• It was through this search that I came to a little known pregnancy hormone called relaxin which is produced ten times higher during pregnancy in most mammals. (prohealth.com)
  • Since its discovery in the 1920s, relaxin has enjoyed a reputation as a peptide hormone of pregnancy. (nih.gov)
  • Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals. (abcam.com)
  • Relaxin, a hormone of the insulin-growth factor family, promotes collagen remodeling. (nih.gov)
  • Relaxin-2, also called H2 relaxin, is a peptide hormone that plays an important role in female reproduction. (rndsystems.com)
  • Relaxin is best known as a hormone of parturition that promotes growth and softening of the cervix, development of the mammary gland, and has a marked impact on the uterus. (rndsystems.com)
  • PITTSBURGH, Aug. 22 - The pregnancy hormone relaxin induces a healthy physiological response in blood vessels, increasing dilation and benefiting blood pressure and kidney function, scientists at Magee-Womens Research Institute report in the August issue of the American Journal of Physiology, a publication of the American Physiological Society. (prohealth.com)
  • Linking relaxin with nitric oxide is another peptide hormone called endothelin which has a receptor on endothelial cells that increases nitric oxide,' he added. (prohealth.com)
  • Relaxin is an ovarian hormone that was discovered in 1926,' said Jacqueline Novak, Ph.D., primary study author and assistant professor of obstetrics, gynecology and reproductive sciences at the University of Pittsburgh School of Medicine. (prohealth.com)
  • But our studies on relaxin suggest that it may be time to evaluate other female hormones besides estrogen for affects on cardiovascular health - particularly in light of the newest findings on hormone-replacement therapy. (prohealth.com)
  • The naturally occurring hormone relaxin is known to have antifibrotic properties in multiple organ systems and it affects both synthesis and degradation aspects of collagen homeostasis. (ahajournals.org)
  • Relaxin H2 is the major stored and circulating isoform of the peptide hormone relaxin in humans. (bachem.com)
  • Relaxin is a circulating hormone with functions in pregnancy, parturition, and other aspects of female reproduction. (mysciencework.com)
  • The anti-fibrotic, vasodilatory and pro-angiogenic therapeutic properties of recombinant relaxin peptide hormone have been investigated in several diseases, and recent clinical trial data has shown benefit in treating acute heart failure. (nih.gov)
  • In addition to edema, the rest of your ligaments are loosening because of the hormone Relaxin, allowing your bones to spread out. (northshore.org)
  • We found that the ovarian hormone relaxin is a potent vasodilator in the systemic and renal circulations, and that it contributes to the remarkable changes in the vasculature during pregnancy. (usablenet.com)
  • This hormone relaxes your body's smooth muscles, including those in the urinary tract. (pregnancycorner.com)
  • Serelaxin, a recombinant form of the hormone relaxin-2 which is present in both men and women, is currently being assessed by the FDA and the European Medicines Agency. (pharmatimes.com)
  • The peptide hormone relaxin reaches peak circulating concentrations at the end of the first trimester in pregnant women, and is thought to promote angiogenesis. (asnevents.com.au)
  • The hormone relaxin increases the flexibility of your soft tissues and joints and can remain in the body for up to six months after delivery, making you prone to joint strains or sprains. (sixphysio.com)
  • Also at the moment in your pregnancy, the hormone relaxin helps to loosen your joints. (myartyshow.com)
  • Your body is softening to accommodate your growing child, with the assistance of a hormone known as relaxin. (amarandjannelle.com)
  • The role of relaxin in human endometrial function has not been well understood because of the paucity of in vivo studies in women or in suitable primate models. (biomedsearch.com)
  • Relaxin also significantly inhibits endometrial levels of estrogen receptor alpha and significantly inhibits levels of progesterone isoforms B and A. The findings that relaxin stimulates new blood vessel formation while maintaining endometrial connective tissue integrity are consistent with a significant role of relaxin in the establishment and/or maintenance of early pregnancy. (biomedsearch.com)
  • however, the role of relaxin in male reproduction is debated. (mysciencework.com)
  • The aim of this study was to investigate the role of relaxin in uterine vascular adaptations during early pregnancy. (asnevents.com.au)
  • The negative effects of relaxin on MMP expression in the endometrium are in distinct contrast to the positive regulation of MMPs previously shown in fibroblasts from other tissues including the cervix. (biomedsearch.com)
  • The observed long-term effects of relaxin H2 on connective tissues may be due to alterations in the turnover of collagen and proteoglycans. (bachem.com)
  • Recent studies have revealed effects of relaxin on other systems in the body. (naturalspro.com)
  • The global effects of relaxin on sperm membrane integrity, mean fluorescence of PI (RFI), mitochondrial membrane integrity, and mean fluorescence of JC-1 were 0.333, 0.03, 0.788, and 0.417, respectively. (biomedcentral.com)
  • We examined the effects of relaxin-deficiency on uterine gene expression in early pregnancy, focusing specifically on angiogenic genes. (asnevents.com.au)
  • Ligand for LGR7, relaxin-3 receptor-1 and relaxin-3 receptor-2 (By similarity). (uniprot.org)
  • Oxytocin and estrogen receptor expression in the myometrium of pregnant relaxin-deficient (Rlx-/-) m. (biomedsearch.com)
  • Effects of the sucking stimulus on relaxin receptor (LGR7) expression in the mammary apparatus of th. (biomedsearch.com)
  • It is known that relaxin (RLN1) and receptor (RXFP1) are expressed locally in LV tissue, yet the biological function of the endogenous relaxin message-receptor system is not fully understood. (ahajournals.org)
  • Thus, the unregulated endogenous relaxin-receptor system in the mREN2 fibrosis model seems to be an adaptive response which is trying to keep the fibrosis in check. (ahajournals.org)
  • Here, we show that the relaxin receptor RXFP1 (Relaxin Family Peptide Receptor 1) is expressed in human spermatozoa, and it mainly localizes in the astrodome. (mysciencework.com)
  • Here we present the first small-molecule series of human relaxin/insulin-like family peptide receptor 1 agonists. (nih.gov)
  • Mutagenesis studies indicate that the small molecules activate relaxin receptor through an allosteric site. (nih.gov)
  • These compounds have excellent physical and in vivo pharmacokinetic properties to support further investigation of relaxin biology and animal efficacy studies of the therapeutic benefits of relaxin/insulin-like family peptide receptor 1 activation. (nih.gov)
  • It is unlikely, however, that relaxin operates through an α-inhibitory receptor. (bioscientifica.com)
  • We also observed that, unexpectedly, relaxin was equally potent in the vasculature of males, and to explain this finding we hypothesized the existence of local relaxin ligand-receptor expression and function in arteries, which we subsequently supported with both molecular and functional evidence. (usablenet.com)
  • G-protein coupled receptors as potential drug candidates in preeclampsia: targeting the relaxin-insulin-like family peptide receptor 1 for treatment and prevention. (usablenet.com)
  • Importantly, NI neurons are also a primary source of the neuropeptide, relaxin-3 , which acts via the G i -protein-coupled receptor, RXFP3 . (asnevents.com.au)
  • In 2002, the ancestral relaxin gene RLN3 was identified from genome databases. (nih.gov)
  • In the human there are three non allelic relaxin genes, RLN1, RLN2 and RLN3. (abcam.com)
  • RLN3 (Relaxin 3) is a Protein Coding gene. (genecards.org)
  • Combined with the discovery of the relaxin family peptide receptors, interest in the role of the relaxin family peptides in the central nervous system has been reignited. (nih.gov)
  • This review explores the relaxin family peptides that are expressed in or act upon the brain, the receptors that mediate their actions, and what is currently known of their functions. (nih.gov)
  • Relaxin-2 confers its activity by binding to leucine-rich guanine nucleotide-binding (G-protein) coupled receptors, LGR7 and LGR8. (rndsystems.com)
  • Other genes included receptors for relaxin ( Rxfp1 ), VEGFA ( Vegfr2 ) and estrogen ( Esr1 , Esr2 ). (asnevents.com.au)
  • We hypothesized that the use of target-controlled remifentanil infusion (TCI) with the non-muscle relaxant (NMR) would be associated with comparable surgical conditions and reduced total costs compared with the use of neuromuscular blockers during thoracotomy. (clinicaltrials.gov)
  • Has anyone tried a muscle relaxant for FM pain? (prohealth.com)
  • He has also prescribed a topical muscle relaxant ointment through a compounding pharmacy. (prohealth.com)
  • The purpose of the present research was to determine the physiological roles of endogenous relaxin in pregnant rats by passive immunization with a monoclonal antibody specific for rat relaxin (MCA1). (illinois.edu)
  • Relaxin 2 (Human) Antibody for Immunohistochemistry antibody storage GENTAUR recommends for long therm storage to freeze at -24 C. For short time storage up to 30 days we suggest fridge storage at 1 to 10 C. Prevent multiple freeze taw cycles of Relaxin 2 (Human) Antibody for Immunohistochemistry. (antibody-antibodies.com)
  • Relaxin 2 (Human) Antibody for Immunohistochemistry Human samples 80 % of the research is conducted on human samples. (antibody-antibodies.com)
  • GENTAUR suppliers human normal cells, cell lines, RNA extracts and lots of antibodies and ELISA kits to Human proteins as well as Relaxin 2 (Human) Antibody for Immunohistochemistry. (antibody-antibodies.com)
  • The protein encoded by this gene is a member of the relaxin family. (abcam.com)
  • This gene encodes a member of the relaxin family of insulin-like hormones that is expressed predominantly in the brain and plays a role in physiological processes such as stress, memory and appetite regulation. (genecards.org)
  • Relaxin [the key ingredient in Vitalaxin] has a diverse range of effects, including the production and remodeling of collagen, increase in elasticity and relaxation of muscles, tendons and ligaments during pregnancy, particularly in the pelvis. (prohealth.com)
  • It relaxes the ligaments in the pelvis, allowing it to stretch and flex as needed during the delivery. (naturalspro.com)
  • It also relaxes other pelvic ligaments. (naturalspro.com)
  • Your teeth sit in ligaments, and with the relaxin loosening the ligaments, you get some mobility which can cause discomfort. (whattoexpect.com)
  • Relaxin also impacts different ligaments all through the body which might lead to potential overstretching and joint instability (6). (myartyshow.com)
  • Human relaxin gene 3 (H3) and the equivalent mouse relaxin (M3) gene. (jax.org)
  • Relaxin-deficiency results in increased angiogenic gene expression in the uterus of early pregnant mice. (asnevents.com.au)
  • Quantitative RT-PCR was used to measure gene expression in uterine tissue prior to implantation (days 1-4) in wild type ( Rln +/+ ) and relaxin-deficient mice ( Rln -/- ). (asnevents.com.au)
  • Gene expression was also quantified in the uteri of Rln -/- mice at day 4 of pregnancy after 3 days of relaxin (0.2μg/μl/hour, Alzet® osmotic minipump) or saline (0.9%) treatment. (asnevents.com.au)
  • These studies demonstrate that relaxin-deficiency impacts uterine gene expression in early pregnant mice. (asnevents.com.au)
  • Hormonal changes, especially fluctuating levels of Relaxin and Progesterone, are mainly to blame. (northshore.org)
  • As one example, we are currently investigating the cardiovascular adaptations and obstetrical outcomes of pregnancies in women conceiving by Assisted Reproductive Technologies (ART) (in comparison to spontaneously conceived pregnancies), because ART occurs in the setting of nil or as many as 20 corpora lutea, thus dramatically effecting the circulating levels of relaxin and other potentially vasoactive corpus luteal hormones. (usablenet.com)
  • Be careful not to overstretch because muscles are more pliable due to higher levels of relaxin. (optimyz.com)
  • This antifibrotic effect of relaxin did not appear to be mediated by systemic hemodynamic changes since the mean arterial pressure was not significantly different among the groups. (nih.gov)
  • The most well-documented effect of relaxin is the impact it has on women's reproductive functions. (naturalspro.com)
  • Effect of relaxin on human sperm functions. (mysciencework.com)
  • Collectively, studies 1 and 2 provided strong support for the hypothesis that relaxin enables rapid and safe delivery of the pups, at least partly, by promoting growth and softening of the cervix. (illinois.edu)
  • Relaxin's short life-span (hours) but long-lasting protective actions led us to test the hypothesis that relaxin acts at a genomic level to reverse maladaptive remodeling in aging and HF. (readbyqxmd.com)
  • In addition, relaxin negatively regulates expression of endometrial matrix metalloproteinases (MMP), causing decreased endometrial levels of MMP-1 and MMP-3 proteins and increased protein levels of their endogenous inhibitor, tissue inhibitor of metalloproteinase 1. (biomedsearch.com)
  • Ingredients: distilled water, homeopathic micro-lipolysed protein relaxin. (naturalspro.com)
  • Relaxin is produced by the ovary, and targets the mammalian reproductive system to ripen the cervix, elongate the pubic symphysis and inhibit uterine contraction. (abcam.com)
  • Relaxin exerts dramatic uterine effects in this model, including a pronounced increase in uterine weight and stimulation of endometrial angiogenesis. (biomedsearch.com)
  • Actions of the uterine relaxant, fenoterol, on uteroplacental hemodynamics in human subjects. (biomedsearch.com)
  • The action of fenoterol, a uterine relaxant of the adrenergic beta-mimetic group of drugs, has been investigated on placental, myometrial, and cardiac blood pools. (biomedsearch.com)
  • When a woman is pregnant, the uterine lining and the placenta join in and produce relaxin, too. (naturalspro.com)
  • During ovulation, relaxin relaxes a woman's uterine wall. (naturalspro.com)
  • Porcine relaxin (250 guinea-pig units/mg) infused intravenously into anaesthetized rats at 20 μg/h reversibly abolished spontaneous intra-uterine pressure cycles yet left the myometrium responsive to oxytocin in doses of 4-8 mu. (bioscientifica.com)
  • Relaxin (5 or 10 μg) was capable of completely suppressing uterine activity driven by prostaglandin F 2α infusion in oestrogen-treated ovariectomized rats. (bioscientifica.com)
  • This study, which mainly targeted small renal arteries isolated from rats, is consistent with our earlier work showing that relaxin increases renal blood flow and kidney filtration by as much as 40 percent in non-pregnant rats,' said Kirk P. Conrad, M.D., senior study author and an investigator at the Magee-Womens Research Institute. (prohealth.com)
  • When a woman becomes pregnant, relaxin rapidly increases in the blood. (prohealth.com)
  • If a woman gets pregnant, relaxin becomes even more of a key player. (naturalspro.com)
  • So this is the first trial, and it's to see if relaxin is safe to administer to pregnant women, but they're also going to check and see if it works at all, 'cause it seems like it ought to. (preeclampsia.org)
  • When women are pregnant, ligament softening hormones like relaxin allow their joints to move more than usual to prepare their bodies for delivery. (optimyz.com)
  • Specifically, relaxin affects kidney arteries by revving up production of nitric oxide in a layer of cells lining the inside of blood vessels called the endothelium. (prohealth.com)
  • This nutrient naturally relaxes the blood vessels throughout your body, lowering your likelihood of high blood pressure. (naturalspro.com)
  • INOMAX relaxes pulmonary blood vessels, improves oxygenation and treats HRF in this delicate newborn population. (fiercebiotech.com)
  • The new millennium bought with it the sequence of the human genome and subsequently new directions for relaxin research. (nih.gov)
  • Pilot clinical data suggest that recombinant human relaxin may be effective in treating patients with decompensated CHF. (clinicaltrials.gov)
  • Participants receive recombinant human relaxin (rhRlx) via continuous IV infusion for 48 hours at a rate of 100 µg/kg/day (corresponding to a dose of 4.2 µg/kg/hr). (clinicaltrials.gov)
  • Recombinant human relaxin (rhRlx) diluted for continuous IV infusion. (clinicaltrials.gov)
  • The RELAX-AHF (Relaxin in Acute Heart Failure [AHF]) Phase lll study ( NCT00520806 ) examined the effects of serelaxin (recombinant human relaxin-2) in patients with AHF, and demonstrated favorable tolerability with benefits on short- and longer-term outcomes. (ahajournals.org)
  • 5. An isolated human H-1 relaxin DNA sequence consisting essentially of a DNA sequence encoding its signal, its A peptide chain, its B peptide chain, its C peptide chain or any combination of two or more of said chains with the signal. (patents.com)
  • We aimed to evaluate the significance of hepatic GR in clinical OLT and verify the impact of recombinant human relaxin (rhRLX), which may function as GR agonist in tissue/disease-specific manner. (readbyqxmd.com)
  • Serelaxin, a recombinant form of human relaxin-2, is currently regarded as a novel drug for treatment of acute heart failure. (readbyqxmd.com)
  • Shows the effects of recombinant human relaxin on implantation in M. fascicularis at various ultrasound observation time points. (biomedcentral.com)
  • Membrane Target Systems: Relaxin RXFP3 (human) membrane preparation, in CHO-K1 cells. (perkinelmer.com)
  • In nonclinical studies, relaxin administration to monkeys has been associated with increased vessel density in the endometrium, and in previous human trials relaxin administration has been highly correlated with increased menstrual bleeding in women. (preeclampsia.org)
  • One of the subunit chains of A(4-24)(B7-24)H2 , a synthetic analogue of human relaxin. (guidetopharmacology.org)
  • Relaxin decreases renal interstitial fibrosis and slows progression of renal disease. (nih.gov)
  • In rodent models of pulmonary and dermal fibrosis, relaxin reduced interstitial fibrosis. (nih.gov)
  • By morphometric measurement, relaxin administration was associated with a significant decrease in interstitial fibrosis at the corticomedullary junction. (nih.gov)
  • Relaxin may have a useful application in decreasing interstitial fibrosis and thereby slowing the progression of renal disease. (nih.gov)
  • Relaxin and renal fibrosis. (nih.gov)
  • We are currently conducting experiments to examine whether exogenous administration of relaxin can assist the endogenous adaptive response and reverse LV fibrosis and normalize diastolic function in this model. (ahajournals.org)
  • Relaxin may not be a miracle-worker, but it combats one type of aging: tissue fibrosis. (naturalspro.com)
  • Relaxin, however, keeps tissue fibrosis to a minimum so your body stays younger and more efficient. (naturalspro.com)
  • Relaxin decreases tissue fibrosis in the kidney, heart, lungs, and liver and promotes wound healing. (naturalspro.com)
  • and our findings on this integrative neural network will be reviewed, in particular recent findings on brain physiology and arousal processes using pharmacogenetic approaches, with implications for the therapeutic potential of relaxin-3/RXFP3. (asnevents.com.au)
  • I first examined the hypothesis that the influence of endogenous relaxin on birth is attributable, at least partly, to its effects on the cervix. (illinois.edu)
  • Accordingly, I examined the hypothesis that endogenous relaxin contributes to the development of the mammary apparatus and lactational performance. (illinois.edu)
  • In conclusion, the present research establishes two vital physiological needs for endogenous relaxin during pregnancy. (illinois.edu)
  • Relaxin is an endogenous cardiovascular peptide, and its plasma level is usually increased in patients with CHF. (readbyqxmd.com)
  • Locally produced relaxin may affect testis and vas deferens function in rats. (abcam.com)
  • Rats were injected with BEA one week prior to implantation of an osmotic pump delivering relaxin (2 microg/hour) or vehicle continuously for 28 days. (nih.gov)
  • In the relaxin-treated BEA rats, serum creatinine was normal, and albumin excretion was slightly decreased. (nih.gov)
  • Experiments have shown relaxin to be 'a potent renal vasodilator even in male rats,' said Dr. Novak. (prohealth.com)
  • The second study also demonstrated that pups born of relaxin deficient rats exhibited reduced weight and postpartum survival rate. (illinois.edu)
  • JTV-506, a new K(ATP) channel opener, relaxes pulmonary artery isolated from monocrotaline-treated pulmonary hypertensive rats. (curehunter.com)
  • This cluster produces a variety of reproductive nutrients and hormones, and that includes relaxin. (naturalspro.com)
  • Relaxin belongs to the same family of hormones as insulin. (naturalspro.com)
  • Progesterone relaxes the muscles of the ureter, causing some dilation, and also allowing for reflux-the backwards flow of urine from the bladder back up into the ureter, which can potentially introduce bacteria further up. (pregnancycorner.com)
  • While researchers don't know all the details, they believe relaxin improves sperm motility to increase the chances for conception. (naturalspro.com)
  • Furthermore, relaxin induced an increase in sperm hyperactivation, intracellular calcium and cAMP, and acrosome reaction. (mysciencework.com)
  • Taken together, these data demonstrate that relaxin influences positively many sperm functions linked to fertilizing ability, and it preserves sperm functionality, with possible practical value in assisted reproduction techniques. (mysciencework.com)
  • In males, relaxin enhances motility of sperm in semen. (naturalspro.com)
  • During the first trimester of pregnancy, levels rise and additional relaxin is produced by the decidua. (naturalspro.com)
  • Leukotriene D4 relaxes canine renal and superior mesenteric arteries. (ahajournals.org)
  • Previous clinical studies have strongly suggested that relaxin is a systemic and renal vasodilator. (preeclampsia.org)
  • Relaxin concentrations were low in the blood (x ± SD, 0.16 ± 0.03 nM) and very high in the seminal plasma (x ± SD, 10.3 ± 4.0 nM), confirming its secretion mainly by the prostate. (mysciencework.com)
  • Only VegfA mRNA increased significantly in response to relaxin treatment. (asnevents.com.au)
  • Throughout the pregnancy, relaxin also prevents unnecessary contractions in the uterus to avoid early delivery. (naturalspro.com)
  • Furthermore, this study also determined that the relaxin-induced growth of the cervix is brought about, in part, by promoting the cellular proliferation of cervical epithelial and stromal cells. (illinois.edu)
  • Relaxin-Max relaxes the body for improved sleep and relieves problems with gait and stiff muscles. (naturalspro.com)
  • In people over 50 years old who have a relaxin deficiency, relaxin helps to relax stiff and sore muscles in the legs and hands after a heavy days work. (naturalspro.com)
  • Albuterol is a medication that relaxes the muscles of the airways and improves breathing. (lifelearn-cliented.com)
  • Data is expressed as implantation calculated as a percentage of the number of gestational sacs or fetus per embryo transferred (n = 11) in recipient monkeys receiving vehicle (control, yellow) or relaxin (treatment, blue). (biomedcentral.com)
  • The relaxin-3 peptide is highly expressed in a small region of the brain and in species from teleost to primates and has both conserved sequence and sites of expression. (nih.gov)
  • The actions of relaxin are highly species specific. (biomedsearch.com)
  • In summary, this is the first study to determined that relaxin promotes growth of the vagina during pregnancy in any species. (illinois.edu)
  • Synthetic peptide corresponding to residues surrounding amino acid 130 of rat Relaxin 1. (abcam.com)
  • RelaxinMax contains homeopathic relaxin, a natural amino acid and peptide, that helps to relax the entire body for improved sleep and other biochemical functions needed during the sleep cycle or circadian rhythm. (naturalspro.com)
  • Fortunately, your body is equipped with anti-inflammatory tools, and relaxin is one of them. (naturalspro.com)
  • Whereas the β-adrenergic blocker, propranolol, had no effect on relaxin-induced inhibition, phentolamine, an α-blocker, significantly delayed the relaxin effect. (bioscientifica.com)
  • Despite mixed results in recent clinical trials, Relaxin-therapy for 2-days could reduce mortality by 37% at 180-days post-treatment, in patients with acute decompensated HF. (readbyqxmd.com)
  • Serum relaxin levels were not associated with symphyseal distension or disabling pain. (diva-portal.org)
  • Relaxin regulates endometrial structure and function in the rhesus monkey. (biomedsearch.com)