Renal cell line tumor. Medical search. Frequent questions

Clear cell renal cell carcinoma (CCRCC) is a renal cortical tumor typically characterized by malignant epithelial cells with clear cytoplasm and a compact-alveolar (nested) or acinar growth pattern interspersed with intricate, arborizing vasculature. (medscape.com)
Typical gross presentation of clear cell renal cell carcinoma (lower left) with golden color due to intracellular lipid accumulation. (medscape.com)
The renal tumors are frequently multifocal and/or bilateral and are always of the clear cell renal cell carcinoma (CCRCC) histologic type. (medscape.com)
Intratumoral heterogeneity, including in clear cell renal cell carcinoma, is a potential cause of drug resistance and metastatic cancer progression. (nih.gov)
We specified the heterogeneous population marked by endoglin (also known as CD105) in a preclinical model of clear cell renal cell carcinoma progression. (nih.gov)
Highly malignant derivatives of human clear cell renal cell carcinoma OS-RC-2 cells were established as OS5Ks by serial orthotopic inoculation in our previous study. (nih.gov)
In conclusion, the renal microenvironment, rather than the hypothesized ENG + cell-centered hierarchy, maintains cellular heterogeneity in clear cell renal cell carcinoma. (nih.gov)
Primary clear cell renal cell carcinoma (ccRCC) and the paired adjacent non-tumour tissues were then collected to examine the expression of CMTM4 by western blotting, immunohistochemistry, and quantitative RT-PCR. (biomedcentral.com)
This study is being performed as a single-arm open-label study in order to rapidly provide information on the potential benefits of the combination of pembrolizumab and lenvatinib in participants with previously untreated advanced/metastatic non-clear cell renal cell carcinoma. (survivornet.com)
Clear cell renal cell carcinoma are positive for CAIX (carbonic anhydrase IX), vimentin, CD10, and RCC antigen by immunohistochemistry. (renalandurologynews.com)
Treatment with the first-line combination of pembrolizumab and lenvatinib led to durable anti-tumor activity in patients with non-clear cell renal cell carcinoma. (urologytimes.com)
Metastatic clear cell renal cell carcinoma is a disease without a comprehensive animal model for thorough preclinical investigation. (jove.com)
Clear cell renal cell carcinoma or CCRCC, is the most common subtype of kidney cancer. (jove.com)
Aims: Our main aim in this thesis is to develop chronic peritoneal dialysis (PD) in anuric rodents, to better understand the pharmacokinetic properties of orellanine and to evaluate orellanine as an experimental treatment against metastasized clear cell renal cell carcinoma (ccRCC). (gu.se)
Go to Clear Cell Renal Cell Carcinoma and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)
Context While vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibition are effective strategies in treating clear cell renal cell carcinoma (ccRCC), the most effective therapeutic approach for patients with non-clear cell RCC (non-ccRCC) is unknown. (lu.se)

Abstracts BackgroundClear cell renal cell carcinoma (ccRCC) cell lines with distinct metastatic potential are crucial to study the mechanism of ccRCC metastasis. (biopaqc.com)
ResultsTwo successive cell lines named NRCC from the primary ccRCC and MRCC from the metastatic ccRCC were established respectively. (biopaqc.com)
ConclusionsCancer cells isolated from metastatic ccRCC have more malignant and metastatic potential than those from the primary tumor from the patients who shared the similar race background. (biopaqc.com)
Desk 2 Tumorigenicity and metastasis of both cell lines pursuing orthotopic transplantation in nude mice Debate In this research we successfully set up two ccRCC cell lines from two Chinese language sufferers with ccRCC. (biopaqc.com)
Tumors in which eosinophilic cells predominate were previously classified as "granular cell" carcinoma but are currently included among CCRCCs in the 2004 World Health Organization classification of renal tumors based on the presence of vasculature and genetic alterations typical of CCRCC. (medscape.com)
[ 10 ] Some tumors previously diagnosed as CCRCC in younger patients may in fact represent the Xp11 translocation tumor type, which has recently been analyzed. (medscape.com)
The ccRCC cell lines A498 and 786-O and the normal renal tubular epithelial cell line HK-2 were also tested for CMTM4 expression by western blotting. (biomedcentral.com)
Western blotting then confirmed that CMTM4 was dramatically reduced in 86.9 % (53/61) of ccRCC tissues compared with the paired adjacent non-tumour tissues, as well as in the 786-O and A498 ccRCC cell lines. (biomedcentral.com)
CMTM4 is downregulated and exhibits tumour-suppressor activities in ccRCC, and could be exploited as a target for ccRCC treatment. (biomedcentral.com)
Clear cell RCC (ccRCC) is the most common subtype among the malignant RCCs, accounting for 70-80%, followed by papillary (15%), chromophobe (4-5%), and other fewer subtypes[ 2 ]. (medsci.org)
In this mouse model, heterogeneous CCRCC is implanted to the renal capsule of the mouse. (jove.com)
The third paper had two parts: an in vitro part examining the effect of orellanine on HTEC, epithelial cells, ccRCC cells, and other cancer cell lines, and an in vivo part with a xenograft rat model testing the effect of orellanine on metastasized ccRCC tumors. (gu.se)
Orellanine induced necrosis, apoptosis, and disruption of cellular functions and growth on HTEC and ccRCC cells while having no significant effect on other tested cell lines at the same doses. (gu.se)
There are three main histological subtypes of RCC, including clear cell RCC (ccRCC), papillary RCC, and chromophobe RCC, which jointly represent over 85% of all primary renal malignancies [ 3 ]. (biomedcentral.com)

Clear cell RCC is the most common histologic subtype of malignant tumors of the kidney. (renalandurologynews.com)
research shows that about 90% of the blood system of malignant tumors with at least the height of single gene methylation is closely related since this is a reversible process of genetic modification can be through to handle to restore the normal expression of gene methylation, to achieve the purpose of prevention and treatment of tumor [ 10 ]. (hindawi.com)
Von Hippel-Lindau Disease (VHL) Von Hippel-Lindau disease is a rare hereditary neurocutaneous disorder characterized by benign and malignant tumors in multiple organs. (msdmanuals.com)

The European Commission's approval of KEYTRUDA plus chemotherapy for the treatment of certain patients with esophageal and HER2-negative GEJ cancer provides a new option in the first-line setting that has shown significant improvements in progression-free and overall survival. (merck.com)
Although endoglin has been proposed as a marker for renal cancer-initiating cells, the OS5K-3 ENG + population did not enrich other reported cancer-initiating cell markers or differentiate into the ENG - population. (nih.gov)
Therefore, the effect of the microenvironment should be considered when evaluating the proliferative capability of renal cancer cells in the experimental settings. (nih.gov)
The mechanism by which α -TOS kills cancer cells is not completely understood. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
The antitumorigenic function of ASC/TMS1 in renal cancer was partially regulated by activation of p53 and p21 signaling. (oncotarget.com)
The review highlights the discovery of oncogenes and suppressor tumor genes, underlining the crucial role of these achievements in cancer diagnosis and therapies. (jcancer.org)
Cancer has been in existence on Earth even before the appearance of man, as evidenced by paleontological findings of tumors in animals ( 1 , 2 ). (jcancer.org)
In this study, by comparing the activity of normal cell lines and cancer cell lines after treating with resveratrol, it was found that resveratrol has more significant cytotoxicity in cancer cell lines. (mdpi.com)
Resveratrol could play a toxic role through inducing apoptosis of the cancer cell in a time- and concentration-dependent manner. (mdpi.com)
Moffitt Cancer Center continues to distinguish itself as a world leader in the development of novel immunotherapy treatments, capitalizing on the natural power of the body's immune system to defend itself against the growth and spread of cancerous cells. (moffitt.org)
Immunotherapies include checkpoint inhibitory antibodies, chimeric antigen receptor (CAR) T-cells, cancer vaccines, and oncolytic viruses. (moffitt.org)
Now researchers at Moffitt are working to develop a dendritic cell vaccine targeting HER3, a protein involved in the growth and spread of many different cancer types. (moffitt.org)
Dendritic cell vaccines can potentially be used to treat different cancer types. (moffitt.org)
Dr. Jad Chahoud , a medical oncologist in the Department of Genitourinary Oncology at Moffitt Cancer Center, is conducting a study on dendritic cells for kidney cancer. (moffitt.org)
Endometrial carcinoma begins in the inner lining of the uterus, which is known as the endometrium, and is the most common type of cancer in the uterus. (businesswire.com)
The decision was made in consultation with the FDA following the April 29 Oncologic Drugs Advisory Committee evaluation of this third-line gastric cancer indication for KEYTRUDA as a monotherapy because it failed to meet its post-marketing requirement of demonstrating an overall survival benefit in a Phase 3 study. (merck.com)
Patients being treated with KEYTRUDA for metastatic gastric cancer in the third- or further-line setting should discuss their care with their health care provider. (merck.com)
Merck's clinical program in gastric cancer includes the first-line Phase 3 studies KEYNOTE-811, KEYNOTE-859 and LEAP-015, as well as KEYNOTE-585 in the neoadjuvant and adjuvant treatment setting. (merck.com)
High and specific binding of 68 Ga-BMS-986192 to human PD-L1-expressing cancer cells was confirmed, which closely correlates with the respective PD-L1 expression level determined by flow cytometry and immunohistochemistry staining. (snmjournals.org)
Whether it be in our multidisciplinary clinic or a discussion in our tumor board conference, our kidney cancer providers recognize care is not delivered in a vacuum and work together to offer the best approach to your care. (uclahealth.org)
Ninety percent of all kidney cancer is renal cell carcinoma. (uclahealth.org)
5%) form of kidney cancer that begins in the urinary drainage/collecting system (renal pelvis and ureter) instead of the kidney itself. (uclahealth.org)
Therapies that stimulate the body's immune system to attack cancer cells. (uclahealth.org)
When a patient has chronic abdominal pain, bowel changes, reflux, unexplained vomiting, constipation, diarrhea, blood in the stool or cancer or tumors, a physician may request examination of the upper or lower gastrointestinal tract. (radnet.com)
Even though developed for AML patients, our pan-cancer analyses demonstrate a wider application of the IPRP signature for prognostic prediction and analysis of tumor-immune interplay also in multiple solid tumors. (nature.com)
FF-10832 is a liposomal formulation which encapsulates gemcitabine* 1 , an approved anti-cancer agent indicated for the treatment of a variety of solid tumors. (fujifilm.com)
The primary focus of the trial is to establish the safety and tolerability of FF-10832 in combination with KEYTRUDA in patients with advanced solid tumors, and evaluate its preliminary efficacy in non-small cell lung cancer (NSCLC)* 2 and urothelial cancer (UC)* 3 patients who have progressed after standard therapy, including immune checkpoint inhibitor therapy. (fujifilm.com)
2: Cancer of the lung which is not of the small cell carcinoma type. (fujifilm.com)
3: Cancer that begins in urothelial cells that line the urethra, bladder, ureters, renal pelvis, and other related organs. (fujifilm.com)
Anti-CTLA-4 and anti-PD-1 antibodies are immune checkpoint inhibitors that block proteins like CTLA-4 and PD-1 from binding with their partners, preventing the "off" signal to be sent and ultimately allowing for the activation of immune cells that can now recognize and attack cancer cells. (fujifilm.com)
6: A subtype of T cells of the immune system that attack aberrant cells, such as cancer cells, infected cells (particularly with viruses), or cells that are damaged in another way. (fujifilm.com)
cancer in the organs and ducts that make and store bile, the liquid made by the liver), renal cell carcinoma (RCC, a type of cancer that begins in the kidneys), breast cancer, and certain other solid tumors. (medlineplus.gov)
It works by helping your immune system to slow or stop the growth of cancer cells. (medlineplus.gov)
In the present study, we demonstrated significantly miRNA-187 down-regulation in cervical cancer tissues and cell lines compared to their normal counterparts. (oncotarget.com)
Gain- and loss-of-function studies showed that miRNA-187 suppressed cervical cancer cell proliferation, migration, and invasion, and promoted cervical cancer cell apoptosis. (oncotarget.com)
Exposure of cancer cells to chemotherapeutic agents may result in reduced sensitivity to structurally unrelated agents, a phenomenon known as multidrug resistance, MDR. (biomedcentral.com)
The purpose of this study is to investigate cell growth inhibition of wild type and the corresponding MDR cells by Tumor Treating Fields - TTFields, a new cancer treatment modality that is free of systemic toxicity. (biomedcentral.com)
human breast cancer cells MCF-7 and their mitoxantrone-resistant sub lines MCF-7/Mx and human breast cancer cells MDA-MB-231 and their doxorubicin resistant MDA-MB-231/Dox cells. (biomedcentral.com)
Multidrug resistance (MDR) [ 1 ] is encountered when cancer cells are exposed to chemotherapeutic agents for a few replication cycles. (biomedcentral.com)
Three decades of multidrug resistance research have identified a number of mechanisms by means of which cancer cells elude the effects of chemotherapeutic agents. (biomedcentral.com)
Seven compounds inhibited the growth of some cancer cell lines, whereas one of the 2-quinoline derivatives displayed favorable activity against all tested cancer cells with GI 50 values of 0.92-13 μM. (springer.com)
Previous studies have implicated V-ATPases in human cancer cell invasion. (tufts.edu)
Prior work from our laboratory comparing a subunit expression in human breast cancer cell lines has shown that both a3 and a4 are highly expressed in highly invasive MDA-MB231 cells compared to poorly invasive MCF7 cells and that knockdown of either isoform using isoform-specific siRNAs significantly inhibits invasion of MDA-MB231 cells. (tufts.edu)
To determine whether expression of V-ATPases at the plasma membrane is important in breast cancer cell invasion, we have employed an inhibitory antibody that selectively blocks plasma membrane V-ATPase activity. (tufts.edu)
Renal cell carcinoma (see the image below) is the most common type of kidney cancer in adults. (medscape.com)
Renal cancer occurs in a sporadic (nonhereditary) and a hereditary form, and both forms are associated with structural alterations of the short arm of chromosome 3 (3p). (medscape.com)
Genetic studies of the families at high risk for developing renal cancer led to the cloning of genes whose alteration results in tumor formation. (medscape.com)
Renal cell carcinoma (RCC) is the most common renal cancer. (msdmanuals.com)
Wilms Tumor Wilms tumor is an embryonal cancer of the kidney composed of blastemal, stromal, and epithelial elements. (msdmanuals.com)
Purpose Treating solid tumors with cancer immunotherapy (CIT) can result in unconventional responses and overall survival (OS) benefits that are not adequately captured by Response Evaluation Criteria In Solid Tumors (RECIST) v1.1. (medscape.com)
Patients and Methods Atezolizumab data from clinical trials in non-small-cell lung cancer, metastatic urothelial carcinoma, renal cell carcinoma, and melanoma were evaluated. (medscape.com)
Patient summary We examined the literature to determine the most effective treatments for advanced kidney cancer patients whose tumors are not of the clear cell subtype. (lu.se)
Major emphasis is placed is involved in identifying molecular molecular events and pathways that on discerning events that precede or biomarkers of exposure and cancer underpin carcinogenesis, thereby elu- drive tumour initiation and progression risk. (who.int)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
In the present study, the effects of extracellular ENO1 on glycolysis and other related pro-cancer activities were investigated in multiple myeloma (MM) cells in vitro and in vivo. (bvsalud.org)
Notably, addition of extracellular ENO1 protein in cancer cell culture enhanced glycolytic activity, hypoxia-inducible factor 1-α (HIF-1α) expression, glycolysis-related gene (GRG) expression and pro-cancer activities, such as cell migration, cell viability and tumor-promoting cytokine secretion. (bvsalud.org)

Even though microenvironment plays an important role in evolutionary process of the metastatic cells from their main tumors the selected metastatic malignancy cells maintain their characteristics following long-term cultures. (biopaqc.com)
Mouse tumor inoculation models revealed that the tumor-forming capabilities of OS5K-3 ENG + and ENG - cells in vivo were highly dependent on the microenvironment, with the renal microenvironment most preferable to ENG + cells. (nih.gov)
tumor microenvironment. (nih.gov)
Our results revealed that iPSC-derived RPCs can protect AKI rat from renal function impairment and severe tubular injury by up-regulating the renal tubules formation, promoting cell proliferation, reducing apoptosis, and regulating the microenvironment in the injured kidney. (biomedcentral.com)
The recently described role of the Wnt/β-catenin pathway in the regulation of immune cell infiltration of microenvironment tumor resumes interest because of its potential impact to rection of immune therapy. (chemdiv.com)

Affected individuals are susceptible to tumors of multiple organ systems, including cysts and tumors of the kidney, which occur in 25-45% of cases with a mean age at onset of 40 years. (medscape.com)
Cell-based therapy with mesenchymal stem cells or renal progenitor cells (RPCs) resident in the kidney has appeared to be an effective strategy for the treatment of AKI. (biomedcentral.com)
Acute kidney injury (AKI) is characterized by acute tubular injury and a rapid decline in renal function [ 1 ]. (biomedcentral.com)
In response to acute injury, the adult kidney shows some level of regeneration characterized by the proliferation of the surviving cells and the replacement of the necrotic tubular cells with functional tubular epithelium [ 3 ]. (biomedcentral.com)
However, progenitor cells in the adult kidney are rare, which limits the application of these cells. (biomedcentral.com)
On the other hand, the failure of radiation to control RCC in the curative or adjuvant setting may have more to do with the tolerance of neighboring structures to the kidney than intrinsic tumor resistance. (cancernetwork.com)
Orellanine is a fungal nephrotoxin selectively toxic to the human tubular epithelial cells (HTEC) of the kidney nephrons leading to kidney failure. (gu.se)
Renal cell carcinoma (RCC) originates from either the cancerous renal cortex or renal tubular epithelial cells, and is the second most lethal urological malignancy, accounting for 90-95% of kidney neoplasms. (biomedcentral.com)
Renal cell carcinoma (RCC) accounts for approximately 3% of adult malignancies and 90-95% of neoplasms arising from the kidney. (medscape.com)

In general the expression of the most genes at 24?h culture wasn't significant different between MRCC and NRCC cells except that this expression of was significantly higher in MRCC cells than in NRCC cells (and was not significantly different between MRCC and NRCC cells. (biopaqc.com)
Genes to Cells. (wikipedia.org)
CMTM4 is a member of this family and is located at chromosome 16q22.1, a locus that harbours a number of tumour suppressor genes. (biomedcentral.com)
Additional screens for MMTV provirus entry sites in tumors revealed several other upregulated genes that are associated with other gene development pathways such as INT2, INT3, and INT4 [4,5,6]. (chemdiv.com)
It is believed that the occurrence of leukemia is the result of genetic and epigenetic changes in protooncogene and tumor suppressor genes [ 8 ]. (hindawi.com)
The tumor suppressor genes are inactivated, and the oncogenes are dominant during the formation of the tumor [ 9 ]. (hindawi.com)
These genes are either tumor suppressors ( VHL , TSC ) or oncogenes ( MET ). (medscape.com)

In this MEDtalk, medical oncologist Laurence Albiges presents a phase 3 trial investigating potential benefits of using triplets in frontline therapy for patients with previously untreated advanced renal-cell carcinoma. (bpno.no)

Metastatic renal cell carcinoma (mRCC) accounts for one-third of all newly diagnosed renal cell cancers. (mdpi.com)
Sphingolipids are modified in multiple cancers and are responsible for tumor proliferation, progression, and metastasis. (frontiersin.org)
Renal cell carcinoma is one of the most common cancers in the urinary system, causing over 140,000 deaths worldwide each year[ 1 ]. (medsci.org)
Importance: The protein p53 is an unequivocal tumor suppressor that is altered in half of all cancers. (stanford.edu)
Fujifilm is focused on the development of liposomes/LNPs to meet unmet medical needs, including hard-to-treat cancers such as advanced solid tumors," said Junji Okada, general manager of pharmaceutical products division, FUJIFILM Corporation. (fujifilm.com)
Increasingly, renal cell cancers are diagnosed at an earlier stage, and nephron-sparing surgery and thermal ablation are gaining acceptance as a treatment of choice for smaller tumors. (medscape.com)

Great hope has been given to micronutrients as anticancer agents, since they present natural compounds with beneficial effects for normal cells and tissues. (nature.com)
A significant downregulation was also detected in sixty-seven paired renal tumors compared with adjacent non-cancerous tissues. (oncotarget.com)
Moreover, ASC/TMS1 hypermethylation was further detected in 41.1% (83/202) of RCC tumors, but only 12% in adjacent non-cancerous tissues. (oncotarget.com)
In vivo, 68 Ga-BMS-986192 uptake was high at 1 h after injection in PD-L1-positive tumors (9.0 ± 2.1 percentage injected dose [%ID]/g) and kidneys (56.9 ± 9.2 %ID/g), with negligible uptake in other tissues. (snmjournals.org)
The transplantation of iPSC-derived RPCs decreased the levels of biomarkers indicative of renal injury and attenuated the necrosis and apoptosis of renal tissues, but resulted in the up-regulation of renal tubules formation, cell proliferation, and the expression of pro-renal factors. (biomedcentral.com)
Moreover, the expression of C1QBP and XDH was lower in RCC tumors compared with the tumor-associated normal tissues, and their down-regulation was associated with higher Fuhrman grade. (medsci.org)
Targeted' therapy starts with the discovery of a protein that is expressed on the surface of tumor cells but not (or in a limited way) in normal human tissues. (sarcomahelp.org)

The effects of CMTM4 on cellular apoptosis and cell cycle progression were analysed by flow cytometry, and cell cycle hallmarks were detected by western blotting and RT-PCR. (biomedcentral.com)
Mechanistically, protein profiling through mass spectroscopy revealed that K+CS uniquely affects the cellular pathways of DNA damage repair, DNA synthesis and cell cycle progression. (confex.com)
In vivo , orthotopic tumor xenografts assay was performed to investigate the role of C1QBP in RCC progression. (medsci.org)
Hypoxia is considered a critical contributor to renal cell carcinoma progression, including invasion and metastasis. (biomedcentral.com)

Randomization was stratified by tumor histology (squamous cell carcinoma vs. adenocarcinoma), geographic region (Asia vs. ex-Asia), and Eastern Cooperative Oncology Group (ECOG) performance status (PS) (0 vs. 1). (merck.com)
The most common types of NSCLC are adenocarcinoma, squamous cell carcinoma, and large cell undifferentiated carcinoma. (fujifilm.com)

They're injecting HER2 pulsed dendritic cells (MCC 20915) made from the patient back into their breast tumor before chemotherapy. (moffitt.org)
Nussе and Varmus identified components of the Wnt/β-catenin pathway in 1982 in a study of oncogenic breast tumor viral diseases (MMTV) [1]. (chemdiv.com)
Function of Plasma Membrane V-ATPases in Breast Tumor Cell Invasion. (tufts.edu)
To further examine whether expression of particular a subunit isoforms is critical to invasiveness of breast tumor cells, two closely related cell lines have been examined. (tufts.edu)
These studies suggest that human breast tumor cells employ particular a subunit isoforms to target V-ATPases to the plasma membrane, where they aid in tumor cell invasion. (tufts.edu)

Sphingolipids are an extensive class of lipids with different functions in the cell, ranging from proliferation to cell death. (frontiersin.org)
These specially tuned fields have no effect on quiescent cells while having an anti-proliferation and destructive effect on mitotic cells. (biomedcentral.com)
Finally, we studied the effects of arsenide trioxide and 5-azacitidine on the proliferation of leukemia cells and the TGF- β signaling pathway. (hindawi.com)
At the same time, arsenide trioxide and 5-azacitidine are associated with the inhibition of cellular proliferation of acute leukemia cells and also promote the elevated expression of TGF- β signaling pathway-linked proteins, including TGF- β , Smad2, Smad3, and Smad4. (hindawi.com)

CMN-001 is indicated for the treatment of intermediate/poor-risk patients with advanced renal cell carcinoma (RCC) in combination with nivolumab plus ipilimumab as first-line therapy and in combination with lenvatinib plus everolimus as 2nd line therapy post-first-line failure. (moffitt.org)
Darmstadt, Germany and New York, US, May 14, 2019 - Merck KGaA, Darmstadt, Germany, which operates its biopharmaceutical business as EMD Serono in the US and Canada, and Pfizer Inc. (NYSE: PFE) today announced that the US Food and Drug Administration (FDA) has approved BAVENCIO® (avelumab) in combination with INLYTA® (axitinib) for the first-line treatment of patients with advanced renal cell carcinoma (RCC). (pfizer.com)

The diagnostic procedures performed were a complete blood count (CBC), serum chemistry, routine blood films, a bone marrow biopsy, radiographs, immunocytochemistry to type the leukemic cell line, magnetic resonance imaging (MRI), and computed tomography (CT). (vin.com)
Objective: This systemic review and meta-analysis focuses on the prognostic value of p53 Abs expressed in the serum of patients with solid tumors. (stanford.edu)
Renal function indexes, serum inflammatory factors, and tumor markers were evaluated. (biomedcentral.com)
Nursing based on oxygen administration decreased the value of renal function indexes, serum inflammatory factors, and tumor markers in renal cell carcinoma patients. (biomedcentral.com)
Many studies are using a combination of ultrasound, serum CA125 testing, and other tumor markers. (medscape.com)
Lastly, administration of an ENO1 mAb reduced tumor growth and serum lactate levels in an MM xenograft model. (bvsalud.org)

Kaempferol has been shown to inhibit cell growth, induce apoptosis and cell cycle arrest in several tumors, but not in renal cell carcinoma (RCC). (nih.gov)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
By using cell lines belonging to different hematologic malignancies and solid tumors, we demonstrated ex vivo that the combination of KPT-330 and CS (K+CS) could induce unique and significant antitumor effect at much lower dose of KPT-330 (at 25% of the dose used in the clinic), thereby potentially mitigating prohibitive clinical AEs (Figure 1a-d, and e-g) . (confex.com)
Hypoxia was found to induce A498 cell invasion, migration, and the release of inflammatory cytokines, while repressing human solute carrier family 14 member 1 gene expression. (biomedcentral.com)

KEYTRUDA plus chemotherapy is the first anti-PD1 therapy approved in Europe in this first-line setting, allowing these patients to be treated with immunotherapy earlier in the course of their treatment," said Dr. Scot Ebbinghaus, vice president, clinical research, Merck Research Laboratories. (merck.com)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
The clinical manifestations include the development of clear cell RCC, pheochromocytomas, retinal angiomas, and central nervous system hemangioblastomas. (renalandurologynews.com)
Clear cell RCC is known to have an aggressive course, but one variant recognized by the WHO 2004 classification-multilocular cystic RCC-has an indolent course with a favorable clinical outcome. (renalandurologynews.com)
In the past decade, many clinical trials have been investigating anti-CTLA-4 as well as anti-programmed cell death protein 1 (PD-1) therapies in various solid tumors, including HCC. (stanford.edu)
Compared with solid tumor sampling, the bone marrow or peripheral blood of leukemia patients is easier to access, and therefore an accurate and practical prognostic signature for leukemia patients has potential for more direct clinical application. (nature.com)
Subject to the outcome of clinical studies of specific liposome-drug combinations, including the clinical phase 2a study, liposomes are believed to be capable of delivering active ingredients to tumor sites. (fujifilm.com)
Next, we used methylation-specific polymerase chain reaction (MSP) technology for detecting the methylation of GRHL2 in clinical samples with acute leukemia and cell lines. (hindawi.com)
These data reveal that nursing based on oxygen administration can improve the clinical efficacy of renal cell carcinoma therapies, being safe and effective. (biomedcentral.com)
The treatment for renal parenchymal tumors has changed over time, and this trend continues today as a result of technological progress made with clinical research and improved diagnostic and therapeutic tools. (biomedcentral.com)
In recent years, clinical trials have established targeted therapy as the first-line treatment in patients with metastatic disease. (medscape.com)
Response Evaluation Criteria In Solid Tumors (RECIST) v1.1 end points, originally developed to evaluate the benefit of chemotherapeutic and targeted agents, are accepted measures of clinical efficacy in advanced solid malignancies. (medscape.com)

This report details the diagnosis of lymphoblastic leukemia with suspected B-cell differentiation in a diamondback terrapin ( Malaclemys terrapin ). (vin.com)
Sphingolipids are remarkably diverse and have crucial roles in maintaining barrier function and fluidity, as well as regulating the cell cycle, cell motility, differentiation, adhesion, and apoptosis ( 1 ). (frontiersin.org)
In this study, we induced iPSCs differentiation into RPCs using a nephrogenic cocktail of factors combined with the renal epithelial cell growth medium. (biomedcentral.com)
We showed that the differentiation efficiency of iPSCs to RPCs increased when cultured with renal epithelial cell growth medium after stimulation with a nephrogenic cocktail of factors. (biomedcentral.com)
Stem cells, including embryonic stem cells (ESCs) and adult stem cells, have the potential of self-renewal and differentiation into multiple cell types and therefore hold great promise in regenerative medicine [ 11 - 13 ]. (biomedcentral.com)
Induced pluripotent stem cells (iPSCs) are a type of newly defined stem cell with properties similar to those of ESCs in terms of self-renewal and differentiation. (biomedcentral.com)
It is involved in cell differentiation, maintenance of cell differentiation state, tumorigenesis, and cell senescence, mainly through DNA methylation, histone acetylation, and RNA-related silencing [ 6 ]. (hindawi.com)
Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)

Contrast-enhanced ultrasound evaluation is a safe alternative imaging modality for the assessment of complex cystic renal masses in patients with renal impairment. (radiologykey.com)
Patients with moderate or severe renal impairment require dose interval adjustment of lamivudine and tenofovir disoproxil that cannot be achieved with the combination tablet (see sections 4.4 and 5.2). (who.int)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)

No lung metastasis was detected following the first round of surgical orthotopic implantation (SOI) with MRCC and NRCC tumors. (biopaqc.com)
Furthermore the metastasis to lymph nodes near ventral aorta and hemorrhagic ascites had been often noticeable in the SOI mice transplanted with MRCC tumors. (biopaqc.com)
However metastasis had not been observed on the initial three rounds from the transplantation with NRCC cells. (biopaqc.com)
Due to the insidious identity of HCC, the majority of the patients are diagnosed at advanced stages, where tumor spreading, or distant metastasis unfortunately have already occurred. (stanford.edu)
Tumor growth and the metastasis are asset after 10 weeks. (jove.com)

Whole-body PD-L1 expression PET imaging may potentially allow for a better prediction of response to programmed cell death protein-1-targeted therapies. (snmjournals.org)
Although pharmacological therapy, modern dialysis techniques, and intermittent or continuous renal replacement therapies exist, the therapeutic approaches for AKI remain very limited. (biomedcentral.com)
This means that when a tumor can not be completely resected, or when a tumor has already metastasized, that there are no targeted therapies that specifically will attack the leiomyosarcoma cells. (sarcomahelp.org)
In this two-year study, Dr. van de Rijn and Santosh Gupta, PhD aim to determine whether three proteins that are expressed at various levels in LMS tumors can be used as targets for novel therapies. (sarcomahelp.org)
Previous studies have shown that such a collaboration between two therapies can have a dramatic improvement in outcome in tumor model systems. (sarcomahelp.org)

However, the role of C1QBP in metabolism, oxidative stress, and apoptosis of renal cell carcinoma (RCC) cells have not yet been explored. (medsci.org)

We discovered that salicylates could markedly enhance the anti-tumor activity of CRM1 inhibitors by extending the mechanisms of action beyond CRM1 inhibition. (confex.com)

Overexpression of CMTM4 also markedly inhibited the tumour xenograft growth in nude mice. (biomedcentral.com)
Nude rats bearing the LC-6 JCK tumor xenograft (LC-6 rats) exhibited high bone turnover and HHM. (unboundmedicine.com)

This histology accounts for 75% of renal masses that are evaluated. (renalandurologynews.com)
Next, we examined the renal function-related markers and renal histology to assess the therapeutic effect of the injected cells. (biomedcentral.com)

William Kaelin, Jr. was in 1995 engaged in the study of the von Hippel-Lindau tumor suppressor gene, and after isolation of the first full-length clone of the gene showed that it could suppress tumor growth in VHL mutant tumorigenic cell lines. (nobelprize.org)
Through careful study of the cytogenetics of VHL patients, the gene at this locus was found to be a tumor suppressor gene associated with familial clear cell carcinomas as well as a large majority of sporadic RCC. (renalandurologynews.com)

Using the increase from the cycles from the transplantation with MRCC the length of time of orthotopic LY450108 tumor development to about 10?mm in size became shorter as well as the incidences of hemorrhagic ascites and cachexy became higher (Desk?2). (biopaqc.com)
Orthotopic transplantation of NRCC generated tumor in every mice also. (biopaqc.com)

Clear cell RCC is associated with von Hippel-Lindau (VHL) disease. (renalandurologynews.com)

KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2, thereby activating T lymphocytes which may affect both tumor cells and healthy cells. (merck.com)

5 The BLA.36 antigen is known to stain a subset of B-cells in humans and has been shown to stain cells in many mammals which correspond to CD79a positive cells, a component of the B-cell receptor. (vin.com)
Results of immunocytochemical staining revealed that the neoplastic cells were positive for the BLA.36 antigen, demonstrating a 3-4+ membrane stain. (vin.com)
The neoplastic cells were negative for CD3 antigen, although few circulating small well-differentiated lymphocytes were positive for this marker. (vin.com)
This CMN-001 is an autologous, tumor antigen-loaded dendritic cell immunotherapy. (moffitt.org)
Upper and lower digestive tract endoscopic examination and carcinoembryonic antigen showed no abnormalities, which lessened the likelihood of a tumor relapse. (cdc.gov)
205. Prior chimeric antigen receptor therapy or other genetically modified T cell therapy 206. (who.int)

The investigation of this and other pathways in the HIF-1 cascade has led to a better understanding of the pathophysiology of RCC and the development of inhibitors of these pathways that have shown promise in the treatment of clear cell RCC. (renalandurologynews.com)
Preclinical studies have demonstrated that the combination* 5 of FF-10832 and immune checkpoint inhibitors impact CD8-positive T cells* 6 and may lead to longer survival compared to monotherapy* 7 . (fujifilm.com)

This study investigated the epigenetic alteration and biological function of the pro-apoptotic gene ASC/TMS1 in renal cell carcinoma. (oncotarget.com)
Animal cells undergo fundamental shifts in gene expression when there are changes in the oxygen levels around them. (nobelprize.org)
These changes in gene expression alter cell metabolism, tissue re-modeling, and even organismal responses such as increases in heart rate and ventilation. (nobelprize.org)
Through the combined work of these three laureates it was thus demonstrated that the response by gene expression to changes in oxygen is directly coupled to oxygen levels in the animal cell, allowing immediate cellular responses to occur to oxygenation through the action of the HIF transcription factor. (nobelprize.org)
Overexpression of the solute carrier family 14 member 1 gene could abolish hypoxia-induced invasion, reduce the migration of A498 cells, inhibit the hypoxia-induced release of inflammatory cytokines, and arrest the cell cycle at the G1/S checkpoint. (biomedcentral.com)
The results elucidate a mechanism wherein the solute carrier family 14 member 1 gene participates in the occurrence and development of hypoxia-induced renal cell carcinoma in a mitochondria-dependent manner. (biomedcentral.com)

Conclusions: Orellanine selectively causes renal failure, which is irreversible at high doses. (gu.se)

Must have a histologically-confirmed diagnosis of non-clear cell RCC. (survivornet.com)
The hallmark for a multilocular cystic RCC diagnosis is the presence of small nests of clear cells within the cyst wall. (renalandurologynews.com)

These tumors are rare, and many different subtypes of sarcomas exist. (sarcomahelp.org)
Determination of subtypes of cystic renal cell carcinomas by imaging is still challenging due to overlap of common imaging features. (radiologykey.com)

KEYTRUDA is indicated under accelerated approval in combination with trastuzumab, fluoropyrimidine- and platinum-containing chemotherapy, for the first-line treatment of patients with locally advanced unresectable or metastatic HER2-positive gastric or GEJ adenocarcinoma. (merck.com)
In conventional chemotherapy, a toxic compound is used that attacks tumor cells. (sarcomahelp.org)
Unfortunately, the traditional treatment methods of chemotherapy and radiotherapy have proven to be ineffective and lead to multidrug resistance in target cells. (biomedcentral.com)
Chemotherapy is used only occasionally, in certain tumor types. (medscape.com)

It is a phase 2b randomized trial of autologous dendritic cell immunotherapy (CMN-001) plus standard treatment for advanced renal cell carcinoma after a nephrectomy ( MCC 21083 ). (moffitt.org)

MCF10a is a non-invasive, immortalized, human breast epithelial cell line and MCF10CA1a is a highly invasive, H-Ras-transformed derivative of the MCF10a cell line that has been selected for its ability to form metastases in mice. (tufts.edu)

TOKYO―FUJIFILM Corporation (President and CEO, Representative Director: Teiichi Goto) today announced that it has begun implementation of a phase 2a study in the U.S. to evaluate safety, tolerability, and preliminary efficacy of FF-10832, a liposomal drug candidate, in combination therapy with Merck & Co., Inc., Rahway, N.J., U.S.A.'s anti-PD-1 therapy KEYTRUDA® (pembrolizumab) for patients with advanced solid tumors. (fujifilm.com)

The latest addition to oncotherapy is the use of dendritic cell (DC) vaccine therapy. (moffitt.org)
A dendritic cell vaccine is a cross between a vaccine and a cell therapy. (moffitt.org)

The second most common variant, papillary RCC, has a well-defined genetic abnormality associated with it, much like clear cell RCC. (renalandurologynews.com)
Approximately 10%-15% of renal masses are papillary RCC, with a small portion of these related to the familial syndrome. (renalandurologynews.com)
To review the characteristics of papillary RCC, we first should examine the histologic and structural appearance of papillary tumors. (renalandurologynews.com)
As the name implies, papillary RCC is composed of a single or pseudostratified layer of cells arranged around a fibrovascular core to create the characteristic papillae. (renalandurologynews.com)

This significant synergetic antitumor effect observed with K+CS ex vivo was also validated in vivo by using an NSG mouse model of mantle cell lymphoma (Figure 1h) . (confex.com)
Moreover, the K+CS combination did not show this potent toxic effect on non-malignant cells in vivo and was safe without inducing toxicity to normal organs in NSG mice. (confex.com)
Finally, orellanine induced significant apoptosis and necrosis in the xenografted tumors in vivo. (gu.se)
Orellanine induced significant apoptosis and necrosis in metastasized xenografted tumors in vivo and showed no signs of affecting other organs. (gu.se)

Renal cysts are common incidental findings on imaging studies performed for nonurologic indications. (radiologykey.com)
Commonly encountered cysts on ultrasound (US) and cross-sectional imaging (CT and MR imaging) mostly are benign simple cortical renal cysts. (radiologykey.com)
Complex cysts, on imaging, may be seen as part of benign cysts, renal infection, and cystic neoplasms, including cystic renal cell carcinoma (RCC), which can be distinctly identified due to characteristic imaging features. (radiologykey.com)
Since its introduction in 1986, Bosniak classification for renal cysts has been used by radiologists and urologists as a method to stratify patients to plan treatment. (radiologykey.com)
Bosniak classification is based on findings on contrast-enhanced CT scans, dividing renal cysts into 4 broad categories (I-IV) proposed to distinguish malignant from benign cystic lesions. (radiologykey.com)

A significant inhibition on cell growth, induction of apoptosis and cell cycle arrest were observed in 786-O and 769-P cells after kaempferol treatment compared with the control group. (nih.gov)
The white blood cell (WBC) estimate underwent a steady decline during the first 24 days of treatment. (vin.com)
KEYTRUDA monotherapy is already playing a role for the treatment of certain patients with advanced endometrial carcinoma through the tumor-agnostic MSI-H indication which received accelerated approval four years ago. (businesswire.com)
KEYTRUDA is approved for the treatment of adult and pediatric patients with unresectable or metastatic MSI-H or dMMR solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options. (businesswire.com)
KEYTRUDA is indicated under accelerated approval for the treatment of adult and pediatric patients with unresectable or metastatic microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) solid tumors that have progressed following prior treatment and who have no satisfactory alternative treatment options. (merck.com)
KEYTRUDA is indicated under accelerated approval for the treatment of adult and pediatric patients with unresectable or metastatic tumor mutational burden-high (TMB-H) [≥10 mutations/megabase] solid tumors, as determined by an FDA-approved test, that have progressed following prior treatment and who have no satisfactory alternative treatment options. (merck.com)
It is the evaluation of this genetic abnormality that has led to some of the more significant advances in the treatment of clear cell carcinomas. (renalandurologynews.com)
These studies indicate the importance of the pyroptosis process in tumor development and treatment responses. (nature.com)
The results indicate that TTFields alone and in combination with paclitaxel and doxorubicin effectively reduce the viability of both wild type and MDR cell sub-lines and thus can potentially be used as an effective treatment of drug resistant tumors. (biomedcentral.com)
Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it is also used for palliation in metastatic disease. (medscape.com)
Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)
Although the optimal treatment strategy continues to evolve, three agents that target angiogenesis (sunitinib, bevacizumab, and pazopanib) and a mammalian target of rapamycin (mTOR)-targeted therapy (temsirolimus) have been approved as front-line agents. (medscape.com)
indiscriminate use could promote resistance and render tecovirimat, first line treatment for orthopoxviruses, ineffective for patients. (cdc.gov)
A central venous line should be placed if intensive treatment is scheduled. (cancercentrum.se)
Second-line treatment, such as ACE or FA-Ida might be considered if needed. (cancercentrum.se)

KEYNOTE-158 (ClinicalTrials.gov, NCT02628067 ) is an ongoing global, open-label, non-randomized, multi-cohort, multi-center, Phase 2 study evaluating KEYTRUDA in patients with multiple types of advanced solid tumors - including endometrial carcinoma - that have progressed on standard of care therapy. (businesswire.com)
KEYTRUDA is an anti-programmed death receptor-1 (PD-1) therapy that works by increasing the ability of the body's immune system to help detect and fight tumor cells. (merck.com)

These tumors are notable for the presence of aggregates of foamy macrophages within the papillae and could also have psammoma bodies. (renalandurologynews.com)
They have previously shown in an LMS mouse model that inhibiting the CD47 protein allows immune cells called macrophages to more effectively destroy LMS cells. (sarcomahelp.org)
After secretion by the tumor cells, the CSF1 protein attracts macrophages and these macrophages can help the tumor to grow by helping to provide new blood vessels for the tumor. (sarcomahelp.org)

RCC, an adenocarcinoma, accounts for 90 to 95% of primary malignant renal tumors. (msdmanuals.com)

We established and isolated the metastatic cell stress from pulmonary tumor mass named MRCC-L. MRCC-L looked smaller sized in proportions and grew quicker than their parental MRCC. (biopaqc.com)

The specific set of antigens expressed by a cell population constitutes a unique phenotype. (vin.com)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)

Radical nephrectomy is the standard for larger and central tumors. (medscape.com)

A Gradual Transition Toward Anaplasia in Wilms Tumor Through Tolerance to Genetic Damage. (lu.se)

In conclusion, ASC/TMS1 is a novel functional tumor suppressor in renal carcinogenesis. (oncotarget.com)

cells, such as osteoclasts and renal cells, where they function in bone resorption and urinary acidification, respectively. (tufts.edu)
Storage of bone marrow or blood leukemic cells in biobanks is strongly recommended. (cancercentrum.se)

Therefore the differences in cellular and subcellular morphology cell growth/invasion ability cytogenetics cell markers and expression pattern. (biopaqc.com)
[ 35 ] Tumor markers such as CA125 are not good discriminators of benign lesions from malignant lesions in premenopausal women but have better accuracy in postmenopausal women. (medscape.com)

7,8 Clear cell RCC derives from the proximal tubular epithelium and, in the majority of cases, has a clear cytoplasm with a large prominent nucleus. (renalandurologynews.com)
The tissue of origin for renal cell carcinoma (RCC) is the proximal renal tubular epithelium. (medscape.com)

Her research interest focuses on the molecular oncology and immunotherapies of solid tumors and she published more than 40 peer reviewed papers. (stanford.edu)
Main Outcome(s) and Measure(s): The primary study outcome was to determine the prognostic value of p53 Abs from a large population of patients with solid tumors, as determined before data collection. (stanford.edu)
Cystic renal tumors, overall, have excellent prognosis and less aggressive metastatic behavior compared with solid renal tumors. (radiologykey.com)
Immune-related response criteria (irRC) were developed based on experience with ipilimumab (anti-cytotoxic T-cell lymphocyte-4) in melanoma to better capture the response to CIT per changes in tumor biology and the long-termeffects of CITon solid tumors and to enable additional adaptations as the field evolved. (medscape.com)

Bilateral tumors are rare, occurring in only 0.5% to 3.0% of cases. (renalandurologynews.com)
Introduction and Objective: To report a case of a patient with secondary hyperparathyroidism that developed brown tumour in bilateral maxilla surgically managed with bilateral osteoplasty for aesthetic reasons. (bvsalud.org)

These dendritic cells are like immune system factories and make other molecules that activate critical parts of the innate and adaptive immune system. (moffitt.org)
Blocking the interaction of the immune checkpoint molecule programmed cell death protein-1 and its ligand, PD-L1, using specific antibodies has been a major breakthrough for immune oncology. (snmjournals.org)
Therefore, cell pyroptosis is closely related to the immune process, but it is also essential for tumor development. (nature.com)
Tumor cells can evade attack by cells of the immune system by sending an "off" signal that prevents immune cell activation. (fujifilm.com)
[ 6-8 ] This may be due to anticancer immune activity leading to tumor inflammation or the dynamic nature of immunity, which may depend on tumor, host, or environmental factors. (medscape.com)

Anatomy25

Organisms9

Diseases62

Chemicals and Drugs60

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes53

Disciplines and Occupations1

Information Science4

Health Care7

Clear cell renal cell carc16

CcRCC14

Malignant tumors3

Cancer57

Microenvironment5

Kidney9

Genes7

Previously untreated advanced renal-cell carc1

Cancers6

Tissues7

Progression4

Squamous cell carc2

Breast tumor5

Proliferation4

Patients with advanced renal2

Serum6

Induce4

Clinical12

Differentiation8

Impairment2

Metastatic renal1

Metastasis5

Therapies5

Apoptosis of renal1

Anti-tumor activity1

Xenograft2

Histology2

Suppressor gene2

Orthotopic2

Hippel-Lindau1

Humanized monoclon1

Antigen6

Inhibitors2

Gene6

Conclusions1

Diagnosis2

Subtypes2

Chemotherapy4

Immunotherapy1

Epithelial cell line1

Pembrolizumab1

Dendritic cell2

Papillary4

Vivo4

Cysts5

Treatment15

KEYTRUDA2

Macrophages3

Primary malignant1

Pulmonary1

Antigens expressed2

Nephrectomy1

Wilms1

Carcinogenesis1

Bone2

Markers2

Tubular epithelium2

Solid4

Bilateral2

Immune5