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  • melanogaster
  • We used sequence-based analysis to examine codon bias, gene duplications, and levels of divergence (via d N / d S values and ortholog detection) of the 52 D. melanogaster ACPs in D. simulans , D. yakuba , and D. pseudoobscura . (genetics.org)
  • Sequence comparisons of ACPs shared and not shared between D. melanogaster and D. pseudoobscura show that there are separate classes undergoing distinctly dissimilar evolutionary dynamics. (genetics.org)
  • We asked whether natural selection mediated through the periodic sequence preferences of nucleosomes shapes the evolution of non-protein-coding regions of D. melanogaster by examining the inter- and intra-species genomic variation relative to these fundamental chromatin building blocks. (prolekarniky.cz)
  • The sequence changes across nucleosome-bound regions on the melanogaster lineage mirror the observed nucleosome dinucleotide periodicities. (prolekarniky.cz)
  • eukaryotes
  • Figures and mean lengths for proteins and pseudogenes in four eukaryotes Processed pseudogenes do not have introns (as they are derived from messenger RNA transcripts), and, if recently integrated into the genome, have detectable characteristic features such as a polyadenine tail with an upstream polyadenylation transmission (3,7). (hr010.net)
  • chromatin
  • As the oocyte leaves pachytene, the meiotic chromatin releases the synaptonemal complex components and condenses into a karyosome (blue doughnut). (genetics.org)
  • The HAC have been used successfully to understand the chromatin organization and epigenetic status of human centromeres [ 1 - 3 ], and the structure of the kinetochore [ 4 ]. (pubmedcentralcanada.ca)
  • STRAIN
  • However, once we set aside those that do not happen in the sequenced take flight strain or that are truncations (and would not be recognized by our methods), we are remaining with only three existing ABT-263 annotations [two cytochrome P450 pseudogenes and one -esterase pseudogene (9,12)], each of which are recovered in our study. (hr010.net)
  • dinucleotide
  • One of the most generalizable sequence affinities of the histone octamer is the periodic variation of dinucleotide frequencies across nucleosomal DNA. (prolekarniky.cz)
  • The other type of gap is small and results from homopolymeric and dinucleotide repeat sequences. (fruitfly.org)
  • pseudogenes
  • Data on the sequences and positions of the putative pseudogenes are available at: http://www.pseudogene.org/fly. (hr010.net)
  • As before, we assigned as candidate processed pseudogenes, any sequences that (i) are of considerable size (>70% of the space of the closest coordinating protein sequence) and that have no obvious introns, or (ii) have evidence of polyadenylation and no obvious introns (7). (hr010.net)
  • mammalian
  • The first feature purportedly depicts the fusion event and contains genomic sequences representing a head-to-head fusion of telomeres, the highly specific endcap DNA repeat motifs (TTAGGG) n located at the termini of linear mammalian chromosomes. (wordpress.com)
  • Extensive analyses confirm the underlying construction of the sequence, and expand our understanding of the structure and evolution of mammalian chromosomes, including gene deserts, segmental duplications and highly variant regions. (antiquityofman.com)
  • computational
  • The well-established inaccuracy of purely computational methods for annotating genome sequences necessitates an interactive tool to allow biological experts to refine these approximations by viewing and indepe. (biomedcentral.com)
  • lineages
  • New Zealand 's North Island Robin was originally thought to be a subspecies of the New Zealand Robin , but mitochondrial DNA sequence analysis has shown that the two lineages split prior to the Pleistocene ? (thefullwiki.org)
  • Molecular
  • Felsenstein J (1988) Phylogenies from molecular sequences: inferences and reliability. (springer.com)
  • However, with the improvement of the chain-termination method (see below), Maxam-Gilbert sequencing has fallen out of favour due to its technical complexity prohibiting its use in standard molecular biology kits, extensive use of hazardous chemicals, and difficulties with scale-up. (thefullwiki.org)
  • Differences
  • Sequence-dependent differences in the physical properties of DNA influence its associations with the histone core, as well as the kinetics of nucleosome assembly and stability - . (prolekarniky.cz)
  • regions
  • These patterns are most evident for intronic regions and indicate that non-protein coding regions are evolving toward sequences that facilitate the canonical association with the histone core. (prolekarniky.cz)
  • Although the human genome had been largely finished in its final draft form in 2004, very little was known about the functionality of the many areas outside the protein-coding regions that comprised less than 5 percent of the total DNA sequence. (icr.org)
  • biological
  • Knowledge of DNA sequences has become indispensable for basic biological research, other research branches utilizing DNA sequencing, and in numerous applied fields such as diagnostic, biotechnology , forensic biology and biological systematics . (thefullwiki.org)
  • The advent of DNA sequencing has significantly accelerated biological research and discovery. (thefullwiki.org)
  • regulatory
  • Associated with this widespread transcriptional activity was a wide variety of regulatory DNA sequences or patterns, regulatory motifs, that were involved in protein-DNA interactions and acted as different types of genetic switches. (icr.org)
  • bases
  • In 1976-1977, Allan Maxam and Walter Gilbert developed a DNA sequencing method based on chemical modification of DNA and subsequent cleavage at specific bases. (thefullwiki.org)
  • technology
  • However, despite the continuing progress on sequencing technology, the assembly problem is far from solved. (biomedcentral.com)
  • Thanks Pierre and Keith for the information, I might not have been paying enough attention in the talk to know if Clive was talking about just genotyping or full-on sequencing, but this page implies that the solexa technology is at the heart of full DNA sequencing . (hull.name)