are unknown. (bioxcell.com)
  • RATIONALE AND OBJECTIVE: Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. (ox.ac.uk)
  • Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. (eurekaselect.com)
  • In addition, there is discussion of how intrinsic damage to the endothelium impairs homeostatic responses in vascular tone as well as promotes leukocyte adhesion and exacerbating the reduction in renal blood flow. (eurekaselect.com)
  • Finally, we discuss how acute kidney injury induces permanent alterations in renal vascular structure. (eurekaselect.com)
  • Thrombosis is an important part of the normal hemostatic response that limits hemorrhage caused by microscopic or macroscopic vascular injury. (medscape.com)
  • Allograft ischemia induces delayed graft function and is correlated with increasing rates of rejection. (usuhs.edu)
  • Here we investigate the effect of EUK-134, a synthetic superoxide dismutase and catalase mimetic, (i) on renal dysfunction and injury caused by I/R in vivo and (ii) on proximal tubular cell (PTC) injury and death caused by oxidative and nitrosative stress. (scienceopen.com)
  • However, EUK-134 also reduced nitrosative stress caused by I/R in vivo (reduction of iNOS expression and nitrotyrosine formation), which was reflected by a significant reduction in serum NO levels in rats subjected to renal I/R. Specifically, serum NO levels were reduced from 57 ± 12 (n = 12, I/R only) to 23 ± 3 m M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • In vivo quantification of VCAM-1 expression in renal ischemia reperfusion injury using non-invasive magnetic resonance molecular imaging. (ox.ac.uk)
  • We hypothesized that microparticles of iron oxide targeting VCAM-1 (VCAM-MPIO) would depict "ischemic memory" and enable in vivo assessment of VCAM-1 expression. (ox.ac.uk)
  • During ischemia-reperfusion an in vivo condition of hypoxia HIF family members are induced to regulate tissue repair and remodeling. (biomasswars.com)
  • Thus, we attempt to investigated the possible regulation role of H2S on spinal cord I/R injury in vitro or in vivo. (biomedcentral.com)
  • Hypoxia/reoxygenation (H/R) as well as hypoxic preconditioning (HPC) is widely used for simulating in vivo myocardial I/R and ischemic preconditioning (IPC) in a cell culture model. (spandidos-publications.com)
  • The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
  • At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
  • In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)
  • EUK-134 produced a significant reduction in renal dysfunction and injury caused by I/R. Specifically, serum creatinine levels, an indicator of renal dysfunction, were reduced from 227 ± 11 (n = 12, I/R only) to 146 ± 9 µ M (n = 12, I/R +3 mg/kg EUK-134). (scienceopen.com)
  • OJS inhibited the increase of blood urea nitrogen (BUN) and serum creatinine (SCr) levels and reduced histological changes in the kidney, like loss of brush borders, renal tubular necrosis, and cast formation. (bvsalud.org)
  • 0.001, R 2 =0.81), and predicted the subsequent return of renal function with RT negatively correlated to the regression slopes of creatinine (p = 0.02, R 2 = 0.38) and BUN (p = 0.07, R 2 = 0.26). (usuhs.edu)
  • [ 1 ] At present, serum creatinine, which is used to measure the glomerular filtration rate (GFR), is the most commonly used marker of renal function. (medscape.com)
  • Results: Serum creatinine and TNF-α level were elevated in the ischemic control group and the EP injection group. (elsevierpure.com)
  • Cold ischemic time ranged from 0.5 to 29h and was bimodally distributed between living and cadaveric donors. (usuhs.edu)
  • In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
  • Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. (eurekaselect.com)
  • In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
  • Neonatal rat cardiomyocytes were isolated and subjected to hypoxia/reoxygenation (H/R) injury, with or without HPC. (spandidos-publications.com)
  • remote ischemic conditioning reduced infarct size in ST-elevation myocardial infarction (STEMI) patients when used in the ambulance or emergency department as an adjunct therapy to primary percutaneous coronary intervention (PCI), or when used with thrombolytic drugs. (wikipedia.org)
  • BACKGROUND: Contrast staining (CS) on dual-energy CT (DECT) is common after endovascular therapy (EVT) in acute ischemic stroke (AIS). (bvsalud.org)
  • Although important therapeutic progress has been made over the last two decades, ischemic pathologies such as myocardial infarction and stroke remain one of the first causes of death worldwide. (univ-lyon1.fr)
  • Ischemic stroke is sudden neurologic deficits that result from focal cerebral ischemia associated with permanent brain infarction (eg, positive results on diffusion-weighted MRI). (msdmanuals.com)
  • 8) A bifurcated graft of the neo-graft was anastomosed to the common iliac arteries first, followed by reattachments of the left renal artery, superior mesenteric artery and celiac axis without aortic cross-clamp. (authorea.com)
  • Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)
  • Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)
  • Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
  • The present study aimed to clarify the cardioprotective effect of SA in myocardial I/R injury in vitro and explore the potential molecular mechanisms. (spandidos-publications.com)
  • 6. Leucocyte adhesion molecules may mediate renal IRI by mechanisms other than simply leucocyte migration, such as signal transduction and cell transport. (johnshopkins.edu)
  • The present study was undertaken to study the effects of exogenous H2S on ischemia/reperfusion (I/R) injury of spinal cord and the underlying mechanisms. (biomedcentral.com)
  • Putative pathophysiological mechanisms linking I/R injury and liver cancer recurrence include an increased implantation of circulating cancer cells in the ischemic liver and the upregulation of proliferation and angiogenic factors following the ischemic insult. (123dok.net)
  • Nitric oxide in acute renal failure: NOS versus NOS. (scienceopen.com)
  • Preliminary studies demonstrated that nitric oxide (NO) and its downstream signaling pathway cGMP and cGMP-dependent protein kinase (PKG) was down-regulated in aging kidney, which was associated with aging-related renal functional changes. (uky.edu)
  • Although the mechanism of preconditioning is not yet known, it has been suggested that liver ischemic preconditioning is mediated by the inhibitory action of nitric oxide on endothelin and through the balance of adenosine and xanthine levels (24,27). (lomr.org)
  • The objective of this study is to carry out a literature review on the role of adiponectin in ischemia-reperfusion syndrome. (scielo.org)
  • Serum and renal tissue samples were collected 24 hours after the last treatment and subjected to biochemical and histological examinations, respectively. (ac.ir)
  • 0.7?mg/dl respectively after reperfusion (Fig. 2A B). However pretreatment with 2? (liveconscience.com)
  • Compared to I/R injury groups, H 2 S pretreatment had reduced spinal cord infarct zone, improved hind motor function in rats. (biomedcentral.com)
  • In rat model of I/R injury, pretreatment of pre-miR-30c or 3-MA (an inhibitor for autophagy) can abrogated spinal cord protective effect of H2S. (biomedcentral.com)
  • Apoptotic pathways in ischemic acute renal failure. (bmj.com)
  • Cellular injury was evaluated by detecting cell viability, lactate dehydrogenase (LDH) activity and apoptotic rate. (spandidos-publications.com)
  • Since many situations resulting from traumatic accidents or pathologies are due to cell damage caused by ischemia-reperfusion syndrome, it is relevant to study new therapeutic alternatives that will contribute to reducing these lesions. (scielo.org)
  • Hopefully, these proposed studies will lead to new therapeutic strategy for acute kidney injury in aging population. (uky.edu)
  • Its main objective is to conduct clinical trials aiming to test the effect of therapeutic molecules on ischemia-reperfusion syndromes in collaboration with the Clinical Center of Investigation of Lyon. (univ-lyon1.fr)
  • citation needed] In 1993, Karin Przyklenk and colleagues began using the term "remote" when they observed that cross-clamping on the right side of the heart (right circumflex artery) protected the left side of the heart (LAD territory) from ischemia: that is, the protective trigger was remote from the observed effect. (wikipedia.org)
  • If the ischemic event is limited to 25-40 minutes, autophagy is protective. (ajkdblog.org)
  • However, the protective effect of H2S on I/R injury of spinal cord has not been described. (biomedcentral.com)
  • Taking into account that ischemic preconditioning (IschP) is also a protective mechanism, a comparative study between both preconditioning effects, with the aim to study the effectiveness of both protective procedures, was performed. (lomr.org)
  • Taking into account both protective effects, ischemic and ozone oxidative preconditioning, against liver injury by I/R, the aim of this study is to stablish a comparison between them, in a liver I/R model. (lomr.org)
  • Our new team IRIS (Ischemia-Reperfusion Injury Syndromes), created by the HCERES in January 2021, gathers a fundamental research group and a clinical research group, which drive together an ambitious translational research program. (univ-lyon1.fr)
  • Kidney partial ischemia-reperfusion (IR) injury is defined as a reduction of the renal blood flow (RBF) followed by the recovery of RBF and reoxygenation [ 1 ]. (hindawi.com)
  • To create an experimental model of associated comorbidities, for healing and regeneration studies, protocols for induction of nephropathy by ischemia and reperfusion (I/R) and induction of DM by injection of streptozotocin (STZ) were associated. (scielo.br)
  • Ischemia preconditioning (IPC) against IR also was recognized as a process to minimize the kidney damage caused by IR [ 5 ]. (hindawi.com)
  • This technology may aide in the objective assessment of therapies designed to limit reperfusion injury, and allow for quantitative assessment of allograft ischemic damage. (usuhs.edu)
  • The primary rationale for these developments is that recognition of AKI allows prompt injury-specific intervention that may avert permanent renal damage. (medscape.com)
  • Renal ischemic injury results in permanent damage to peritubular capillaries and influences long-term function. (postgradualninefrologie.cz)
  • Results CK2α manifestation is improved during renal I/R injury To induce I/R injury AKT inhibitor VIII manufacture the renal pedicles were bilaterally clamped for 25?min after which they were reperfused for various time periods (Fig. 1A). (liveconscience.com)
  • This technique is most commonly applied by inflating a blood pressure tourniquet on the upper arm to induce three five-minute cycles of ischaemia, with intervening periods of reperfusion. (researchforlife.org.nz)
  • Hydrogen sulfide (H2S), endogenously derived from L-cysteine in several organs, such as brain, heart, kidney and liver [ 3 ], has been regarded as the third gasotransmitter and endogenous neuromodulator and plays multiple roles in the central nervous system under physiological and pathological states, especially in secondary neuronal injury. (biomedcentral.com)
  • Oxidative and nitrosative stress plays important roles in the pathogenesis of renal ischemia/reperfusion (I/R) injury. (scienceopen.com)