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  • Maturation
  • Leukemia is a type of malignant disease caused by abnormality of Hematological Stem Cells (HSCs), as colony cells lose differentiation or maturation ability for arresting at certain stage during development. (alliedacademies.org)
  • Childhood
  • This treatment information summary on childhood acute myeloid leukemia (AML) is an overview of prognosis, diagnosis, classification, and treatment. (meds.com)
  • Children with Down syndrome have an increased risk of leukemia with a ratio of ALL to AML typical for childhood acute leukemia, except during the first 3 years of life when AML (especially M7) predominates. (meds.com)
  • cytoplasmic
  • He represented with severe thrombocytopenia and thrombocytopenic bleeding with blood film and marrow being devoid of blasts but rather marrow showed numerous smooth, non-budding, cytoplasmic basophilic megakaryocytes in keeping with ITP. (semanticscholar.org)
  • cytogenetic
  • Cytogenetic analysis provides some of the strongest prognostic information available, predicting outcome of both remission induction and postremission therapy, as seen in a trial from the Southwest Oncology Group (SWOG) and the Eastern Cooperative Oncology Group (ECOG) (E-3489). (rexhealth.com)
  • Myelodysplastic syndrome (MDS) is a set of disorders characterized by marrow failure with peripheral blood cytopenias, a peculiar set of morphologic abnormalities in hematopoietic cells, increased marrow blasts in some cases, frequent characteristic cytogenetic abnormalities, and frequent progression to a subset of acute myeloid leukemia (AML). (medscape.com)
  • Recombinant human interferon α can obtain persistent cytogenetic remission of CML, thus elongating lifespan [ 8 ]. (alliedacademies.org)
  • Translocation
  • 7 ] Translocations of chromosomal band 11q23, including most AML secondary to epipodophyllotoxin,[ 8 ] are generally unfavorable for remission duration except possibly where the translocation partner is chromosome 9, i.e., t(9;11). (meds.com)
  • incidence
  • A long-term follow-up of 30 patients who had AML that was in remission for at least 10 years has demonstrated a 13% incidence of secondary malignancies. (healthmedicinet.com)
  • OBJECTIVES: I. Evaluate the incidence of acute graft versus host disease in patients undergoing transplantation with an unrelated or related matched or mismatched antigen donor. (knowcancer.com)
  • leukemic cells
  • Children with AML who have a white blood cell count (WBC) greater than 100,000 per cubic milliliter, secondary AML, and leukemic cells with a monosomy 7 karyotype have low remission induction rates, whereas children with leukemia cell chromosomal abnormalities t(8;21) and inv 16 have a high likelihood of achieving remission. (meds.com)