Renal injury ischemia reperfusion. Medical search. Frequent questions

Therefore, in the present study, we evaluated the effect of mitochondrial complex 1 inhibition by rotenone on the chronic renal damage induced by acute ischemia-reperfusion. (oncotarget.com)
Furthermore, we examined the effect of inhibition of complement-factor C5 on renal I/R injury. (maastrichtuniversity.nl)
abstract = "Inhibition of complement factor C5 protects against renal ischemia-reperfusion injury: inhibition of late apoptosis and inflammation.De Vries B, Matthijsen RA, Wolfs TG, Van Bijnen AA, Heeringa P, Buurman WA.Department of General Surgery, Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Maastricht University, Maastricht, The Netherlands.BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. (maastrichtuniversity.nl)
Inhibition of renal Rho kinase attenuates ischemia/reperfusion-induced injury. (rug.nl)
In this review we discuss current evidence that complement activation contributes to progression of CKD, how complement could cause renal inflammation and whether complement inhibition would slow progression of renal disease. (wjgnet.com)
Thus, inhibition of oxidative stress and myocardial apoptosis is beneficial in the treatment of myocardial I/R injury. (spandidos-publications.com)
In support of the integral involvement of NHE activity during organ ischemia, NHE1 inhibition has been shown to exert a protective effect during cardiac ischemia . (tocris.com)
Effect of inhibition of neuronal nitric oxide synthase and L-arginine supplementation on renal ischaemia-reperfusion injury and the renal nitric oxide system. (tum.de)
The results of the present study demonstrate that selective inhibition of nNOS has no effect on renal injury, indicating that nNOS does not play a central role in the pathophysiology of renal I/R. In addition, although L-arginine has no effect on renal I/R injury in the model used in the present study, its administration increases the mRNA expression of NOS isoforms. (tum.de)
Inhibition of α v ß 5 Integrin Attenuates Vascular Permeability and Protects against Renal Ischemia-Reperfusion Injury. (bvsalud.org)

Sprague-Dawley (SD) rats were subjected to bilateral renal artery clamping for 45 min followed by perfusion restoration for establishing a simulated renal IRI model. (frontiersin.org)
Thus, pioglitazone ameliorates renal IRI by inhibiting the NF-κB signaling pathway and inflammatory response in rats. (frontiersin.org)
In the present work, a hypoxia/reoxygenation (H/R) model in NRK-52E cells and ischemia-reperfusion model in rats were used. (mdpi.com)
The results showed that the TFs significantly attenuated cell injury and markedly decreased serum creatinine (Cr) and blood urea nitrogen (BUN) levels in rats. (mdpi.com)
To investigate the effect of sevoflurane on renal ischemia-reperfusion injury (IRI) in rats and its regulatory effect on reperfusion injury salvage kinase (RISK) signaling pathway. (ajol.info)
Sevoflurane represses the release of inflammatory factors, lowers ROS level and apoptosis of renal cells and improves renal function through activation of RISK signaling pathway in kidney tissues of rats with renal IRI. (ajol.info)
Therefore, we were curious to know if Anwu can have a protective effect on remote organ injury after II/R. The purpose of the present study was to examine the effect of Anwu on the remote renal injury induced by II/R in rats and investigate its mechanism. (phcog.com)
After reperfusion or sham operation, blood and kidneys were collected from the rats for the detection of relative biochemical parameters. (phcog.com)
Anwu has a protective effect against the II/R-induced remote renal injury in rats, which may be related to its regulation of antioxidant, anti-inflammatory, and antiapoptotic pathways. (phcog.com)
In this research the protective effects of the methanolic extract of S. multicaulis was evaluated in renal ischaemia-reperfusion injuries in rats. (healthbiotechpharm.org)
In the treatment groups 1-3, before causing ischemia in the kidneys, rats received 50, 100, and 150 mg/kg/day doses of the extract orally for 20 days, then ischaemia was created. (healthbiotechpharm.org)
Investigating the protective effect of the methanolic extract of Salvia multicaulis on renal ischemia-reperfusion injuries in rats', Health Biotechnology and Biopharma (HBB) , 7(1), pp. 60-77. (healthbiotechpharm.org)
An in vitro method of alcoholic liver injury using precision-cut liver slices from rats. (rug.nl)
In the present study, we examined the effects of the neuronal (n) NOS inhibitor 7-nitroindazole (7-NI) and L-arginine administration on renal I/R injury and the renal NO system in rats. (tum.de)
Following 7 days pretreatment with 7-NI (50 mg/kg per day), L-arginine (2 g/kg per day) or vehicle (dimethylsulphoxide : sesame oil, 1 : 9), the left renal vascular pedicles were clamped for 50 min in male Sprague-Dawley rats and kidneys were removed 24 h after reperfusion (n = 7/group). (tum.de)
Neither 7-NI nor L-arginine had any effect on parameters of renal function, the grade of tissue injury or the number of terminal deoxyribonucleotidyl transferase-mediated dUTP-digoxigenin nick end-labelling (TUNEL)-positive tubular cells compared with vehicle-treated rats. (tum.de)

The production of antioxidant enzymes that scavenge free radicals in ischemic tissue is then impaired, thereby exacerbating the damage caused by these free radicals in the post ischemic reperfusion tissue. (frontiersin.org)
IR injury contributes to disease and mortality in a variety of pathologies, including myocardial infarction, ischemic stroke, acute kidney injury, trauma, circulatory arrest, sickle cell disease and sleep apnea. (wikipedia.org)
Restoration of blood supply, termed reperfusion, has been used to treat ischemic myocardium and prevent further tissue damage. (spandidos-publications.com)
To investigate the effects of renal ischemic preconditioning (IPC) on both renal hemodynamics and the renal interstitial concentrations of adenosine and adenine nucleotides induced by ischemia-reperfusion injury. (eurekamag.com)
Renal hemodynamics responses to ischemia-reperfusion injury in mongrel dog models were determined with or without multiple brief renal ischemic preconditioning treatments, as well as the adenosine A1 receptor antagonist (KW-3902), respectively. (eurekamag.com)
Apoptotic pathways in ischemic acute renal failure. (bmj.com)
hence, NGAL is considered to be a novel urinary biomarker for ischemic injury. (medscape.com)

BACKGROUND: Complement has been implicated in the pathophysiology of renal ischemia-reperfusion (I/R) injury. (maastrichtuniversity.nl)

At 24 h post-operatively, we assessed the serum levels of creatinine and urea nitrogen, expression levels of peroxisome proliferator-activated receptor gamma (PPAR-γ) and NF-κB-related (p-IKK-β and IκB-α) proteins, and mRNA expression levels of the inflammatory cytokines, including TNF-α and MCP-1, in the renal tissue of various study groups. (frontiersin.org)
In rat renal tissue, pioglitazone treatment decreased the serum levels of post-renal IRI creatinine and urea nitrogen, as well as necrosis. (frontiersin.org)
citation needed] Serum creatinine and BUN may be elevated in the setting of acute kidney injury. (wikipedia.org)
Kidney injury was assessed by serum creatinine and histologic injury scoring. (asn-online.org)
Exogenous administration of CFH after reperfusion caused overt AKI with creatinine increase, tubular injury, and enhanced markers of renal inflammation compared with vehicle-treated animals. (stanford.edu)
Influence of ascorbic acid on BUN, creatinine, resistive index in canine renal ischemia-reperfusion injury. (biomedcentral.com)
[ 1 ] At present, serum creatinine, which is used to measure the glomerular filtration rate (GFR), is the most commonly used marker of renal function. (medscape.com)

In this study, we investigated the role of the NF-κB signaling pathway and inflammation in the amelioration of renal IRI using pioglitazone. (frontiersin.org)
In patients with progressive CKD there is histological evidence of inflammation in the interstitium and strategies that reduce inflammation reduce renal injury in pre-clinical models of CKD. (wjgnet.com)
It is therefore possible that inhibiting complement activation would reduce inflammation, lead to reduced fibrosis and preservation of renal function. (wjgnet.com)
N-acetylcysteine is known to impair hemostasis when used for the prevention of perioperative inflammation and ischemia-reperfusion injury. (medscape.com)
The underlying mechanisms behind myocardial I/R injury are associated with a number of factors, including substantial free radical production, intracellular calcium overload, increased inflammation, myocardial necrosis and apoptosis ( 6 ). (spandidos-publications.com)

Because multiple other factors can contribute to AKI development in the complex clinical setting of LuTx, we next investigated the role of exogenous CFH administration in a mouse model of mild bilateral renal ischemia reperfusion injury (IRI). (stanford.edu)

Experimental models of unilateral renal IRI were used in p53(+/+) and p53(-/-) mice. (techscience.com)
The mice were treated with 45 min unilateral renal ischemia and reperfusion (I/R) to induce an acute renal injury. (oncotarget.com)

Organs involved in filtration (e.g., the kidneys and the liver), may be overwhelmed by the high load of cellular break down products, and face injury themselves (e.g., acute kidney injury). (wikipedia.org)
The renal manifestations of SCD range from various tubular and glomerular functional abnormalities to gross anatomic alterations of the kidneys. (medscape.com)

After three days of I/R injury, rotenone at a dose of 200 ppm in food was administered to the mice. (oncotarget.com)
METHODOLOGY AND FINDINGS: Mice subject to unilateral, transient (30 minutes) renal ischemia and subsequent reperfusion received intravenous VCAM-MPIO (4.5 mg iron/kg body weight). (ox.ac.uk)
METHODS: Mice were subjected to 45 min of unilateral ischemia and subsequent contralateral nephrectomy and reperfusion for 2, 12, or 24 hr. (maastrichtuniversity.nl)
Renal tubular cells (RTC) were co-cultured with CD11c+ bone-marrow derived dendritic cells (BMDC) from IL1R1 CD11cKO and IL1R1 CD11cWT mice. (asn-online.org)

Strikingly, after three weeks treatment with rotenone, we found that the unilateral I/R-induced tubular damage, tubulointerstitial fibrosis were all attenuated by rotenone as determined by the tubular injury score, Masson staining, and the levels of collagen-I, collagen-III, fibronectin, PAI-1, and TGF-β. (oncotarget.com)
Cell-specific delivery of a transforming growth factor-beta type I receptor kinase inhibitor to proximal tubular cells for the treatment of renal fibrosis. (rug.nl)

In patients with SCD, supranormal renal hemodynamics-including increased renal blood flow, renal plasma flow, and glomerular filtration rate-occur as early as infancy, but decrease with age. (medscape.com)
Such alterations in renal hemodynamics lead to increased renal growth and glomerular enlargement. (medscape.com)

The microvascular and parenchymal organ damage induced upon ischemia tissue reperfusion is mainly attributed to the reactive oxygen-free radicals, and it has been demonstrated in many organs. (frontiersin.org)

We studied the effect of DMSO, DMSO-ascorbic acid and DMSO- N -acetylcysteine administration on renal injury induced by I/R. Thirty minutes renal ischemia was induced in 50 male, New Zealand rabbits. (biomedcentral.com)

Renal targeting of kinase inhibitors. (rug.nl)
The results demonstrated that SA inhibited apoptosis signaling in H9c2 cardiomyocytes via downregulation of p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) signaling pathways following hypoxia/reoxygenation (H/R) injury. (spandidos-publications.com)

Renal ischemia-reperfusion injury (IRI) is considered as a major cause of acute kidney injury. (frontiersin.org)
Renal ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). (mdpi.com)
Acute kidney injury is associated with alterations in vascular tone that contribute to an overall reduction in GFR. (eurekaselect.com)
Studies in animal models indicate that ischemia triggers alterations in endothelial function that contribute significantly to the overall degree and severity of a kidney injury. (eurekaselect.com)
Finally, we discuss how acute kidney injury induces permanent alterations in renal vascular structure. (eurekaselect.com)
Acute kidney injury (AKI) has been widely recognized as an important risk factor leading to the occurrence and progression of chronic kidney disease (CKD). (oncotarget.com)
Kidney disease: improving global outcomes (KDIGO) Acute Kidney Injury Work Group. (bmj.com)
KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
Acute kidney injury: prevention, detection and management. (bmj.com)
Management of acute kidney injury: core curriculum 2018. (bmj.com)
The definition of acute kidney injury and its use in practice. (bmj.com)
Incidence and outcomes in acute kidney injury: a comprehensive population-based study. (bmj.com)
Acute kidney injury and mortality in hospitalized patients. (bmj.com)
Epidemiology of acute kidney injury in the intensive care unit. (bmj.com)
External validation for acute kidney injury severity scores: a multicenter retrospective study in 14 Japanese ICUs. (bmj.com)
Predicting one-year mortality of critically ill patients with early acute kidney injury: data from the prospective multicenter FINNAKI study. (bmj.com)
Acute kidney injury (AKI) is a leading cause of organ failure in hospitalized and critically ill patients. (asn-online.org)
In support of these findings, in vitro co-culture studies showed that RTC co-cultured with IL1R1 CD11cKO BMDC (in the presence of IL1β or LPS) exhibited higher mRNA levels of the kidney injury marker neutrophil gelatinase-associated lipocalin (NGAL) than those co-cultured with IL1R1 CD11cWT BMDC. (asn-online.org)
Cell-Free Hemoglobin in Acute Kidney Injury after Lung Transplantation and Experimental Renal Ischemia/Reperfusion. (stanford.edu)
Lung transplantation (LuTx) is a clinical condition with a high incidence of acute kidney injury (AKI). (stanford.edu)
Recent studies have shown that ferroptosis is closely related to the pathophysiological processes of many diseases, such as tumors, nervous system diseases, ischemia-reperfusion injury, kidney injury, and blood diseases. (nature.com)
Ferroptosis plays an important regulatory role in the occurrence and development of many diseases, such as tumors, neurological diseases, acute kidney injury, ischemia/reperfusion, etc. (nature.com)
Adapted from de Geus HR, Betjes MG, Bakker J. Biomarkers for the prediction of acute kidney injury: a narrative review on current status and future challenges. (medscape.com)

Therefore, in this study, we aimed to investigate the molecular mechanisms underlying pioglitazone hydrochloride-mediated amelioration of renal IRI with respect to the nuclear factor-kappaB (NF-κB) signaling pathway and inflammatory response using a rat model. (frontiersin.org)

In conclusion, the present study demonstrated that SA inhibits the apoptosis of H9c2 cardiomyocytes following H/R injury via reduced activation of the p38MAPK and JNK signaling pathways. (spandidos-publications.com)

Moreover, BB5.1 treatment significantly protected against I/R-induced renal dysfunction. (maastrichtuniversity.nl)
More distal tubular dysfunction may impair renal acidification and potassium secretion, leading to an incomplete form of distal renal tubular acidosis and hyperkalemia. (medscape.com)

The ischemia-reperfusion syndrome commonly seen in different clinical scenarios leads to acute renal failure and it is known that the free oxygen radicals play an important role in the pathophysiology of this injury. (biomedcentral.com)

It is considered as a major cause of acute renal failure and the main factor in early recovery of renal graft function and long-term survival post renal transplantation. (frontiersin.org)

Spectrum of acute renal failure in the intensive care unit: the PICARD experience. (bmj.com)
14. Liaño F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. (bmj.com)
Madrid Acute Renal Failure Study Group. (bmj.com)
Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. (bmj.com)
17. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. (bmj.com)
Hemodynamically mediated acute renal failure. (bmj.com)

ARA290 Protects Against Renal Ischemia/Reperfusion Injury. (ox.ac.uk)

citation needed] Tissue swelling and fasciotomy Following ischemia, reperfusion induces local tissue swelling. (wikipedia.org)

In conclusion, CFH is a possible factor contributing to postoperative AKI after LuTx and promotes AKI in an experimental model of mild transient renal ischemia. (stanford.edu)

The subjects were divided into five groups: (A) Sham, unilateral nephrectomy, no ischemia induced. (biomedcentral.com)
After reperfusion left nephrectomy was performed on each subject before euthanasia. (biomedcentral.com)

Hemolysis, vaso-occlusion, and ischemia-reperfusion injury are the clinical hallmarks of sickle cell disease (SCD). (medscape.com)

Attenuation of ischemia-reperfusion injury in a canine model of autologous renal transplantation. (musc.edu)

Renal IRI models were created in model and sevoflurane groups, while sham group had no ligation. (ajol.info)

Ischemia": an inadequate blood supply to an organ or part of the body. (wikipedia.org)
citation needed] "Reperfusion": the restoration of blood flow to an organ or tissue after having been blocked. (wikipedia.org)
In addition to their integral involvement in the control of intracellular pH and volume, the NHE family has also been implicated in diseases including hypertension and organ ischemia. (tocris.com)
The involvement of NHE activity during organ ischemia is complex: H + efflux driven by the NHE corrects the drop in intracellular pH, yet the concurrent influx of Na + ions leads to Ca 2+ overload through the actions of the NCX. (tocris.com)
Penetrating injuries may or may not penetrate the peritoneum and, even if they do, they may not cause organ injury. (msdmanuals.com)
Blunt injury may alternatively cause only a hematoma in a solid organ or the wall of a hollow viscus. (msdmanuals.com)
Hemorrhage due to low-grade solid organ injury, minor vascular laceration, or hollow viscus laceration is often low-volume, with minimal physiologic consequences. (msdmanuals.com)

In addition, there is discussion of how intrinsic damage to the endothelium impairs homeostatic responses in vascular tone as well as promotes leukocyte adhesion and exacerbating the reduction in renal blood flow. (eurekaselect.com)
RATIONALE AND OBJECTIVE: Vascular cell adhesion molecule-1 (VCAM-1) is upregulated in ischemia reperfusion injury (IRI), persisting after restoration of blood flow. (ox.ac.uk)
Recognizing this, surgeons frequently prophylactically release (i.e., incise) fascia of arm and leg fascial compartments after repair of a proximal vascular injury. (wikipedia.org)
[ 3 ] The low incidence of hypertension is attributed to reduced vascular reactivity, compensatory systemic vasodilatation associated with microvascular disturbances from sickling of RBCs and thrombotic complications, elevated levels of prostaglandins and nitric oxide, and possibly renal sodium and water wasting associated with suboptimal medullary concentrating activity. (medscape.com)

While developmental senescence and acute senescence may positively contribute to the fine-tuning of embryogenesis and injury repair, chronic senescence, when unresolved promptly, plays a crucial role in kidney fibrogenesis and CKD progression. (frontiersin.org)

Recent studies suggest that the use of antioxidants can provide renal protection, reducing parenchymal lesions and expression of inflammatory mediators, improving renal function, resulting in a better outcome. (biomedcentral.com)

Wijeysundera et al sought to determine whether N-acetylcysteine is associated with increased blood loss and blood product transfusion in 89 patients with preexisting moderate renal insufficiency undergoing cardiac surgery. (medscape.com)

Unlike the other NHE isoforms, NHE3 is recycled between apical membranes and the endosomal compartment of epithelial cells where it has a significant involvement in renal and intestinal Na + absorption. (tocris.com)

Ischemia-reperfusion (IR) tissue injury is the resultant pathology from a combination of factors, including tissue hypoxia, followed by tissue damage associated with re-oxygenation. (wikipedia.org)
The underlying mechanisms of renal injury or sickle cell nephropathy (SCN) relate mainly to hypoxia and ischemia. (medscape.com)

citation needed] While some investigations suggest a possible beneficial effect of mesenchymal stem cells on heart and kidney reperfusion injury, to date, none have explored the role of stem cells in muscle tissue exposed to ischemia-reperfusion injury. (wikipedia.org)

Intestinal ischemia/reperfusion (II/R) can cause injury of remote organs, including acute renal injury. (phcog.com)
In our previous study, we found that Anwu can improve the intestinal function after ischemia/reperfusion. (phcog.com)

The histopathological evaluation of renal tissue was also conducted. (frontiersin.org)

One 10-min IPC, adenosine A1 receptor antagonist (KW-3902) also shortened the recovery time of renal blood flow (RBF) and urine flow (UF), as well as mean blood pressure (BP). (eurekamag.com)
renal adenosine A1 receptor activation during the renal ischemia-reperfusion injury is detrimental to renal function. (eurekamag.com)
Journal Article] Study of peroxisome proliferators-activated receptor (PPAR)-gamma in renal ischemia-reperfusion injury. (nii.ac.jp)

The Food and Drug Administration (FDA) is announcing a public workshop to discuss the effects of ischemia/ reperfusion injury ( IRI ) on outcomes in kidney transplantation. (myast.org)

The findings imply that reactive oxygen species play a causal role in I/R-induced renal injury, and that antioxidants exert renoprotective effects, probably by radical scavenging and antioxidant activities, in this way diminishing renal function deterioration. (biomedcentral.com)

Complement activation is known to occur in many diverse renal diseases, including glomerulonephritis, thrombotic microangiopathies and transplant rejection. (wjgnet.com)

However, the mechanism underlying complement-mediated renal I/R injury is thus far unknown. (maastrichtuniversity.nl)
This paradox, known as the pH paradox, is the driving mechanism behind reperfusion injury following cardiac, renal or cerebral ischemia . (tocris.com)
The nature and severity of abdominal injuries vary widely depending on the mechanism and forces involved, thus generalizations about mortality and need for operative repair tend to be misleading. (msdmanuals.com)

More importantly, the bioprinted constructs with neural cell integration facilitate rapid innervation and mature into organized muscle tissue that restores normal muscle weight and function in a rodent model of muscle defect injury. (nature.com)

The resulting increased blood viscosity contributes to ischemia and eventual infarction that involves the renal microcirculation. (medscape.com)

Lee, D. Targeted echogenic and anti-inflammatory polymeric prodrug nanoparticles for the management of renal ischemia/reperfusion injury. (beilstein-journals.org)

Renal ischemia-reperfusion injury (IRI) is a common pathophysiological phenomenon in clinical settings. (frontiersin.org)

Renal indexes were not significantly different among all groups. (phcog.com)

However, reperfusion following a period of prolonged ischemia can often cause myocardial ischemia-reperfusion (I/R) injury, leading to damage of cardiac tissues ( 5 ). (spandidos-publications.com)

The hypoxic, acidotic, and hyperosmolar environment of the inner medulla are known to promote sickling of red blood cells (RBCs) with resultant impairment in renal medullary blood flow, ischemia, microinfarction, and papillary necrosis. (medscape.com)

The primary management goals in sickle cell nephropathy (SCN) are the prevention of complications and the reduction of morbidity, primarily from progression to end-stage renal disease (ESRD). (medscape.com)

The present study aimed to clarify the cardioprotective effect of SA in myocardial I/R injury in vitro and explore the potential molecular mechanisms. (spandidos-publications.com)

Putative mediators of vasoconstriction that may contribute to the initial loss of renal blood flow and GFR are highlighted. (eurekaselect.com)
Two blood samples were taken at baseline and after the reperfusion phase. (biomedcentral.com)

2022 United States Renal Data System (USRDS) annual data report: epidemiology of kidney disease in the United States. (bmj.com)

To investigate the course of tubular cell senescence and expressions of p53, p21, and Rb during the late phase of ischemia/reperfusion (IRI) in the kidney, and assess the effects of the p53-Rb pathway on tubular cell senescence. (techscience.com)

The role of nitric oxide synthases (NOS) and the nitric oxide (NO) substrate l-arginine in renal ischaemia-reperfusion (I/R) has been studied extensively. (tum.de)

To investigate the involvement of complement in I/R injury, we studied the activation and deposition of complement in a murine model of renal I/R injury. (maastrichtuniversity.nl)

Anatomy31

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Diseases62

Chemicals and Drugs79

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Phenomena and Processes33

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Pathophysiology of renal1

Creatinine7

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Unilateral renal2

Kidneys2

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Damage induced1

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Canine1

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