Carcinoma, Renal CellKidney NeoplasmsNephrectomyVon Hippel-Lindau Tumor Suppressor ProteinAdenoma, OxyphilicPyrrolesBenzenesulfonatesPhenylurea CompoundsAdenocarcinoma, Clear CellNiacinamideKidneyIndolesvon Hippel-Lindau DiseaseNeoplasm MetastasisLeiomyomatosisAntineoplastic AgentsFumarate HydrataseChromosomes, Human, Pair 3PrognosisTumor Markers, BiologicalCarcinoma, PapillaryImmunohistochemistryKidney Diseases, CysticInterferon-alphaNeoplasm StagingInterleukin-2Treatment OutcomePyridinesKidney Tubules, ProximalAngiogenesis InhibitorsGene Expression Regulation, NeoplasticCell Line, TumorKidney TubulesImmunotherapyDisease-Free SurvivalNeoplasms, Multiple PrimarySurvival RateSurvival AnalysisRetrospective StudiesCarbonic AnhydrasesAngiomyolipomaTumor Cells, CulturedTomography, X-Ray ComputedLymphocytes, Tumor-InfiltratingProtein Kinase InhibitorsMolecular Targeted TherapyHand-Foot SyndromeRNA, MessengerKaplan-Meier EstimateTissue Array AnalysisTumor Suppressor ProteinsInjections, SubcutaneousSirolimusNeoplasm ProteinsReverse Transcriptase Polymerase Chain ReactionUrogenital NeoplasmsHypoxia-Inducible Factor 1, alpha SubunitBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsNeoplasm GradingPAX2 Transcription FactorVascular Endothelial Growth Factor AAntigens, NeoplasmNeovascularization, PathologicGenes, Tumor SuppressorDisease ProgressionDrug Administration ScheduleRecombinant ProteinsTumor BurdenTOR Serine-Threonine KinasesHemangioblastomaLLC-PK1 CellsMice, NudeNitrilotriacetic AcidApoptosisLigasesKidney CortexUbiquitin-Protein LigasesNeoplastic Syndromes, HereditaryImmunoenzyme Techniques