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  • inhibition
  • Consistently in vitro , TGF-β1 treatment increased GSK3β expression and GSK3 inhibition abolished TGF-β1-induced SMAD3 activation and α-smooth muscle actin (α-SMA) expression in cultured renal fibroblasts. (biologists.org)
  • Recent animal data suggest that inducible nitric oxide synthase (iNOS) derived nitric oxide (NO) plays an important role in the pathogenesis of renal ischaemiareperfusion injury (IRI) and that inhibition of iNOS ameliorates IRI. (oup.com)
  • neutrophil
  • Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery," The Lancet , vol. 365, no. 9466, pp. 1231-1238, 2005. (hindawi.com)
  • Blood samples were drawn from all animals to evaluate plasma neutrophil gelatinase-associated lipocalin (NGAL) at the beginning, 15 minutes after ischemia, 15 minutes after reperfusion, and 6 hours after the surgical procedure (T0, T1, T2, and T3, respectively). (dovepress.com)
  • Although implicated in some studies, the role of the neutrophil in renal IRI is not as clear as originally thought and other leukocyte populations have been implicated in the disease pathogenesis ( 8 ). (jimmunol.org)
  • An elevation of myeloperoxidase activity and inflammatory foci were detected in the liver at 6h after renal IR, indicating neutrophil infiltration. (umanitoba.ca)
  • Slit2 prevents neutrophil recruitment and renal ischemia-reperfusion injury. (fluxionbio.com)
  • Protective
  • We measured plasma and renal EO variations and markers of glomerular and tubular damage (nephrin, KIM-1, Kidney-Injury-Molecule-1, α1 Na-K ATPase) and the protective effect of the ouabain inhibitor, rostafuroxin. (mdpi.com)
  • However, the detailed mechanism by which IMD protects against renal IRI and the association of this protective effect with ERS have not been investigated. (biomedcentral.com)
  • In this study, the protective effects of ERCs on renal ischemia-reperfusion injury (IRI) were examined. (biomedcentral.com)
  • Collectively, these results suggest that Slit2 may hold promise as a strategy to combat renal IRI without compromising the protective innate immune response. (fluxionbio.com)
  • These results suggest a general protective effect of dietary restriction against renal IRI, regardless of age, sex, body mass and genetic background. (beds.ac.uk)
  • Exogenous treatment with H2S can induce a reversible hypometabolic state, which can protect organs from ischemia/reperfusion injury, but whether cystathionine γ-lyase (CSE), which produces endogenous H2S, has similar protective effects is unknown. (ox.ac.uk)
  • serum
  • These data are the first demonstration of a pathogenic role for B cells in ischemic acute renal failure, with a serum factor as a potential underlying mechanism of action. (jimmunol.org)
  • Here, we showed that as compared to untreated controls, administration of ERCs effectively prevented renal damage after IRI, indicated by better renal function and less pathological changes, which were associated with increased serum levels of IL-4, but decreased levels of TNF-α, IFN-γ and IL-6. (biomedcentral.com)
  • tissue
  • Increases in mRNA levels of TGF-beta1, connective tissue growth factor, and endothelin-1 after ischemia/reperfusion injury were also exaggerated in the same order (from lowest to highest): WT, B2R-null, and B1RB2R-null. (nih.gov)
  • 0.01) as well as severe tissue damage 18 days post ischemia. (egms.de)
  • 2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. (clinsci.org)
  • Renal myeloper-oxidase (MPO) activity (for polymorphonuclear leukocyte infiltration) and malondialdehyde (MDA) levels (for tissue lipid peroxidation) were determined. (ul.pt)
  • MSCs have been investigated with immunomodulatory, anti-inflammatory and tissue repair properties which could attenuate ischemic injury and accelerate the regeneration process in the condition of renal IRI. (eurekaselect.com)
  • Here, human renal tissue revealed abundant expression of CSE, localized to glomeruli and the tubulointerstitium. (ox.ac.uk)
  • experimental models
  • In this study, we investigated the role of mast cells in both the early and late phases of the inflammatory response in experimental models of acute and chronic renal IRI using our recently developed mouse model that allows conditional ablation of mast cells. (jimmunol.org)