Remifentanil is used for sedation as well as combined with other medications for use in general anesthesia. (wikipedia.org)
The use of remifentanil has made possible the use of high-dose opioid and low-dose hypnotic anesthesia, due to synergism between remifentanil and various hypnotic drugs and volatile anesthetics. (wikipedia.org)
Remifentanil can be administered as part of an anesthesia technique called TIVA (total intravenous anesthesia) using computer controlled infusion pumps in a process called target controlled infusion (TCI). (wikipedia.org)
In combination with propofol, remifentanil is used for anesthesia of patients undergoing electroconvulsive therapy. (wikipedia.org)
Due to its quick metabolism and short effects, remifentanil has opened up new possibilities in anesthesia. (wikipedia.org)
Eight male, clinically healthy New Zealand White rabbits were intubated under xylazine-ketamine-isoflurane anesthesia. (vin.com)
In a randomized, prospective, parallel, controlled trial, 216 patients undergoing elective thoracic pulmonary resection under one-lung ventilation with propofol-remifentanil anesthesia were randomized 1:1 to receive either limb RIPC or conventional lung resection (control). (silverchair.com)
Our hypothesis is that the use of a remifentanil bolus dose given prior to emergence of a desflurane-based anesthesia will reduce the incidence of perioperative coughing from 70% to 35% compared to lidocaine. (druglib.com)
Efficacy of a Bolus Dose of Remifentanil Compared to a Bolus Dose of Intravenous lidoca ne on the Incidence of Coughing During Emergence of Anesthesia. (druglib.com)
The effect of a remifentanil infusion given in combination with isoflurane as the volatile agent has been shown to reduce the incidence of perioperative coughing without delaying the emergence of anesthesia. (druglib.com)
Drugs such as fentanyl, morphine, remifentanil, lidocaine, ketamine and/or dexmedetomidine have been used in clinical anesthesia in order to provide better cardiovascular stability by reducing inhalant agent requirements. (vin.com)
We think that, the desflurane group be preferred as a priority with less remifentanil expenditure, lower blood pressure values, higher rSO 2 values, no 20% decrease in rSO 2 values, faster extubation, and statistically significant early recovery. (clinmedjournals.org)
Different effects of sevoflurane, desflurane, and isoflurane on early and late left ventricular diastolic function in young healthy adults. (unibas.ch)
Shorter-acting volatile agents (eg, sevoflurane and desflurane) are associated with a higher incidence of ED than longer-acting agents (eg, halothane and isoflurane) are. (medscape.com)
Comparative study of emergence agitation between isoflurane with isoflurane-remifentanil infusion in. (ac.ir)
Background:Few studies have so far been conducted concerning the effect of remifentanil infusion on emergence agitation in children undergoing Adenotonsillectomy. (ac.ir)
It is administered in the form remifentanil hydrochloride and in adults is given as an intravenous infusion in doses ranging from 0.1 microgram per kilogram per minute to 0.5 (µg/kg)/min. (wikipedia.org)
This means that accumulation does not occur with remifentanil and its context-sensitive half-life remains at 4 minutes after a 4-hour infusion. (wikipedia.org)
This is because remifentanil will be rapidly eliminated from the blood plasma on termination of the remifentanil infusion, hence the effects of the drug will quickly dissipate even after very long infusions. (wikipedia.org)
After isoflurane discontinuation, the animals received either propofol (group P, n=4) or propofol plus remifentanil (group P/R, n=4) by continuous intravenous infusion for a maximum period of 38 hours. (vin.com)
METHODS: Patients received either remifentanil 0.5 microg kg(-1) over 30 s, followed by an infusion of 0.1 microg kg min(-1) (group R) or alfentanil 10 microg kg(-1) over 30 s, followed by an infusion of saline (group A). Anaesthesia was then induced with propofol, rocuronium, and 1% isoflurane with 66% nitrous oxide in oxygen. (druglib.com)
In conclusion, both propofol and remifentanil lead to tolerance with regard to their sedative and analgesic effect in PMV rabbits within the first few hours. (vin.com)
Methods: The study was approved by the local ethics committee, including data from 60 patients scheduled for ambulatory surgery undergoing general anaesthesia with propofol and remifentanil, using TCI. (researchgate.net)
Conclusion: The qCON was able to reliably detect LOC during general anaesthesia with propofol and remifentanil. (researchgate.net)
Alfentanil2
Effects of remifentanil and alfentanil on the cardiovascular responses to induction of anaesthesia and tracheal intubation in the elderly. (druglib.com)
BACKGROUND: We compared the effects of remifentanil and alfentanil on arterial pressure and heart rate at induction of anaesthesia and tracheal intubation in 40 ASA I-III patients aged greater than 65 yr, in a randomized double-blind study. (druglib.com)
Lidocaine1
Time elapsed between the bolus dose of remifentanil or lidocaine and extubation. (druglib.com)
Analgesia3
While opiates function similarly, with respect to analgesia, the pharmacokinetics of remifentanil allows for quicker post-operative recovery. (wikipedia.org)
14 ± 1.2 h), adequate sedation/analgesia was achieved by administration of progressively decreasing doses down to 187 ± 72% of propofol ID in group P, 123 ± 43% of propofol ID in group P/R and 184 ± 58% of remifentanil ID. (vin.com)
General anaesthesia with isoflurane reduces plasma endocannabinoid AEA concentrations, and this could be a consequence of stress reduction after loss of consciousness . (mdwiki.org)
Concentrations2
There were no significant differences in remifentanil or propofol effect-site concentrations for movers vs. non-movers. (researchgate.net)
Consistency of remifentanil concentrations in propofol-remifentanil infusions. (apagbi.org.uk)
Rats5
Here we investigated whether remifentanil postconditioning exerts neuroprotective effects against global cerebral ischemia/reperfusion injury in rats and its potential mechanisms. (springer.com)
The results suggest that remifentanil postconditioning exhibits neuroprotective effects against global cerebral ischemia/reperfusion injury in rats, and its mechanisms might involve inhibition of neuronal apoptosis through the PI3K pathway. (springer.com)
Zhang Y, Chen ZW, Girwin M et al (2005) Remifentanil mimics cardioprotective effect of ischemic preconditioning via protein kinase C activation in open chest of rats. (springer.com)
Jeong S, Kim SJ, Jeong C et al (2012) Neuroprotective effects of remifentanil against transient focal cerebral ischemia in rats. (springer.com)
Rats were then anesthetized with isoflurane, and induction time was quantified as loss of righting reflex. (silverchair.com)
Anesthetic1
Isoflurane , sold under the trade name Forane among others, is a general anesthetic . (mdwiki.org)
Cesarean section1
This allows remifentanil to be used in unique circumstances such as cesarean section. (wikipedia.org)
Therefore, the present study aimed to determine the effect of adding remifentanilinfusion to Isoflurane and reducing the concentration of Isoflurane on the reduction of agitation recovery in children undergoing Adenotonsillectomy.Material and Methods: In a clinical trial study, 86 patients who candidate for Adenotonsillectomy were selected and randomly divided in two groups. (ac.ir)
Remifentanil does not impair left ventricular systolic and diastolic function in young healthy patients. (unibas.ch)
Second set of tangential questions- does anyone consider using remifentanil in patients with chronic pain conditions at increased risk for hyperalgesia? (studentdoctor.net)
Effects4
The neuroprotective effects of remifentanil preconditioning against cerebral ischemia/reperfusion injury have been recently reported. (springer.com)
However, the neuroprotective effects of remifentanil postconditioning were abolished by pretreatment of the PI3K inhibitor LY294002. (springer.com)
Side effects of isoflurane include a decreased ability to breathe (respiratory depression), low blood pressure , and an irregular heartbeat . (mdwiki.org)
Isoflurane likely binds to GABA , glutamate and glycine receptors, but has different effects on each receptor. (mdwiki.org)
Reduces1
Although the concurrent administration of propofol with remifentanil does not affect the ID of propofol, it reduces the rate and delays the occurrence of its tolerance. (vin.com)
Increased power in the electroencephalogram and decreased activity in the electromyogram caused by isoflurane covaried with pontine reticular formation GABA levels. (silverchair.com)
Decreasing pontine reticular formation GABA levels comprises one mechanism by which isoflurane causes loss of consciousness, altered cortical excitability, muscular hypotonia, and decreased respiratory rate. (silverchair.com)
Isoflurane acts as a positive allosteric modulator of the GABA A receptor in electrophysiology studies of neurons and recombinant receptors. (mdwiki.org)
Sedative1
This project was designed to compare the dose requirements and the development of tolerance on the sedative/analgesic effect of propofol versus propofol plus remifentanil administered in rabbits under prolonged mechanical ventilation (PMV). (vin.com)
Acid1
Remifentanil is metabolized to a compound (remifentanil acid) which has 1/4600th the potency of the parent compound. (wikipedia.org)
Dose1
Owing to synergism between remifentanil and hypnotic drugs (such as propofol) the dose of the hypnotic can be substantially reduced. (wikipedia.org)
Potent1
Remifentanil, marketed under the brand name Ultiva is a potent, short-acting synthetic opioid analgesic drug. (wikipedia.org)
Time1
Remifentanil is used as an opioid analgesic that has a rapid onset and rapid recovery time. (wikipedia.org)
Injury2
We found remifentanil postconditioning markedly improved the spatial learning and memory as well as attenuated neuronal apoptosis in hippocampus caused by cerebral ischemia/reperfusion injury. (springer.com)
Zhang Y, Irwin MG, Wong TM (2004) Remifentanil preconditioning protects against ischemic injury in the intact rat heart. (springer.com)
Blood1
The relatively short context-sensitive half-life of remifentanil allows the desired blood plasma level to be achieved quickly, and also for the same reason, recovery occurs quickly. (wikipedia.org)
Global1
The average lifetime of isoflurane in the atmosphere is 3.2 years, its global warming potential is 510 and the yearly emissions add up to 880 tons. (mdwiki.org)
Drug1
Remifentanil is considered a metabolic soft drug, one that is rapidly metabolized to an inactive form. (wikipedia.org)
Relative1
When remifentanil is used together with a hypnotic (i.e. one that produces sleep) it can be used in relative high doses. (wikipedia.org)