• Renal interstitial fibrosis (RIF) is a common pathological feature of progressive injury in CKD and predominantly includes renal tubular epithelial cell atrophy, inflammatory cell infiltration, and the excessive deposition of extracellular matrix (ECM) [ 2 , 3 ]. (ijbs.com)
  • The cause of late renal allograft loss, once known as chronic allograft nephropathy, has been renamed "interstitial fibrosis and tubular atrophy" (IF/TA) to reflect the histologic pattern seen on biopsy. (biomedcentral.com)
  • Interstitial fibrosis and tubular atrophy (IF/TA) describes the histologic characteristics of allograft destruction over time. (biomedcentral.com)
  • CNI can cause microvascular and glomerular damage, arteriolar hyaline deposition, tubular atrophy, and striped interstitial fibrosis. (biomedcentral.com)
  • Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expression. (nature.com)
  • Renal biopsy revealed tubular atrophy, interstitial fibrosis and segmental glomerulosclerosis. (nih.gov)
  • The aging kidneys undergo a wide range of macrostructural changes, such as decreased cortical volume, increased surface roughness, and augmented numbers and sizes of cysts [ 11 ], which correspond to the typical microstructural features of glomerulosclerosis, tubular atrophy, interstitial fibrosis, and nephron loss [ 12 ]. (hindawi.com)
  • The primary endpoint was moderate-to-severe interstitial fibrosis and tubular atrophy assessed by protocol biopsy at 3 years evaluated by a single pathologist blinded to the study group. (biomedcentral.com)
  • Valganciclovir prophylaxis, as compared with valacyclovir, was associated with a reduced risk of moderate-to-severe interstitial fibrosis and tubular atrophy in patients after renal transplantation. (biomedcentral.com)
  • Moderate-to-severe interstitial fibrosis and tubular atrophy (IFTA) is strong predictor of deteriorated graft survival [ 16 ]. (biomedcentral.com)
  • Variable amount of tubular atrophy and interstitial fibrosis depending on the point in the natural history of the condition that the biopsy is performed. (medscape.com)
  • Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis. (rupress.org)
  • Proximal tubular epithelial cells from mice which develop autoimmune interstitial nephritis were found to express the nephritogenic target antigen, 3M-1. (rupress.org)
  • Early steroid treatment improves the recovery of renal function in patients with drug-induced acute interstitial nephritis. (qxmd.com)
  • The role of steroid treatment in drug-induced acute interstitial nephritis (DI-AIN) is controversial. (qxmd.com)
  • tures of acute interstitial nephritis. (cdc.gov)
  • Thirty-seven patients presented with noncaseating granulomatous interstitial nephritis (GIN), and 10 with interstitial nephritis without granulomas. (nih.gov)
  • Interstitial nephritis is a kidney disorder in which the spaces between the kidney tubules become swollen (inflamed). (stlukes-stl.com)
  • Interstitial nephritis may be temporary ( acute ), or it may be long-lasting ( chronic ) and get worse over time. (stlukes-stl.com)
  • The acute form of interstitial nephritis is most often caused by side effects of certain drugs. (stlukes-stl.com)
  • Allergic reaction to a drug (acute interstitial allergic nephritis). (stlukes-stl.com)
  • Acute interstitial nephritis (AIN) is caused by acute inflammation of the renal tubulo-interstitium, commonly mediated by a hypersensitivity reaction to medications. (bmj.com)
  • Most patients have some residual renal impairment after an episode of acute interstitial nephritis. (bmj.com)
  • [1] Raghavan R, Eknoyan G. Acute interstitial nephritis - a reappraisal and update. (bmj.com)
  • He is co-inventor of the pending patent application (number 16/536718), 'System and methods for diagnosing acute interstitial nephritis. (bmj.com)
  • Acute interstitial nephritis (AIN) is inflammation of the renal interstitium leading to acute renal dysfunction. (logicalimages.com)
  • To model the effect in vivo, the authors used a transgenic mouse which over-expressed UMOD leading to salt-sensitive hypertension and interstitial nephritis . (medscape.com)
  • One major producer of HA in the kidney is the renomedullary interstitial cell, which displays receptors and/or synthesis enzymes for the hormones mentioned above. (diva-portal.org)
  • This review summarizes the current knowledge regarding interstitial HA in the role of regulating kidney function during normal and pathological conditions. (diva-portal.org)
  • Renal replacement therapy (RRT) is yet the primary treatment for end-stage renal disease (ESRD) patients that does not actually improve kidney function and also creates a heavy economic burden in several countries [ 1 , 2 ]. (nature.com)
  • However, the role of Plk1 in kidney tubular interstitial fibrosis has not been reported. (nature.com)
  • In this study, we explored the role of Plk1 in the classical kidney fibrosis model, UUO, and cultured fibroblast and renal tubular epithelial cells by using specific Plk1 inhibitors, genetic silencing, and heterozygous global knockout mice. (nature.com)
  • Although kidney transplantation has been an important means for the treatment of patients with end stage of renal disease, the long-term survival rate of the renal allograft remains a challenge. (biomedcentral.com)
  • The mechanisms leading to IF/TA in the transplanted kidney include inflammation, activation of renal fibroblasts, and deposition of extracellular matrix proteins. (biomedcentral.com)
  • Renal medullary fibroma is a benign kidney tumour. (wikipedia.org)
  • some septum measured by kidney culture of cap- dice, renal involvement, or throm- tissue showed minimal enlargement. (cdc.gov)
  • Acute renal failure (ARF) is a frequent tients who required kidney biopsy. (who.int)
  • If the primary lesion is severe enough and long-standing, progressive and often fatal kidney failure, affecting all renal compartments, may develop. (vin.com)
  • DIS ameliorated renal fibrosis by inhibiting the NF‑κB signaling pathway‑mediated inflammatory response, which may be a therapeutic pathway for delaying chronic kidney disease. (spandidos-publications.com)
  • See also Chronic Kidney Disease and Chronic Renal Failure . (medscape.com)
  • A successful kidney transplant offers enhanced quality and duration of life and is more effective (medically and economically) than long-term dialysis therapy for patients with chronic or end-stage renal disease. (medscape.com)
  • The UMOD story got a lot more interesting when Trudu et al published an intriguing set of experiments establishing a link between uromodulin, hypertension, and kidney disease via activation of the renal sodium co-transporter NKCC2. (medscape.com)
  • Safety of esomeprazole strontium has not been studied in patients with severe renal impairment. (nih.gov)
  • Not recommended for use in patients with severe renal impairment (8.6, 12.3) . (nih.gov)
  • Patients with terminal deletions often have severe phenotypic features including sacral agenesis and holoprosencephaly [ 2 , 3 ], whereas, the above mentioned interstitial deletions have characteristic dysmorphic facial features, intellectual disability, and language impairment which will be further described in this report. (hindawi.com)
  • Patients with severe renal impairment or on dialysis should also initiate therapy with 600 mg once daily. (globalrph.com)
  • No dose adjustment in patients with renal impairment is generally recommended. (who.int)
  • Renal biopsies, including three patients who underwent a second biopsy, showed a progression of interstitial fibrosis related to the delay in steroid treatment. (qxmd.com)
  • Six of eight patients with a renal biopsy demonstrated acute flavored or bubblegum-flavored SC product and was found to tubular injury, and three of eight patients demonstrated fea- meet the case definition (Table 1, case 4). (cdc.gov)
  • 3. Have rapidly progressing glomerulonephritis defined as a 50% or greater decline in the eGFR within 3 months with renal biopsy findings of glomerular crescent formation seen in at least 50% of glomeruli. (who.int)
  • Several studies have determined that the extent of tubulointerstitial involvement is correlated better with renal function deterioration than glomerular changes. (nature.com)
  • Estimates of glomerular filtration rate (GFR) are most often used as an indicator of renal function/dysfunction. (vin.com)
  • The complications of drug abuse encompass a spectrum of glomerular, interstitial, and vascular diseases. (erowid.org)
  • Renal fibrosis is mainly divided into two parts: glomerular fibrosis and interstitial fibrosis ( 4 ) and the present study only focused on renal interstitial fibrosis, which is characterized by infiltration of inflammatory cells and deposition of collagen fiber with various degrees of renal insufficiency. (spandidos-publications.com)
  • Renal cell dysfunction and decreased levels of vasopressin (ADH) lead to production of a large volume of dilute urine (cold diuresis). (msdmanuals.com)
  • The patient also developed renal insufficiency secondary to severe rhabdomyolysis. (hawaii.edu)
  • Cocaine causes rhabdomyolysis, severe hypertension, occasionally renal failure in the absence of rhabdomyolysis, and may hasten progression to uremia in patients with underlying renal insufficiency. (erowid.org)
  • In conclusion, this study demonstrated that Plk1 plays a pathogenic role in renal tubulointerstitial fibrosis by regulating autophagy/lysosome axis. (nature.com)
  • A complete cardiac workup, including angiography, is not necessary in every transplant candidate, but patients with a significant history, symptoms, type 1 diabetes, or hypertensive renal disease should undergo a thorough evaluation to rule out significant coronary artery disease (CAD). (medscape.com)
  • Cases were divided into community-ac- spite substantial advances in renal replace- quired ARF, defined as renal failure devel- ment therapy and health care delivery, oping outside the hospital, and hospital- morbidity and mortality rates associated acquired ARF, defined as renal failure that with ARF have remained high [ 1-3 ]. (who.int)
  • This study shows that diabetes is associated with an increase in the vasoconstrictive hormone Ang II and the inflammatory cytokine TNF-α, both of which play a role in accelerating renal function decline in diabetic nephropathy. (psu.edu)
  • For many years, chronic allograft nephropathy (CAN) was used to describe the progressive loss of renal function in transplanted kidneys over time not related to acute rejection. (biomedcentral.com)
  • Diabetic nephropathy (DN) has been the leading cause of CKD and renal failure in developed countries. (hindawi.com)
  • [ 1 ] Transplantation is the renal replacement modality of choice for patients with diabetic nephropathy and pediatric patients. (medscape.com)
  • Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
  • Because dialysis and transplant centers are required to report specific information regarding each patient diagnosed with end-stage renal disease (ESRD) to the United States Renal Data System (USRDS), data regarding the causes of ESRD are readily available in the Annual Data Report published by the USRDS. (medscape.com)
  • We conducted the current study to investigate the clinical, laboratory, and histologic features at presentation and the outcome of renal sarcoidosis (RS). (nih.gov)
  • Renal function improvement was inversely related to initial histologic fibrosis score. (nih.gov)
  • RS is most often and permanently responsive to corticosteroid treatment, but some degree of persistent renal failure is highly frequent and its degree of severity in the long run is well predicted from both histologic fibrotic renal score and response obtained at 1 month. (nih.gov)
  • Histologic features of interstitial immune infiltrate, eosinophils, and tubulitis are considered characteristic of this disease. (bmj.com)
  • This study aimed to compare the efficacy of valganciclovir and valacyclovir prophylaxis for CMV after renal transplantation with the focus on chronic histologic damage within the graft. (biomedcentral.com)
  • The development of renal interstitial fibrosis (RIF) represents an important step in the progression of chronic proteinuric nephropathies. (mcw.edu)
  • The Munich Wistar Fromter (MWF) rat represents a valuable model to study the progression in proteinuric renal disease. (mcw.edu)
  • This study demonstrates the power of genetic linkage analysis for the dissection of physiologic pathways involved in renal disease progression. (mcw.edu)
  • Renal fibrosis is an important pathological alteration in the progression of CKD to end-stage renal disease. (spandidos-publications.com)
  • Among treated patients, over half showed a complete recovery of baseline renal function, whereas the rest remained in renal failure. (qxmd.com)
  • Ingestion of ethylene glycol leads to systemic toxicity beginning with CNS effects, followed by cardiopulmonary effects, and finally renal failure. (cdc.gov)
  • Snakebite, malaria, liver diseases and Multivariate logistic regression analysis road traffic accidents are common health was carried out to study potential factors problems in Saudi Arabia [ 7-9 ], and the that might affect survival of acute renal contribution of these conditions to the de- failure. (who.int)
  • This report was undertaken to tion, duration of renal failure and having study the pattern of ARF in hospitalized pa- concomitant liver disease were included tients in southern Saudi Arabia. (who.int)
  • Chronic renal failure (CRF) occurs in every dog and cat breed at any age, but older animals are more frequently affected than younger ones (Polzin, 1995). (vin.com)
  • The exact mechanism of immunosuppressive drug-mediated renal toxicity is not fully understood. (biomedcentral.com)
  • If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity. (medscape.com)
  • Its pathogenesis has not been fully elucidated and existing therapy is not effective in improving renal transplant function. (biomedcentral.com)
  • Cytomegalovirus (CMV) prophylaxis may prevent CMV indirect effects in renal transplant recipients. (biomedcentral.com)
  • From November 2007 through April 2012, adult renal transplant recipients were randomized, in an open-label, single-center study, at a 1:1 ratio to 3-month prophylaxis with valganciclovir ( n = 60) or valacyclovir ( n = 59). (biomedcentral.com)
  • In a preclinical model of mouse xenografted with human renal cancer, we analysed the bio-distribution of a single dose (160 μg/kg) intravenously injected of poly-ethylene glycol (PEG)ylated gold nanoshells (~150 nm), in blood, normal and tumoral tissues. (springer.com)
  • In human renal cancer xenografts, ICP-MS showed an early decrease of gold, with 1-week stability before decrease at Day 15. (springer.com)
  • Some forms of DPLD are related to occupational, environmental, drug, and/or radiation exposure, as well as systemic illness such as collagen-vascular disease (see Interstitial Lung Disease Associated With Collagen-Vascular Disease ). (medscape.com)
  • It is evident that both cyclosporine and tacrolimus can cause renal and systemic vasoconstriction through increased release of endothelin-1, activation of the renin-angiotensin system, increased production of thromboxane A 2 , and decreased production of vasodilators such as nitric oxide and prostacyclin [ 7 ]. (biomedcentral.com)
  • These systemic disorders and the associated renal diseases and cutaneous manifestations are tabulated in Table 1, below. (medscape.com)
  • Progressive fibrosis is the major pathological feature of CKD, which leads to end-stage renal disease (ESRD). (nature.com)
  • The common pathological feature of CKD is the loss of tubular cells and progressive interstitial fibrosis. (nature.com)
  • In our previous study, we demonstrated that norcantharidin (NCTD) is a potential therapeutic agent for renal interstitial fibrosis (RIF). (ijbs.com)
  • Identifying the mediators and factors that trigger IF/TA may be useful in early diagnosis and development of novel therapeutic strategies for improving long-term renal allograft survival and patient outcomes. (biomedcentral.com)
  • Consequently, dermatologic manifestations of renal disease may be divided into 3 general categories including: (1) dermatologic manifestations of diseases associated with the development of ESRD, (2) dermatologic manifestations of uremia, and (3) dermatologic disorders associated with renal transplantation. (medscape.com)
  • Candidates for renal transplantation undergo an extensive evaluation to identify factors that may have an adverse effect on outcome. (medscape.com)
  • If successful, this protocol reduces antibody levels to the point where renal transplantation becomes feasible. (medscape.com)
  • The patients, commonly complicated with cardiovascular diseases and neurologic disorders, are at high risk to progress into end-stage renal disease (ESRD) and death. (hindawi.com)
  • Dermatologic manifestations of renal disease are not uncommon findings in patients with end-stage renal disease (ESRD). (medscape.com)
  • Review of the 2019 report reveals that diabetes mellitus remains the most common cause of ESRD, responsible for approximately 42% of all patients on renal replacement therapy. (medscape.com)
  • The underlying histopathology of IPF is usual interstitial pneumonitis (UIP). (medscape.com)
  • Other major histopathologic forms of idiopathic interstitial pneumonias include the following: desquamative interstitial pneumonia (DIP), respiratory bronchiolitis interstitial lung disease (RBILD), acute interstitial pneumonitis (AIP), also known as Hamman-Rich syndrome, nonspecific interstitial pneumonia (NSIP), cryptogenic organizing pneumonia (COP) (see Imaging in Bronchiolitis Obliterans Organizing Pneumonia ), and lymphocytic interstitial pneumonia (LIP) (see Lymphocytic Interstitial Pneumonia ). (medscape.com)
  • however, these drugs are limited by certain clinical side effects that lead to residual damage to renal function [ 4 ]. (ijbs.com)
  • The purpose of this article is to integrate renal and cutaneous aspects of disease as well as highlight some important, although frequently underappreciated, clinical or laboratory findings that ally renal and skin diseases. (medscape.com)
  • Pathologically, all DPLDs manifest histologically with disease largely within the interstitial compartment of the lung. (medscape.com)
  • In patients with major organ involvement, such as lymphocytic interstitial lung disease, consider therapy with steroids and immunosuppressive agents, such as cyclophosphamide. (medscape.com)
  • Bakir AA, Dunea G. "Drugs of abuse and renal disease" Curr Opin Nephrol Hypertens . (erowid.org)
  • 2%: Intrinsic renal disease (e.g. (fpnotebook.com)
  • The study included 51 patients receiving ICI therapy between 2016 and 2020 for metastatic renal or urothelial carcinoma. (medpagetoday.com)
  • It is thought to begin with acute injury to the pulmonary parenchyma, leading to chronic interstitial inflammation, then to fibroblast activation and proliferation, and finally progressing to the common endpoint of pulmonary fibrosis and tissue destruction. (medscape.com)
  • The specific physico-chemical properties of HA enable a unique hydration capacity, and in the last decade it was revealed that in the interstitium of the renal medulla, where the HA content is very high, it changes rapidly depending on the body hydration status while the HA content of the cortex remains unchanged at very low amounts. (diva-portal.org)
  • Antidiuretic hormone, nitric oxide, angiotensin II, and prostaglandins are classical hormones/compounds involved in renal fluid handling and are important regulators of HA turnover during variations in hydration status. (diva-portal.org)
  • Recovery of Ang II and TNF-α in renal interstitial fluid (RIF) was measured in conscious rats before and weekly for 12 wk after induction of diabetes with streptozocin and in response to oral valsartan (10 mg/kg·d). (psu.edu)
  • Diuresis plus fluid leakage into the interstitial tissues causes hypovolemia. (msdmanuals.com)
  • Al- developed during hospitalization for non- though reliable statistics on the prevalence renal-related problems in patients whose of ARF among different tropical countries serum creatinine level on admission was are not available, statistics based on refer- normal. (who.int)
  • Pivotal in these events is the production of local growth factors which lead to interstitial fibrosis, and the increased production of endothelin and decreased production of bradykinin and NO, which lead to glomerulosclerosis. (vin.com)
  • In addition, uremia and conditions associated with renal replacement therapy are fraught with numerous and, often, relatively unique cutaneous disorders. (medscape.com)
  • Relapses were purely renal (n = 3) and purely extrarenal (n = 10) or both (n = 4), often a long time after presentation, with in some cases severe cardiac or central nervous system involvement. (nih.gov)
  • Among distal 7q interstitial deletions, the involvement of the 7q36.1 and 7q36.2 has only been evaluated by cytogenetic techniques in a few reports [ 4 - 7 ]. (hindawi.com)
  • After withdrawal of the presumed causative drug, we found that when steroid treatment was delayed (by an average of 34 days) renal function did not return to baseline levels compared to those who received steroid treatment within the first 2 weeks after withdrawal of the offending agent. (qxmd.com)
  • Our study shows that steroids should be started promptly after diagnosis of DI-AIN to avoid subsequent interstitial fibrosis and an incomplete recovery of renal function. (qxmd.com)
  • The age, weight and renal function of the patient are shown below. (medicines.org.uk)
  • Individualise dosing based on expected susceptible pathogens, severity and site of infection, age, weight and renal function of the patient. (mims.com)
  • AIN often resolves with withdrawal of the precipitating agent, with the degree of reversal in renal function dependent on the length of exposure and the extent of tubular damage. (logicalimages.com)