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  • disorders affectin
  • In this review, the physiology of energy metabolism in muscle is described, followed by the presentation of distinct disorders affecting skeletal and cardiac muscle: glycogen storage diseases types III, V, VII, fatty acid oxidation defects, and respiratory chain defects (i.e., mitochondriopathies). (hindawi.com)
  • arteries
  • The present study was designed to analyze the effect of long-term incubation with interleukin-1β (IL-1β) on endothelium-dependent relaxation in rat mesenteric resistance arteries. (aspetjournals.org)
  • However, there are few studies analyzing the contribution of proinflammatory mediators to the effect of cytokines on endothelium-dependent relaxation in resistance arteries ( Vila and Salaices, 2005 ). (aspetjournals.org)
  • The purpose of the present study was, first, to determine the effect of long-term incubation with IL-1β on endothelium-dependent relaxation of rat mesenteric resistance arteries (MRA) and, second, to analyze the mechanisms involved in the effect of IL-1β thoroughly. (aspetjournals.org)
  • This lignan also induced relaxation (pD 2 = 4.0 ± 0.04) of isolated arteries pre-contracted with S(−)-Bay K 8644. (mdpi.com)
  • cardiac
  • however functional impairment of skeletal and cardiac muscle in both children and adults may be caused by inborn errors of energy metabolism as well. (hindawi.com)
  • Myocarditis is an inflammatory disease of the heart muscle often resulting in cardiac dysfunction and death, especially in young patients [ 1 , 2 ]. (hindawi.com)
  • baseline
  • Participants completed detailed dietary questionnaires at baseline ( 13 ) and provided fasting serum samples (stored at -70°C). Height, weight, and blood pressure were measured at baseline and annually during the trial (except height). (aacrjournals.org)
  • Two controls ( n = 464) were matched to each case based on clinic, intervention group, date of baseline blood draw (±45 d), age (±5 y), and serum availability. (aacrjournals.org)
  • Hearts of transgenic mice with ssTnI replacing cTnI show reduced relaxation, blunted response to β-A stimulation ( 4 ) and protection against ischemia/reperfusion injury ( 5 ), while hearts of transgenic mice with cTnI N-terminal 1-28 amino acid residue deletion show a higher baseline stroke volume and a relaxation rate, similar to wild-type mouse hearts under β-A stimulation ( 6 ). (spandidos-publications.com)
  • high doses
  • It remains unclear whether or not there is a need to use high doses of muscle relaxants in order to mitigate the risk for bone fracture in cancer patients with bone metastases. (hindawi.com)
  • Given the adverse side effects associated with high doses of muscle relaxants [ 5 - 9 ], it is important to assess whether low doses are sufficient to protect against bone fractures in high-risk patients. (hindawi.com)
  • also found that a drug that strengthens muscle contractions at low doses and damages muscle at high doses in humans has similar effects in the model. (elifesciences.org)
  • impairment
  • The impairment of ACh relaxation induced by IL-1β was also partially reversed by the xanthine oxidase inhibitor allopurinol (1 mM) but not by either the NADPH oxidase inhibitor apocynin (0.3 mM) or the inducible NOS inhibitor N -3-aminomethylbenzylacetamidine (1 μM). (aspetjournals.org)
  • reacts rapidly with NO, producing peroxynitrite ( Milstien and Katusic, 1999 ), which, in turn, reduces NO bioavailability, thereby contributing to the impairment of endothelium-dependent relaxation ( Cai and Harrison, 2000 ). (aspetjournals.org)
  • Diclofenac did not affect the MAS-induced impairment in the responses to acetylcholine, whereas charybdotoxin plus apamin virtually abolished the relaxation in both male wild-type and MAS mice. (ahajournals.org)
  • toxicology
  • Human myobundles provide an enabling platform for predictive drug and toxicology screening and development of novel therapeutics for muscle-related disorders. (elifesciences.org)
  • contractions
  • This revealed that the bundles had weaker contractions in response to statins and the malaria drug chloroquine, just like normal muscles do-and that this effect worsened if more of each drug was used. (elifesciences.org)
  • weakness
  • Patients suffering from metabolic myopathies due to compromised energy metabolism may present with exercise intolerance, muscle pain, reversible or progressive muscle weakness, and myoglobinuria. (hindawi.com)
  • SUG, depending on the dose, can reverse a moderate or deep NMB without muscle weakness [ 3 ]. (medsci.org)
  • Therefore
  • It has been suggested that TM relaxation may increase conventional outflow by increasing tissue porosity and lead to decline in IOP, therefore, it could be a therapeutic target for glaucoma. (omicsonline.org)
  • hence
  • 20,22 Upon cell uptake, the clustering and confinement of these particles in endosomal and lysosomal compartments affects their abilities to alter the relaxation rate and hence relaxivity of the surrounding water molecules. (rsc.org)
  • studies
  • Background: Several studies have examined serum creatinine as a marker for prostate cancer stage, recurrence, and prognosis. (aacrjournals.org)
  • Studies among prostate cancer patients have shown that serum creatinine is associated with more advanced disease ( 2 , 3 ) and with decreased survival ( 3 , 4 ), although this relationship is not supported by some studies ( 5 - 8 ). (aacrjournals.org)
  • The most significant muscle group involved is the diaphragm, and several studies have shown that hiccups are often unilateral, involving only the left hemi-diaphragm 7 , 8 . (wiley.com)
  • placebo
  • A Cochrane systematic review including 18 randomized controlled trials (with a total of 1321 patients) on the efficacy and safety of SUG concluded that it was more effective than placebo (no medication) or neostigmine in reversing muscle relaxation caused by NMB during surgery and is relatively safe. (medsci.org)
  • patients
  • As well as this model being used to screen for harmful effects of drugs before clinical trials, the technique used to create the model could be used to grow muscle tissue from patients with muscle diseases. (elifesciences.org)
  • Also, the technique could be eventually developed to grow healthy muscle tissue to implant in patients who have been injured. (elifesciences.org)
  • experimental
  • As such, it would be useful to have experimental models that would allow scientists to test whether potential drugs damage or treat muscle tissue. (elifesciences.org)
  • shown
  • In the C. elegans pharyngeal nervous system, slo-1 is expressed in neurons, not muscle, and cell-specific rescue experiments have previously shown that emodepside inhibits serotonin-stimulated feeding by interfering with SLO-1 signaling in the nervous system. (aspetjournals.org)