TumorClear cell renal cell carcAdvanced neuroendocrine tumorsPNETNeoplasmsHepatocellular carcinomaPancreasTumoursSunitinibPancreatic neuroendocrine tumors with diseaseCancersModerately differentiated neuroendocrine tumorsCell carcinomasTuberous sclerosMetastasisMalignantCarcinoidChromophobe renalCancerMicrocysticAngiomyolipomasPituitarySutentUrothelial carcinomaMetastatic diseasePatientsCystsChromogranin2022SomatostatinNeoplasmHepatic
Tumor14
- They are also at an increased risk of developing a type of kidney cancer called clear cell renal cell carcinoma and a type of pancreatic cancer called a pancreatic neuroendocrine tumor. (medlineplus.gov)
- More than 12,000 people in the United States are diagnosed with a neuroendocrine tumor each year. (dana-farber.org)
- Finally, we will discuss distinctive novel/emerging renal neoplasms previously considered under the spectrum of ChRCC, low-grade oncocytic renal tumor and eosinophilic vacuolated tumor, with regard to their current significance and implications for future classification strategies. (lww.com)
- Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
- In neuroendocrine tumors (NETs), liver metastases (LM) represent the most crucial prognostic factor, irrespective of the primary tumor site. (oaepublish.com)
- It is indicated for the treatment of renal cell carcinoma, gastrointestinal stromal tumors after disease progression or in case of no tolerance to imatinib, and unresectable Pancreatic Neuroendocrine Tumor PNET (those that cannot be operated). (ccates.org.br)
- Sunitinib (marketed as Sutent by Pfizer, and previously known as SU11248) is an oral, small-molecule, multi-targeted receptor tyrosine kinase inhibitor that was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor. (ncats.io)
- The imaging findings were concerning for lymphoma or a neuroendocrine tumor. (pbpath.org)
- A diagnosis of well-differentiated pancreatic neuroendocrine tumor, Grade 1, lipid rich variant was rendered. (pbpath.org)
- Given how unusual these histologic features are compared to a typical low grade neuroendocrine tumor, immunohistochemical stains are an essential adjunct aid. (pbpath.org)
- Sutent, an oral multikinase inhibitor, was previously approved for the treatment of advanced/metastatic renal cell carcinoma and unresectable and/or metastatic malignant gastrointestinal stromal tumor after failure of imatinib mesilate treatment due to resistance or intolerance. (genengnews.com)
- Six patients were diagnosed with breast cancer, two with neuroendocrine tumor and one with renal cell carcinoma. (upf.edu)
- Sutent is prescribed for the treatment of gastrointestinal stromal tumors ( GIST), late-stage renal carcinoma (RCC) and pancreatic neuroendocrine tumor (pNET). (israelpharm.com)
- Recommended Dose For GIST And RCC: The recommended dose of Sunitinib for gastrointestinal stromal tumor (GIST) and advanced renal cell carcinoma (RCC) is one 50 mg oral dose taken once daily, on a schedule of 4 weeks of treatment followed by 2 weeks off (Schedule 4/2). (saifpharma.com)
Clear cell renal cell carc3
- Untreated locally advanced and/or metastatic clear cell renal cell carcinoma. (medexmd.com)
- Locally advanced and/or metastatic clear cell renal cell carcinoma, if the previous cytokine therapy was ineffective. (medexmd.com)
- Therapy must be conducted by the doctor, experienced in the treatment of metastatic clear cell renal cell carcinoma or gastrointestinal stromal tumors. (medexmd.com)
Advanced neuroendocrine tumors2
- A drug that simultaneously strikes cancer cells' growth circuits and pipeline to the bloodstream produced encouraging results in a clinical trial involving patients with advanced neuroendocrine tumors, according to a study led by Dana-Farber Cancer Institute investigators. (dana-farber.org)
- Although advances have been made in recent years, there remains a critical need for new and effective therapies for patients with advanced neuroendocrine tumors, particularly patients whose cancer has progressed on currently available options," said Chan. (dana-farber.org)
PNET5
- In a phase II trial of the hypoxia-inducible factor-2alpha inhibitor belzutifan in 61 patients with VHL disease, objective response rates were 49 percent in systemic therapy-naive renal cell carcinoma (RCC), 30 percent in central nervous system (CNS) hemangioblastomas, and 91 percent in pancreatic neuroendocrine tumors (pNET) [6,7]. (nursingcenter.com)
- 1.2) Progressive, well-differentiated pancreatic neuroendocrine tumors (pNET) in patients with unresectable locally advanced or metastatic disease. (ncats.io)
- Belzutifan is a hypoxia-inducible factor (HIF) inhibitor indicated for the treatment of adult patients with von Hippel-Lindau (VHL) disease who require therapy for associated renal cell carcinoma (RCC), central nervous system (CNS) hemangioblastomas, or pancreatic neuroendocrine tumors (pNET) who do not require immediate surgery. (affygility.com)
- Sutent is indicated for the treatment of pancreatic neuroendocrine tumors (pNET), a type of cancer of the pancreas that cannot be surgically removed and is advanced or metastatic. (israelpharm.com)
- Recommended Dose For pNET: The recommended dose of Sunitinib for pancreatic neuroendocrine tumors (pNET) is 37.5 mg taken orally once daily continuously without a scheduled off-treatment period. (saifpharma.com)
Neoplasms7
- Renal neuroendocrine neoplasms are rare, with little to no data available on prognosis and treatment outcomes. (elsevierpure.com)
- Neuroendocrine tumors (NETs) are rare neoplasms originating from diffuse neuroendocrine cells. (oaepublish.com)
- Highly aggressive, poorly differentiated neoplasms were defined as Grade-3 neuroendocrine carcinomas (NECs) when originating from the gastrointestinal tract, or as small- or large-cell NECs when appearing in the lung. (oaepublish.com)
- [ 2 ] Well- to moderately differentiated neuroendocrine neoplasms (WMD-NEN) are a highly heterogeneous group of tumors comprising low-grade (G1) and intermediate-grade (G2) NETs of the gastrointestinal tract, typical and atypical carcinoids of the lung and thymus, and other cancers such as medullary thyroid carcinoma and pheochromocytoma/paraganglioma. (oaepublish.com)
- Ki-67 assessment of pancreatic neuroendocrine neoplasms: Systematic review and meta-analysis of manual vs. digital pathology scoring. (who.int)
- Pulmonary carcinoids are well differentiated low to intermediate grade lung neuroendocrine tumours (LNETs), that belong to the group of lung neuroendocrine neoplasms which also include highly aggressive lung neuroendocrine carcinomas (LNECs). (who.int)
- These data have been combined with previously published LNET data to perform integrative analysis using multi-omics factor analysis (MOFA), resulting in a molecular map of lung neuroendocrine neoplasms for exploration. (who.int)
Hepatocellular carcinoma2
- The results suggest cabozantinib, which has been approved by the U.S. Food and Drug Administration for some patients with renal cell carcinoma, hepatocellular carcinoma, or thyroid cancer, can benefit patients with neuroendocrine tumors that continue to grow and spread after previous treatment, researchers say. (dana-farber.org)
- Cometriq (cabozantinib) is FDA approved for use in patients with medullary thyroid cancer, Cabometyx (cabozantinib) is FDA approved for use in patients with advanced renal cell carcinoma, hepatocellular carcinoma previously treated with sorafenib, adult and pediatric patients 12 years and older with locally advanced or metastatic differentiated thyroid cancer, and in combination with Opdivo (nivolumab) in patients with advanced renal cell carcinoma (FDA.gov). (jax.org)
Pancreas7
- pancreatic neuroendocrine tumours (tumours of the hormone-producing cells in the pancreas) that have spread or cannot be removed with surgery. (europa.eu)
- The tumors begin in neuroendocrine cells - which have characteristics of nerve and hormone-producing cells - and can arise in multiple sites in the body, most often in the gastrointestinal tract, lungs, and pancreas. (dana-farber.org)
- The study enrolled 197 patients with advanced extra-pancreatic neuroendocrine tumors (which arise outside the pancreas) and 93 patients with pancreatic neuroendocrine tumors. (dana-farber.org)
- Sutent (sunitinib) is approved for neuroendocrine tumors of the pancreas, advanced renal cell carcinoma, and GIST (FDA.gov). (jax.org)
- Pancreatic neuroendocrine tumour is an uncommon cancer arising in the pancreas. (medexmd.com)
- Vascular tumors may also occur in the kidneys (renal cell carcinoma), pancreas (cysts, microcystic cystadenomas, or pancreatic neuroendocrine tumors) and/or adrenal glands (pheochromocytoma). (cancerhealthcenter.com)
- Загальні відомості про карциноїдні пухлини Carcinoid tumors develop from neuroendocrine cells in the gastrointestinal tract (90%), pancreas, pulmonary bronchi, and rarely the genitourinary tract. (msdmanuals.com)
Tumours2
- For pancreatic neuroendocrine tumours, Sunitinib Accord is given at a dose of 37.5 mg once a day without a rest period. (europa.eu)
- Commonly prescribed for: Hematologic malignancies such as leukaemias, renal cell carcinomas, gastrointestinal stromal tumours , soft tissue sarcomas and neuroendocrine tumours. (oralmedicineoralpathology.com)
Sunitinib7
- Sunitinib is approved for treatment of gastrointestinal stromal tumors, renal cell carcinoma and pancreatic neuroendocrine tumors. (helsinki.fi)
- The aim for this study was to investigate whether caloric restriction improves sunitinib-induced cardiovascular toxicity and renal damage in rats, and to study activated cellular pathways. (helsinki.fi)
- Based on this study it was observed that the dose 3 mg/kg sunitinib was well tolerated in rats because it did not cause more extensive hypertension, worse hypertrophy or renal damage compared to untreated SHR groups. (helsinki.fi)
- Sutent (sunitinib), is marketed by Pfizer for the treatment of cancer including gastrointestinal stromal tumors, advanced renal cell carcinoma, and pancreatic neuroendocrine tumors. (patentdocs.org)
- ADR: IPSEY) today announced three-year minimum, 44-month median, follow-up results from the Phase III CheckMate -9ER trial showing that Cabometyx® (cabozantinib) in combination with nivolumab provides survival and response rate benefits after three-years in the first-line treatment of advanced renal cell carcinoma (aRCC), compared to sunitinib. (news-medical.net)
- Patients with advanced renal cell carcinoma who received the checkpoint inhibitor combination nivolumab (Opdivo) plus ipilimumab (Yervoy) experienced longer treatment-free survival (TFS) over a 42-month period than patients who received the targeted therapy sunitinib (Sutent), regardless of the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk group, according to new analysis of the CheckMate-214 clinical trial. (news-medical.net)
- Advanced Renal Cell Carcinoma (RCC): Sunitinib is indicated for the treatment of advanced renal cell carcinoma. (saifpharma.com)
Pancreatic neuroendocrine tumors with disease2
- Pfizer's Sutent gained approval from the European Commission for the treatment of unresectable or metastatic, well-differentiated pancreatic neuroendocrine tumors with disease progression in adults. (genengnews.com)
- Sutent 12,5 mg is intended for the treatment of inoperable and/or metastatic pancreatic neuroendocrine tumors with disease development in adult people. (medexmd.com)
Cancers3
- While renal cell carcinoma is one of the most frequently diagnosed cancers, chromophobe renal cancer only accounts for five percent of renal cancer cases. (wikipedia.org)
- L'objectif de cette étude était de déterminer la fréquence des cancers gynécologiques en pratique oncologique à Lomé et d'en étudier les aspects épidémiologiques et histo-cliniques. (bvsalud.org)
- Il s'agitd'une étude rétrospective et descriptive portant sur tous les cancers gynécologiques reçus en oncologie entre le 1erJanvier 2016 et le 31 Décembre 2021. (bvsalud.org)
Moderately differentiated neuroendocrine tumors1
- A recent report from the ESMO Precision Medicine Working Group also supports TMB testing for a number of solid tumors, including cervical cancer, well- and moderately differentiated neuroendocrine tumors, salivary cancer, thyroid cancer, and vulvar cancer. (genomeweb.com)
Cell carcinomas2
- Clinicopathological and molecular features of hereditary leiomyomatosis and renal cell cancer-associated renal cell carcinomas. (cdc.gov)
- For MCPyV, which is present in ≈80% of rare but aggressive cutaneous Merkel cell carcinomas (MCCs) ( 17 , 25 - 27 ), seroprevalence among healthy persons was shown to be 42%-77% ( 20 , 21 , 28 , 29 ). (cdc.gov)
Tuberous scleros2
- Afinitor (everolimus) is FDA approved for use in neuroendocrine tumors of pancreatic, lung or gastrointestinal tract origin, advanced renal cell carcinoma, in adult and pediatric patients aged 1 year and older with tuberous sclerosis complex who have subependymal giant cell astrocytoma, and in combination with Aromasin (exemestane) in hormone receptor-positive, HER2-negative breast cancer (FDA.gov). (jax.org)
- Visceral manifestations of tuberous sclerosis complex include cardiac rhabdomyomas, renal angiomyolipomas, and pulmonary lymphangiomyomatosis, whereas its cutaneous signs include facial angiofibromas, subungual fibromas, Shagreen patches, and hypomelanotic macules. (medscape.com)
Metastasis2
- At diagnosis, about 65-95% of gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show hepatic metastasis. (oaepublish.com)
- Eur Urol, EAU-EBU update series 5:26-37 Google Scholar Saitoh H (1981) Distant metastasis of renal adenocarcinoma. (indexindex.com)
Malignant1
- Metastatic renal cell carcinoma is a type of renal cancer that suggests malignant transformations in the renal tubule cells. (medexmd.com)
Carcinoid2
- Jennifer Chan, MD, MPH , director of the Program in Carcinoid and Neuroendocrine Tumors at Dana-Farber , will present the findings of the CABINET trial at the annual European Society for Medical Oncology (ESMO) Congress on October 22, 2023, in Madrid, Spain. (dana-farber.org)
- Endocrinologically active tumors of the diffuse peripheral endocrine or paracrine system (neuroendocrine tumors) produce various amines and polypeptides with corresponding symptoms and signs, including carcinoid syndrome. (msdmanuals.com)
Chromophobe renal6
- Chromophobe renal cancer is part of a rare, genetic disorder known as Birt-Hogg-Dubé syndrome. (wikipedia.org)
- Furthermore, 30% of patients with Birt-Hogg-Dubé syndrome will also develop chromophobe renal cancer. (wikipedia.org)
- Chromophobe Renal Cell Carcinoma: A Review of an Uncommon Entity. (wikipedia.org)
- The Histologic Diversity of Chromophobe Renal Cell Carcinoma. (lww.com)
- Chromophobe renal cell carcinoma (ChRCC) is the third most common renal cell carcinoma in adults. (lww.com)
- WHO 2022 landscape of papillary and chromophobe renal cell carcinoma. (who.int)
Cancer8
- What Is Kidney Cancer (Renal Cell Carcinoma)? (wikipedia.org)
- One third of patients with cancer of unknown primary origin have poorly or undifferentiated carcinoma. (medscape.com)
- Further validation of the testing approach comes from NCCN: TMB analysis using an FDA-approved test is recommended ahead of second-line treatment decisions for cervical cancer , uterine sarcoma and endometrial carcinoma , vulvar cancer , bone cancer , and cancer of unknown primary . (genomeweb.com)
- Bethesda, MD, http://seer.cancer.gov/csr/1975_2005/, based on November 2007 SEER data submission, posted to the SEER web siteJanzen NK, Kim HL, Figlin RA, Belldegrun AS (2003) Surveillance after radical or partial nephrectomy for localized renal cell carcinoma and management of recurrent disease. (indexindex.com)
- Cancer 48:1487-1491Article CAS PubMed Google Scholar Hofmann HS, Neef H, Krohe K, Andreev P, Silber RE (2005) Prognostic factors and survival after pulmonary resection of metastatic renal cell carcinoma. (indexindex.com)
- Eur Urol 48:77-81 discussion-2Article PubMed Google Scholar Piltz S, Meimarakis G, Wichmann M et al (2003) Surgical treatment of pulmonary metastases from renal cancer. (indexindex.com)
- It can also be used for people who are at high risk of recurrent renal cancer after having had kidney surgery. (israelpharm.com)
- More specifically, it is approved for use in the case of renal cell carcinoma (a type of kidney cancer), central nervous system hemangioblastomas, and pancreatic neuroendocrine tumors. (cancerhealthcenter.com)
Microcystic3
- Rare patterns of ChRCC have been described over the last few decades, showing a wide histologic spectrum including those with adenomatoid microcystic pigmented, multicystic, neuroendocrine, small cell, and papillary features. (lww.com)
- According to the WHO classification, SCNs are classified into microcystic SCA, macrocystic SCA, solid serous adenoma, von Hippel-Lindau-associated serous cyst neoplasm, and mixed serous-neuroendocrine neoplasm (2). (spg.pt)
- Microcystic serous cystadenoma mimicking pancreatic neuroendocrine neoplasm: report of a resected case with preoperative diagnostic difficulty and review of the literature. (spg.pt)
Angiomyolipomas1
- formerly subependymal giant cell astrocytoma [SEGA]), cardiac rhabdomyomas, renal angiomyolipomas, multiple retinal nodular hamartomas and pulmonary lymphangiomyomatosis (LAM). (medscape.com)
Pituitary1
- Integrated proteogenomic characterization across major histological types of pituitary neuroendocrine tumors. (freshbioscience.com)
Sutent2
- Sutent is intended for the use of advanced and/or metastatic renal cell carcinoma in adult people. (medexmd.com)
- Sutent is also used to treat advanced renal cell carcinoma (RCC) and as an adjuvant treatment for adult patients at high risk of recurrent RCC following nephrectomy (surgical removal of a kidney. (israelpharm.com)
Urothelial carcinoma1
- In a placebo-controlled phase III trial of over 700 patients with urothelial carcinoma (UC) and high-risk disease after radical cystectomy, one year of adjuvant nivolumab improved disease-free survival (median 21 versus 11 months) [1]. (nursingcenter.com)
Metastatic disease1
Patients3
- Cabozantinib significantly improved outcomes in patients with previously treated extra-pancreatic and pancreatic neuroendocrine tumors and may become a new treatment option for patients. (dana-farber.org)
- Sanction allows use of the drug to treat patients with pancreatic neuroendocrine tumors. (genengnews.com)
- Today's sanction in pancreatic neuroendocrine tumors is based on results from a randomized, Phase III trial conducted in 171 patients. (genengnews.com)
Cysts1
- Minor criteria include pitting of dental enamel, gingival fibromas, hamartomatous rectal polyps, radiographic evidence of bone cysts, multiple renal cysts, "confetti" skin lesions among other features. (medscape.com)
Chromogranin1
- The neoplastic cells routinely express pan-cytokeratin and neuroendocrine markers chromogranin and synaptophysin (focal to diffuse staining). (pbpath.org)
20221
- A new research paper was published in Oncotarget on August 4, 2022, entitled, "Kinase activity profiling in renal cell carcinoma, benign renal tissue and in response to four different tyrosine kinase inhibitors. (news-medical.net)
Somatostatin1
- Gallium‐68 ( 68 Ga)‐1,4,7,10‐tetraazacyclo‐dodecane‐1,4,7,10‐tetraacetic acid DOTA‐peptides highlight neuroendocrine tumors ( NETs ) through binding the somatostatin receptors that are overexpressed on the surfaces of their cells. (radiologykey.com)
Neoplasm1
- Pancreatic Neuroendocrine Neoplasm Associated with a Familial MAX Deletion. (cdc.gov)
Hepatic1
- Leigh syndrome can also have detrimental multisystemic affects on the cardiac, hepatic, gastrointestinal, and renal organs. (beds.ac.uk)