TransplantationRecipientsDysfunctionRejection in renalSurvivalBiopsiesUnited States Renal Data SystemNephropathyGraftBiopsyOutcomesCadavericFailureStage renal diseasePatientsOutcomeRetrospective studyRecipientPost-transplantDiseaseNephrologyESRDGraftsRuptureDonorClinical ResearchFunctionComplicationAssessmentVersusRiskLossCommittee
Transplantation15
- Prospective study of a triple immunosuppressive combination in renal transplantation: cyclosporin A-corticoids-azathioprine]. (nih.gov)
- The risk of CMV infection and CMV disease following transplantation is highest in CMV-seronegative recipients of renal allografts from CMV-seropositive donors (D+/R−), i.e. recipients who have no immunity to the virus and receive a kidney from a donor who has been infected previously [2]. (alliedacademies.org)
- In addition to the direct effects of viral infection, there is also evidence of an association between CMV infection/disease and acute allograft rejection in the setting of renal and other solid organ transplantation [3-5]. (alliedacademies.org)
- 51 renal allograft recipients 2-3 weeks after transplantation and 26 healthy volunteers received 3.0T MR DTI examination. (gitlab.io)
- We found marked induction of HO mRNA and protein in renal allografts at day 5 after transplantation. (elsevierpure.com)
- In addition, I oversee a portfolio of projects involving end stage renal disease, kidney transplantation, bone and mineral metabolism, and urological epidemiology. (nih.gov)
- Is anuria prior to pediatric renal transplantation associated with poor allograft outcomes? (rochester.edu)
- Among these, new-onset diabetes after transplant (NODAT) is a serious and frequent metabolic complication after renal transplantation and is considered a risk for patients undergoing renal transplantation. (thieme-connect.de)
- External iliac arterial obstruction is relatively rare in renal transplantation, and may cause surgical failure and ipsilateral leg ischaemia. (uwi.edu)
- Four patients with external iliac arterial obstruction caused by Satinsky atrauma forceps in renal transplantation were analysed and summarized. (uwi.edu)
- External iliac arterial rupture and obstruction caused by Satinsky atrauma forceps in renal transplantation is rare, but may cause severe and depressing outcome. (uwi.edu)
- For example, in developing and developed countries alike, kidney transplantation not only yields survival rates and quality-of-life that are far superior to those obtained with other treatments for end-stage renal disease, such as haemodialysis, but is also less costly in the long run. (who.int)
- Transplantation of Renal Allograft After Removal of Renal Cell Carcinoma: Case Report and Review of the Literature. (umassmed.edu)
- If proven effective and safe in clinical trials, their innovative approach will contribute to improve outcomes in renal transplantation. (astellas.com)
- Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2008 Jan 23 (1): 364-8. (cdc.gov)
Recipients16
- To investigate this association, we analyzed polymorphisms of CCR5-∆32, CCR5-59029-A/G, CCR2-V64I and MCP-1 G/A (-2518) in 173 renal transplant recipients and 169 healthy blood donors. (nih.gov)
- Impact of chemokine receptor CCR2 and CCR5 gene polymorphism on allograft outcome in North Indian renal transplant recipients. (nih.gov)
- Liver functional abnormalities were seen in 13 (19.7%) of 66 recipients of cadaveric renal homografts treated with cyclosporin A and prednisone. (nih.gov)
- A single institution, randomized, prospective trial of cyclosporin versus azathioprine-antilymphocyte globulin for immunosuppression in renal allograft recipients. (nih.gov)
- Background: Cytomegalovirus (CMV)-seronegative recipients of renal allografts from CMV-seropositive donors (D+/R−) have a higher rate of acute rejection than other renal transplant recipients. (alliedacademies.org)
- We recently demonstrated that seromismatched recipients of renal allografts had a significantly higher rate of acute rejection than non-seromismatched recipients, supporting a forward relationship [7]. (alliedacademies.org)
- The study includes 1641 adults, recipients of first cadaveric (CAD, N = 1195) or living related renal grafts (LRD, N = 446), transplanted in one institution. (elsevierpure.com)
- Post-transplant ejection fraction and renal failure in cardiac transplant recipients: An analysis of the OPTN database. (ucsfhealth.org)
- Expanding the Donor Pool: First Use of Hepatitis B Virus Nat Positive Solid Organ Allografts Into Seronegative Recipients. (uc.edu)
- Use of HCV Ab+/NAT- donors in HCV naïve renal transplant recipients to expand the kidney donor pool. (uc.edu)
- 1 ] Renal transplant recipients' survival time has gradually increased because of the improved survival rate during the perioperative period and enhancements in treatment with antirejection drugs. (thieme-connect.de)
- 3 ] NODAT may severely impact both short- and long-term outcomes of renal transplant recipients in terms of graft and patient survival. (thieme-connect.de)
- Background: Since 2014 Luminex crossmatch (LXM) is being performed regularly in India for post-transplant management of renal allograft recipients. (iomcworld.com)
- In kidney transplant recipients, BKPyV viremia contributes indirectly and directly to premature allograft failure. (astellas.com)
- In kidney transplant recipients, complications from kidney stone events can also lead to rejection and allograft failure. (stanford.edu)
- There is limited information on the incidence of kidney stone events in transplant recipients.METHODS: We identified 83,535 patients from the United States Renal Data System who received their first kidney transplant between January 1st, 2007 and December 31st, 2018. (stanford.edu)
Dysfunction7
- Thirteen G-2 patients developed chronic allograft dysfunction (CAD). (nih.gov)
- Renal allograft compartment syndrome (RACS) is graft dysfunction secondary to intracompartment hypertension. (psu.edu)
- However, many normally functioning allografts have T-cell infiltrates and histological ACR, and many nonimmune processes cause allograft dysfunction. (usuhs.edu)
- 11. Moderate renal dysfunction may not require a cisplatin dose reduction: a retrospective study of cancer patients with renal impairment. (nih.gov)
- She had received pulse steroids 16 months before the hepatitis occurred to treat acute lung allograft dysfunction. (cdc.gov)
- Typically, renal dysfunction due to humoral transplant rejection or other pathologies results in the increase of protein excreted in urine (1-5). (chromatographyonline.com)
- Methods: A retrospective study was performed on 169 consecutive LXM performed at a single center to investigate suspected allograft dysfunction (n=147) and for monitoring DSA in normally functioning allografts (n=22). (iomcworld.com)
Rejection in renal1
- Selective conversion from azathioprine to cyclosporin for steroid-resistant rejection in renal transplants: an alternative therapy. (nih.gov)
Survival7
- The objective of this study was to determine if CMV seromatching has an effect on renal allograft function and allograft survival. (alliedacademies.org)
- The secondary end-point was renal allograft survival. (alliedacademies.org)
- The objective of this study was to determine if CMV matching has an effect on renal allograft function and allograft survival that is independent of its effect of acute rejection Results: Three hundred and thirty-three patients (216 males) underwent first cadaveric renal transplant during this time period. (alliedacademies.org)
- Acute rejection (AR) is a strong predictor of renal allograft survival. (elsevierpure.com)
- We compared actuarial renal allograft and patient survival using Kaplan-Meier log-rank test between ID-LDRT and 5M-LDRT as well as 6M-CRT and 5M-CRT. (atcmeetingabstracts.com)
- Gunabushanam V, Nusrat R, Lam H, Sood P, Hariharan S, Donaldson J, Humar A, Wijkstrom M. Renal Allograft Survival of HLA-Identical Living Donors (ID-LDRT) and 6-HLA Matched Cadaveric Donors (6M-CRT) Compared with 5 HLA-Matched Controls [abstract]. (atcmeetingabstracts.com)
- Effect of the shipment of cadaveric renal allografts on allograft survival. (hal.science)
Biopsies5
- Polyomavirus in Renal Allograft Biopsies? (medscape.com)
- How common is polyomavirus (BKV) in renal allograft biopsies, and what are the reliable differentiation points with respect to tubulo-interstitial rejection? (medscape.com)
- Personally, I do not agree with the Basel viewpoint on interstitial inflammation in renal allograft biopsies with BKV infection. (medscape.com)
- Donor-specific antibodies against HLA, MICA, and GSTT1 in patients with allograft rejection and C4d deposition in renal biopsies. (qxmd.com)
- Pre- and posttransplantation sera from 19 patients fulfilling the criteria for AMR including C4d deposition in renal biopsies were included. (qxmd.com)
United States Renal Data System2
- As Director of Kidney and Urology Epidemiology for KUH, my portfolio includes oversight of the United States Renal Data System and Urologic Diseases of America. (nih.gov)
- I am the approval authority for all data requests for the United States Renal Data System research files, and requests to merge such data with other data sources. (nih.gov)
Nephropathy4
- A relationship between CMV infection/disease and chronic allograft nephropathy (CAN) has been proposed from animal studies, although human studies have been inconclusive. (alliedacademies.org)
- A relationship between CMV infection/disease and chronic allograft nephropathy (CAN) has been proposed, and several animal studies have demonstrated mechanisms by which CMV infection/disease may enhance the process of chronic allograft nephropathy [8-10]. (alliedacademies.org)
- Chronic allograft nephropathy (CAN) is a kidney disorder which is the leading cause of kidney transplant failure, occurring months to years after the transplant. (wikipedia.org)
- Nephron number determines susceptibility to renal mass reduction-induced CKD in Lewis and Fisher 344 rats: implications for development of experimentally induced chronic allograft nephropathy. (cdc.gov)
Graft2
- We investigated the traffic of allograft-responding leukocytes between the host and graft without handling of these cells in vitro. (silverchair.com)
- The entrapment of labeled leukocytes in a relevant graft was specific: when an allograft and an autograft were simultaneously transplanted, a more than 50-fold entrapment was observed in the allograft, compared with the autograft. (silverchair.com)
Biopsy3
- The recipient had a fever 8 days after receiving the renal allograft, and a biopsy of it showed acute rejection. (cdc.gov)
- The accurate diagnosis of renal allograft rejection currently depends upon a biopsy. (chromatographyonline.com)
- Aim This study was planned to evaluate the possible role of the LXM in the post-transplant setting for the detection and characterization of HLA-specific IgG antibodies and to correlate with allograft biopsy and renalfunction. (iomcworld.com)
Outcomes2
Cadaveric1
- The objective of this study was to determine whether the shipment of cadaveric kidneys according to these new exchange rules affects allograft outcome in the Eastern region of France. (hal.science)
Failure8
- Keywords: Varicella, Chickenpox, End stage renal failure, End stage renal disease, Varicella vaccine Background Patients suffering from chronic kidney disease (CKD) and end stage renal disease (ESRD) / end stage renal failing (ESRF) (both ESRF and ESRD are henceforth known as ESRD) are increasing worldwide. (eurodyn2011.org)
- African Americans have long been recognized as a group of Americans with the highest prevalence and earliest onset of hypertension and associated increased risk of stroke, heart failure, renal failure, and death. (nih.gov)
- There is considerable heterogeneity 1 but overall non-Hispanic Blacks (in this manuscript, the term African American is used for US studies whereas the term Black is used for international studies) have an earlier onset, higher prevalence, and disproportionately high risk of complications for hypertension, including stroke, heart failure, renal disease, and mortality compared to non-Hispanic Whites and Mexican Americans2,3. (nih.gov)
- also called acute renal failure) in hospitalized patients is also a significant problem in the United States. (nih.gov)
- In the kidney interstitial fibrsosis is characteristic of all progressive nephropathies that lead to renal failure. (ncl.ac.uk)
- Time from receipt of kidney transplant to death-censored renal allograft failure. (ucsfhealth.org)
- 6. Urinary Calprotectin Differentiates Between Prerenal and Intrinsic Acute Renal Allograft Failure. (nih.gov)
- Balakrishnan S, Smith B, Bentall A , Kukla A, Merzkani M, Stegall M, Schinstock C. Effect of Maintaining Immunosuppression After Kidney Allograft Failure on Mortality and Retransplantation. (mayo.edu)
Stage renal disease3
- A man with end-stage renal disease received the donated kidney that was transplanted. (cdc.gov)
- The incidence of end-stage renal disease (ESRD) has also been steadily increasing in the adult US population. (nih.gov)
- A phase Ib, open-label, single arm study to assess the safety, pharmacokinetics, and impact on humoral sensitization of SANGUINATE infusion in patients with end-stage renal disease. (uc.edu)
Patients3
- Patients were divided into three groups with good allograft function, moderately impaired allograft function and severely impaired allograft function according to the estimated glomerular filtration rateApparent diffusion coefficient (ADC) and fractional anisotropy (FA) values were compared between groups with significant differences being found. (gitlab.io)
- This program also encompasses diet and nutrition in patients with ESRD and in patients on renal replacement therapy. (nih.gov)
- U.S. Renal Data System (USRDS) data indicate that from 1992-2003 the number of patients with ESRD has increased from 250 to 338 per million population. (nih.gov)
Outcome3
- Previous studies have suggested the influence of common genetic variation on renal transplant outcome. (qub.ac.uk)
- We detected a locus on chromosome 19 that associated with 5 year eGFR in the recipient GWAS suggesting that recipient genotype may be used to predict medium-term renal allograft outcome. (qub.ac.uk)
- Impact of donor and recipient cytokine genotypes on renal allograft outcome. (cdc.gov)
Retrospective study1
- METHODS: This retrospective study analysed all renal transplants performed in the four centres of the French Eastern region during 3 years (1996 to 1998). (hal.science)
Recipient1
Post-transplant1
- The D+/R− group does not appear to have poorer renal allograft function 3 years post-transplant. (alliedacademies.org)
Disease6
- Renal allograff acute cellular rejection (ACR) is a T-cell mediated disease that is diagnosed histologically. (usuhs.edu)
- For epidemiologic research, I am interested in descriptive, analytic, and interventional epidemiologic research projects in renal and non-cancer urologic disease. (nih.gov)
- The mechanisms and pathophysiology underlying renal disease and its progression. (nih.gov)
- Advances clinical studies and epidemiologic research on renal disease. (nih.gov)
- Despite substantial improvements in United States general population awareness, treatment and control of hypertension during recent decades, African Americans continue to have a disproportionately high prevalence of hypertension and risk of blood pressure (BP)-related cardiovascular and renal disease complications compared to non-Hispanic Whites. (nih.gov)
- Becasue of the importance of fibrosis in clinical disease it is vital that we understand the mechanisms of renal fibrosis so that novel therapeutic targets can be identified and drugs developed. (ncl.ac.uk)
Nephrology2
- I also lead the teaching on Renal Week which provides nephrology teaching to year 4 students on the MBBS programme. (ncl.ac.uk)
- Additionally, she was instrumental in the founding of two fellowships (General Nephrology and Transplant Nephrology) and was the founding leader for the renal block, Mayo Medical School in Arizona. (mayoclinic.org)
ESRD2
- Evidence released to date shows that varicella vaccination work and secure Nos3 in ESRD and sufferers DL-AP3 on renal substitute therapy [10C13]. (eurodyn2011.org)
- Specific to renal research in transplant and dialysis, I support basic, translational and clinical studies in all aspects of ESRD. (nih.gov)
Grafts1
- Skin allografts or amnion grafts are effective burn-wound dressings and are within the reach of low- or medium-income countries. (who.int)
Rupture1
- Since the endarterial rupture was not found and fixed in time, the renal allograft was lost. (uwi.edu)
Donor3
- Production of antibodies against donor-specific antigens is one of the central mechanisms of allograft rejection. (qxmd.com)
- This antibody-mediated rejection (AMR) is evidenced by the presence of circulating donor-specific antibodies and deposition of complement component C4d on renal endothelium. (qxmd.com)
- Reducing Donor-specific Antibody During Acute Rejection Diminishes Long-term Renal Allograft Loss: Comparison of Early and Late Rejection. (uc.edu)
Clinical Research1
- I lead the renal clinical research group at the Freeman. (ncl.ac.uk)
Function4
- One other case with tubulitis and viral inclusions (but no intimal arteritis) showed complete restoration of renal function after corticosteroid treatment. (medscape.com)
- Meanwhile, differences of DTI images and tractography demonstrated the potential of DTI to visually discriminate allograft with varied function. (gitlab.io)
- 2. Difference in decline in renal function due to cisplatin after a short or long hydration scheme in non-small-cell lung cancer: A retrospective cohort study (HYCIS-XL). (nih.gov)
- Acute Kidney Injury (AKI) Acute kidney injury is a rapid decrease in renal function over days to weeks, causing an accumulation of nitrogenous products in the blood (azotemia) with or without reduction in amount of urine. (msdmanuals.com)
Complication1
- Prompt diagnosis and management of this kind of complication is essential to rescue the patient and allograft. (uwi.edu)
Assessment1
- Quantitative analysis of selected gene transcripts may enhance the clinical assessment of allografts. (usuhs.edu)
Versus1
- Separate submission of standard lymphadenectomy in 6 packets versus en bloc lymphadenectomy in bladder cancer. (rochester.edu)
Risk2
- This group does, however, have an increased risk of early allograft loss due to acute rejection. (alliedacademies.org)
- Increased allograft length and width should be considered as a potential risk for RACS. (psu.edu)
Loss1
- In conclusion, the observed association of CCR2-64I with AR should be added to the spectrum of immunogenetic factors known to be involved in allograft renal loss. (nih.gov)
Committee1
- He has an active research group within the department of Inflammation Biology at King's College London, is chief investigator of the OuTSMART study, and chairs the Renal Project Board Steering Committee. (guysandstthomas.nhs.uk)