AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
KidneyEndothelial CellsUmbilical VeinsCells, CulturedHuman Umbilical Vein Endothelial CellsEndotheliumEndothelium, VascularNeovascularization, PhysiologicCattleCell AdhesionAortaVascular Endothelial Growth Factor AEndothelium, CornealCapillariesCell MovementNeovascularization, PathologicAntigens, CD31Vascular Cell Adhesion Molecule-1MicrocirculationIntercellular Adhesion Molecule-1E-SelectinSignal TransductionRNA, MessengerNitric Oxide Synthase Type IIIVascular Endothelial Growth Factor Receptor-2Cell Adhesion MoleculesNitric OxideEndothelial Growth FactorsBlood VesselsMicrovesselsCell LineVascular Endothelial Growth FactorsCapillary PermeabilityCell DivisionAngiogenesis InhibitorsLymphokinesTumor Necrosis Factor-alphaStress, MechanicalApoptosisCell ProliferationGene Expression Regulationvon Willebrand FactorReceptor, TIE-2ImmunohistochemistryPulmonary ArteryDose-Response Relationship, DrugPhosphorylationUp-RegulationBlotting, WesternFibroblast Growth Factor 2Time FactorsCoculture TechniquesMice, Inbred C57BLReceptors, Vascular Endothelial Growth FactorRetinal VesselsThrombinCell SurvivalEpoprostenolReverse Transcriptase Polymerase Chain ReactionSwineEnzyme ActivationEnzyme InhibitorsNitric Oxide SynthaseCell CommunicationCulture Media, ConditionedBlood-Brain BarrierAngiopoietin-1Receptors, Cell SurfaceAntigens, CDRNA, Small InterferingGene ExpressionCorneal Endothelial Cell LossTransfectionPericytesEndothelium, LymphaticInterleukin-8Receptors, Growth FactorNF-kappa BMuscle, Smooth, VascularRecombinant ProteinsMonocytesMolecular Sequence DataLeukocytesThromboplastinUmbilical CordP-SelectinCaveolin 1Angiogenesis Inducing AgentsLamininFlow CytometryNeutrophilsReactive Oxygen SpeciesCoronary VesselsAngiopoietin-2Mice, KnockoutMembrane ProteinsInflammationFluorescent Antibody TechniqueInterleukin-1Thrombomodulin
Vascular endothGlomerularCarcinomaDysfunctionOxidative stressProgenitor cellsVEGFKidneyPatientsCytokinesLiver and renalEpithelialMedullaEndotheliumCapillaryChanges in renalPhenotypesDiabetesMacrophagesInflammationIschemiaBasement membraneCapillariesProliferationRegulatesAcuteTubular cellsSerumSystemicInducesHematologicInhibitionHepaticFiltrationNitricFailureAdhesion moleculeGlucoseHumanHemorrhagicThrombomodulinPathogenesisCortexDiseaseInflammatoryEPCsInjuryActivateImpairmentReducesKidneysDifferentiationMolecular
Vascular endoth5
  • Because deficiency of vascular endothelial growth factor ( VEGF ) results in thrombotic microangiopathy , we addressed the possibility that Gsα knockout may result in impaired VEGF production . (bvsalud.org)
  • We investigate the association of serum hepatocyte growth factor (HGF) and serum vascular endothelial growth factor (VEGF) levels with clinicopathologic parameters in untreated clear cell RCC patients. (tokushima-u.ac.jp)
  • Moreover, immunohistochemical staining, quantitative real-time PCR and Western blotting analysis detected the expression levels of CD31, CD34, vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2). (annalsoftransplantation.com)
  • Antiangiogenic therapies remain the standard of care in the front-line setting for renal cell carcinoma, although vascular endothelial growth factor (VEGF) blockade is not sufficient, and many patients do not respond to such treatment. (jnccn.org)
  • In addition, cytokines, such as vascular endothelial growth factor (VEGF), accumulate in the vitreous cavity of diabetic patients and lead to capillary leakage. (medscape.com)
Glomerular11
  • As the first layer of renal filtration barrier, whether high glucose triggers glomerular endothelial cells (GECs) pyroptosis in the pathogenesis of diabetic nephropathy (DN) is unclear. (diabetesjournals.org)
  • In this study, human renal glomerular endothelial cells (HRGECs) were exposed to high glucose in vitro, exogenous sodium butyrate was used as an intervention reagent, and then caspase 1 inhibitor Ac-YVAD-CMK pre-treated or silencing GSDMD by siRNA on HRGECs. (diabetesjournals.org)
  • Ultrastructurally, the glomerular filtration barrier of the Gsα-deficient animals featured endothelial gaps, thickened basement membrane , and fibrin -like intraluminal deposits, which are classic signs of thrombotic microangiopathy . (bvsalud.org)
  • Renal filtration depends on the integrity of epithelial and endothelial monolayers in the tubular and glomerular apparatus. (biomedcentral.com)
  • Tubular and glomerular cells represent target cells of hantavirus infection. (biomedcentral.com)
  • Hantaviral N protein was detected in tubular and glomerular cells and cell-to-cell contact structures were changed in biopsy samples of patients with serologically confirmed PUUV infections [ 3 ]. (biomedcentral.com)
  • Human renal glomerular endothelial cells (HRGEnC) (ScienCell) were maintained in endothelial cell medium ECM (ScienCell). (biomedcentral.com)
  • The characteristic renal lesion of preeclampsia "glomeruloendotheliosis" is manifested primarily by swelling of the glomerular capillary endothelial cells. (health.am)
  • Importantly, renal biopsies from two patients with vasculitis showed leukocyte-derived microvesicles bearing B1-receptors docking on glomerular endothelial cells. (lu.se)
  • Microvesicles derived from B1-receptor-transfected human embryonic kidney cells transferred B1-receptors to wild-type human embryonic kidney cells, lacking the receptor, and to glomerular endothelial cells. (lu.se)
  • The renal corpuscle consists of Bowman's capsule and glomerular capillaries, responsible for plasma filtration (image A) & (image B). Network of capillaries that invaginate into Bowman's capsule. (onteenstoday.com)
Carcinoma11
  • No adequate serum predictive biomarker currently exists, which can identify the activity of renal cell carcinoma (RCC). (tokushima-u.ac.jp)
  • Ipsen remains on track to submit the regulatory dossier for cabozantinib as a treatment for first-line advanced renal cell carcinoma in Europe in the third quarter of 2017. (businesswire.com)
  • It has been an exciting 15 years for renal cell carcinoma," noted Eric Jonasch, MD, Associate Professor, Department of Genitourinary Medical Oncology, Division of Cancer Medicine, and Director of the Von Hippel-Lindau Clinical Center at The University of Texas MD Anderson Cancer Center. (jnccn.org)
  • During his presentation at the NCCN 20th Annual Conference, Dr. Jonasch focused on the host of systemic therapies now available for metastatic renal cell carcinoma (RCC) that have category 1 evidence in the most recent version of the NCCN Guidelines. (jnccn.org)
  • What's New in the Field of Neoadjuvant Therapy and Renal Cell Carcinoma? (medscape.com)
  • Welcome to season 2 of Medscape's InDiscussion series on renal cell carcinoma (RCC). (medscape.com)
  • Darmstadt, Germany and New York, US, May 14, 2019 - Merck KGaA, Darmstadt, Germany, which operates its biopharmaceutical business as EMD Serono in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has approved BAVENCIO® (avelumab) in combination with INLYTA® (axitinib) for the first-line treatment of patients with advanced renal cell carcinoma (RCC). (pfizer.com)
  • The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
  • Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
  • Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
  • Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
Dysfunction11
  • Approximately 30% of patients had preadmission renal dysfunction. (scienceopen.com)
  • Recently, endothelial dysfunction (ED) has been demonstrated in these patients, but the mechanisms remain elusive. (mdpi.com)
  • Endothelial dysfunction is a critical initiating factor contributing to cardiovascular diseases, involving the gut microbiome-derived metabolite trimethylamine N-oxide (TMAO). (nature.com)
  • This study aims to clarify the time-dependent molecular pathways by which TMAO mediates endothelial dysfunction through transcriptomics and metabolomics analyses in human microvascular endothelial cells (HMEC-1). (nature.com)
  • The discrepancies between studies on TMAO-induced endothelial dysfunction may be attributed to different cell types and animal models used, including different metabolic backgrounds, as well as to distinct TMAO treatment concentrations and durations. (nature.com)
  • The hematologic changes of preeclampsia, ie, thrombocytopenia and microangiopathic hemolytic anemia, are similar to those found in thrombotic thrombocytopenic purpura or hemolytic uremic syndrome - disorders in which endothelial dysfunction is thought to be important. (health.am)
  • Activation of the clotting cascade and increased sensitivity to pressors are compatible with endothelial cell dysfunction. (health.am)
  • Endothelial dysfunction and oxidative stress are evident in patients with ADPKD, preserved renal function, and controlled hypertension. (tau.ac.il)
  • We hypothesized that in early ADPKD, the reactive oxygen species (ROS)-producing nicotinamide adenine dinucleotide phosphate hydrogen (NAD(P)H)-oxidase complex-4 (NOX4), a major source of ROS in renal tubular epithelial cells (TECs) and endothelial cells (ECs), induces EC mitochondrial abnormalities, contributing to endothelial dysfunction, vascular abnormalities, and renal disease progression. (tau.ac.il)
  • Endothelial dysfunction precedes capillary loss, and the latter correlates with worsening of renal disease. (tau.ac.il)
  • However, the biomarkers sICAM-1 and sE-selectin (as mechanism of this immune dysregulation markers of endothelial dysfunction) in dia- is still unclear. (who.int)
Oxidative stress4
  • TMAO treatment for either 24H or 48H induces reduced cell viability and enhanced oxidative stress. (nature.com)
  • In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
  • 25-hydroxyvitamin D3 inhibits oxidative stress and ferroptosis in retinal microvascular endothelial cells induced by high glucose through down-regulation of miR-93. (nih.gov)
  • Renal oxidative stress, mitochondrial morphology (electron microscopy), and NOX4 expression were assessed in 4-and 12-week-old PCK and Sprague-Dawley (wild-type, WT) control rats (n = 8 males and 8 females each). (tau.ac.il)
Progenitor cells3
  • The objective of this study was to determine whether homing of endothelial progenitor cells (EPCs) induced by ischemic preconditioning (IPC) contributed to the protection of renal acute ischemia-reperfusion injury (IRI) in male rats. (annalsoftransplantation.com)
  • Cigarette smoking depletes and impairs the function of endothelial progenitor cells (EPCs). (stem-kine.com)
  • Diabetes is associated with a low level of endothelial progenitor cells (EPCs). (stem-kine.com)
VEGF4
  • We detected VEGF expression in JG cells of control mice , and cAMP agonists regulated VEGF expression in cultured renin -producing cells . (bvsalud.org)
  • We measured serum levels of HGF and VEGF in 45 patients with untreated clear cell RCC and 45 healthy controls using an enzyme-linked immunosorbent assay (ELISA). (tokushima-u.ac.jp)
  • These results provided evidence that IPC-mediated homing of EPCs played an important role in the protection of renal acute IRI, involving promotion of cell proliferation and angiogenesis through release of several angiogenic factors, such as VEGF, Ang-1, and Ang-2. (annalsoftransplantation.com)
  • The majority of clear cell RCC tumors have lower than normal levels of a protein called von Hippel-Lindau, which leads to higher levels of MET, AXL and VEGF. (businesswire.com)
Kidney24
  • Increased permeability of the renal capillaries is a common consequence of sepsis-associated acute kidney injury. (scienceopen.com)
  • The phenotype of RECs differs throughout the kidney cortex, medulla and glomeruli, as cells in these compartments have different functional requirements and are exposed to unique microenvironments. (nature.com)
  • Intracellular cAMP, the production of which is catalyzed by the α-subunit of the stimulatory G protein (Gsα), controls renin synthesis and release by juxtaglomerular (JG) cells of the kidney , but may also have relevance for the physiologic integrity of the kidney . (bvsalud.org)
  • Our data demonstrate that Gsα deficiency in JG cells of adult mice results in kidney injury , and suggest that JG cells are critically involved in the maintenance and protection of the renal microvascular endothelium . (bvsalud.org)
  • Postcapillary venule endothelial cells in kidney express a multispecific chemokine receptor that is structurally and functionally identical to the erythroid isoform, which is the Duffy blood group antigen. (jci.org)
  • Immunoblot analysis of erythrocyte and kidney detergent lysates, with a monoclonal antibody (Fy6) to the Duffy antigen, revealed that the renal isoform had a molecular mass of 43-45 kD, which could be distinguished from that observed in erythroid cells (38-47 kD). (jci.org)
  • Chemical cross-linking of kidney membranes to 125I-melanoma growth stimulatory activity (MGSA) indicated that the renal chemokine receptor had a molecular mass of 38-45 kD. (jci.org)
  • Immunocytochemical staining of kidney with Fy6 localized expression to endothelial cells present in postcapillary venules. (jci.org)
  • Hemorrhagic fever with renal syndrome (HFRS) caused by pathogenic hantaviruses in Europe and Asia is often characterized by acute kidney injury (AKI) with massive proteinuria. (biomedcentral.com)
  • Infection of kidney cells with hantavirus species PUUV and HTNV causes a significant reduction of migration capacity. (biomedcentral.com)
  • The current review focuses on the role of the eCB system in normal kidney function and various diseases, such as diabetes and obesity, that directly contributes to the development of renal pathologies. (degruyter.com)
  • Microvesicles derived from neutrophils also transferred B1-receptors to wild-type human embryonic kidney cells and induced calcium influx after stimulation. (lu.se)
  • Kidney failure is usually a major complication of the disease, and patients require renal replacement therapy early in life. (hindawi.com)
  • Microhematuria and subsequently proteinuria are hallmarks of kidney involvement, which are due to primary basement membrane alterations that mainly cause endothelial thrombosis and podocyte contraction and ulterior irreversible detachment. (hindawi.com)
  • Renal corpuscle, also called malpighian body, filtration unit of vertebrate nephrons, functional units of the kidney. (onteenstoday.com)
  • The renal veins drain the kidney and the renal arteries supply blood to the kidney. (onteenstoday.com)
  • Renal artery, one of the pair of large blood vessels that branch off from the abdominal aorta (the abdominal portion of the major artery leading from the heart) and enter into each kidney. (onteenstoday.com)
  • Excretory pathway in kidney - Blood is carried by the renal artery to the nephron from there to renal pyramid leading to pelvis to the ureter, then to the urinary bladder and finally to the urethra which passes it to outside. (onteenstoday.com)
  • Renal artery stenosis is the narrowing of arteries transporting blood to the kidney (s). (onteenstoday.com)
  • Vascular abnormalities are the most important non-cystic complications in Polycystic Kidney Disease (PKD) and contribute to renal disease progression. (tau.ac.il)
  • Our most recent work is focused on the novel role of RNA binding proteins (RBPs) in the development of Autosomal Dominant Polycystic Kidney Disease (ADPKD), which is the commonest genetic form of renal failure. (sheffield.ac.uk)
  • We wanted to focus specifically on patients with clear cell kidney cancer , and that's why we mandated the biopsy ahead of time. (medscape.com)
  • We ultimately ended up enrolling 24 patients with clear cell kidney cancer, all biopsy proven, all locally advanced disease, and gave them axitinib for a total of 12 weeks. (medscape.com)
  • Sleep apnea, chronic kidney disease, obesity, or renal artery stenosis are other causes of secondary hypertension. (msdmanuals.com)
Patients19
  • Acute renal failure in critically ill patients: a multinational, multicenter study. (scienceopen.com)
  • Prospective observational study of ICU patients who either were treated with renal replacement therapy (RRT) or fulfilled at least 1 of the predefined criteria for ARF from September 2000 to December 2001 at 54 hospitals in 23 countries. (scienceopen.com)
  • Serum HGF might be a diagnostic and prognostic indicator in clear cell RCC, especially for patients with grade 2 or high stage RCC. (tokushima-u.ac.jp)
  • Therefore, we investigated the effects of patients' sera on endothelia cells (ECs) in vitro. (mdpi.com)
  • There is an increased potential for developing corneal edema in patients with low endothelial cell counts. (nih.gov)
  • SIMBRINZA has not been specifically studied in patients with severe renal impairment (CrCl less than 30 mL/min). (nih.gov)
  • Eligible patients were required to have locally advanced or metastatic clear-cell RCC, ECOG performance status 0-2, and had to be intermediate or poor risk per the IMDC criteria (Heng, JCO, 2009). (businesswire.com)
  • As opposed to important hypertension, supplementary hypertension affects considerably fewer patients, grows at a youthful age, and it is associated with an identifiable trigger such as for example endocrine or renal disorder and oral contraceptive make use of. (eprf.ca)
  • Increased urinary angiotensin-converting enzyme 2 in renal transplant patients with diabetes. (ohri.ca)
  • The patients, commonly complicated with cardiovascular diseases and neurologic disorders, are at high risk to progress into end-stage renal disease (ESRD) and death. (hindawi.com)
  • Circulating Endothelial Progenitor Cell Levels Predict Cardiovascular Events in End-Stage Renal Disease Patients on Maintenance Hemodialysis. (stem-kine.com)
  • IFN and IL-10 were signi cantly elevated in patients with diabetic nephropathy (DN) and end-stage renal disease (ESRD) compared with controls and diabetic patients without DN. (who.int)
  • IL-10 (biomarqueurs de modi cations de l'état in ammatoire) et de biomarqueurs solubles sICAM-1 et sE-sélectine (biomarqueurs du dysfonctionnement endothélial) chez des patients diabétiques atteints et non atteints de néphropathie. (who.int)
  • Les IFN et les IL-10 étaient signi cativement élevés chez ceux qui présentaient une néphropathie diabétique (ND) et une maladie rénale en phase terminale (MRPT) par rapport aux témoins et aux patients diabétiques sans ND. (who.int)
  • T-cells have 2 subsets of betic patients with and without nephropathy. (who.int)
  • Th2 cells produce cy- patients which might reduce the morbidity tokine interleukins IL-4 and IL-10, which and mortality due to infection. (who.int)
  • stage renal disease (ESRD) [ 2 ] and with impaired immunity in HD patients [ 3 ]. (who.int)
  • Diabetic group ( n = 17): patients with in patients with chronic renal failure and type 2 diabetes without renal involve- under HD, and disturbances in endothelial ment (normoalbuminuria). (who.int)
  • Patients with systemic disorders, such as diabetes or renal failure, may develop CME from breakdown of the blood-retinal barrier primarily due to vascular compromise. (medscape.com)
Cytokines4
  • PCS (n = 17), PCS/CFS (n = 13), and healthy controls (HC, n = 14) were screened for serum anti-endothelial cell autoantibodies (AECAs) and dysregulated cytokines. (mdpi.com)
  • Furthermore, senescent cells, with the secretory features known as the senescence-associated secretory phenotype (SASP), could produce proinflammatory cytokines, such as tumor necrosis factor- α (TNF- α ), interleukin-6 (IL-6), and monocyte chemoattractant protein1 (MCP-1), to greatly affect the neighboring cells [ 17 , 18 ]. (hindawi.com)
  • introduced a new concept of CKD-associated secretory phenotype (CASP), which indicates that senescent renal cells could secrete SASP components of various cytokines such as IL-1, IL-6, and TNF- α [ 19 , 20 ]. (hindawi.com)
  • Alternatively, CME associated with uveitis or following cataract surgery is most likely caused by the cytokines released by activated inflammatory cells. (medscape.com)
Liver and renal1
  • Analysis of systemic effects showed minimal to no changes in liver or aorta transcriptomics, 58 analyzed plasma proteins, or liver and renal histopathology. (cdc.gov)
Epithelial2
  • In contrast to reports on the response of epithelial cells, in mRECs hyperosmolarity reduced the expression of S lc12a2 , which encodes a Na + -K + -Cl - cotransporter. (nature.com)
  • Human renal epithelial cells (HREpCs) (PromoCell) were cultured in renal epithelial cell growth medium-2 (PromoCell). (biomedcentral.com)
Medulla1
  • We observed the effect of ulinastatin in a septic rat model using contrast-enhanced ultrasonography (CEUS) to evaluate the perfusion of the renal cortex and medulla. (scienceopen.com)
Endothelium2
Capillary2
  • In addition to the typical quiescent arterial, capillary and venous endothelial cell phenotypes, we identified angiogenic RECs and interferon-activated RECs in healthy adult animals, raising questions about their potential functions in vascular regeneration and immune surveillance, respectively. (nature.com)
  • Prostaglandins can cause breakdown of the blood-retinal barrier, including vasodilation, increased capillary permeability from compromise of tight endothelial junctions in the retinal capillaries, and decreased removal of fluid by the retinal pigment epithelium (RPE). (medscape.com)
Changes in renal1
Phenotypes2
  • The renal vasculature comprises a wide range of specialized REC phenotypes and our previous work on endothelial cells showed that angiogenesis and cellular quiescence engage specific metabolic pathways," explains Carmeliet. (nature.com)
  • In addition, at 48H, BPs linked to inflammatory phenotypes were activated (confirming KEGG results), while BPs linked to extracellular matrix (ECM) structural organisation, endothelial cell proliferation, and collagen metabolism were repressed. (nature.com)
Diabetes4
  • Diabetic nephropathy (DN) is a leading selectin), and soluble thrombomodulin--are cause of chronic renal failure and is a grow- providing further evidence of the relation- ing concern given the increasing incidence ship between endothelial cell activation and of type 2 diabetes. (who.int)
  • The autoimmune nature of diabetes and inflammatory cytokine IL-10 (as markers the major contribution of lymphocyte T- of inflammatory changes) and the soluble cells are well established. (who.int)
  • Diabetes and retinal vein occlusion can both lead to CME by causing vascular instability directly (vascular endothelial cell damage). (medscape.com)
  • In diabetes, endothelial cells are damaged by advance glycosylation end-products. (medscape.com)
Macrophages1
Inflammation6
  • In older HIV-positive people with or at risk of cardiovascular disease, 24 weeks of low-dose methotrexate (LDMTX) reduced CD8-cell numbers and activation but did not quell other markers of inflammation or improve endothelial function [1]. (natap.org)
  • They hypothesized (1) that LDMTX would cause no more than a 15% increase in probability of "safety events" (including drops in CD4 count and virologic failure) compared with the background rate, and (2) that reducing inflammation would improve endothelial function assessed by flow-mediated vasodilation of the brachial artery. (natap.org)
  • Levels of CD8 cells, an inflammation indicator, fell significantly more with LDMTX than with placebo at weeks 8, 12, and 24 (-103 versus -2 cells, P = 0.001). (natap.org)
  • Here we determined whether leukocyte-derived microvesicles bear B1-kinin receptors during vasculitis, and if microvesicles transfer functional B1-receptors to recipient cells, thus promoting inflammation. (lu.se)
  • Browse the articles below for more information on circulating stem cells as they relate to longevity, inflammation, exercise, and more. (stem-kine.com)
  • Various pharmacologic studies have indicated that morroniside has therapeutic effects on diabetic angiopathies, renal damage, lipid metabolism and inflammation and bone resorption [ 1 - 4 ]. (ijpsonline.com)
Ischemia1
  • Furthermore, APC reduces the ischemia / reperfusion-induced renal injury and the stress-induced gastric mucosal injury in rats. (eurekaselect.com)
Basement membrane1
Capillaries2
Proliferation1
  • Recently I uncovered that ANKHD1 controls cell proliferation by directly binding to and modulating a subset of tumour-suppressor microRNAs (https://www.ncbi.nlm.nih.gov/pubmed/29695508). (sheffield.ac.uk)
Regulates2
  • Normally, activation of the CB 1 receptor regulates renal vascular hemodynamics and stimulates the transport of ions and proteins in different nephron compartments. (degruyter.com)
  • APC regulates the coagulation system by inactivating the activated form of factors V and VIII in the presence of protein S. Tumor necrosis factor-α(TNF-α) plays critical roles in the development of disseminated intravascular coagulation, acute respiratory distress syndrome and shock in sepsis by inducing endothelial cell damage through activation of neutrophils. (eurekaselect.com)
Acute1
  • Although acute renal failure (ARF) is believed to be common in the setting of critical illness and is associated with a high risk of death, little is known about its epidemiology and outcome or how these vary in different regions of the world. (scienceopen.com)
Tubular cells1
  • Other reports also show that DN is highly associated with accelerated aging in various types of cells such as tubular cells, podocytes, mesangial cells, and endothelial cells [ 21 - 23 ]. (hindawi.com)
Serum1
  • Serum from preeclamptic women, when applied to human umbilical vein endothelial cell cultures, produces no morphologic abnormalities in the cells but releases procoagulants, vasoconstrictors, and mitogens. (health.am)
Systemic2
  • Furthermore, periodontitis has been shown to be associated with systemic cardiovascular disease ( 5 - 7 ), which suggests its close association with vascular endothelial cells. (spandidos-publications.com)
  • Alport syndrome is a chromosome X-linked hereditary disease with systemic involvement, mainly affecting the renal, pulmonary, visual, and auditory systems. (hindawi.com)
Induces1
  • A series of caspases proteins have been shown to be activated by the death induced signal complex [a form of death ligand that binds to the corresponding death receptor on the cell surface ( 13 )], which in turn induces apoptosis. (spandidos-publications.com)
Hematologic1
  • Authors concluded LDMTX at 15mg/week was tolerated without hematologic/renal/hepatic side effects. (natap.org)
Inhibition1
  • APC reduces the pulmonary endothelial cell injury and hypotension in rats administered endotoxin (ET) by inhibiting TNF-α production through inhibition of its transcription. (eurekaselect.com)
Hepatic1
  • No studies were located in humans or animals regarding the effects on the respiratory, hematological, musculoskeletal, hepatic, renal, and dermal/ocular systems after inhalation exposure to thallium. (cdc.gov)
Filtration1
  • Cell adhesion and individual cell motility play a pivotal role in the establishment and maintenance of cell-to-cell contacts, polarity, and renal filtration. (biomedcentral.com)
Nitric2
Failure4
  • An autosomal truncating dominant mutation in this gene has also been associated with renal failure in the condition hypotrichosis-lymphedema-telangiectasia-renal defect syndrome (HLTRS). (wikipedia.org)
  • Diabetic nephropathy (DN) has been the leading cause of CKD and renal failure in developed countries. (hindawi.com)
  • however, the Black Creek Canal virus and the Bayou virus of the southeastern United States, as well as the Andes virus of South America, have been linked to renal failure and share some similarities with HFRS. (medscape.com)
  • found evidence and they did not require insulin therapy of endothelial cell injury in renal failure for glucose control. (who.int)
Adhesion molecule1
  • Vascular endothelial (VE)-cadherin is a strictly endothelial-specific adhesion molecule that can control the permeability of the blood vessel wall. (scienceopen.com)
Glucose3
  • Previous research showed that the gut microbiota metabolites-butyrate, reversed high glucose induced IL-1β release in mesangial cells. (diabetesjournals.org)
  • Our results showed that high glucose increased the protein level of GSDMD, GSDMD-N and cleaved-caspase-1, and induced the release of IL-1β and LDH, PI positive staining cells also increased synchronously. (diabetesjournals.org)
  • In vitro, the addition of OXPHOS inhibitors to a culture medium in which glucose was replaced with galactose to promote aerobic metabolism compromised the survival of human umbilical vein endothelial cells, but only under hyperosmolar conditions. (nature.com)
Human9
  • We analyzed the cellular consequences of hantavirus infection by measuring adhesion and migration capacity of human renal cells infected with Puumala (PUUV) or Hantaan (HTNV) virus. (biomedcentral.com)
  • However, the underlying mechanisms and effects of hantavirus infection on human renal cells have not been investigated so far. (biomedcentral.com)
  • To identify the consequences of hantavirus infection, we analyzed adhesion and motility capacity of human renal cells infected with hantaviruses PUUV or HTNV. (biomedcentral.com)
  • The human podocyte cell line was derived from human normal podocytes conditionally transformed with a temperature-sensitive mutant of the simian virus 40 (SV40) large T antigen. (biomedcentral.com)
  • However, the effects of NAC on LPS‑induced apoptosis of human umbilical vein endothelial cells (HUVECs) and the associated mechanisms are not well characterized. (spandidos-publications.com)
  • In a preclinical model of mouse xenografted with human renal cancer, we analysed the bio-distribution of a single dose (160 μg/kg) intravenously injected of poly-ethylene glycol (PEG)ylated gold nanoshells (~150 nm), in blood, normal and tumoral tissues. (springer.com)
  • In human renal cancer xenografts, ICP-MS showed an early decrease of gold, with 1-week stability before decrease at Day 15. (springer.com)
  • Figure 1: We use human ADPKD-derived cells which grow in three-dimensional organotypic cultures. (sheffield.ac.uk)
  • In recent studies, morroniside showed the protective actions against the cytotoxicity produced by exposure to H 2 O 2 in human SH-SY5Y cells [ 5 , 6 ]. (ijpsonline.com)
Hemorrhagic1
  • The clinical syndrome became known as hemorrhagic fever with renal syndrome (HFRS), formerly Korean hemorrhagic fever, and the virus was named Hanta after the Hantaan River of Korea. (medscape.com)
Thrombomodulin1
Pathogenesis1
  • It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. (cancerindex.org)
Cortex1
  • To further characterize this heterogeneity, the researchers applied single-cell RNA sequencing (scRNA-seq) to mRECs, as wells as RECs from the cortex and glomeruli, from both control mice under euhydration and mice deprived from drinking water for 12, 24, 36 and 48 hours. (nature.com)
Disease5
  • and it is a significant risk aspect for most common factors behind mortality and morbidity including heart stroke, myocardial infarction, congestive center failing, and end-stage renal disease in lots of segments of the populace (1). (eprf.ca)
  • The present case illustrates the reduction rate of urinary podocyte loss and proteinuria after amiloride administration and suggests the molecular pathways involved in Alport renal disease. (hindawi.com)
  • Nox and renal disease. (ohri.ca)
  • NADPH oxidase 5 and renal disease. (ohri.ca)
  • and (4) other chronic diseases such as occupational neurologic and renal disease. (cdc.gov)
Inflammatory3
  • These studies implicate the Duffy antigen/chemokine receptor in the complex interactions between postcapillary endothelial cells and granulocytes, which are modulated by pro-inflammatory chemokines. (jci.org)
  • Studies have shown that periodontitis is associated with altered expression of inflammatory mediators in gingival fibroblasts and periodontal membrane cells ( 3 , 4 ). (spandidos-publications.com)
  • These observations strongly suggest that APC might be involved not only in regulation of the coagulation system, but in regulation of inflammatory responses by preventing endothelial cell injury. (eurekaselect.com)
EPCs1
  • At 72 hours after reperfusion, renal function and morphology showed significant improvements in the EPCs-treated group. (annalsoftransplantation.com)
Injury3
  • The relatively new theory of endothelial injury explains many of the clinical findings in preeclampsia. (health.am)
  • Several findings suggest endothelial injury in preeclampsia. (health.am)
  • PTGER1 Deletion Attenuates Renal Injury in Diabetic MoModels. (ohri.ca)
Activate1
  • The abnormal perfusion stimulates the production of substances in the blood that activate or injure endothelial cells. (health.am)
Impairment3
  • However, the detailed mechanisms of renal impairment induced by hantaviruses are not well understood. (biomedcentral.com)
  • The direct impairment of migration capacity of renal cells by hantaviral N proteins may contribute substantially to proteinuria observed in the clinical picture of hantavirus infection. (biomedcentral.com)
  • Severe renal impairment may limit the metabolism of the brinzolamide component. (nih.gov)
Reduces1
  • In contrast, activation of the renal CB 2 receptors reduces the deleterious effects of these chronic diseases. (degruyter.com)
Kidneys1
Differentiation2
  • In the 1980's, Arnold Caplan and his colleagues published an isolation method of fibroblast-like stromal cells from bone marrow and first identified them as mesenchymal stem cells (MSCs) because of their multilineage differentiation potential ( Caplan, 1991 ). (frontiersin.org)
  • Such information is mediated immunity, secreting the cytokine crucial to determine the optimal approach interferon-gamma (IFN) that inhibits Th2 to improve the immune response of DN cell differentiation. (who.int)
Molecular1
  • Here we have examined the molecular properties of the renal isoform. (jci.org)