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  • oxidative stress
  • J. Kim, Y. M. Seok, K. Jung, and K. M. Park, "Reactive oxygen species/oxidative stress contributes to progression of kidney fibrosis following transient ischemic injury in mice," The American Journal of Physiology: Renal Physiology , vol. 297, no. 2, pp. (hindawi.com)
  • Previous clinical and animal studies have identified that oxidative stress and inflammation are main pathological components in renal IR injury. (umanitoba.ca)
  • We have identified that during renal IR, down-regulation of hepatic Nrf2/glutathione production and up-regulation of NF-kappaB/cytokine expression are responsible for increased oxidative stress and inflammatory response, which, in turn, exert detrimental effects to distant organs. (umanitoba.ca)
  • Serum
  • These data are the first demonstration of a pathogenic role for B cells in ischemic acute renal failure, with a serum factor as a potential underlying mechanism of action. (jimmunol.org)
  • To identify a possible mechanism involved in the protection from renal injury seen in the μMT mice, transfer experiments of B cells or serum from wild-type mice were investigated. (jimmunol.org)
  • Here, we showed that as compared to untreated controls, administration of ERCs effectively prevented renal damage after IRI, indicated by better renal function and less pathological changes, which were associated with increased serum levels of IL-4, but decreased levels of TNF-α, IFN-γ and IL-6. (biomedcentral.com)
  • attenuation of renal
  • This study demonstrates that the novel anti-inflammatory and immunoregulatory effects of ERCs are associated with attenuation of renal IRI, suggesting that the unique features of ERCs may make them a promising candidate for cell therapies in the treatment of ischemic acute kidney injury in patients. (biomedcentral.com)
  • pathogenesis of renal
  • Involvement of the endothelin and nitric oxide systems in the pathogenesis of renal ischemic damage in an experimental diabetic model," Life Sciences , vol. 91, no. 13-14, pp. 669-675, 2012. (hindawi.com)
  • Given new evidence for the role of adaptive immunity in renal IRI, we therefore postulated that B cells could participate in the pathogenesis of renal IRI. (jimmunol.org)
  • Physiology
  • Although renin-angiotensin system participates importantly in the homeostasis of renal physiology, it also is closely associated with the renal pathological milieu, including the progression of renal disease. (ahajournals.org)
  • ameliorate renal
  • Currently, therapies to treat AKI are not available, so identification of new targets which, upon diagnosis of AKI, can be modulated to ameliorate renal damage is essential. (aspetjournals.org)
  • This review evaluates the different experimental strategies that have been investigated to prevent or ameliorate renal IRI. (biomedcentral.com)
  • tissue
  • 0.01) as well as severe tissue damage 18 days post ischemia. (egms.de)
  • Quantitative DRS could provide a convenient and fast tool for artery identification and evaluation of the depth, spatial extent, and duration of selective tissue ischemia in laparoscopic PN. (spie.org)
  • 2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. (clinsci.org)
  • Renal myeloper-oxidase (MPO) activity (for polymorphonuclear leukocyte infiltration) and malondialdehyde (MDA) levels (for tissue lipid peroxidation) were determined. (ul.pt)
  • MSCs have been investigated with immunomodulatory, anti-inflammatory and tissue repair properties which could attenuate ischemic injury and accelerate the regeneration process in the condition of renal IRI. (eurekaselect.com)
  • Methods
  • Animal experiments focus on understanding the mechanism behind IRI and try to find methods to minimize IRI either before, during or after ischemia. (biomedcentral.com)
  • neutrophil
  • Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery," The Lancet , vol. 365, no. 9466, pp. 1231-1238, 2005. (hindawi.com)
  • Although implicated in some studies, the role of the neutrophil in renal IRI is not as clear as originally thought and other leukocyte populations have been implicated in the disease pathogenesis ( 8 ). (jimmunol.org)
  • An elevation of myeloperoxidase activity and inflammatory foci were detected in the liver at 6h after renal IR, indicating neutrophil infiltration. (umanitoba.ca)
  • Protective
  • We aimed to investigate the protective effects of an intravenous anesthetic remifentanil in renal I/R injury in the rat in comparison with dex. (dovepress.com)
  • However, the detailed mechanism by which IMD protects against renal IRI and the association of this protective effect with ERS have not been investigated. (biomedcentral.com)
  • occlusion
  • Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1 α and apoptotic genes in a middle cerebral artery occlusion-induced focal ischemia rat model," Journal of Neurochemistry , vol. 102, no. 6, pp. 1831-1841, 2007. (hindawi.com)
  • In addition, the rates of ischemia induction and recovery were compared for main renal artery versus tertiary segmental artery occlusion, and it was found that the tertiary segmental artery occlusion trends toward faster recovery after ischemia, which suggests a potential benefit of selective ischemia. (spie.org)
  • injury
  • Patients undergoing long-lasting, abdominal, and urogenital surgeries with risk factors such as advanced age, peripheral artery disease, diabetes mellitus, renovascular disease, and congestive heart failure are candidates for acute kidney injury (AKI) due to impaired renal perfusion and decreased functional renal reserve. (dovepress.com)
  • The NGAL levels and histopathological findings reflected protection by dex against renal I/R injury. (dovepress.com)
  • Both mitogenic and inflammatory phenomena accompany the renal response to ischemic injury. (semanticscholar.org)
  • Previous studies have shown that several nuclear-binding members of the immediate early genes are prominently expressed after renal ischemia and may underlie the mitogenic response to such injury. (semanticscholar.org)
  • The glycogen synthase kinase-3 (GSK3) family of protein kinases consists of GSK3α and GSK3β isoforms, and plays an important role in injury and repair of renal tubular epithelial cells in AKI. (biologists.org)
  • Acute kidney injury is one consequence of this problem, and this deprivation of fresh blood is one of the largest causes of complete renal failure. (blood-test.biz)
  • Disease states, injury, and even certain types of surgery can be triggers for renal ischemia. (blood-test.biz)
  • In conclusion, results from our research have demonstrated that renal IR can induce acute liver injury. (umanitoba.ca)
  • experimental models
  • In this study, we investigated the role of mast cells in both the early and late phases of the inflammatory response in experimental models of acute and chronic renal IRI using our recently developed mouse model that allows conditional ablation of mast cells. (jimmunol.org)