ProteinsProteinCBFBPromoterGenesSubunitRUNX1AcuteGenomicTranscriptionalHeterodimericMolecularHematopoiesisSpecificityEmbryoSTAT3SimilaritySequencesInhibitionPlatelet ActivationVitroRCSB PDBFamilyAntibodyRegulatoryEnhancerSigma FactorPost-translationalSpecificRisk factorsDeficiencyCellsDomainFunctionGeneticSiteProteaseSignalingOrganisationEvidenceExpressionEnzymeIndicators
Proteins10
- Together, these proteins form one version of a complex known as core binding factor (CBF). (medlineplus.gov)
- Genetic, biochemical and structural studies have implicated Argonaute proteins as the catalytic core of the RNAi effector complex, RISC. (rcsb.org)
- Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
- Splicing is a complex, multistep process involving hundreds of proteins: some are responsible for recognising the splice sites, while others stabilise the binding of the spliceosome to the mRNA or cut out the introns and join the exons. (imb.de)
- First, FUBP1 stabilises the binding of other splicing proteins to the 3' splice site, helping the cell to recognise the correct exon-intron boundary. (imb.de)
- The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
- Sigma factors are a class of proteins constituting essential dissociable subunits that confer sequence-specific DNA binding properties to RNA polymerase (RNAP). (hindawi.com)
- Histone H3 is one of the DNA-binding proteins found in the chromatin of all eukaryotic cells. (fishersci.com)
- H3 along with four core histone proteins binds to DNA forming the structure of the nucleosome. (fishersci.com)
- Lupus anticoagulants are a heterogeneous group of antibodies directed against phospholipids and phospholipid-binding proteins. (medscape.com)
Protein22
- Two of these genes, RUNX1 and CBFB , provide instructions for making the two pieces of a protein complex known as core binding factor (CBF). (medlineplus.gov)
- The fusion protein can form CBF, but it is thought that the presence of the MYH11 portion of the fusion protein prevents CBF from binding to DNA, impairing its ability to control gene activity. (medlineplus.gov)
- The RUNX1 gene provides instructions for making a protein called runt-related transcription factor 1 (RUNX1). (medlineplus.gov)
- Like other transcription factors, the RUNX1 protein attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
- This protein interacts with another protein called core binding factor beta or CBFβ (produced from the CBFB gene), which helps RUNX1 bind to DNA and prevents it from being broken down. (medlineplus.gov)
- This gene encodes the GA-binding protein transcription factor, beta subunit. (nih.gov)
- Note: In August, 2008, the nomenclature of the GA binding protein transcription factors was clarified. (nih.gov)
- Matrix protein p17 has two main functions: in infected cell, it targets Gag and Gag-pol polyproteins to the plasma membrane via a multipartite membrane-binding signal, that includes its myristoylated N-terminus. (proteopedia.org)
- It binds in the cytoplasm the human BAF protein which prevent autointegration of the viral genome, and might be included in virions at the ration of zero to 3 BAF dimer per virion. (proteopedia.org)
- Capsid protein p24 forms the conical core that encapsulates the genomic RNA-nucleocapsid complex in the virion. (proteopedia.org)
- The core is constituted by capsid protein hexamer subunits. (proteopedia.org)
- ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. (atlasgeneticsoncology.org)
- To better understand how mRNAs are spliced in normal cells and how this is disrupted in cancer, Julian and his colleagues Katja and Michael set out to study FUBP1 (far upstream binding protein 1), which is known to be frequently mutated in gliomas, and to determine whether it has a role in splicing. (imb.de)
- First, the general TFs (GTFs), including preinitiation complex components TFIIA, TFIIB, TFIID, TFIIE, TFIIF, and THIIH, are the primary protein factors that are required for the initiation of transcription from the TATA box (or TATA element), then elongation is executed by RNA polymerase II (RNA pol II) [ 1 ]. (intechopen.com)
- A model is proposed where the relative levels of active antagonist (RsbV1) and switch-protein anti-sigma factor (RsbW) control the availability of σ 66 and subsequently act as a molecular 'throttle' for Chlamydia growth and development. (plos.org)
- Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. (lu.se)
- Interacts with HCV core protein. (lu.se)
- Prothrombin (factor II of the coagulation cascade) is a critical protein in hemostasis. (medscape.com)
- Levels of other vitamin K-dependent procoagulant factors (factors VII, IX, and X) and anticoagulant factors (protein C and protein S) are also decreased in vitamin K deficiency. (medscape.com)
- It not only plays a critical role in clot formation but also activates the protein C anticoagulant system by binding to thrombomodulin on the endothelial surface, indirectly controlling its own production. (medscape.com)
- In addition to its procoagulant properties, thrombin assists in controlling its own production by activating protein C when it is bound to thrombomodulin. (medscape.com)
- Activated protein C inactivates factors Va and VIIIa by means of proteolytic cleavage. (medscape.com)
CBFB1
- Core binding factors are composed of: a non-DNA-binding CBFβ chain (CBFB) a DNA-binding CBFα chain (RUNX1, RUNX2, RUNX3) de Bruijn M, Speck N (2004). (wikipedia.org)
Promoter5
- CmABF1 and CmCBF4 were selected as candidate TFs that could directly bind to promoter fragments of CmADC in vitro and in planta to promote its transcription. (eurekalert.org)
- CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
- Within the RNAP holoenzyme, sigma factors provide promoter recognition specificity to the polymerase and contribute to DNA strand separation, then they dissociate from RNAP core enzyme and transcription initiation follows [ 1 ]. (hindawi.com)
- Besides the vegetative sigma factor, which recognizes the "standard" promoter, many bacteria possess alternative sigma factors that confer altered promoter specificity upon RNAP [ 2 ]. (hindawi.com)
- C promoter binding factor/ Suppressor of Hairless/ lag- 1). (bvsalud.org)
Genes8
- It forms heterodimeric complexes with CORE BINDING FACTOR ALPHA SUBUNITS, and regulates GENETIC TRANSCRIPTION of a variety of GENES involved primarily in CELL DIFFERENTIATION and CELL CYCLE progression. (wakehealth.edu)
- The spectrum of genes harboring germline variants in pediatric MDS has also recently begun to expand beyond transcription factors, including ANKRD26 17 and SRP72 18 . (nature.com)
- They can bind directly to DRE/CRT (dehydration-responsive element/C repeat) cis -acting elements in the promoters of cold-regulated (COR) genes and trigger their expression to help plants withstand the bitter cold. (eurekalert.org)
- Promoters of housekeeping genes contain built-in activating motifs for factors such as GABPA and YY1, which decrease the responsiveness of promoters to distal enhancers. (nature.com)
- For example, steroid and thyroid hormones directly bind to nuclear receptors, which induce expression of specific genes. (intechopen.com)
- In addition, many of the remaining clusters are adjacent to genes expressed in a pattern characteristic of genes regulated by these factors. (sdbonline.org)
- Sequences of previously described binding sites were collected for these five factors present in the cis-regulatory regions of known target genes. (sdbonline.org)
- We therefore suggest a new mechanism involving a cofactor that is regulated as well as recruited by one of the master genes to bind to the antagonistic partner that is necessary for bistability and hence switch-like behavior. (lu.se)
Subunit5
- Core Binding Factor beta Subunit" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (wakehealth.edu)
- A non-DNA binding transcription factor that is a subunit of core binding factor. (wakehealth.edu)
- This graph shows the total number of publications written about "Core Binding Factor beta Subunit" by people in this website by year, and whether "Core Binding Factor beta Subunit" was a major or minor topic of these publications. (wakehealth.edu)
- Below are the most recent publications written about "Core Binding Factor beta Subunit" by people in Profiles. (wakehealth.edu)
- Association of single nucleotide polymorphisms in the nuclear respiratory factor-2 beta subunit-encoding the GABPB1 gene within the occupational environment. (nih.gov)
RUNX11
- Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. (medlineplus.gov)
Acute3
- Core binding factor acute myeloid leukemia (CBF-AML) is one form of a cancer of the blood-forming tissue (bone marrow) called acute myeloid leukemia. (medlineplus.gov)
- Exceptions are acute promyelocytic leukemia (APL) and core binding factor AML (i.e. (cap.org)
- Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia. (cdc.gov)
Genomic4
- POL_HV1Z2 ] Gag-Pol polyprotein and Gag polyprotein may regulate their own translation, by the binding genomic RNA in the 5'-UTR. (proteopedia.org)
- A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. (yeastgenome.org)
- By using published DNA binding specificity data for five transcription factors active in the early Drosophila embryo, genomic regions containing unusually high concentrations of predicted binding sites were identified for these factors. (sdbonline.org)
- Using CIS-ANALYST, the distribution of Bcd, Cad, Hb, Kr, and Kni binding sites were examined in a 1-Mb genomic region surrounding the well-characterized eve locus at a site_p value of 0.0003. (sdbonline.org)
Transcriptional2
- C-repeat binding factors (CBFs) act at the crossroads of the transcriptional regulatory network that underlies cold stress response. (eurekalert.org)
- Given that OKSM (Yamanaka) factors convert somatic cells into induced pluripotent stem (iPS) cells, alterations in transcriptional state could affect destiny of the cells. (intechopen.com)
Heterodimeric1
- The Core binding factor (CBF) is a group of heterodimeric transcription factors. (wikipedia.org)
Molecular2
- Molecular pathogenesis of core binding factor leukemia: current knowledge and future prospects. (medlineplus.gov)
- The research groups of Julian König and Katja Luck (Institute of Molecular Biology, IMB, Mainz, Germany), together with the group of Michael Sattler (Institute of Structural Biology and Technical University of Munich, Germany) have discovered that the proto-oncogene FUBP1 has a previously unknown function as a core splicing component at long introns. (imb.de)
Hematopoiesis1
- In occurs through the inhibition of DNA binding of cognate cis- hematopoiesis there exist several lineage branch points with regulatory motif while in the other case DNA binding is unaffected identified key transcription factors and external signals [3-5]. (lu.se)
Specificity1
- To investigate whether binding site clustering could help to explain the specificity of these factors for eve , a simple notion of binding site clustering was incorporated into CIS-ANALYST, allowing searches for segments of a specified length containing a minimum number of predicted binding sites. (sdbonline.org)
Embryo1
- The transcription factors Bicoid (Bcd), Caudal (Cad), Hunchback (Hb), Krüppel (Kr), and Knirps (Kni) act at very early stages of Drosophila development to define the anterior-posterior axis of the embryo. (sdbonline.org)
STAT31
- Their roles in intracellular signalling pathways suggest factors such as STAT3 might be involved in ageing and/or age-related disease [ 266 ]. (senescence.info)
Similarity1
- This capsid restriction by TRIM5 is one of the factors which restricts HIV-1 to the human species (By similarity). (proteopedia.org)
Sequences3
- The binding sequences for each factor were aligned by using the motif-assembly program, and the binding specificities of each factor were modeled with position weight matrices (PWMs). (sdbonline.org)
- PWMs are a useful way to represent binding specificities and provide a statistical framework for searching for novel instances of the motif in genome sequences (Berman, 2002). (sdbonline.org)
- Recently, genome sequences revealed that in addition to rpoS , an rpoS -like sigma factor was found in V. alginolyticus 12G01. (hindawi.com)
Inhibition1
- 1979. Transition and heavy metal inhibition of ligand binding to muscarinic acetylcholine receptors from rat brain. (cdc.gov)
Platelet Activation1
- Thrombin also stimulates platelet activation and converts factors V and VIII into activated cofactors for factors Xa and IXa respectively. (medscape.com)
Vitro1
- Mutation and in vitro DNA binding studies completed on a subset of the CRMs provide evidence for a direct regulatory relationship. (sdbonline.org)
RCSB PDB1
- RCSB PDB Core Operations are funded by the National Science Foundation (DBI-1832184), the US Department of Energy (DE-SC0019749), and the National Cancer Institute , National Institute of Allergy and Infectious Diseases , and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM133198. (rcsb.org)
Family1
- Transcription factors like those of the STAT family are activated by growth factors and cytokines. (senescence.info)
Antibody3
- We estimated SARS-CoV-2 seroprevalence among residents of Hillsborough County, Florida, USA, to determine factors independently associated with SARS-CoV-2 antibody status overall and among asymptomatic antibody-positive persons. (cdc.gov)
- The goals of this study were to estimate SARS-CoV-2 seroprevalence among Hillsborough County residents and to determine the demographic and behavioral factors independently associated with SARS-CoV-2 antibody status overall and among asymptomatic antibody-positive persons. (cdc.gov)
- Particle-enhanced assays were based on the reaction between a soluble analyte and the corresponding antigen or antibody bound to polystyrene particles. (cdc.gov)
Regulatory2
- pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
- A common feature of these cis-regulatory modules is the presence of multiple binding sites for multiple transcription factors. (sdbonline.org)
Enhancer1
- Whether this cluster of binding sites might be the gt posterior enhancer was evaluated. (sdbonline.org)
Sigma Factor2
- In this study, a gene encoding for an rpoS -like sigma factor, rpoX , has been cloned and characterized. (hindawi.com)
- They partially and/or temporarily replace the vegetative sigma factor and are thus crucial for many stress responses [ 2 ]. (hindawi.com)
Post-translational1
- The N-terminal tail of histone H3 protrudes from the globular nucleosome core and can undergo several different types of post-translational modifications that influence cellular processes. (fishersci.com)
Specific3
- While this article focuses on specific VR issues, most of the origins are core optimization areas such as poly counts, common performance mistakes, and knowing the more efficient but relative quality solution to apply. (intel.com)
- Recent global analyses of gene transcripts revealed that specific transcription factors (TFs) and their networking systems physiologically correspond to the onset of human diseases, including cancer. (intechopen.com)
- Post translationally, histones are modified in a variety of ways to either directly change the chromatin structure or allow for the binding of specific transcription factors. (fishersci.com)
Risk factors2
Deficiency1
- Heterozygotes for prothrombin deficiency have factor II levels of 30-60% of the reference range. (medscape.com)
Cells1
- By comparing the complete genomes from cancerous and normal cells for about 800 patients, we have successfully pinpointed the genetic factors behind some of the toughest pediatric cancers. (stjude.org)
Domain1
- The FH domain is a winged helix DNA-binding domain. (nih.gov)
Function2
- Indeed, when the researchers analysed sequencing data from glioma patients, they found that patients with FUBP1 loss-of-function mutations had more skipping of exons with long adjacent introns than patients with mutations in other splicing factors. (imb.de)
- Factor XIIIa, activated by thrombin, carries out this function. (medscape.com)
Genetic2
- Because this genetic change affects CBF, the condition is classified as core binding factor AML (CBF-AML). (medlineplus.gov)
- Biochemical studies suggest that in one case this transcription factors to implement particular genetic programs. (lu.se)
Site3
- A tRNA(3)-Lys binds to the primer-binding site (PBS) situated at the 5'-end of the viral RNA. (proteopedia.org)
- They find that FUBP1 is responsible for stabilising the binding of other splicing factors to the 3' splice site. (imb.de)
- A significant fraction of these binding site clusters overlap known CRMs that are regulated by these factors. (sdbonline.org)
Protease1
- This powerful protease is at the core of the coagulation cascade. (medscape.com)
Signaling1
- ABA-responsive element (ABRE)-binding factors (ABFs) are core components in ABA signaling and are broadly involved in plant growth and development, as well as responses to biotic and abiotic stresses such as cold. (eurekalert.org)
Organisation1
- are quantifiable measurements, agreed to beforehand, that reflect the critical success factors of an organisation. (who.int)
Evidence1
- A growing body of evidence has identified fibrinogen as an important risk factor for cardiovascular disease, the major cause of death in the U.S. The objective of including this measure was to provide data on laboratory, clinical, and socio-demographic correlates of fibrinogen levels. (cdc.gov)
Expression2
- To study the effects and importance of fluoride on FBs in the development of extraperiosteal calcification and the ossification of skeletal fluorosis, the presence of the osteogenic phenotype, which is indicated by the expression of core-binding factor a1 (Cbfa1) and osteocalcin (OCN), in an FB cell line (L929) and in osteoblasts (OBs) exposed to fluoride was determined. (fluoridealert.org)
- p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
Enzyme1
- It shows no stimulation by ATP, suggesting that factors promoting product release are missing from the recombinant enzyme. (rcsb.org)