Renal cell carcinoma metastatic. Medical search. Frequent questions

Metastatic renal cell carcinoma (mRCC) accounts for one-third of all newly diagnosed renal cell cancers. (mdpi.com)
Objectives: Sarcomatoid metastatic renal cell carcinoma (mRCC) represents an aggressive subset of disease, and a definitive therapeutic strategy is lacking. (simulations-plus.com)
The role of cytoreductive nephrectomy (CN) in treatment of locally advanced or metastatic renal cell carcinoma (mRCC) in the era of targeted therapies (TT) is still not clearly defined. (muni.cz)
Tyrosine kinase inhibitors (TKIs) are currently approved for the treatment of metastatic renal cell carcinoma (mRCC). (biomedcentral.com)
Histopathological examination of these immune check points in metastatic lesions of mRCC should be noticed, and its accurate diagnosis may be one of the effective ways to realize the individualized treatment. (biomedcentral.com)
Among all RCC patients, nearly 20-30% of them were initially diagnosed as metastatic RCC (mRCC), and 20-40% of patients with localized disease will eventually develop metastatic disease after surgery [ 3 ]. (biomedcentral.com)
Metastatic renal cell carcinoma (mRCC) is nearly incurable and accounts for most of the mortality associated with RCC. (northwestern.edu)
A new study from a team based in Italy demonstrates that a higher free triiodothyronine to free thyroxine (fT3/fT4) ratio is associated with prolonged progression-free survival (PFS) and overall survival (OS) in metastatic renal cell carcinoma (mRCC). (medpagetoday.com)
In metastatic renal cell carcinoma (mRCC), survival benefit associated with objective response rates of 16-20 % with high- dose interleukin-2 (HDIL-2) is well established and discussed. (bvsalud.org)

A personalized immunotherapy (AGS-003) nearly doubled expected progression-free survival and overall survival when added to standard sunitinib (Sutent) in patients with unfavorable-risk metastatic renal cell carcinoma, according to results from a single-arm phase II study. (urologytimes.com)
The results support an ongoing phase III study of the approach in which patients with metastatic clear-cell RCC are being randomized to personalized immunotherapy plus sunitinib or sunitinib alone, with overall survival as the primary endpoint, said first author Asim Amin, MD, PhD. (urologytimes.com)
At the Genitourinary Cancers Symposium in Orlando, FL, Dr. Amin described long-term survival in 21 patients with intermediate- or poor-risk metastatic RCC who were treated with autologous dendritic cell immunotherapy in combination with sunitinib. (urologytimes.com)
The ongoing phase III ADAPT (The Autologous Dendritic Cell Immunotherapy Plus Standard Treatment of Advanced Renal Cell Carcinoma) study is using this approach to personalized immunotherapy, with the goal of randomizing 450 patients. (urologytimes.com)
The high vascularity and responsiveness to immunotherapy of renal cell carcinoma (RCC) makes such a tumour a potential target for IM862. (ox.ac.uk)
Immunotherapy and targeted therapy have improved the outlook for metastatic RCC. (wikipedia.org)
Neoadjuvant immunotherapy with the programmed cell death protein 1 (PD-1) inhibitor nivolumab (Opdivo) is safe and feasible in early-stage non-small cell lung cancer (NSCLC). (ascopost.com)
Immunotherapy with an anti-programmed cell death protein 1 (PD-1) inhibitor-pembrolizumab (Keytruda)-showed encouraging responses in patients with advanced cutaneous T-cell lymphoma (either mycosis fungoides or Sézary syndrome). (ascopost.com)
TORONTO and HOUSTON, March 30, 2023 (GLOBE NEWSWIRE) -- Medicenna Therapeutics Corp. ("Medicenna" or "the Company") (NASDAQ: MDNA TSX: MDNA), a clinical stage immunotherapy company, today announced updated data from its Phase 1/2 ABILITY study of MDNA11, a next-generation IL-2 with superior CD122 (IL-2 receptor beta) binding without CD25 (IL-2 receptor alpha) affinity thereby preferentially stimulating cancer killing effector T cells and NK cells. (tmcnet.com)
Nivolumab, a cancer immunotherapy, is a checkpoint inhibitor that functions by blocking the programmed cell death 1 (PD-1)/programmed death ligand 1 pathway and restoring immunity against tumor cells ( 2 ). (cdc.gov)

Liver metastasis, high-grade tumor, absence of CN, non-clear cell histology, and MSKCC (Memorial Sloan-Kettering Cancer Center) poor prognosis status were associated with adverse treatment outcomes. (muni.cz)
At that point, CT imaging of the chest showed no evidence of metastasis and he was considered to have stage 2 clear cell carcinoma of the kidney. (targetedonc.com)
About 25-30% of patients have metastatic disease at diagnosis, and fewer than 5% have a solitary metastasis. (medscape.com)
The study also revealed increased risk of death due to renal cell carcinoma in patients who did not undergo surgical resection of metastasis. (medscape.com)
Usually medically treated metastatic breast cancer patients survive longer before they succumb to lung, liver, and brain metastasis compared to other solid organ metastatic lesions. (msdmanuals.com)
Using machine learning to predict lymph node metastasis in patients with renal cell carcinoma: A population-based study. (cdc.gov)
A clinical prediction model for predicting the risk of liver metastasis from renal cell carcinoma based on machine learning. (cdc.gov)

Metastatic melanoma is a type of skin cancer that has spread across other parts of the body. (cancer.gov)
These investigators examined hereditary predisposition syndromes related to the co-occurrence of melanoma and/or mesothelioma with renal cell carcinoma and their germline associations with BAP1, FLCN, and MITF p.E318K alterations. (medpagetoday.com)
Blockade of pathways involving PD-1 and its ligand is a promising treatment for cancers (melanoma, nonsmall cell lung cancer, metastatic renal cell carcinoma, head and neck carcinomas, Hodgkin lymphoma, and urothelial carcinoma) ( 4 ), although the role of PD1/programmed death ligand 1 in immune suppression and the mechanism of action of antibodies remain to be better defined. (cdc.gov)
Patients and Methods Atezolizumab data from clinical trials in non-small-cell lung cancer, metastatic urothelial carcinoma, renal cell carcinoma, and melanoma were evaluated. (medscape.com)
Immune-related response criteria (irRC) were developed based on experience with ipilimumab (anti-cytotoxic T-cell lymphocyte-4) in melanoma to better capture the response to CIT per changes in tumor biology and the long-termeffects of CITon solid tumors and to enable additional adaptations as the field evolved. (medscape.com)

Elevated plasma interleukin 6 predicts poor response in patients treated with sunitinib for metastatic clear cell renal cell carcinoma. (urotoday.com)

Clear cell renal cell carcinoma (ccRCC) is the most common type among renal cell carcinomas, and anti-angiogenic treatment is currently first line therapy in metastatic ccRCC (mccRCC). (urotoday.com)
Forty-six patients with metastatic or non-resectable ccRCC treated with sunitinib were included. (urotoday.com)
Clear cell renal cell carcinoma or CCRCC, is the most common subtype of kidney cancer. (jove.com)
The purpose of this protocol is to introduce and compare the two animal models recently established for metastatic CCRCC. (jove.com)
In this mouse model, heterogeneous CCRCC is implanted to the renal capsule of the mouse. (jove.com)
Von Hippel Lindau (VHL) is a tumour suppressor that is lost in the majority of clear cell RCC (ccRCC) cases. (northwestern.edu)
RNA-seq revealed several HIF-1α-regulated genes that are upregulated in our VHL knockout cells and whose overexpression signifies an aggressive form of ccRCC in the cancer genome atlas (TCGA) database. (northwestern.edu)
There are several prognostic models that have been proposed for the risk classification of metastatic ccRCC. (encyclopedia.pub)
This study will evaluate the efficacy, safety, and pharmacokinetics of Tobemstomig (PD1-LAG3) in combination with axitinib alone or with tiragolumab (anti-TIGIT) and axitinib, as compared to pembrolizumab and axitinib in participants with previously untreated, unresectable locally advanced or metastatic clear-cell renal cell carcinoma (ccRCC). (genentech-clinicaltrials.com)
Rhabdoid differentiation is found in 3-7.5% of RCCs, most commonly in CCRCC, although rare cases have been reported involving papillary RCC, chromophobe RCC, and collecting duct (Bellini duct) carcinoma. (medscape.com)
Context While vascular endothelial growth factor-targeted therapy and mammalian target of rapamycin inhibition are effective strategies in treating clear cell renal cell carcinoma (ccRCC), the most effective therapeutic approach for patients with non-clear cell RCC (non-ccRCC) is unknown. (lu.se)
Objective To systematically review relevant literature comparing the oncological outcomes and adverse events of different systemic therapies for patients with metastatic non-ccRCC. (lu.se)
Conclusions This systematic review and meta-analysis represent a robust summary of the evidence base for systemic treatment of metastatic non-ccRCC. (lu.se)

Renal cell carcinoma, sarcomatoid subtype, was morphologically established. (oncovestnik.ru)
The given clinical observation demonstrates a patient with one of the most unfavorable variants of renal cell carcinoma ― sarcomatoid subtype. (oncovestnik.ru)
Sarcomatoid renal cell carcinoma (SRCC) is currently defined in the 2004 World Health Organization (WHO) classification of renal tumors as any histologic type of renal cell carcinoma (RCC) containing foci of high-grade malignant spindle cells. (medscape.com)
Focal spindling due to noncohesion of tumor cells is not considered to represent sarcomatoid differentiation. (medscape.com)
Sarcomatoid differentiation also occurs in around 29% of carcinomas of the collecting duct of Bellini. (medscape.com)
Currently, the 2004 WHO classification of renal tumors recognizes this transformation as "sarcomatoid change" or "sarcomatoid features" arising within RCC, rather than as a separate histologic entity. (medscape.com)
Go to Renal Cell Carcinoma Treatment Protocols , Clear Cell Renal Cell Carcinoma , and Sarcomatoid and Rhabdoid Renal Cell Carcinoma for complete information on these topics. (medscape.com)

Other genetically linked conditions also increase the risk of RCC, including hereditary papillary renal carcinoma, hereditary leiomyomatosis, Birt-Hogg-Dube syndrome, hyperparathyroidism-jaw tumor syndrome, familial papillary thyroid carcinoma, von Hippel-Lindau disease and sickle cell disease. (wikipedia.org)

PD-1, PD-L1 and PD-L2 were differentially expressed between primary and metastatic tumors. (biomedcentral.com)
Among them, the heterogeneity of the tumor may play an important role, especially the heterogeneity between the primary and metastatic tumors. (biomedcentral.com)
Collision tumors are rarely reported in patients with von Hippel-Lindau (VHL) disease, even though VHL patients often present with multi-organ tumor syndromes, like hemangioblastoma and renal cell carcinoma (RCC). (figshare.com)
however, occasional tumors composed entirely of rhabdoid cells have been described in which no RCC component is detected despite extensive sampling. (medscape.com)
Objective: Laryngeal verrucous carcinoma (LVC) comprises 1% to 4% of all laryngeal tumors. (researchgate.net)
Patient summary We examined the literature to determine the most effective treatments for advanced kidney cancer patients whose tumors are not of the clear cell subtype. (lu.se)
Malignant tumors may be primary or metastatic. (msdmanuals.com)
Participants must have histologically or cytologically confirmed metastatic small cell carcinoma of the bladder (SCCB) or other high grade neuroendocrine tumors (HGNETs) of the urinary tract (which includes renal pelvis, ureter, and urethra, and excludes neuroendocrine tumors of the prostate). (who.int)
Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)

The left radical nephrectomy was performed in September 2015, and the results showed that this was a clear cell carcinoma, a stage T2a. (targetedonc.com)
Machine learning to improve prognosis prediction of metastatic clear-cell renal cell carcinoma treated with cytoreductive nephrectomy and systemic therapy. (cdc.gov)

Materials and Methods: Between 1980 and 1997 we performed surgery on 45 patients (56 lesions) with metastatic renal cell carcinoma of bone. (tau.ac.il)
Postoperatively pain was significantly relieved in 91% of patients, while 89% achieved a good to excellent functional outcome, and 94% with metastatic lesions of the pelvic girdle and lower extremities were ambulatory. (tau.ac.il)
In the metastatic pancreatic cancer patient who had previously achieved a confirmed partial response, tumor reduction of both target lesions continued. (tmcnet.com)
Published case series of orthopedic surgical management of metastatic lesions in cancer centers show that breast cancer remains the most common cancer requiring orthopedic intervention. (msdmanuals.com)
Differentiation of benign from malignant solid renal lesions using CT-based radiomics and machine learning: comparison with radiologist interpretation. (cdc.gov)
Participants must have metastatic disease defined as new or progressive lesions. (who.int)

In the phase II study, 21 patients with unfavorable-risk metastatic RCC were treated. (urologytimes.com)
Only about 13% of sunitinib-treated, unfavorable-risk metastatic RCC patients survive longer than 30 months. (urologytimes.com)
The U.S. Food and Drug Administration (FDA) granted lenvatinib (Lenvima) Breakthrough Therapy designation for investigational use in patients with advanced or metastatic renal cell carcinoma who were previously treated with a vascular endothelial growth factor (VEGF)-targeted therapy. (ascopost.com)
Lenvatinib is a multiple receptor tyrosine kinase inhibitor currently indicated for the treatment of patients with locally recurrent or metastatic, progressive, radioactive iodine-refractory differentiated thyroid cancer. (ascopost.com)
The study included 7,047 patients with metastatic RCC who were grouped into 3 time periods: 2001-2005 (time period 1), 2006-2007 (time period 2), and 2008-2009 (time period 3). (renalandurologynews.com)
Eight patients received conditioning with fludarabine and low-dose total body irradiation followed by hematopoietic cell transplantation from an HLA-matched sibling donor. (aacrjournals.org)
Patients were monitored for donor engraftment of myeloid and lymphoid cells, for clinical response by serial imaging, and for immunologic response by in vitro isolation of donor-derived CD8 + CTLs recognizing recipient minor histocompatibility (H) antigens. (aacrjournals.org)
Clones from three patients with a partial response or stable disease recognized antigens expressed on renal cell carcinoma tumor cells. (aacrjournals.org)
Treatment of metastatic renal cell carcinoma with allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning with fludarabine/total body irradiation is feasible and may induce tumor regression or stabilization in some patients. (aacrjournals.org)
Simple Summary: The treatment of metastatic renal cell carcinoma is traditionally initiated with the removal of the diseased kidney with the tumor in many patients. (muni.cz)
In consequence, actual treatment guidelines ( 12 ) recommend a targeted first-line therapy with VEGFR-inhibitors, like sunitinib ( 9 ), pazopanib ( 10 ), or bevacizumab plus immune stimulative IFN, for patients with advanced or metastatic RCC with low to intermediate risk [per Motzer- or MSKCC-Score ( 13 ) /IDMC score International Metastatic Database Consortium (IMDC) adverse risk factors] ( 8 ). (iiarjournals.org)
Combination lenvatinib and pembrolizumab demonstrated antitumor activity in patients with metastatic renal cell carcinoma (RCC) regardless of prior treatment, according to trial results published in The Lancet Oncology . (cancertherapyadvisor.com)
There were 2 patients with non-clear cell RCC who were excluded from the efficacy analysis but included in the safety analysis. (cancertherapyadvisor.com)
Lenvatinib plus pembrolizumab might therefore be a future potential standard-of-care treatment for patients with metastatic clear cell RCC after disease progression with ICI therapy. (cancertherapyadvisor.com)
Based on our case report, we systematically reviewed the characteristics of collision tumor composed of hemangioblastoma and metastatic RCC in VHL patients. (figshare.com)
Treatment protocols for renal cell carcinoma are provided below, including treatment of localized and advanced disease and recommendations for patients with predominantly clear cell carcinoma and those with predominantly non-clear cell carcinoma. (medscape.com)
We report on the clinical course of 15 patients with metastatic renal cell carcinoma (RCC) who were treated with recombinant beta-interferon as part of a phase I-II study. (elsevierpure.com)
Thus, at our institution, in a cohort of 15 patients with metastatic RCC, recombinant beta-interferon when given i.v. at a dose ≤720 x 10 6 U three times per week, yielded no clinical antitumor activity. (elsevierpure.com)
Mani, S , Todd, M & Poo, WJ 1996, ' Recombinant beta-interferon in the treatment of patients with metastatic renal cell carcinoma ', American Journal of Clinical Oncology: Cancer Clinical Trials , vol. 19, no. 2, pp. 187-189. (elsevierpure.com)
Adding surgery and/or radiation to systemic therapy (multimodal therapy) improved clinical outcomes in patients with renal cell carcinoma (RCC) with brain metastases, reports a university-based research team. (medpagetoday.com)
At a planned interim analysis, the trial showed no difference in recurrence-free survival (RFS) between arms in a population of patients that included both clear cell and non-clear cell subtypes, and was stopped early. (northamericanreport.com)
In March 2022, Allogene Therapeutics, Inc. announced that the US Food and Drug Administration (FDA) had granted Fast Track designation (FTD) to ALLO-316, the Company's first AlloCAR T solid tumor clinical candidate for the treatment of patients with advanced or metastatic clear cell renal cell carcinoma (RCC). (northamericanreport.com)
The FDA granted FTD based on the potential of ALLO-316 to address the unmet need for patients with difficult-to-treat renal cell carcinomas (RCC) who have failed standard RCC therapies. (northamericanreport.com)
Patients with renal cell cancer (RCC) develop metastatic spread in approximately 33% of cases. (northamericanreport.com)
Conclusions: Surgical excision is safe and reliable for restoring mechanical bone stability, relieving pain and providing good function in most patients with metastatic renal cell carcinoma who meet the criteria for surgical intervention. (tau.ac.il)
Extension of overall survival beyond objective responses in patients with metastatic renal cell carcinoma treated with high-dose interleukin-2. (bvsalud.org)
A randomized phase III study METEOR evaluated the efficacy of cabozantinib versus everolimus in patients with renal cell carcinoma that progressed after anti-VEGFR therapy with targeted drugs. (oncovestnik.ru)
Commentary on "Conditional survival of patients with metastatic renal cell carcinoma treated with VEGF-targeted therapy: A population-based study. (elsevierpure.com)
For patients with advanced non-small cell lung cancer (NSCLC) harboring the ALK gene rearrangement, ceritinib (Zykadia) provided longer progression-free survival than chemotherapy in patients previously treated with chemotherapy and crizotinib (Xalkori), but gastrointestinal toxicity was. (ascopost.com)
Commenting on this talk during the discussion afterward, Youn Kim, MD , of Stanford University School of Medicine, Stanford, California, said: "At our center, we use high-throughput sequencing of T-cell receptors daily in patients with cutaneous T-cell lymphomas, and it is a billable. (ascopost.com)
We report a case of progressive multifocal leukoencephalopathy after treatment with nivolumab, a PD-1 blocker that is used to restore impaired T-cell responses in patients with cancer and infections. (cdc.gov)
Targeted therapy and immunomodulatory agents are considered standard of care in patients with metastatic disease. (medscape.com)
Surgical resection is recommended in selected patients with metastatic renal carcinoma. (medscape.com)
Candidates for active surveillance include selected patients older than 70 years who have asymptomatic renal masses and slow growth documented on serial imaging. (medscape.com)
The treatment of metastatic renal cell carcinoma is problematic, and, whenever possible, patients should be directed to approved and controlled clinical trials. (medscape.com)
as monotherapy for the treatment of those patients who have received at least two chemotherapy regimens for their metastatic disease. (who.int)

A few months later, hepatic and contralateral renal metastases were detected. (biomedcentral.com)
The hepatic and renal masses were confirmed to be metastases. (biomedcentral.com)
[ 18 ] A study by Alt et al found that complete resection of multiple renal cell carcinoma metastases may be associated with long-term survival. (medscape.com)

During December 2008, in a setting of stable disease, he underwent hepatic resection and enucleation of the left renal mass. (biomedcentral.com)
Composite resection of the metastatic lesion was performed, and the mandible was reconstructed with an osteomyocutaneous free tissue transfer and a custom plate. (agd.org)
Surgical resection remains the only known effective treatment for localized renal cell carcinoma, and it also is used for palliation in metastatic disease. (medscape.com)

In the report, detailed description of the drug is given which includes mechanism of action of the drug, clinical studies, NDA approvals (if any), and product development activities comprising the technology, Metastatic Renal Cell Carcinoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details. (northamericanreport.com)
This clinical trial is recruiting people who have renal cell carcinoma (RCC). (genentech-clinicaltrials.com)
A clinical case of a 32-year-old patient with metastatic renal cell carcinoma is presented. (oncovestnik.ru)
The 2009 American Urological Association guideline for management of the clinical T1 renal mass recommends reviewing all available treatment options and the associated benefits and risks with the patient. (medscape.com)

Pathological examination of the surgical specimens demonstrated pT3cN0Mx conventional (clear cell) renal carcinoma, Fuhrman Grade 3 with negative surgical margins. (biomedcentral.com)
MRI Radiomics for the Prediction of Fuhrman Grade in Clear Cell Renal Cell Carcinoma: a Machine Learning Exploratory Study. (cdc.gov)

Advanced/Metastatic Renal Cell Carcinomas" Encyclopedia , https://encyclopedia.pub/entry/13867 (accessed December 07, 2023). (encyclopedia.pub)

The use of checkpoint inhibitors in advanced and metastatic renal cell carcinomas (RCCs) has rapidly evolved over the past several years. (encyclopedia.pub)
In July 2021, City of Hope and Osel Inc. announced that the City of Hope had granted an exclusive worldwide license to Osel for intellectual property on the novel use of an LBP CBM588 to enhance the efficacy of checkpoint inhibitors to treat cancer, including metastatic renal cell carcinoma. (northamericanreport.com)

During a Targeted Oncology™ Case-Based Roundtable™ event, Pedro C. Barata, MD, MSc, and participants discussed dosing and toxicity issues related to tivozanib and lenvatinib/everolimus in a patient who has received 2 prior lines of therapy for metastatic clear cell renal cell carcinoma. (targetedonc.com)

Although there is a wide array of histology in these cancer types, the vast majority of kidney cancers are of clear cell histology [ 2 ] [ 3 ] . (encyclopedia.pub)
Deep learning can predict survival directly from histology in clear cell renal cell carcinoma. (cdc.gov)

risk of esophageal squamous cell carcinoma. (who.int)
A prospective of five cervical cancer screening tests assessed the risk of esophageal squamous cell carcinoma. (who.int)

Renal cell carcinoma is a form of kidney cancer that starts in the lining of the small tubes in the kidney. (cancer.gov)
Renal cell carcinoma is the most common type of kidney cancer in adults. (northamericanreport.com)
Renal cell carcinoma (RCC) is the most common form of kidney cancer. (genentech-clinicaltrials.com)
Renal cell carcinoma (RCC) is a kidney cancer that originates in the lining of the proximal convoluted tubule, a part of the very small tubes in the kidney that transport primary urine. (wikipedia.org)
Kidney cancer, or renal cancer, is one of the most common cancers affecting adults in the United States and the 14th most common cancer worldwide. (medicalnewstoday.com)
Metastatic disease does not commonly spread to bone below the mid forearm or mid calf, but when it occurs in those sites, it results most often from lung or sometimes kidney cancer. (msdmanuals.com)

In this way, it complements sunitinib-induced suppression of regulatory T cells and myeloid-derived suppressor cells. (urologytimes.com)
Safety and efficacy of nivolumab in combination with sunitinib or pazopanib in advanced or metastatic renal cell carcinoma: the CheckMate 016 study. (biomedcentral.com)
Cabozantinib-s-malate and sunitinib malate may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. (mayo.edu)

Are you surprised that targeted therapeutics for metastatic renal cell carcinoma (RCC) have not improved survival? (renalandurologynews.com)
Targeted therapeutic agents for treating metastatic RCC has not led to an improved survival. (renalandurologynews.com)
A study published recently in Urologia Internationalis (online ahead of print) found that the advent of targeted therapeutic agents for treating metastatic renal cell carcinoma (RCC) -which began with the FDA approval of sorafenib in 2005-has not led to an improvement in survival rates. (renalandurologynews.com)
All these treatment options are approximately comparable in terms of progression-free survival (PFS) and can be used under the premise of favorable to moderate prognosis according to the Memorial Sloan-Kettering Cancer Center (MKSCC)-criteria for first-line therapy of advanced or metastatic RCC. (iiarjournals.org)
Metastatic RCC: Does fT3/fT4 Predict Survival? (medpagetoday.com)
This applies as well in the adjuvant treatment of surgically resected renal cell carcinoma, for which no therapy has yet been found to offer survival benefit. (medscape.com)
Artificial intelligence-based prediction of overall survival in metastatic renal cell carcinoma. (cdc.gov)

The most commonly used classification systems in contemporary trials are the Memorial Sloan Kettering Cancer Center (MSKCC) and the International Metastatic RCC Database Consortium (IMDC) models. (encyclopedia.pub)

Must have a histologically-confirmed diagnosis of non-clear cell RCC. (survivornet.com)
Immunohistochemical analysis of a biopsy specimen was used to make the diagnosis of metastatic clear cell renal cell carcinoma in this patient, whose primary malignancy was previously unknown. (agd.org)
BUN measurements are used in the diagnosis of certain renal and metabolic diseases. (cdc.gov)
The test is frequently requested in conjunction with the serum creatinine test for the differential diagnosis of prerenal, renal, and postrenal uremia. (cdc.gov)
Glucose measurements are used in the diagnosis and treatment of pancreatic islet cell carcinoma and of carbohydrate metabolism disorders, including diabetes mellitus, neonatal hypoglycemia, and idiopathic hypoglycemia. (cdc.gov)

However, immune checkpoints may express differently between primary and metastatic tumor. (biomedcentral.com)
Therefore, we aimed to compare the differential expressions of PD-1, PD-L1 and PD-L2 between the primary and metastatic sites of renal cell carcinoma (RCC). (biomedcentral.com)

The therapeutic approach for renal cell carcinoma is guided by the probability of cure, which is related directly to the stage or degree of tumor dissemination. (medscape.com)

Our findings indicate that loss of VHL could be driving tumour cell dissemination through stabilization of HIF-1α in RCC. (northwestern.edu)
A significant anticancer activity has been reported recently in AIDS-related Kaposi's sarcoma, a tumour of endothelial cell origin. (ox.ac.uk)
The tumour arises from the cells of the proximal renal tubular epithelium. (wikipedia.org)
Classification of renal tumour using convolutional neural networks to detect oncocytoma. (cdc.gov)
well as cytologic study for tumour cells. (who.int)

Evidence-based recommendations on pembrolizumab (Keytruda) plus chemotherapy with or without bevacizumab for persistent, recurrent or metastatic cervical cancer in adults. (bvsalud.org)

abstract = "Purpose: We describe the efficacy of surgical excision of metastatic renal cell carcinoma of bone for achieving local tumor control, pain control and functional outcome with emphasis on the indications and techniques of surgical intervention as well as oncological outcome. (tau.ac.il)

Tumor growth and circulating tumor cells are asset after 10 days of implantation before the embryo hatches. (jove.com)
CD8 + CTL-recognizing minor H antigens on tumor cells can be isolated posttransplant and could contribute to the graft- versus -tumor effect. (aacrjournals.org)
The key procedure of anti-tumor respond is the activation of T cell and tumor cells can inhibit this process through binding its immune checkpoints to receptors expressed on T-cell, thus leading to immune escape. (biomedcentral.com)

This study is being performed as a single-arm open-label study in order to rapidly provide information on the potential benefits of the combination of pembrolizumab and lenvatinib in participants with previously untreated advanced/metastatic non-clear cell renal cell carcinoma. (survivornet.com)
Evidence-based recommendations on lenvatinib (Kisplyx) with pembrolizumab (Keytruda) for untreated advanced renal cell carcinoma in adults. (bvsalud.org)

A comprehensive texture feature analysis framework of renal cell carcinoma: pathological, prognostic, and genomic evaluation based on CT images. (cdc.gov)

Mutation of the VHL tumor suppressor gene is observed in up to 80% in clear cell kidney cancers, leading to increased rates of VEGF secretion in RCC ( 11 ), thus being a promising candidate for VEGF-targeted therapy. (iiarjournals.org)
Cancers of the kidney and renal pelvis are the sixth most common cancers among men and the ninth most common cancers in women. (encyclopedia.pub)
Renal cell carcinoma is one of the ten most commonly diagnosed cancers in the world. (oncovestnik.ru)

In February 2022, Eisai and Merck & Co., Inc., announced that the Japanese Ministry of Health, Labour and Welfare (MHLW) had approved the combination of LENVIMA, the orally available multiple receptor tyrosine kinase inhibitor discovered by Eisai, plus KEYTRUDA, the anti-PD-1 therapy from Merck & Co., for radically unresectable or metastatic renal cell carcinoma (RCC). (northamericanreport.com)
People can take part if their RCC is untreated and has spread to nearby cells (locally advanced) and cannot be removed with surgery (unresectable), or that has spread to other parts of the body (metastatic). (genentech-clinicaltrials.com)
Evidence-based recommendations on trastuzumab deruxtecan (Enhertu) for treating HER2-positive unresectable or metastatic breast cancer after 1 or more anti-HER2 treatments in adults. (bvsalud.org)

He had an evaluation done by CT scan in the emergency room that showed that he had diverticulitis, which was likely the cause of the abdominal pain, but he was found to have an 8-centimeter left renal mass, that was found incidentally. (targetedonc.com)

These conditions include Von Hippel-Lindau syndrome, hereditary papillary renal cell carcinoma, Birt-Hogg-Dube syndrome, and familial renal cancer. (medicalnewstoday.com)

The work of the Cancer Genome Atlas Project [ 4 ] resulted in the discovery that clear cell renal cell carcinomas (ccRCCs) are defined primarily by mutations in the von-Hippel Lindau/hypoxia-inducible factor (VHL/HIF) pathway, which is directly involved in angiogenesis [ 3 ] . (encyclopedia.pub)

This phase I trial assessed the safety, efficacy, and immunologic responses to minor histocompatibility antigens following nonmyeloablative allogeneic hematopoietic cell transplantation as treatment for metastatic renal cell carcinoma. (aacrjournals.org)
Allogeneic hematopoietic stem cell transplantation is the only potentially curative treatment for myelofibrosis. (ascopost.com)
Experimental treatment approaches include vaccines and nonmyeloablative allogeneic peripheral blood stem cell transplantation. (medscape.com)

among these, about 80% are clear cell renal carcinomas histologically ( 2 ). (iiarjournals.org)

Up to 75% of RCCs are diagnosed in organ-confined stages (T1 and T2), whereas one fourth is already locally advanced or presenting as metastatic disease having a poor prognosis ( 1 ). (iiarjournals.org)

DelveInsight's, " Metastatic Renal Cell Carcinoma Pipeline Insight , 2022," report provides comprehensive insights about 40+ companies and 50+ pipeline drugs in the Metastatic Renal Cell Carcinoma pipeline landscape. (northamericanreport.com)

Has locally advanced/metastatic disease (ie, Stage IV per the American Joint Committee on Cancer). (survivornet.com)
However, new treatments are needed for people with locally advanced or metastatic RCC. (genentech-clinicaltrials.com)
The standard first treatment that is approved in a number of countries for people with locally advanced or metastatic RCC is pembrolizumab given together with axitinib. (genentech-clinicaltrials.com)

RR CC was named for its morphologic resemblance to pediatric malignant rhabdoid tumor (MRT) of the kidney, which is a highly aggressive tumor characterized by cells that resemble rhabdomyoblasts and by genetic alterations involving chromosome 22, particularly the hSNF5/INI1 gene on 22q11.2. (medscape.com)

Mice underwent intrarenal implantation using luciferase-expressing Renca, a murine renal adenocarcinoma cell line. (biologists.com)
We report the illustrative case of a 29-year-old woman who underwent palliative surgery for widely metastatic renal cell carcinoma. (johnshopkins.edu)
Berry underwent an abdominal scan that showed her renal abnormality. (medscape.com)

DelveInsight's metastatic renal cell carcinoma pipeline analysis depicts a robust space with 40+ active players working to develop 50+ pipeline therapies. (northamericanreport.com)

Evaluation of radiomics and machine learning in identification of aggressive tumor features in renal cell carcinoma (RCC). (cdc.gov)

Has received prior therapy with an anti-programmed cell-death 1 (PD-1), anti-programmed cell-death ligand 1 (PD-L1), or anti-programmed cell-death ligand 2 (PD-L2) agent or with an agent directed to another stimulatory or co-inhibitory T-cell receptor (e.g. (survivornet.com)
The data also showed post-treatment expansion of anti-cancer NK cells but not eosinophils, which are associated with vascular leak syndrome (a known side effect of the only approved IL-2 therapy). (tmcnet.com)

However, there were a few acinar structures composed of clear cells scattered in hemangioblastoma, and these acinar structures were subsequently confirmed as clear cell RCC. (figshare.com)

Anatomy10

Organisms3

Diseases86

Chemicals and Drugs46

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes24

Disciplines and Occupations1

Information Science5

Health Care18

MRCC9

Immunotherapy10

Metastasis7

Melanoma5

Treated with sunitinib for metastatic1

CcRCC13

Sarcomatoid7

Hereditary papillary renal carcinoma1

Tumors9

Nephrectomy2

Lesions6

Patients36

Metastases3

Resection3

Clinical4

Fuhrman Grade2

20231

Checkpoint Inhibitors2

Oncology1

Histology2

Squamous Cell Carc2

Kidney cancer6

Sunitinib3

Survival7

Database Consortium1

Diagnosis5

Primary and metastatic2

Therapeutic approach1

Tumour5

Recurrent1

Abstract1

Tumor cells3

Lenvatinib2

Genomic1

Cancers3

Unresectable3

Left renal mass1

Papillary1

Hypoxia1

Allogeneic3

Histologically1

RCCs1

20221

Locally3

Malignant1

Underwent3

Therapies1

Aggressive tumor1

Therapy2

Hemangioblastoma1