DiseasesAnalytical, Diagnostic and Therapeutic Techniques and Equipment
Leukemia, Biphenotypic, AcuteImmunophenotypingLeukemiaLeukemia, Myeloid, AcutePrecursor Cell Lymphoblastic Leukemia-LymphomaRemission Induction
Refractory Acute MyeloidComplete remission rateLymphoblastic leukaemiaMyeloid leukemiasLeukaemiaLymphocytic leukemiasLymphoidMegakaryoblastic leukemiaChemotherapyHematologicChronic myeloidInclude acuteAmbiguous lineagePatientsAggressiveSubtypeTherapyImmunophenotypeChimericMolecularOncologyDurationAdultTransplantationDiagnosesAbnormalitiesCytarabineSubtypesStemClassificationTreatmentRateAffectsBoneTypePathwaysDiseaseSymptomsCellsChildrenTypesResultsOccur
Refractory Acute Myeloid2
  • Gilteritinib is an AXL receptor tyrosine kinase inhibitor used to treat relapsed or refractory acute myeloid leukemia. (drugbank.com)
  • Gilteritinib is indicated for the treatment of adult patients who have relapsed or refractory acute myeloid leukemia with an FLT3 mutation detected by an FDA-approved test. (drugbank.com)
Complete remission rate2
  • Perform preliminary efficacy analysis of combination of MEK162 and induction chemotherapy (3 +4 ) in patients with RAS-mutated AML by measuring complete remission rate, 2-year overall survival, and duration of response. (mycancergenome.org)
  • The complete remission rate of the six patients in this study using conventional chemotherapy was 60%, with a median survival time of 7.5 months. (bvsalud.org)
Lymphoblastic leukaemia2
  • One of the first cancers where major developments occurred for adolescents and young adults was acute lymphoblastic leukaemia. (leukaemia.org.au)
  • Intensification of treatment for adults with acute lymphoblastic leukaemia: results of U.K. Medical Research Council randomized trial UKALL XA. (medscape.com)
Myeloid leukemias2
  • Leukemias affecting these cells are called myeloid leukemias. (healthline.com)
  • This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
Leukaemia2
  • Biphenotypic acute leukaemia (BAL) is an uncommon type of leukemia which arises in multipotent progenitor cells which have the ability to differentiate into both myeloid and lymphoid lineages. (wikipedia.org)
  • About 5% of acute leukaemia cases are BAL. (wikipedia.org)
Lymphocytic leukemias2
  • In lymphoblastic or lymphocytic leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (rxharun.com)
  • Most lymphocytic leukemias involve a specific subtype of lymphocyte, the B cell. (rxharun.com)
Lymphoid3
  • Leukemia is a group of clonal diseases derived from a single cell with a genetic alteration in bone marrow or peripheral lymphoid tissue, and each type is determined by the specificity of the source cell. (sld.cu)
  • There was a significant improvement in survival of Acute Myeloid Leukemia, Chronic Lymphoid leukemia, CML and ALL, the latter approximately with 90% cure rate in children. (sld.cu)
  • One of the six individuals exhibited a biphenotypic immunophenotype, one exhibited a simple myeloid immunophenotype, and the other four exhibited myeloid and lymphoid expression. (bvsalud.org)
Megakaryoblastic leukemia1
Chemotherapy6
  • Introduction: Mold-active primary antifungal prophylaxis (PAP) is widely recommended in neutropenic patients (pts) with newly diagnosed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS) who undergo remission-induction chemotherapy (RIC). (confex.com)
  • PRIMARY OBJECTIVES: I. Determine maximum tolerated dose (MTD) of MEK162 (MEK inhibitor MEK162 ) in patients with RAS-mutated acute myeloid leukemia ( AML ) when combined with sequential induction chemotherapy (3 +4 ) as measured by development of grade 3-4 dose-limiting toxicities (DLT). (mycancergenome.org)
  • The patient was treated with induction chemotherapy including imatinib followed by haploidentical stem cell transplantation and achieved complete remission. (bvsalud.org)
  • Neuromuscular impairments in adult survivors of childhood acute lymphoblastic leukemia: associations with physical performance and chemotherapy doses. (medscape.com)
  • Intensive postremission chemotherapy without maintenance therapy in adults with acute lymphoblastic leukemia. (medscape.com)
  • The value of high-dose systemic chemotherapy and intrathecal therapy for central nervous system prophylaxis in different risk groups of adult acute lymphoblastic leukemia. (medscape.com)
Hematologic2
  • Primary or Secondary acute myeloid leukemia (AML) Patients in first of second Morphological Complete Remission (CR), Morphological Complete Remission with incomplete hematologic recovery (CRi), or Morphologic Leukemia-free State (MLFS) as defined by the European LeukemiaNet (ELN) recommendations for AML Response Criteria (Dohner, 2017). (uchicagomedicine.org)
  • In phase III clinical trials, gilteritinib reported a complete remission or complete remission with partial hematologic recovery in 21% of the patients. (drugbank.com)
Chronic myeloid2
  • As the therapy is used, each leukemia subtype had its peculiarities regarding the treatment, especially the introduction of imatinib for chronic myeloid leukemia (CML) and prophylactic cranial irradiation for cases of ALL. (sld.cu)
  • The Philadelphia chromosome is the hallmark of chronic myeloid leukemia (CML). (bvsalud.org)
Include acute1
  • Other conditions that should be considered in the evaluation of suspected acute ALL include acute biphenotypic leukemia and natural killer (NK)-cell leukemia. (medscape.com)
Ambiguous lineage1
  • Acute leukemias of ambiguous lineage, not otherwise specified (ALAL-NOS) is a rare type of acute leukemia. (biomedcentral.com)
Patients7
  • The objective of this research was to synthesize studies that characterize the clinical and epidemiological profile of patients with leukemia, the types of treatments used, duration and outcomes for the cases. (sld.cu)
  • It is concluded a prevalence of leukemia in pediatric patients, with a predominance of the subtype Acute Lymphoblastic Leukemia (ALL). (sld.cu)
  • Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
  • Data of the six patients was collected and analyzed, including clinical characteristics, cytogenetics, gene mutation profile, prior therapy, complete remission (CR) rate, overall survival (OS, survival duration was defined from diagnosis of the disease to dead). (biomedcentral.com)
  • As noted earlier, patients with acute lymphoblastic leukemia (ALL) may present with fever without any other evidence of infection. (medscape.com)
  • In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)
  • The interest in FLT3 transmembrane tyrosine kinases was raised when studies reported that approximately 30% of the patients with acute myeloid leukemia presented a mutationally activated isoform. (drugbank.com)
Aggressive3
  • The rearrangement of MLL are related with different kinds of aggressive acute leukemias. (wikipedia.org)
  • Philadelphia chromosome-positive (Ph+) T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive type of acute leukemia. (bvsalud.org)
  • One subtype is B-cell prolymphocytic leukemia, a more aggressive disease. (rxharun.com)
Subtype1
  • BACKGROUND: Philadelphia chromosome-positive acute myeloid leukemia (Ph+ AML) is a rare leukemia subtype first classified by the World Health Organization in 2016. (bvsalud.org)
Therapy4
  • Although PCZ is the preferred agent for PAP, the incorporation of targeted agents into acute leukemia therapy calls for more individualized choices in PAP. (confex.com)
  • Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults. (medscape.com)
  • Short course high dose mitoxantrone with high dose cytarabine is effective therapy for adult lymphoblastic leukemia. (medscape.com)
  • Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy. (rxharun.com)
Immunophenotype2
  • If the patient has leukemia, the morphology and immunophenotype check is needed to make sure the type of leukemia. (wikipedia.org)
  • Value of immunophenotype in intensively treated adult acute lymphoblastic leukemia: cancer and leukemia Group B study 8364. (medscape.com)
Chimeric1
  • Acute leukemias induced by MLL chimeric oncoproteins are among the subset of cancers distinguished by a paradoxical dependence on GSK-3 kinase activity for sustained proliferation. (stanford.edu)
Molecular1
  • Molecular complete remission was confirmed 29 days after haplo-PBSCT. (bvsalud.org)
Oncology1
  • Guideline] NCCN Clinical Practice Guidelines in Oncology: Acute Lymphoblastic Leukemia, Version 2:2015. (medscape.com)
Duration1
Adult5
  • Myeloid markers in adult acute lymphocytic leukemia. (medscape.com)
  • Treatment of adult acute lymphoblastic leukemia. (medscape.com)
  • Treatment of 218 adult acute lymphoblastic leukemias. (medscape.com)
  • Phase III trial of brief intensive treatment of adult acute lymphocytic leukemia comparing daunorubicin and mitoxantrone: a CALGB Study. (medscape.com)
  • Cytarabine with high-dose mitoxantrone induces rapid complete remissions in adult acute lymphoblastic leukemia without the use of vincristine or prednisone. (medscape.com)
Transplantation3
  • Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
  • An 18-year-old man underwent allogenic bone marrow transplantation (BMT) for Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ALL). (bvsalud.org)
  • The patient has maintained long-term remission since the haplo-PBSCT, and his kidney function was restored by the kidney transplantation from his father. (bvsalud.org)
Diagnoses1
Abnormalities1
  • Most of biphenotypic leukemia in children is due to the rearrangement of MLL Besides them, other gene abnormalities has been reported. (wikipedia.org)
Cytarabine1
  • Giving MEK inhibitor MEK162, cytarabine, and idarubicin may be an effective treatment for acute myeloid leukemia. (mycancergenome.org)
Subtypes1
  • The survival rates vary by age: 85% in children and 50% in adults.Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt's leukemia, and acute biphenotypic leukemia. (rxharun.com)
Stem2
  • 3) We are defining the properties of cancer stem cells that initiate and sustain the unique disease features of acute leukemias through the use of various adoptive animal models. (stanford.edu)
  • We demonstrate here that GSK-3 maintains the MLL leukemia stem cell transcriptional program by promoting the conditional association of CREB and its coactivators TORC and CBP with homedomain protein MEIS1, a critical component of the MLL-subordinate program, which in turn facilitates HOX-mediated transcription and transformation. (stanford.edu)
Classification1
  • Before 2008, the diagnosis of BAL was based on a score system proposed by the European Group for the Immunological Classification of Leukemias (EGIL) which could differentiate from other kinds of acute leukemia. (wikipedia.org)
Treatment3
  • This trial will have the following sequential phases: screening, baseline, induction treatment and count recovery, response assessment, consolidation treatment (if remission is achieved), and follow-up for relapse and survival assessment. (clincosm.com)
  • The safety of this treatment will be evaluated, and researchers want to learn if NK cells will help in treating acute myeloid leukemia. (uchicagomedicine.org)
  • Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (rxharun.com)
Rate2
  • When used correctly, the rate of remission is close to 90%, according to one 2018 review . (healthline.com)
  • What is the survival rate of hairy cell leukemia-variant? (healthline.com)
Affects4
  • Leukemia is a form of cancer that affects your blood cells, bone marrow, and other related tissues. (healthline.com)
  • HCL-V affects B cells, so it's classified as a chronic lymphocytic leukemia (CLL). (healthline.com)
  • Leukemia is a cancer of the blood or bone marrow.It is a form of cancer that affects the body's ability to make healthy blood cells. (rxharun.com)
  • Chronic lymphocytic leukemia (CLL) - most often affects adults over the age of 55. (rxharun.com)
Bone2
  • Chronic lymphocytic leukemia ( CLL ) is a type of cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell ). (wikipedia.org)
  • Acute myeloid leukemia is cancer that impacts the blood and bone marrow with a rapid progression. (drugbank.com)
Type3
  • Hairy cell leukemia-variant is an extremely rare and unique type of leukemia (cancer) that was once grouped with another type but is now considered a separate condition. (healthline.com)
  • In myeloid or myelogenous leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (rxharun.com)
  • Acute lymphoblastic leukemia (ALL ) - is the most common type of leukemia in young children. (rxharun.com)
Pathways1
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
Disease2
  • It's a chronic form of leukemia, meaning it's typically a more slowly developing form of the disease. (healthline.com)
  • Subjects not achieving remission will continue to be followed for long-term trial endpoints such as disease progression and survival. (clincosm.com)
Symptoms2
Cells4
  • Persistent fever, infection prolonged healing: Most of the white blood cells are leukemia cells, no normal function, leading to decreased immunity, susceptible to infection. (wikipedia.org)
  • One rare form of leukemia is hairy cell leukemia (HCL) , named for the hair-like filaments found on affected white blood cells. (healthline.com)
  • Acute leukemia - is characterized by a rapid increase in the number of immature blood cells. (rxharun.com)
  • Chronic leukemia - is characterized by the excessive buildup of relatively mature, but still abnormal, white blood cells. (rxharun.com)
Children2
Types2
  • The hybrid gene product ABL/BCR is an oncogene which could lead several types of leukemia including BAL. (wikipedia.org)
  • Let's take a look at the basics of HCL-V and how it's different from other types of leukemia. (healthline.com)
Results1
  • Results: We identified 232 pts with AML/MDS (n=186), ALL (n=43), and biphenotypic leukemia (n=3). (confex.com)
Occur1