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  • induce
  • As his condition improved, Pinkel began working with eminent researcher Sidney Farber in Boston, experimenting with aminopterin, which could induce temporary remissions in some leukemia cases. (wikipedia.org)
  • Fistulizing disease Maintenance of remission after surgery for Crohn's disease A combination of azathioprine and infliximab treatment may be more effective than a single dose of infliximab to induce steroid-free remission for people with active Crohn's disease. (wikipedia.org)
  • 7+3" in the context of chemotherapy is an acronym for a chemotherapy regimen that is most often used today (as of 2014) as first-line induction therapy (to induce remission) in acute myelogenous leukemia, excluding the acute promyelocytic leukemia form, which is better treated with ATRA and/or arsenic trioxide and requires less chemotherapy (if requires it at all, which is not always the case). (wikipedia.org)
  • The goal is to induce remission initially with medications, followed by the administration of maintenance medications to prevent a relapse of the disease. (wikipedia.org)
  • The medications used to induce and maintain a remission somewhat overlap, but the treatments are different. (wikipedia.org)
  • relapse
  • Patients who are deemed at high or very high risk of relapse with standard therapy often receive four or more drugs in the induction regimen. (unm.edu)
  • 6 patients had relapse, of which 5 had further cyclophosphamide and two achieved remission. (bmj.com)
  • Because human renal tissue cannot be obtained sequentially during remission and relapse, animal models are often used to study progression of lupus nephritis. (biomedcentral.com)
  • To elucidate the molecular mechanisms involved in renal inflammation during the progression, remission and relapse of nephritis we performed a transcriptome analysis of renal tissue from two murine lupus models, NZB/WF1 mice that develop proliferative glomerulonephritis and NZM2410 mice that develop glomerulosclerosis with minimal inflammation. (biomedcentral.com)
  • Remission induction reversed most, but not all, of the inflammatory changes and progression towards relapse was associated with recurrence of inflammation, mitochondrial dysfunction and metabolic stress signatures. (biomedcentral.com)
  • Among the patients who relapsed during remission induction stage, 52.9% had secondary relapse during follow-up. (biomedcentral.com)
  • chemotherapy
  • Remission induction for adults consists of multiagent chemotherapy and injection of chemotherapy into the spinal fluid (intrathecal injection) to prevent relapses in the central nervous system (CNS). (unm.edu)
  • Standard remission induction therapy currently consists of administering chemotherapy drugs over approximately one month. (unm.edu)
  • TCMHs with or without chemotherapy, in 57 trials, showed statistically significant differences for the improvement of mortality in nine trials, quality of life in 16 trials, rate of remission in 11 trials, and leukopenia in five trials. (cochrane.org)
  • ALL is typically treated initially with chemotherapy aimed at bringing about remission. (wikipedia.org)
  • There were four phases: remission induction, remission consolidation or intensification, specific pre-emptive meningeal treatment and continuation chemotherapy for 3 years. (wikipedia.org)
  • mortality
  • However, the mortality rate during remission induction was 10% for older patients compared 2% for younger patients. (unm.edu)
  • Although some chemotherapies or bio-therapies have made progress in the remission of this disease, the mortality from gastric cancer remains high. (cochrane.org)
  • assess
  • To assess the effectiveness of Chinese medicinal herbs in the short-term remission of advanced or late gastric cancer. (cochrane.org)
  • patients
  • Given the patients' age and the adverse event profile of GCs, steroid- free remission is the most desired target in patients with PMR, but typical GC sparing agents are often insufficient. (clinicaltrials.gov)
  • The response and remission rates between the patients with concomitant steroid, biologic or tacrolimus and without concomitant medication were 80.6% and 70.9% (P=0.28), 61.3% and 53.1% (P=0.13), respectively. (ecco-ibd.eu)
  • All 12 cases responded to cytapheresis, notably, 4 EN patients showing rapid remission after the first 2 cytapheresis sessions. (ecco-ibd.eu)
  • 30% of patients (15/50) were able to stop immunosuppression while maintaining remission. (bmj.com)
  • The patients not achieving the therapeutic goals were considered to have failed of remission induction. (biomedcentral.com)
  • There were 26 patients in our cohort who failed of remission induction, including 16 (20.8%) on GC monotherapy, and 10 (7.2%) on combination therapy comprising GC and IM. (biomedcentral.com)
  • Eosinophilia, higher baseline RI, more than five organs involved and dacryoadenitis were risk factors for remission induction failure with GC monotherapy, and the incidence of remission induction failure was 71.4% in the patients with more than three risk factors. (biomedcentral.com)
  • After 6-month treatment, the patients who failed of remission induction had significantly higher erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and IgG4. (biomedcentral.com)
  • In our cohort, 20.8% of patients failed of remission induction with GC monotherapy, while 7.2% of patients failed of remission induction with combination therapy comprising GC and IM. (biomedcentral.com)
  • Preliminary data in pediatric patients with short duration of disease have shown a remission rate of 60% and normalization of CRP in about 50% of patients treated with azithromycin and metronidazole in combination. (clinicaltrials.gov)
  • The investigators also hypothesize that remission will be accompanied by normalization of CRP in a high proportion of patients with active CD. (clinicaltrials.gov)
  • The ADE induction (unlike, say, combinations of 7+3 with vinca alkaloids or prednisolone) is still sometimes used, especially in poor-risk AML patients. (wikipedia.org)
  • free
  • The free radical induction theory, discussed below, proposes that 5-ASA is serving not just as an anti-inflammatory agent, but also as a free radical trap, destroying the hydroxyl and other radicals that may damage colonic epithelial barrier. (wikipedia.org)
  • include
  • Drugs used during remission induction usually include Oncovin® (vincristine), Elspar® (L-asparaginase) or Oncaspar® (peg-L-asparaginase), and an anthracycline such as Adriamycin® (doxorubicin). (unm.edu)
  • patient
  • The addition of vinca alkaloids (vincristine or vinblastine) to the "7+3" regimen, which addition was quite popular in AML in old times (when the biology of AML and the differences between AML and ALL was poorly understood) proved to be harmful in AML, lowering the chance of the patient to get remission. (wikipedia.org)