• Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
  • It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)
  • Acute kidney injury (AKI) is a major concern following cardiac surgery and has the potential to significantly impact patient outcomes. (nature.com)
  • Cardiac surgery-associated acute kidney injury (CSA-AKI) occurs in ≥50% of patients with chronic kidney disease (CKD) undergoing cardiac surgery with cardiopulmonary bypass (CPB) 2 . (nature.com)
  • Due to the reduced renal reserve in these patients, the consequences are particularly poor and may include longer hospital stays with complications, increased need for acute dialysis, and further progression to end-stage kidney disease (ESKD) 3 . (nature.com)
  • Cell-Free Hemoglobin in Acute Kidney Injury after Lung Transplantation and Experimental Renal Ischemia/Reperfusion. (stanford.edu)
  • Lung transplantation (LuTx) is a clinical condition with a high incidence of acute kidney injury (AKI). (stanford.edu)
  • BACKGROUND/AIMS: Acute kidney injury (AKI) carries high morbidity and mortality, and the inducible nitric oxide synthase (iNOS) is a potential molecular target to prevent kidney dysfunction. (uandes.cl)
  • investigate the role of C-type lectin Mincle in promoting cell death and acute kidney injury. (rupress.org)
  • Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • Progressive AKI leads to acute renal failure (ARF)[ 1 ]. (biomedcentral.com)
  • When kidney CD4+ cells of post-acute kidney injury (post-AKI) rats were stimulated with angiotensin II and elevated Na+ (10-7 M/170 mM) in vitro, there was an enhanced response in intracellular Ca2+ and IL-17 expression, which was blocked by SOCE inhibitors 2APB, YM58483/BTP2, or AnCoA4. (jci.org)
  • Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema? (phypha.ir)
  • Kidney-lung cross-talk and acute kidney injury. (phypha.ir)
  • 9. Doi K, Ishizu T, Fujita T, Noiri E. Lung injury following acute kidney injury: kidney-lung crosstalk. (phypha.ir)
  • Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
  • Remote organ failure in acute kidney injury. (phypha.ir)
  • The mitophagy in platelets may restrict hyperactivation of the inflammasome and relieve acute kidney injury (AKI). (bvsalud.org)
  • Effective pharmaceutical interventions for cisplatin-induced acute kidney injury (Cis-AKI) are currently lacking. (bvsalud.org)
  • A long journey for acute kidney injury biomarkers. (ac.ir)
  • Gong L, He J, Sun X, Li L, Zhang X, Gan H. Activation of sirtuin1 protects against ischemia/reperfusion-induced acute kidney injury. (ac.ir)
  • Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)
  • Acute kidney injury and early allograft dysfunction are 2 common complications after liver transplant. (ectrx.org)
  • To explore the potential heterogeneity of acute kidney injury (AKI) and evaluate the prognostic differences among AKI subphenotypes in critically ill patients with cardiovascular diseases. (biomedcentral.com)
  • Acute kidney injury (AKI) is a serious clinical event characterized by a sudden decline in renal function, with a 3.2-78% incidence in admission to the intensive care unit (ICU) [ 1 ] and a significant correlation with mortality [ 2 ]. (biomedcentral.com)
  • Approximately 20% of patients with acute brain injury (ABI) also experience acute kidney injury (AKI), which worsens their outcomes. (beds.ac.uk)
  • Acute kidney injury (AKI) in intensive care units (ICUs) is an independent risk factor for death. (beds.ac.uk)
  • In the context of neurocritical care, AKI diagnosis holds significance for acute brain injury (ABI) management. (beds.ac.uk)
  • This article summarizes the epidemiology and outcomes of AKI in neurocritically ill adults admitted to the ICU, focusing on prevalent ABI conditions like traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (SAH), intracerebral hemorrhage (ICH), and acute stroke. (beds.ac.uk)
  • Clinical evidence suggests that tissue injury in both acute kidney injury and heart failure has immune-mediated inflammatory consequences that can initiate remote organ dysfunction. (biomedcentral.com)
  • Clinical evidence suggests that tissue injury such as acute kidney injury (AKI) is not an isolated event and it has become apparent that much of the increased risk of death is derived from distant complications [ 5 , 6 ]. (biomedcentral.com)
  • In the organ crosstalk, the combination of AKI with acute lung injury remains a formidable challenge for clinicians treating critically ill patients. (biomedcentral.com)
  • SUMMARY: One of the reasons for acute kidney damage is renal ischemia. (bvsalud.org)
  • Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
  • Outcome of acute kidney injury: how to make a difference? (springeropen.com)
  • Acute kidney injury (AKI) is one of the most frequent organ failure encountered among intensive care unit patients. (springeropen.com)
  • Microscopic studies of tissues exposed to ischemia/reperfusion (I/R) have revealed an acute inflammatory response. (lomr.org)
  • Acute ischemia apparently produces minor tissue damage, the major damage is apparently secondary to reperfusion (11). (lomr.org)
  • Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
  • Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)
  • METHODS: We used 30 minutes of bilateral renal ischemia, followed by 24 hours of reperfusion in Balb/c mice. (uandes.cl)
  • A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
  • Furthermore, we examined the effect of inhibition of complement-factor C5 on renal I/R injury. (maastrichtuniversity.nl)
  • Inhibition of C5 strongly inhibited late inflammation, as measured by neutrophil influx and induction of the murine CXC chemokines macrophage inflammatory protein-2, KC, and lipopolysaccharide-induced CXC chemokine. (maastrichtuniversity.nl)
  • abstract = "Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation.De Vries B, Matthijsen RA, Wolfs TG, Van Bijnen AA, Heeringa P, Buurman WA.Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands.BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. (maastrichtuniversity.nl)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
  • Given that apoptosis and swelling are critical events for I/R injury CK2 inhibition may have some role in the pathogenesis of I/R injury. (liveconscience.com)
  • Based on conflicting evidence of apoptotic induction and anti-inflammation of CK2 inhibition we assessed the effects of TBBt within the intrinsic response to renal I/R injury. (liveconscience.com)
  • CK2α inhibition attenuates renal I/R injury To assess the function of CK2α in renal I/R injury we pretreated mice with TBBt a CK2α inhibitor 3 and 24?h prior to inducing I/R injury and blood samples were collected 24?h after reperfusion. (liveconscience.com)
  • Above all, PGRN also provides protection in the initial phase following myocardial ischemia-reperfusion injury. (biomedcentral.com)
  • Renal ische-mia‐reperfusion injury (IRI) induces oxidative stress, inflammation, epithelium and endothelium damage, and cessation of renal function. (uandes.cl)
  • Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
  • These supplements can help to ameliorate oxidative stress, inflammation, proteinuria and progressive renal damage. (drprincetta.com)
  • In addition, ozone was able to induce an adaptation to oxidative stress with a preservation of the antioxidant endogenous systems in an animal model of renal ischemia-reperfusion (20). (lomr.org)
  • Taking into account both protective effects, ischemic and ozone oxidative preconditioning, against liver injury by I/R, the aim of this study is to stablish a comparison between them, in a liver I/R model. (lomr.org)
  • The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
  • hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)
  • Recently Kim et al.25 shown that inactivation of CK2 in the mouse mind enhances production of ROS and neuronal cell death after ischemic injury via increased NADPH oxidase activity. (liveconscience.com)
  • Ischemic preconditioning, short periods of ischemia with intermittent reperfusion, has been shown to protect the myocardium from a subsequent longer ischemic insult (21-23). (lomr.org)
  • Native kidneys and skeletal muscle were imaged as reference tissues and renal explants analysed by histology and electron microscopy. (hindawi.com)
  • The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
  • The present study evaluated LOXL2 expression in human and mouse kidney tissues, as well as in cultured renal cells. (omicsdi.org)
  • The flow cytometry analysis demonstrated an elevated expression of innate and mature dendritic cells in I/R renal tissues. (bvsalud.org)
  • Small intestine, lung, and kidney tissues were evaluated and scored in terms of cell degeneration, inflammation, and congestion, as well as caspase-3 (Cas-3) and cluster of differentiation 31 (CD31) immunostainings were carried out. (rjme.ro)
  • nuclear aspect-κB (NF-κB) which sets off the discharge of some inflammatory mediators such as for example tumor necrosis aspect-α (TNF-α) interleukin (IL)-1β and IL-61 6 On the tissues level ROS and inflammatory cytokines activate enzymes which are mixed AKT inhibitor VIII manufacture up in procedures of necrosis and apoptosis the last mentioned of which is normally most significant in reperfusion damage7. (liveconscience.com)
  • Rats treated with high-salt diet (5-9 weeks after I/R) manifested progressive disease indicated by enhanced inflammation, fibrosis, and impaired renal function. (jci.org)
  • I/R injury significantly impaired renal function in control mice as BUN and creatinine levels increased from 54.2? (liveconscience.com)
  • BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. (maastrichtuniversity.nl)
  • In recent years, the complement system has been implicated in the pathophysiology and progression of many disorders, notably modulating inflammation and causing endothelial and organ damage 1 . (nature.com)
  • Nitric oxide production (by iNOS) may play several roles in renal pathophysiology, including induction of tubular damage. (biomedcentral.com)
  • The term cardiorenal syndrome (CRS) is often used to describe this condition and represents an important model for exploring the pathophysiology of cardiac and renal dysfunction. (biomedcentral.com)
  • Complement activation induces synthesis of pro-inflammatory cytokines and the membrane attack complex directly causes cell injury, apoptosis and necrosis, which in turn cause further complement activation and a vicious circle of inflammation and cell damage 4 . (nature.com)
  • Calcium oxalate (CaOx), the major constituent of most kidney stones, induces inflammatory infiltration and injures renal tubular cells. (biomedcentral.com)
  • 11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
  • CONCLUSIONS: Renal I/R is followed by activation of the complement system and intrarenal deposition of C3 and MAC. (maastrichtuniversity.nl)
  • Danger-associated molecular patterns (DAMPs) are endogenous ligands released from renal tubular cells following ischemia/reperfusion injury that activate the complement system through the classical, lectin and alternative pathways. (nature.com)
  • Moreover, BB5.1 treatment significantly protected against I/R-induced renal dysfunction. (maastrichtuniversity.nl)
  • This study reports the clinical and pathological features of 12 cases of primary Sjogren syndrome (pSS) with renal involvement presenting with proximal tubular dysfunction in a single center, and investigates the possible correlation of ectopic germinal center formation and megalin/cubilin down-expression. (biomedcentral.com)
  • Using optical coherence tomography (OCT) we have recently shown that the retina and choroid are thinned in patients with CKD and this thinning relates to the degree of kidney dysfunction as well as inflammation and endothelial dysfunction. (ed.ac.uk)
  • The current definition has been expanded into five subtypes whose etymology reflects the primary and secondary pathology, the time frame, as well as cardiac and renal co-dysfunction secondary to systemic disease [ 1 ] (Table 1 ). (biomedcentral.com)
  • Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. (thno.org)
  • Using mouse models of ischaemia-reperfusion injury, we are investigating the cardiovascular and renal sequelae of AKI and examining new experimental medicine strategies to reduce the risks of developing these. (ed.ac.uk)
  • The trial had to exhibit at least one of the following results: major adverse cardiovascular events (MACE), cardiovascular death or hospitalization for heart failure, cardiovascular death, hospitalization for heart failure, renal or cardiovascular adverse events, or non-cardiovascular death. (bvsalud.org)
  • The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)
  • In particular, the long Pentraxin 3 (PTX3) has been shown to regulate several aspects of vascular and tissue inflammation during solid organ transplantation. (unicatt.it)
  • One of the primary causes of ARF is I/R which is a drop in blood flow leading to inadequate supply of oxygen and nutrients to renal tissue which can be caused by, amongst others, surgery, organ transplantation and shock [ 1 ]. (biomedcentral.com)
  • Renal ischemia/reperfusion injury (IRI) may influence distance organ such as lung. (phypha.ir)
  • Platelets are highly involved in inflammation and organ injury under pathological conditions. (bvsalud.org)
  • Also, ozone therapy applied in an experimental model of liver ischemia-reperfusion, protected the organ against the injury caused by this surgical procedure, decreasing transaminases and lactate figures, preserving the hepatocellular integrity and reducing the ROS by the stimulation and/or preservation of the endogenous antioxidant systems (19). (lomr.org)
  • Penetrating injuries may or may not penetrate the peritoneum and, even if they do, they may not cause organ injury. (msdmanuals.com)
  • Interestingly, PTX3 deposits co-localized with activation of the terminal Complement complex (C5b-9) on endothelial cells, indicating that PTX3-mediated Complement activation occurred mainly at the renal vascular level. (unicatt.it)
  • We are studying the effects of apelin on systemic and renal haemodynamics and endothelial function in healthy volunteers and in patients with CKD. (ed.ac.uk)
  • GCH (GTP cyclohydrolase I)-transgenic mice, with a specific increase in endothelial BH 4 levels, exhibited a similar reduction in vascular immune cell infiltration compared with BH 4 -deficient controls, suggesting that BH 4 reduces vascular inflammation via endothelial cell signalling. (silverchair.com)
  • To investigate the involvement of complement in I/R injury, we studied the activation and deposition of complement in a murine model of renal I/R injury. (maastrichtuniversity.nl)
  • Our study investigated the role of PTX3 as possible modulator of Complement activation in a swine model of renal ischemia/reperfusion (I/R) injury. (unicatt.it)
  • In animal models of hepatic ischemia-reperfusion injury, use of octreotide resulted in a possible protective effect. (ectrx.org)
  • Renal biopsy revealed tubulointerstitial nephritis, with tubular epithelial cell degeneration, tubular atrophy, interstitial inflammation and focal fibrosis. (biomedcentral.com)
  • Tubulointerstitial fibrosis is a common end point of chronic kidney diseases, and preventing its progression is key to avoiding renal failure. (omicsdi.org)
  • The present study demonstrated that LOXL2 is expressed in compartments of renal tissue, where it appears to contribute to the progression of tubulointerstitial fibrosis. (omicsdi.org)
  • Renal expression of trefoil factor 3 mRNA in association with tubulointerstitial fibrosis in IgA nephropathy. (omicsdi.org)
  • The aim of this study is to detect the TFF3 mRNA in kidney and elucidate the relationship between renal TFF3 mRNA and tubulointerstitial fibrosis in IgA nephropathy (IgAN). (omicsdi.org)
  • The renal TFF3 mRNA expression was significantly associated with the urinary TFF3 secretion and the tubulointerstitial fibrosis score in the IgAN group alone. (omicsdi.org)
  • Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)
  • have compared 3,769 to 13,598 matched patients treated or not treated with renal replacement therapy (RRT) in ICU and observed a higher incidence of end-stage renal disease with RRT (2.63 vs. 0.91/100 patient-years, hazard ratio = 3.23 [2.70-3.86]) [ 20 ]. (springeropen.com)
  • Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
  • In rats, following renal ischemia/reperfusion (I/R), there was a rapid and sustained influx of Orai1+ CD4 T cells and IL-17 expression was restricted to Orai1+ cells. (jci.org)
  • Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
  • 8. Dehghani A, Saberi S, Nematbakhsh M. Role of Mas receptor antagonist A799 in renal blood flow response to Ang 1-7 after bradykinin administration in ovariectomized estradiol-treated rats. (phypha.ir)
  • The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
  • In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
  • Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)
  • At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
  • The histopathological evaluation of renal tissue was also conducted. (frontiersin.org)
  • In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)
  • Pioglitazone also decreased the mRNA expression of TNF-α and MCP-1 in the renal tissue. (frontiersin.org)
  • Ischemia due to early hypoperfusion followed by ischemia reperfusion injury (IRI) results in renal tissue damage 4 . (nature.com)
  • When challenged with a high-fat diet, mice that received β1-/- bone marrow displayed enhanced adipose tissue macrophage inflammation and liver insulin resistance compared with animals that received WT bone marrow. (edu.au)
  • Renal fibrosis is the hallmark of chronic kidney disease progression and is characterized by an exaggerated wound-healing process with the production of renal scar tissue. (omicsdi.org)
  • Renal enzymes, creatinine and urea levels were measured biochemically in serum. (rjme.ro)
  • Two cohorts of mice underwent renal transplantation with either a syngeneic isograft or allograft kidney. (hindawi.com)
  • Studies of renal transplant recipients and patients undergoing cardiac surgery suggest that damage and inflammation caused by IRI and CPB is amplified by complement activation 4 . (nature.com)
  • Wijeysundera et al sought to determine whether N-acetylcysteine is associated with increased blood loss and blood product transfusion in 89 patients with preexisting moderate renal insufficiency undergoing cardiac surgery. (medscape.com)
  • I discovered that a good place to begin in understanding kidney disease is a thorough review of basic renal physiology. (drprincetta.com)
  • Furthermore, we determined the major components of GLSP triterpenes, including Ganoderic acid A, Ganoderic acid B, Ganoderic acid C6, Ganoderic acid G, and Ganodermanontriol, and found that these triterpenes promoted ABCA1/G1-mediated cholesterol efflux and inhibited inflammation in macrophage, and inactivated RUNX2-mediated osteogenesis in VSMC. (thno.org)
  • We measured the expression of elements associated with kidney injury, inflammation, macrophage polarization, mesenchymal transition, and nephrogenic genes by qRT-PCR in the renal cortex and medulla. (uandes.cl)
  • This work describes the spatiotemporal orchestration of recently recruited monocyte-derived and resident macrophages during Wallerian degeneration induced by chronic constriction injury of the sciatic nerve and unveils distinct contribution of these two macrophage subsets in myelin degradation and neurofiber regeneration. (rupress.org)
  • There is no imaging modality available to measure the development of graft fibrosis and current practice involves a biopsy when renal function deteriorates [ 8 ]. (hindawi.com)
  • Monocytes and macrophages are known to play a role in chronic renal allograft damage [ 10 ] and are key promoters of fibrosis in other organs, such as the liver [ 11 , 12 ]. (hindawi.com)
  • They appear to be the key factors in driving renal fibrosis, independent of the underlying kidney disease. (omicsdi.org)
  • After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
  • A significant increment was seen in female serum level of nitrite compared with males after 3h reperfusion. (phypha.ir)
  • [ 1 ] At present, serum creatinine, which is used to measure the glomerular filtration rate (GFR), is the most commonly used marker of renal function. (medscape.com)
  • Interestingly, even patients who apparently recovered from AKI at ICU discharge (based on serum creatinine) but with positive biomarkers of kidney injury had a higher risk of death during the year following ICU discharge. (springeropen.com)
  • In addition, ectopic germinal centers characterized by CD21 + follicular dendritic cells were present in the renal interstitium. (biomedcentral.com)
  • We describe the presence of EGCs in the renal interstitium, the prevalence of Th17/IL-17 expression, and alterations in megalin and cubilin expression, to investigate their possible correlation. (biomedcentral.com)
  • The specific physico-chemical properties of HA enable a unique hydration capacity, and in the last decade it was revealed that in the interstitium of the renal medulla, where the HA content is very high, it changes rapidly depending on the body hydration status while the HA content of the cortex remains unchanged at very low amounts. (diva-portal.org)
  • In vitro , we determined the major components of GLSP triterpenes by HPLC, and subsequently assessed the protective effects of these main active components on lipid metabolism, inflammation, and calcification in RAW264.7 and HASMC cells. (thno.org)
  • Renal biopsy remains the gold-standard for detecting allograft rejection but is associated with significant morbidity and mortality. (hindawi.com)
  • We investigated the renal mRNA expression of TFF3 by real-time PCR analysis in biopsy specimens from patients with IgAN, other glomerulonephritis (OGN) and minor glomerular abnormalities (MGA). (omicsdi.org)
  • Immunostaining of the renal specimen of IgAN patients revealed that TFF3 is located in the renal tubular epithelial cells. (omicsdi.org)
  • In conclusion, these data indicate that PTX3 might be a potential therapeutic target to prevent Complement-induced I/R injury. (unicatt.it)
  • Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
  • Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
  • In addition, AG reduced kidney injury (NGAL, clusterin, Arg‐2, and TFG‐β1) and improved kidney function (glo-merular filtration rate) during IRI. (uandes.cl)
  • This study showed that octreotide infusion in the first 3 days after liver transplant could improve renal and allograft function and reduce infection and length of hospital stay. (ectrx.org)
  • Ischemia/ reperfusion was found to affect renal function and induce histopathological alterations. (bvsalud.org)
  • 7 days) sustained recovery, relapse with (relapse no recovery) or without altered renal function at hospital discharge (relapse recovery) and sustained renal failure [ 18 ]. (springeropen.com)
  • Patients with altered renal function at hospital discharge (never reversed or relapse no recovery) had the worst outcome. (springeropen.com)
  • Complement activation plays a crucial role in the regulation of inflammation and late apoptosis. (maastrichtuniversity.nl)
  • Membrane attack complexes (MACs) formed following complement activation ultimately injure the kidney due to epithelial renal tubular cell apoptosis. (nature.com)
  • We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates in the activation of Th17 cells and influences renal injury. (jci.org)
  • In vivo, YM58483/BTP2 (1 mg/kg) attenuated IL-17+ cell activation, inflammation, and severity of AKI following either I/R or intramuscular glycerol injection. (jci.org)
  • β1-/- macrophages displayed increased levels of diacylglycerol and markers of inflammation, effects that were reproduced in WT macrophages by inhibiting fatty acid oxidation and, conversely, prevented by pharmacological activation of AMPK β1-containing complexes. (edu.au)
  • In previous work, we reported that the pharmacological inhibitions of iNOS before ischemia/reperfusion (I/R) attenuate the I/R-induced AKI in mice. (uandes.cl)
  • We investigated whether ultrasmall paramagnetic particles of iron oxide- (USPIO-) enhanced magnetic resonance imaging (MRI) can detect experimental chronic allograft damage in a murine renal allograft model. (hindawi.com)
  • In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)
  • The role of monocytes and macrophages in chronic renal allograft damage has been well established [ 9 ]. (hindawi.com)
  • RESULTS: Remarkably, we found that 1400W affects the renal cortex and medulla in different ways. (uandes.cl)
  • Vimentin and FGF2 levels but not in the renal medulla. (uandes.cl)
  • Magnetic resonance imaging (MRI) offers detailed characterization of the kidney structure without using ionizing radiation and is suitable for monitoring renal allograft damage with repeated scanning. (hindawi.com)
  • The primary rationale for these developments is that recognition of AKI allows prompt injury-specific intervention that may avert permanent renal damage. (medscape.com)
  • 15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
  • We aimed to determine the ameliorative impact of diacerein on renal ischemia/reperfusion injury (I/R) condition, exploring the underlying mechanisms. (bvsalud.org)
  • The aim of this study was to determine gender differences in renal IR inducedlung injury in different reperfusion time. (phypha.ir)
  • abstract = "Pentraxins are a family of evolutionarily conserved pattern recognition molecules with pivotal roles in innate immunity and inflammation, such as opsonization of pathogens during bacterial and viral infections. (unicatt.it)