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  • GLUT1
  • The facilitative glucose transport protein GLUT1 has important roles in positron emission tomography (PET) imaging of human diseases. (openmedscience.com)
  • GLUT1 has widespread expression and catalyses the energy-independent facilitated diffusion of glucose down its concentration gradient across red blood cell membranes, blood-brain and blood-tissue barriers and membranes of some oragnelles. (openmedscience.com)
  • diabetic
  • The effects of anti-diabetic drugs on glucose metabolism and activation of brown adipose tissue as a preventative measure or treatment for obesity and diabetes have been investigated using [ 18 F]FDG PET. (openmedscience.com)
  • glycemic
  • However, despite significant advances in the availability of more physiological insulin preparations, insulin delivery devices including continuous subcutaneous insulin infusion (CSII) pumps and continuous glucose monitoring (CGM) systems, most patients fail to achieve glycemic targets. (touchendocrinology.com)
  • Despite the wide range of antihyperglycemic drugs available, current therapeutic strategies fall short of optimal glycemic control, especially in patients with long-standing T2DM with complications and/or multiple cardiovascular disease risk factors ( 2 , 3 ). (diabetesjournals.org)
  • However, in order to achieve and maintain glycemic control as the disease progresses, patients often require therapies in addition to metformin ( 2 , 3 ). (diabetesjournals.org)
  • In contrast to A1C, it reflects changes in glycemic control over a period of 1-2 weeks ( 5 ). (diabetesjournals.org)
  • Impairment
  • Importantly, these effects were maintained in a sub-group with the most advanced renal impairment, pre-defined as those with glomerular filtration rate (GFR) less than 45 ml/min/1.73 m2. (equities.com)
  • A1C reduction % Contraindicated Type I DM, DKA Meglinides Repaglinide (Prandin ), Nateglinide (Starlix ) Increase the release of insulin from the pancreas Side Effects Comments Hypoglycemia, weight gain Take before meals No meal No medication (Repaglinide) caution with renal and hepatic impairment Thiazolidinediones Medication(s) How does it work? (docplayer.net)
  • hypoglycemia
  • This leads to lowering of blood glucose levels with a lower risk of hypoglycemia than sulfonylureas (see here ). (drmloghmanadham.com)
  • Mild hypoglycemia may be treated with administration of oral glucose. (thefreedictionary.com)
  • Treat severe hypoglycemia with IV D50W followed by continuous IV infusion of more dilute dextrose solution at a rate sufficient to keep serum glucose at approximately 100 mg/dL. (thefreedictionary.com)
  • Glynase ) Glipizide (Glucotrol ) Glimeperide (Amaryl ) A1C reduction 1 2% Contraindicated Type I DM, DKA Increase the release of insulin from the pancreas Side Effects Comments Hypoglycemia, weight gain All renally cleared Glyburide on Beers Criteria Caution in irregular eating pattern Medication(s) How does it work? (docplayer.net)
  • kidney
  • IntroductionIt is only in recent years that the attention was drawn on the important role of the kidney in glucose homeostasis. (amazonaws.com)
  • The Relationship of Kidney Function to the Glucose Utilization of the Extraabdominal Tissues. (amazonaws.com)
  • Early non-human studiesThe first researchers in this field, Bergman and Drury brought the first clues about the involvement of the kidney in glucose homeostasis in 1938 . (amazonaws.com)
  • The role of the kidney in glucose homeostasis has recently gained renewed attention. (diabetesjournals.org)
  • Bruns, Tim 2018-05-29 00:00:00 Background: The role of the kidney in glucose homeostasis has gained global interest. (deepdyve.com)
  • Under normal physiological conditions, approximately 180 g of glucose is filtered by the kidney daily. (bjcardio.co.uk)
  • Glucagon
  • Effects of Glucagon on Renal and Hepatic Glutamine Gluconeogenesis in Normal Postabsorptive Humans. (amazonaws.com)
  • This analysis evaluated: (1) the effects of DAPA + ExQW on changes in substrates [free fatty acids (FFAs), glycerol, beta-OH-butyrate, and glucose], hormones (glucagon and insulin), and insulin secretion [insulinogenic index (IGI)] via an oral glucose tolerance test (OGTT) and (2) associations between bodyweight loss and baseline characteristics (e.g. (springer.com)
  • increases
  • Evidence from animal studies indicates that hyperinsulinemia, without changes in glucose, increases ventilation via a carotid body-mediated mechanism. (bioportfolio.com)
  • SGLTs
  • Almost all of this is re-absorbed into the circulation via sodium glucose co-transporters (SGLTs). (bjcardio.co.uk)
  • SGLTs transport sodium and glucose into cells using the sodium gradient created by sodium/potassium ATPase pumps at the basolateral cell membranes. (bjcardio.co.uk)
  • Ca 2+ through the Na + /Ca 2+ exchanger, NCX, H + via the Na + /H + exchanger, NHE, etc.), uptake of energy substrates (glucose through the family of Na + -glucose cotransporters, SGLTs, and aminoacids through Na + -aminoacid cotransporter) and, in the case of excitable cells, generation of action potentials (via voltage-gated Na + channels). (frontiersin.org)
  • Hepatic
  • Effects of a novel selective peroxisome proliferator-activated receptor α modulator, pemafibrate (K-877), on hepatic and peripheral glucose uptake in patients with hypertriglyceridemia and insulin resistance. (bioportfolio.com)
  • dapagliflozin
  • body mass index (BMI) 30-45 kg/m 2 ] were randomized to double-blind oral dapagliflozin 10 mg (DAPA) once daily plus subcutaneous long-acting exenatide 2 mg QW (ExQW) or placebo over 24 weeks, followed by an open-label extension from 24-52 weeks during which all participants received active treatment. (springer.com)
  • Self Monitored Blood Glucose
  • During treatment, patients will be monitored for safety by review of adverse events, results from laboratory tests, 12-lead electrocardiograms (ECGs), vital signs measurements, body weight, physical examinations, and self-monitored blood glucose (SMGB) measurements. (bioportfolio.com)
  • Glucosuria
  • Metabolic effects with DAPA + ExQW included less FFA suppression versus placebo during the OGTT, suggesting compensatory lipid mobilization for energy production when glucose availability was reduced because of glucosuria. (springer.com)
  • reduction
  • First, the author searched for the published articles about the possible anti-atherosclerotic effects beyond glucose lowering of SGLT2i, by using PubMed, and found that SGLT2i are proved to be significantly associated with weight loss and reduction of blood pressure by a relatively large number of studies. (omicsonline.org)
  • patients
  • As expected, Henry said, there was a dose-dependent increase in urine glucose for patients on the drug. (medpagetoday.com)
  • Patients should record these glucose values in a diary. (bioportfolio.com)
  • Second, we retrospectively picked up patients who had been continuously prescribed SGLT2i by a chart-based analysis, and compared the data before the SGLT2i treatment with the data at 1, 2, 3 and 6 months after the SGLT2i treatment started, and found that SGLT2i significantly reduced HbA1c and body weight and improved liver function. (omicsonline.org)
  • Patients inadequately controlled on ≥1,500mg of metformin/day entered a single-blind placebo run-in period for 2 weeks. (clinicaladvisor.com)
  • All patients will take single-blind placebo capsules for 2 weeks before randomization. (bioportfolio.com)
  • The purpose of this study is to determine whether subcutaneous continuous glucose monitoring in critically ill patients is clinically feasible accurate and reliable. (bioportfolio.com)
  • The aim of this study was to elucidate the characteristics of accuracy of subcutaneous continuous glucose monitoring (SCGM) in the perioperative period for neurosurgical and cardiac surgery patients. (bioportfolio.com)
  • Our time, which makes achieving blood glucose control targets hypothesis was that direct stimulation of renal nerves at difficult for many diabetic patients (Blak et al. (deepdyve.com)
  • 2-4 Guidelines recommend a target glycosylated haemoglobin (HbA 1c ) of 7% or less, but a large number of patients fail to meet this target and, as of yet, no ideal pharmacological blood glucose-lowering agent exists. (bjcardio.co.uk)
  • The purpose of this study was to assess the 1,5-AG levels in patients with HNF-1α MODY and in type 2 diabetic subjects with a similar degree of metabolic control. (diabetesjournals.org)
  • In addition, we examined 43 type 2 diabetic patients and 47 nondiabetic control subjects. (diabetesjournals.org)
  • Thus, its clinical usefulness in evaluation of some groups of patients, for example, pregnant women and subjects with end-stage renal disease, is obvious ( 7 , 8 ). (diabetesjournals.org)
  • Patients taking other antihyperglycemic agents discontinued the agent and underwent an 8-week washout followed by a 2-week, single-blind, placebo run-in period. (centerwatch.com)
  • Patients not taking oral antihyperglycemic agents entered the 2-week, single-blind, placebo run-in period directly. (centerwatch.com)
  • continuous glucose
  • The recent development of real-time continuous glucose monitoring (RT-CGM) enables continuous display of glucose con. (bioportfolio.com)
  • The objective of this nationwide population-based cohort study was to evaluate the correlation between continuous glucose monitoring (CGM) use and glucose variability in pre-schoolers with type 1 diab. (bioportfolio.com)
  • Perioperative Characteristics of the Accuracy of Subcutaneous Continuous Glucose Monitoring: Pilot Study in Neurosurgery and Cardiac Surgery. (bioportfolio.com)
  • concentration
  • Glucose is then transported passively by GLUT2 along its concentration gradient into the interstitium. (bjcardio.co.uk)
  • Its renal loss is stimulated in hyperglycemic conditions by glycosuria, which results in a lowered plasma concentration. (diabetesjournals.org)
  • By controlling the function of various sarcolemmal and mitochondrial ion transporters, intracellular Na + concentration ([Na + ] i ) regulates Ca 2+ cycling, electrical activity, the matching of energy supply and demand, and oxidative stress in cardiac myocytes. (frontiersin.org)
  • tolerance
  • Oral Glucose Tolerance is Associated with Neuroelectric Indices of Attention Among Adults with Overweight and Obesity. (bioportfolio.com)
  • Increased Lipolysis, Diminished Adipose Tissue Insulin Sensitivity and Impaired β-cell Function Relative to Adipose Tissue Insulin Sensitivity in Obese Youth with Impaired Glucose Tolerance (IGT). (bioportfolio.com)
  • The FAS system will be used in this study to monitor glucose levels during a glucose tolerance test (GTT) performed in Dr.Orzeck practice. (bioportfolio.com)
  • clamp technique
  • They used the glucose clamp technique in order to maintain euglycemia in two groups of rabbits - one functionally hepatectomized and another one functionally hepatectomized and nephrectomized. (amazonaws.com)