InfectionSyphilisNeisseriaOrganismIntracellularInfectionsMicrobiotaEpidemiologicalPathogenBacterialPathogens2020ComparativeIncidenceHumansMolecularEpidemiologySusceptibilityDoxycyclineDefenseGenomeVariationsSurveillanceEvidenceTreatmentRiskAdditionDataDevelopmentCommon causeProvideDiseaseFormProblemMonitorQuestions
Infection8
- Background Chlamydia trachomatis (CT) infection remains highly prevalent. (bmj.com)
- In a given patient, however, whether the infection is due to primary infection or reactivation of latent virus is unclear. (medscape.com)
- Chlamydiae are obligate, intracellular parasites with a unique reproductive cycle that involves 2 forms: (1) an extracellular form adapted to survival in the environment, which allows the infection to be transmitted from one person to another, and (2) an intracellular form that replicates and produces more extracellular forms. (medscape.com)
- Chlamydia is the most commonly reported sexually transmitted infection (STI) in Canada and is recognized as an important public health concern. (nccid.ca)
- In either case, the best strategies for preventing PID are: a) prevention of lower-genital-tract infection with Chlamydia trachomatis and Neisseria gonorrhoeae among both men and women, b) when this fails, early detection of lower-tract infection followed by prompt and effective treatment. (cdc.gov)
- herpes simplex virus types 1 and 2 (hsv-1 and hsv-2) are common infectious agents worldwide and the primary infection of hsv remains a major problem in the pregnant women in china nowadays. (liverpool.ac.uk)
- This unique resource will be used to monitor the host response (including how the immune system responds to the infection), determine the complete genome sequence of infecting C. difficile and identify the intestinal microbiota by sequencing and culturing. (ukri.org)
- To develop appropriate sustained interventions, a holistic integrated view of the pathogen, the host response and the intestinal microbiota during infection is required. (ukri.org)
Syphilis2
- His medical history included syphilis, gonorrhea, and genital chlamydia infections. (cdc.gov)
- Syphilis remains a common cause of morbidity and mortality during pregnancy, despite the continued sensitivity of T. pallidum to penicillin, the widespread availability of inexpensive, accurate tests, and substantial efforts to encourage routine screening through early prenatal care. (glowm.com)
Neisseria1
- We performed NAAT on pharyngeal samples to test for C. trachomatis and Neisseria gonorrhoeae . (cdc.gov)
Organism5
- Our program is studying host immune responses and organism factors contributing to reinfection. (bmj.com)
- The reason for this is unclear, but it is possible lower organism loads could elicit weaker protective cellular immune responses, predisposing to greater reinfection risk. (bmj.com)
- The organism enters host cells and resides in the cytoplasm in a membrane-bound parasitophorous vacuole (PV). (life-science-alliance.org)
- Rigorous statistical comparisons of data from the organism, intestinal microbiota and host response in relation to a patient disease severity index will enable selected genes/proteins to be chosen for functional analysis. (ukri.org)
- can be present as either a commensal organism or a pathogen in the vagina, and dogma dictates that changes in the host vaginal environment are necessary for the organism to induce pathological effects. (paperzz.com)
Intracellular2
- Thus, intracellular bacteria frequently encode the capacity to regulate host lipogenesis as well as to modulate the lipid composition of host membranes. (microbialcell.com)
- therefore, host lipids and their biosynthesis pathways have emerged as critical regulators of intracellular replication for vacuolar pathogens both as organelle membrane building blocks as well as nutrients [8] [9] . (microbialcell.com)
Infections8
- Here, we review the many functions of autophagy in bacterial infections with a focus on macrophages, the first line of host defenses, and the replicative niche of numerous pathogens. (frontiersin.org)
- Fungal infections can occur in immunocompetent hosts, but they are more likely to occur in individuals with abnormal immune systems. (medscape.com)
- Introduction: Trichomoniasis remains one of the most common sexually transmitted infections, which is curable. (bvsalud.org)
- Representing one of a series of NCCID evidence reviews on partner notification for sexually transmitted and blood borne infections, this component will also distinguish issues particular to PN for Chlamydia, to the extent that the literature allows. (nccid.ca)
- Repeat Chlamydia infections in females are common (20-30%) (Hosenfeld et al. (nccid.ca)
- Successful management of Chlamydia relies on timely identification, diagnosis and treatment of infections (5). (nccid.ca)
- While a great deal of effort has focused on defining their role in immunity to infections, studies now reveal T RM cells as a vital component of the host immune response to cancer. (frontiersin.org)
- Healthy mammalian hosts activate immune responses against pathogenic infections. (life-science-alliance.org)
Microbiota6
- The gut microbiota comprises diverse bacteria, fungal and viral components, which are critical in developing host immunity. (bvsalud.org)
- In addition to the pathogen, the host immune response and/or host microbiota are also likely important determinants of clinical outcome, but remain largely unexplored. (ukri.org)
- Our central hypothesis is that variations in C. difficile genetics, the composition of the resident intestinal microbiota and the host immune response to the bacterium shape the clinical outcome. (ukri.org)
- We will investigate the three-way interaction between pathogen, host and microbiota by monitoring a unique group of patients with and without CDI. (ukri.org)
- Robust statistical analysis comparing disease severity, host response, infecting pathogen and the composition of intestinal microbiota will facilitate subsequent studies on C. difficile to determine how and why it causes disease. (ukri.org)
- A comprehensive understanding of C. difficile, the host response and the intestinal microbiota will strengthen our understanding of the microorganism and to develop novel strategies to reduce the burden of CDI. (ukri.org)
Epidemiological1
Pathogen1
- To this end we will evaluate in unprecendented detail the pathogen genome sequence, intestinal microbial composition and the host response in a case-control study of CDI hospitalised patients. (ukri.org)
Bacterial2
- Bacterial compartment is captured by autophagosome either via ubiquitination (A.2, 3) or host glycan recognition by galectins (A.3). (frontiersin.org)
- Often starting as a phagosome in the endocytic compartment, these bacteria-occupied vacuoles transition into organelles with novel molecular features via remodeling of host proteins and lipids through the highly coordinated actions of bacterial factors [3] [5] . (microbialcell.com)
Pathogens2
- The family of Chlamydiaceae comprises 3 pathogens that can infect humans: Chlamydia trachomatis, Chlamydia psittaci, and Chlamydia pneumoniae. (lecturio.com)
- Host membranes are inherently critical for niche homeostasis of vacuolar pathogens. (microbialcell.com)
20202
- The questions contained on this web page were submitted by participants during the 2021 STI Treatment Guidelines Webinar hosted December 18, 2020 . (cdc.gov)
- Even at the end of 2020, much about this virus remains unclear. (giantmicrobes.com)
Comparative1
- The objectives of this review are to describe the structure of PN (partner notification) for Chlamydia and provide an analysis of key findings concerning effective practice, including the definition and measurement of outcome indicators, results of comparative studies and reviews of PN practice for Chlamydia, factors associated with improved outcomes, challenges in PN and strategies to address them, and key knowledge gaps. (nccid.ca)
Incidence1
Humans1
- In 2003 the virus that causes this respiratory illness jumped from its animal host to humans. (giantmicrobes.com)
Molecular1
- however, the molecular mechanisms of renewal and differentiation remain obscure in many cases, including the fallopian tube, a central organ of human reproduction. (nature.com)
Epidemiology1
- In recent years, a great deal has been learnt about the epidemiology, pathophysiology and treatment of reactive arthritis and chlamydia-induced reactive arthritis, specifically. (wikipedia.org)
Susceptibility1
- Despite its long history, the genetic basis for the susceptibility of 129 mice to teratoma development remains unclear. (top5binarybrokers.com)
Doxycycline1
- Management generally involves ceftriaxone, but treatment with doxycycline should be pursued if a coinfection with Chlamydia trachomatis ( C. trachomatis ) is not excluded. (lecturio.com)
Defense1
- However, the impact of autophagy goes beyond xenophagy and involves intensive cross-talks with other host defense mechanisms. (frontiersin.org)
Genome1
- Cytopathologic viruses, such as herpes simplex virus-1 (HSV-1) and HSV-2, live integrated into the host genome in the nervous system. (medscape.com)
Variations1
- LGV genotyping confirmed C. trachomatis serovar L2b on the basis of sequence variations compared with serovar L2 ( 2 ). (cdc.gov)
Surveillance1
Evidence1
- From within a unique ER-derived vacuole L. pneumophila promotes host lipogenesis and experimental evidence indicates that cholesterol production might be one facet of this response. (microbialcell.com)
Treatment3
- CT reinfection occurs in up to 20% of persons within months after treatment, likely contributing to sustaining the high chlamydia prevalence. (bmj.com)
- Quality STI prevention, which includes effective screening and treatment, remains the cornerstone of protecting the health and wellness of Americans. (cdc.gov)
- Partner notification (PN)-also referred to as contact tracing, case investigation, or partner counseling and referral services, among other terms (6)-provides a process for querying individuals recently diagnosed with Chlamydia (or another STI or HIV) about their sexual partners to obtain their contact information and facilitate partner examination and treatment, where necessary. (nccid.ca)
Risk1
- Chlamydia represents a risk for serious, long-term complications, disproportionately affecting women (e.g. (nccid.ca)
Addition1
- In addition, mannosebinding-lectin (MBL) is an epithelial-cell associated host protein that binds to Candida mannan, activates complement, and thus inhibits Candida growth. (paperzz.com)
Data2
- Prospective epidemiologic data suggest that chlamydia-induced reactive arthritis is underdiagnosed. (wikipedia.org)
- Recent data has been suggesting that Chlamydia-induced reactive arthritis might be a common condition that clinicians are simply failing to recognise. (wikipedia.org)
Development1
- Although aberrant immune cell activation induced by the imbalance between T helper Th1/Th17 and Treg cells is implicated in the RA development, its etiopathogenesis remains unclear. (bvsalud.org)
Common cause1
- Chlamydia trachomatis is thought to be the most common cause of reactive arthritis, in general. (wikipedia.org)
Provide1
- T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
Disease2
- Lymphogranuloma venereum (LGV) is typically a genital ulcer disease with inguinal adenopathy, caused by L serovars of Chlamydia trachomatis . (cdc.gov)
- Up to 30% of patients treated successfully for symptomatic CDI succumb to recurrent disease, but it is unclear why only some patients relapse. (ukri.org)
Form1
- According to this view, while most roots were indeed of three letters, there were some roots of two letters and even some of just one letter, such as Z for the verb HZH hizza sprin- kled, since this is the only remaining letter in the conjugated form YZW yazzu they will sprinkle. (top5binarybrokers.com)
Problem1
- Remediation of residually contaminated soils remains a widespread problem. (univie.ac.at)
Monitor1
- It remains the prescriberпїЅs accountability to monitor the affected person at common intervals for unwanted effects of therapy. (ehd.org)