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  • infiltration
  • Both groups of mice had similar renal phagocyte infiltration postischemia assessed by myeloperoxidase levels and similar levels of CD4 + T cell infiltration postischemia. (jimmunol.org)
  • Renal myeloper-oxidase (MPO) activity (for polymorphonuclear leukocyte infiltration) and malondialdehyde (MDA) levels (for tissue lipid peroxidation) were determined. (ul.pt)
  • An elevation of myeloperoxidase activity and inflammatory foci were detected in the liver at 6h after renal IR, indicating neutrophil infiltration. (umanitoba.ca)
  • Serum
  • These data are the first demonstration of a pathogenic role for B cells in ischemic acute renal failure, with a serum factor as a potential underlying mechanism of action. (jimmunol.org)
  • To identify a possible mechanism involved in the protection from renal injury seen in the μMT mice, transfer experiments of B cells or serum from wild-type mice were investigated. (jimmunol.org)
  • Serum transfer, but not B cell transfer, restored the injury phenotype, indicating that a circulating factor mediates the protection seen in B cell-deficient mice. (jimmunol.org)
  • Here, we showed that as compared to untreated controls, administration of ERCs effectively prevented renal damage after IRI, indicated by better renal function and less pathological changes, which were associated with increased serum levels of IL-4, but decreased levels of TNF-α, IFN-γ and IL-6. (biomedcentral.com)
  • inflammatory
  • Nicotine protects kidney from renal ischemia/reperfusion injury through the cholinergic anti-inflammatory pathway," PLoS ONE , vol. 2, no. 5, article e469, 2007. (hindawi.com)
  • In this study, we investigated the role of mast cells in both the early and late phases of the inflammatory response in experimental models of acute and chronic renal IRI using our recently developed mouse model that allows conditional ablation of mast cells. (jimmunol.org)
  • This study demonstrates that the novel anti-inflammatory and immunoregulatory effects of ERCs are associated with attenuation of renal IRI, suggesting that the unique features of ERCs may make them a promising candidate for cell therapies in the treatment of ischemic acute kidney injury in patients. (biomedcentral.com)
  • Additionally, PPAR γ agonists reduce inflammatory response during renal I/R injury [ 11 , 12 ]. (hindawi.com)
  • vivo
  • 2. An in vivo model of rat kidney ischaemia was used, with the expected falls in blood and tissue oxygenation seen and confirmed by near-infrared spectroscopy. (clinsci.org)
  • The aim of this study is to evaluate the effect of MMF on NO production and iNOS gene expression in vivo during renal IRI. (oup.com)
  • perfusion
  • Patients undergoing long-lasting, abdominal, and urogenital surgeries with risk factors such as advanced age, peripheral artery disease, diabetes mellitus, renovascular disease, and congestive heart failure are candidates for acute kidney injury (AKI) due to impaired renal perfusion and decreased functional renal reserve. (dovepress.com)