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  • schwannomas
  • Originally described in Japanese patients, it consists of multiple cutaneous schwannomas, central nervous system tumors, and other neurological complications, excluding hallmark signs of NF. (wikipedia.org)
  • Although schwannomas are benign they become detrimental when the growing tumor compresses the nerve. (wikipedia.org)
  • A mechanism involving both the SMARCB1 and NF2 genes may be responsible for the development of the disease because tumor analysis of schwannomas indicates the presence of inactivating mutations in both the SMARCB1 and NF2 genes. (wikipedia.org)
  • Another set of criteria are: Two or more nonintradermal (cutaneous) schwannomas No evidence of vestibular tumor No known NF-2 mutation or One pathologically confirmed nonvestibular schwannoma plus a first degree relative who meets the above criteria. (wikipedia.org)
  • bilateral
  • Tumors of this type usually arise from the cerebrum and may exhibit the classic infiltration across the corpus callosum, producing a butterfly (bilateral) glioma. (wikipedia.org)
  • In cats with unilateral or bilateral zona glomerulosa tumors, the PAC may be very high while the PRA is completely suppressed. (wikipedia.org)
  • paraneoplastic
  • Mucocutaneous dysfunctions of paraneoplastic syndromes can be seen in cases of itching (hypereosinophilia), immune system depression (latent varicella-zoster virus in sensory ganglia), pancreatic tumors (leading to adipose nodular necrosis of subcutaneous tissues, flushes (prostaglandin secretions), and even dermic melanosis (cannot be eliminated via urine and results in grey to black-blueish skin tones). (wikipedia.org)
  • Doege-Potter syndrome (DPS) is a paraneoplastic syndrome in which hypoglycemia is associated with solitary fibrous tumors. (wikipedia.org)
  • occur
  • Majority of these tumors are solitary non-hereditary lesions and approximately 15% of osteochondromas occur as hereditary multiple osteochondromas (HMOs). (wikipedia.org)
  • These tumors usually occur within the anterior wall of the left ventricle or the interventricular septum and rarely involves the right ventricle. (wikipedia.org)
  • nerves
  • Even when they're extremely small, tumors on the nerves that connect the brain to the ear can wreak havoc on a person's hearing and balance. (emaxhealth.com)
  • The types of neurofibromatosis are: Neurofibromatosis type I, in which the nerve tissue grows tumors (neurofibromas) that may be benign, may cause serious damage by compressing nerves and other tissues. (wikipedia.org)
  • citation needed] These tumors can compress the nerves that carry information from the eyes, causing a decrease in peripheral vision. (wikipedia.org)
  • Commonly
  • It is thought to be triggered when tumor cells (in PCD, most commonly ovarian or breast cancer) ectopically express proteins normally expressed in the cerebellum. (wikipedia.org)
  • Tumors most commonly affect long bones in the leg, pelvis, or scapula (shoulder blade). (wikipedia.org)
  • rarely
  • Four subtypes of glioblastoma have been identified: Classical : Ninety-seven percent of tumors in the 'classical' subtype carry extra copies of the epidermal growth factor receptor (EGFR) gene, and most have higher than normal expression of epidermal growth factor receptor (EGFR), whereas the gene TP53 (p53), which is often mutated in glioblastoma, is rarely mutated in this subtype. (wikipedia.org)
  • This tumor is rarely seen in atrial locations. (wikipedia.org)
  • growths
  • Doctors use the term "neoplasm" (tranlates literally as new growth) to describe tumors that are abnormal growths of cells. (healthtap.com)
  • compress
  • Mass effect from the tumor and edema may compress the ventricles and cause hydrocephalus. (wikipedia.org)
  • In addition to the severe hormonal effects related to increased blood cortisol levels, the large tumor can compress adjacent structures. (wikipedia.org)
  • cerebellum
  • Lhermitte-Duclos disease (LDD) (English: /ˌlɛərˈmiːtˌduːˈkloʊ/), also called dysplastic gangliocytoma of the cerebellum, is a rare, slowly growing tumor of the cerebellum, a gangliocytoma sometimes considered to be a hamartoma, characterized by diffuse hypertrophy of the granular layer of the cerebellum. (wikipedia.org)
  • diagnosis
  • Finally, a biopsy of the tumor, taken through a needle during a simple surgical procedure, helps to confirm the diagnosis. (wikipedia.org)
  • The diagnosis of these tumors require physical checkups, imaging studies on the heart, and specialized tests to evaluate the heart. (wikipedia.org)
  • Echocardiography: Most valuable diagnosis because this can evaluate the morphology, location and range of the tumor. (wikipedia.org)
  • unilateral
  • Tumors within the nerve canaliculi initially present with unilateral sensorineural hearing loss, unilateral tinnitus, or disequilibrium (vertigo is rare, on account of the slow growth of neuromas). (wikipedia.org)
  • Grade
  • This characteristic, as well as the presence of hyperplastic blood vessels, differentiates the tumor from Grade 3 astrocytomas, which do not have these features. (wikipedia.org)
  • As of 2016, guidelines incorporated biologic factors, such as tumor grade, cellular proliferation rate, estrogen and progesterone receptor expression, human epidermal growth factor 2 (HER2) expression, and gene expression profiling into the staging system. (wikipedia.org)
  • Although it is a low-grade tumor, its location can potentially obstruct the ventricles and lead to hydrocephalus. (wikipedia.org)
  • The choice of therapy depends upon the location and grade of the tumor and the stage of the disease, as well as the general state of the patient (performance status). (wikipedia.org)
  • Grade II pleomorphic xanthoastrocytomas are known to progress towards grade II tumors, which are more likely to recur after surgical removal. (wikipedia.org)
  • cells
  • Surgical tumor removal is selected as a treatment option to control the spread of cancer cells. (floridahospital.com)
  • Glioblastoma multiforme tumors are characterized by the presence of small areas of necrotizing tissue that are surrounded by anaplastic cells. (wikipedia.org)
  • These are determined by the presence or absence of receptors on the cells of the tumor. (wikipedia.org)
  • In contrast, these phenomena are mediated by humoral factors (such as hormones or cytokines) secreted by tumor cells or by an immune response against the tumor. (wikipedia.org)
  • The tumors involve supporting cells in the nervous system rather than the neurons. (wikipedia.org)
  • In a patient with Cushing's disease, the tumor cells will be stimulated to release corticotropin and elevated plasma corticotropin levels will be detected. (wikipedia.org)
  • occurs
  • Cardiac fibroma, also known as cardiac fibromatosis, is a rare benign tumor of the heart that occurs primarily in infants and children. (wikipedia.org)
  • large
  • While small tumors may be removed with a scalpel and stitches, large tumors and skin cancers often require procedures that leave behind significant tissue or result in bone loss . (howstuffworks.com)
  • kidney
  • Erythrocytosis is common in regions of the liver, kidney, adrenal glands, lung, thymus, and central nervous system (as well as gynecological tumors and myosarcomas). (wikipedia.org)