Relationship between adiponectin levels and metabolic. Medical search. Frequent questions

Previous studies revealed the potential significance of circulating adiponectin levels with respect to the diagnosis and prediction of metabolic syndrome, but uncertainty has been noted across different cohorts. (frontiersin.org)
Systematic evaluation was performed for diagnostic accuracy and predictivity of adiponectin variation for metabolic syndrome in enrolled studies including 1,248 and 6,020 subjects, respectively. (frontiersin.org)
Adiponectin can identify metabolic syndrome with moderate accuracy (area under the curve = 0.81, 95% CI: 0.77-0.84). (frontiersin.org)
Heterogeneity analysis revealed that an increasing index of insulin resistance was independently associated with improving the performance of adiponectin upon metabolic syndrome diagnosis (ratio of diagnostic odds ratio = 3.89, 95% CI: 1.13-13.9). (frontiersin.org)
In addition, reductions in adiponectin were associated with increasing metabolic syndrome incidence in a linear dose-response manner. (frontiersin.org)
In conclusion, adiponectin measurement might have potential benefits in the detection of metabolic syndrome. (frontiersin.org)
Metabolic syndrome (MetS) is defined as a panel of endocrine disorders, including central adiposity, dyslipidemia, hyperglycemia and hypertension ( Kaur, 2014 ). (frontiersin.org)
So, the purpose of this study is to identify the relationship between the physical activity level and the hepatic steatosis presence, metabolic syndrome and the risk of developing type 2 diabetes mellitus in men. (scirp.org)
Because of metabolic changes resulting from HS, currently the HS is recognized as the common cause to the development of metabolic syndrome, including the Type 2 Diabetes Mellitus (DM2) development. (scirp.org)
As an early clinical expression of insulin resistance and metabolic syndrome, AGA is related to being an increased risk factor for cardiovascular diseases, glucose metabolism disorders, type 2 diabetes, and enlargement of the prostate. (wikipedia.org)
Both males aged 40-91 and younger male patients of early onset AGA (before the age of 35), had a higher likelihood of metabolic syndrome (MetS) and insulin resistance. (wikipedia.org)
With younger males, studies found metabolic syndrome to be at approximately a 4× increased frequency which is clinically deemed significant. (wikipedia.org)
Nevertheless, salivary levels of these adipocytokines in patients with metabolic syndrome (MS) have never been investigated. (checkpointinhibitor.com)
syndrome, and evaluate any correlation of these levels with MS.\n\nMethods: Forty-six healthy and 82 MS patients were enrolled. (checkpointinhibitor.com)
Unsurprisingly, the rate of metabolic syndrome is also rising. (bhma.org)
Links are being made between low levels of testosterone and an increased risk of metabolic syndrome among men. (bhma.org)
While there has been a role for the administration of synthetic testosterone, a more holistic approach, whereby patients improve their diet and limit their physical inactivity,can also lead to improved health and reverse the metabolic syndrome.The holistic approach can improve compliance, adherence and lead to lasting change. (bhma.org)
With reduced levels of daily physical activity and diets high in refined carbohydrate, we are seeing a rise in the rate of metabolic syndrome (MetS) among men globally. (bhma.org)
The metabolic syndrome (MetS) is a constellation of metabolic risk factors (including hypertension, dyslipidaemia, abdominal obesity and impaired glucose metabolism), which is associated with a twofold increased risk of cardiovascular disease (CVD) (Ford, 2005), and an even higher risk of T2DM (Grundy, 2008). (bhma.org)
Serumadiponectin levels are influenced by several factors, such as age, sex, body mass index and diabetes (2-5) and are decreased in patients with type 2 diabetes mellitus or metabolic syndrome (5,6). (biochemia-medica.com)
In middle-aged patients with metabolic syndrome, blood concentrations of testosterone were positively correlated witj adiponectin (9). (biochemia-medica.com)
and c) to propose a definition of early risk identification in terms of pre-metabolic syndrome (PreMetSyn). (urv.cat)
Conclusions: Serum uric acid is a good predictive biomarker of metabolic syndrome (MetSyn) and has been associated with non-alcoholic liver fat disease (NAFLD) and type 2 diabetes. (urv.cat)
Serum fibroblast growth factor 21 (FGF21) has been suggested to be a possible biomarker for early detection of metabolic syndrome and type 2 diabetes in adults. (jomes.org)
The current systematic review and meta-analysis of randomized controlled trials (RCTs) was carried out to assess the influence of curcumin intake on weight among patients with metabolic syndrome and related disorders. (frontiersin.org)
Overall, we have found that curcumin intake among patients with metabolic syndrome and related disorders was correlated with a significant reduction in BMI, weight, WC, and leptin, and a significant increase in adiponectin levels, but did not affect HR. (frontiersin.org)
It has been shown that traditional cardiovascular risk factors such as hypertension, obesity, diabetes, dyslipidemia and metabolic syndrome modify the structural and functional characteristics of arteries reducing their compliance and increasing arterial stiffness. (dovepress.com)
Epidemiological studies show that chronic stress increases the risk of diabetes and metabolic syndrome [ 2 ]. (biomedcentral.com)
Rodr guez-Mor n M, Salazar-V zquez B, Violante R, Guerrero-Romero F. Metabolic syndrome among children and adolescents aged 10-18 years. (medigraphic.com)
Kohen-Avramoglu R, Theriault A, Adeli K. Emergence of the metabolic syndrome in childhood: an epidemiological overview and mechanistic link to dyslipemia. (medigraphic.com)
The study was meant to estimate the prevalence of metabolic syndrome in patients with breast cancer and to establish its role as an independent risk factor on occurrence of breast cancer. (ijmpo.org)
Fifty women aged between 40 and 80 years with breast cancer and fifty controls of similar age were assessed for metabolic syndrome prevalence and breast cancer risk factors, including age at menarche, reproductive status, live births, breastfeeding, and family history of breast cancer, age at diagnosis of breast cancer, body mass index, and metabolic syndrome parameters. (ijmpo.org)
Metabolic syndrome prevalence was found in 40.0% of breast cancer patients, and 18.0% of those in control group ( P = 0.02). (ijmpo.org)
Metabolic syndrome is more prevalent in breast cancer patients and is an independent risk factor for breast cancer. (ijmpo.org)
4 ] The metabolic syndrome could impact the risk of breast cancer through alterations in a number of interrelated hormonal pathways, including those involving insulin, estrogen, cytokines, and growth factors. (ijmpo.org)
Introduction: Metabolic syndrome (MS) is a complex pathology that combines several risk factors for cardiovascular disease. (bvsalud.org)
Objective: The aim of this study was to review the literature about the possible association between periodontal disease and metabolic syndrome and to identify the components of this syndrome that may contribute to this association. (bvsalud.org)
Conclusion: It is plausible that these substances may contribute to the development of metabolic syndrome. (bvsalud.org)
Metabolic Syndrome (MS) is the denomination proposed by the World Health Organization (WHO) 42 , which designates a set of risk factors for cardiovascular diseases (CVDs), such as visceral obesity, dyslipidemia, high hypertension, glucose intolerance and insulin resistance 32 , which frequently are presented together. (bvsalud.org)
The relatively high prevalence of the metabolic syndrome is a worldwide phenomenon that seems to be increasing in parallel with the obesity prevalence 16 . (bvsalud.org)
In the Japanese population, more than 20% of the population shows insulin resistance and in the adult population with diabetes mellitus type 2 the prevalence of metabolic syndrome ranges from 38 to 53%, depending on the gender and the criterion used 16 . (bvsalud.org)
VAV is assumed to be metabolically more active than SAV, and is involved in production of cytokines and release of free fatty acids that contribute to inflammation and alterations in insulin metabolism associated with metabolic syndrome and risk of EC [ 8 , 14 ]. (biomedcentral.com)
Metabolic syndrome (MetS) is metabolic alterations characterised by dysglycemia, raised blood pressure, elevated triglyceride levels, low high-density lipoprotein cholesterol levels, and obesity. (umk.pl)
Castro-Barquero S, Ruiz-León AM, Sierra-Pérez M, Estruch R, Casas R. Dietary Strategies for Metabolic Syndrome: A Comprehensive Review. (umk.pl)
Metabolic Syndrome: Past, Present and Future. (umk.pl)
Steckhan N, Hohmann CD, Kessler C, Dobos G, Michalsen A, Cramer H. Effects of different dietary approaches on inflammatory markers in patients with metabolic syndrome: A systematic review and meta-analysis. (umk.pl)
Accessible Version: www.cdc.gov/pcd/issues/2022/21_0231.htm to estimate the effect of anthropometric risk factors on the preval- ence of metabolic syndrome. (cdc.gov)
Risk Factors and Metabolic Syndrome Among Adults in India: A We searched databases PubMed Central, EMBASE, MEDLINE, Systematic Review and Meta-Analysis of Observational Studies. (cdc.gov)
Overweight and obese adults have about 5 times higher odds of having ation in the magnitude or direction of outcome, indicating the lack metabolic syndrome than adults with normal or low body weight. (cdc.gov)
Several studies have explored the effect of anthropometric risk ing central obesity, atherogenic dyslipidemia (ie, low high-density factors on metabolic syndrome. (cdc.gov)
However, no systematic effort has lipoprotein cholesterol [HDL-C], elevated triglycerides, and apoli- explored the effect of overweight and obesity on the prevalence of poprotein B-containing lipoproteins), elevated blood pressure, el- metabolic syndrome in India. (cdc.gov)
Metabolic syndrome recently emerged as a significant anthropometric factors and metabolic syndrome. (cdc.gov)
Hence, we under- and growing public health challenge worldwide resulting from took our meta-analysis to estimate the effect of anthropometric rapid urbanization, excessive energy intake, developing obesity, risk factors on the prevalence of metabolic syndrome to inform re- and sedentary lifestyle habits (2). (cdc.gov)

Adiponectin is a fat tissue-derived adipokine with beneficial effects against diabetes, cardiovascular diseases, and cancer. (phoenixpeptide.com)
The question arises whether training intervention per se is able to reduce the level of this adipokine. (plos.org)
The study population was subdivided in 2 subgroups according to adipokine patterns: group 1 included patients with high adiponectin and low leptin, and group 2 patients had high leptin and low adiponectin. (dovepress.com)
Adiponectin is the adipokine associated with insulin sensitization, reducing liver gluconeogenesis, and increasing fatty acid oxidation and glucose uptake. (encyclopedia.pub)

However, at present both the effect being an important correlate of plasma adiponectin levels (5). (hmamedicalclinic.com)
Saliva and plasma adiponectin and leptin Selleck Liproxstatin-1 levels were analyzed by enzyme-linked immunosorbent assay (ELISA). (checkpointinhibitor.com)

Correlated with weight gain, leptin levels in systemic circulation were increased in HFD-fed mice in both sexes with a significant higher level in AD group compared to VD group. (biomedcentral.com)
In conclusion, in the elderly, the presence at the same time of high leptin levels and low adiponectin levels seems to have synergic effects on arterial stiffness. (dovepress.com)

Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)
The nature of dietary fat determines the extent of metabolic alterations reflected in adipocytes through modifications in the pattern of adipokines secretion and modulation of key genes mRNA expression. (biomedcentral.com)
Appreciating the pathogenesis of HFD-induced metabolic disorders requires a thorough knowledge of adipose tissue physiology and the regulation of adipokines secretion and action including the role of gender in response to these parameters. (biomedcentral.com)
Among adipokines, leptin and adiponectin are the most abundantly secreted peptides [ 11 ]. (plos.org)
Leptin is one of the major adipokines, its increased level indicates the severity of fat accumulation in obesity [ 12 ]. (plos.org)
Aim 3 Little is known about the relationship between POPs, especially as mixtures, and adipokines. (cdc.gov)
Circulating levels of these adipokines are lower in generalized versus partial lipodystrophy as predicted from the loss of fat. (medscape.com)

10 - 16 Serum FGF21 levels have also been suggested to be a potential biomarker for the early detection of MetS and T2DM in adults. (jomes.org)

The rare G allele of +45T>G occurred more frequently than the common T allele in T2DM patients compared with controls, and was associated with lower serum adiponectin levels. (who.int)
We conclude that patients with type 2 diabetes have lower serum adiponectin concentration than healthy individuals, and that there is a weak inverse correlation between adiponectin and testosterone serum concentrations in male diabetics. (biochemia-medica.com)

Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance. (diabetesjournals.org)
Under normal circumstances adiponectin presents anti-inflammatory, pro-apoptotic and anti-proliferative effects (Booth et al . (scielo.br)
The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing, anti-inflammatory, and atheroprotective effects of adiponectin. (diabetesjournals.org)
The last few years have brought a rising body of evidence that adiponectin is a multipotential protein with anti-inflammatory, metabolic, anti-atherogenic, and reactive oxygen species (ROS) protective actions. (encyclopedia.pub)

In the diabetes group, the serum adiponectin level in patients with renal dysfunction (22.3 (21.5-23.1) ng/mL) was higher than in patients with no complications (12.1 (11.45-12.75) ng/mL) and than in patients with coronary artery disease (11.2 (10.25-12.15) ng/mL) (P = 0.009). (biochemia-medica.com)

Circulating levels of adiponectin may be In the present study, we hypothesized that a twice-weekly the link between visceral obesity and certain related metabolic PRT would be particularly useful in the context of a weight- abnormalities which contribute to the development of insulin loss diet in adult obese women, increasing the visceral fat resistance, type 2 diabetes and atherosclerosis (3,8,9). (hmamedicalclinic.com)
Obesity and associated metabolic abnormalities are becoming major health care concerns around the world. (bu.edu)
Obesity is defined as an increase of adipose tissue mass in the body and its accumulation in peripheral organs that leads to metabolic abnormalities such as type 2 diabetes (T2D), insulin resistance and hyperlepidemia [ 1 , 2 ]. (biomedcentral.com)
The high prevalence of obesity and obesity-related metabolic abnormalities (e.g., type 2 diabetes, hypertension) in children and adolescents continues to increase worldwide. (jomes.org)
1 , 2 This has attracted interest to the use of biomarkers to identify persons who are at risk for the development of metabolic abnormalities and for whom preventive measures could be tailored. (jomes.org)

BEVILACQUA, F. The potential role of leptin and adiponectin in obesity: a comparative review. (scielo.br)

Objective -Recent data suggested that sex hormone-binding globulin (SHBG) levels decrease when fat accumulates in the liver and that circulating SHBG may be causally involved in the pathogenesis of type 2 diabetes in humans. (medscape.com)
Recently, two studies applying the Mendelian randomization approach, an elegant tool to study causal relationships between plasma parameters and traits in humans, [ 1 ] suggested that circulating sex hormone-binding globulin (SHBG) may be involved in the pathogenesis of type 2 diabetes in men and women. (medscape.com)
Whereas high testosterone levels were found to be associated with insulin resistance, glucose intolerance, and increased risk of type 2 diabetes in women, in men high testosterone levels appear to protect from insulin resistance and diabetes. (medscape.com)
In contrast, in both sexes, although not consistent among all studies, high estradiol levels were associated with elevated insulin resistance and increased risk of type 2 diabetes. (medscape.com)
For relationships of circulating SHBG with insulin sensitivity and risk of type 2 diabetes, the data were more consistent among sexes. (medscape.com)
Low plasma levels of SHBG were found to be similarly strongly associated with insulin resistance and increased risk of type 2 diabetes, in men and in women in most, [ 7-11 ] but not in all, studies. (medscape.com)
The question now is, besides genetic variability in SHBG , which parameters involved in the natural history of type 2 diabetes regulate plasma levels of SHBG? (medscape.com)
of PRT on circulating adiponectin and the physiological role Moreover, it is known that an excess of abdominal adipose tis- of adiponectin on the improvement of metabolic and cardio- sue is a better predictor of the development of insulin resistance, vascular risk factors with either body or fat mass loss are as yet type 2 diabetes and cardiovascular disease than the total amount incompletely understood (1,13). (hmamedicalclinic.com)
This study was designed to investigate the relationship between serum adiponectin and testosterone in patients with type 2 diabetes. (biochemia-medica.com)
Serum level of adiponectin and testosterone were prospectively measured in 65 patients with type 2 diabetes and in 20 healthy subjects. (biochemia-medica.com)
The circulating concentrations of adiponectin are inversely proportional to adiposity, and low adiponectin concentrations predict the development of type 2 diabetes and cardiovascular disease (2). (biochemia-medica.com)
Therefore, we performed this prospective study to investigate the relationship between plasma testosterone and adiponectin in a group of adult patients with type 2 diabetes. (biochemia-medica.com)
Higher serum betatrophin level in type 2 diabetes subjects is associated with urinary albumin excretion and renal function[J] .Cardiovascular Diabetology,2016,15:3. (magtech.com.cn)
Taking alpha-lipoic acid by mouth or by IV does not improve blood sugar levels in people with type 2 diabetes. (medlineplus.gov)
Elevated levels of uric acid (hyperuricemia) also have implications for the pathogenesis of obesity and have been linked to deteriorated glucose tolerance, impaired fasting glucose and type 2 diabetes 5 . (bvsalud.org)
Some lifestyle changes, including weight reduction, increased levels of physical activity and changes in eating habits can prevent, or at least delay, the onset of type 2 diabetes 2 . (bvsalud.org)

Objective To investigate the effect of curcumin on expression of adiponectin in mice with insulin resistance. (shsmu.edu.cn)
The fasting blood glucose and serum insulin were measured, the insulin action index (IAI) was calculated, the serum adiponectin was determined by ELISA, and the expression of adiponectin mRNA in abdominal subcutaneous adipose tissues and periepididymal adipose tissues was detected by quantitative Real-Time PCR. (shsmu.edu.cn)
Conclusion Curcumin has definite protective effect on mice with insulin resistance, and the mechanism may be the upregulation of expression of adiponectin mRNA. (shsmu.edu.cn)
There are several factors regulating the expression of adiponectin gene ( AdipoQ ), such as: forkhead box O1 (FOXO1), peroxisome proliferator-activated receptor γ (PPAR-γ), CCAAAT-enhancer binding protein α, and sterol regulatory element binding protein 1c (SREBP-1c) [ 9 ] . (encyclopedia.pub)

In conclusion, our data suggest a transcriptional mechanism leading to decreased adiponectin plasma levels in obese women and demonstrate that low levels of adiponectin are associated with higher levels of hs-CRP and IL-6, two inflammatory mediators and markers of increased cardiovascular risk. (diabetesjournals.org)
Adipocytes are a rich source of molecules that modulate cardiovascular and metabolic risk ( 1 , 2 ). (diabetesjournals.org)
Cardiovascular disease, cancer, respiratory and metabolic disease represent 63% of all deaths worldwide and are considered the major causes of morbidity and mortality. (scirp.org)
However, lowering LDL levels is a common clinical practice to reduce oxidation and the risk of major events in patients with cardiovascular diseases (CVD). (hindawi.com)
In conclusion, in obese women a 16‑week combined PRT and weight‑loss diet is accompanied by significant improvements in different cardiovascular risk factors in spite of a significant decrease of circulating adiponectin. (hmamedicalclinic.com)
Obesity (2009) Lifestyle changes such as weight loss and regular physical At present, adiponectin may be the most important and promis- activity are recognized as effective nonpharmacological inter- ing adipocytokine for obtaining a better understanding of the link ventions with beneficial effects on metabolic and cardio vascular between obesity and metabolic and cardiovascular disease (1,2). (hmamedicalclinic.com)
The potential mechanism underlying the relationship between the risk of cardiovascular diseases and metabolically healthy obese (MHO) individuals remains unclear. (go.jp)
Accumulating evidence from randomized controlled trials suggests that consumption of flavan-3-ols and anthocyanidins can be beneficial for metabolic and cardiovascular health. (oregonstate.edu)

These findings suggest that AdipoRs' agonists could be developed into a potential therapeutic agent for metabolic diseases, such as diabetes mellitus, especially for type II diabetes, a long-term metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. (phoenixpeptide.com)
Plasma levels of adiponectin and leptin in healthy individuals or diabetes mellitus patients have been previously reported. (checkpointinhibitor.com)
The average serum testosterone did not differ between the diabetes and the control group, but the average adiponectin in the diabetes group was lower (14.6 (14.2-15.0) vs . 24.3 (24.05-24.55) ng/mL, P = 0.001). (biochemia-medica.com)
However, whether testosterone is also associated with circulating adiponectin in patients with diabetes is not very well understood. (biochemia-medica.com)
In school-aged girls with type 1 diabetes, the decrease in adiponectin concentrations was correlated with increasing levels of testosterone (8). (biochemia-medica.com)
We observed no association between diabetes risk and moderate and high levels of exposure to p,p'-DDE, p,p'-DDT, and p,p'-DDD, relative to non-detection. (cdc.gov)

0.05), whereas the inverse correlation between adiponectin plasma levels or adiponectin gene expression in adipose tissue with plasma IL-6 were largely dependent on the clustering of obesity-associated variables. (diabetesjournals.org)
There was no significant correlation between adiponectin and testosterone in female patients (r = -0.05,P = 0.167). (biochemia-medica.com)

In obese men, serum and interstitial total adiponectin levels are lower than in lean subjects (7). (biochemia-medica.com)
After hyperinsulinemia, serum and interstitial total adiponectin is reduced in both obese and lean men. (biochemia-medica.com)

To elucidate the relationship between plasma levels of adiponectin, adiponectin gene expression in adipose tissue, and markers of inflammation, we obtained blood samples, anthropometric measures, and subcutaneous adipose tissue samples from 65 postmenopausal healthy women. (diabetesjournals.org)
Adiponectin plasma levels and adipose-tissue gene expression were significantly lower in obese subjects and inversely correlated with obesity-associated variables, including high-sensitive C-reactive protein (hs-CRP) and interleukin-6 (IL-6). (diabetesjournals.org)
Adiponectin has been shown to be secreted principal y visceral fat in older men (11) and women (12), improving by visceral adipose tissue (VAT), the size of this visceral fat depot insulin sensitivity (11). (hmamedicalclinic.com)
3) Vascular dysfunction within adipose tissue leads to inflammation and metabolic dysfunction. (bu.edu)
Adverse effects of high-fat diets (HFD) on metabolic homeostasis are linked to adipose tissue dysfunction. (biomedcentral.com)
The goal of this study was to examine the effect of the HFD nature on adipose tissue activity, metabolic disturbances and glucose homeostasis alterations in male mice compared with female mice. (biomedcentral.com)
Body weight, plasmatic parameters and adipose tissue mRNA expression levels of key genes were evaluated after 20 weeks of HFD feeding. (biomedcentral.com)
Circulating adiponectin levels as well as adipose tissue mRNA expression levels were significantly decreased in HFD-fed male mice. (biomedcentral.com)
Although its plasma levels remained unchanged in females, adiponectin mRNA levels were significantly reduced in adipose tissue of both HFD-fed groups with a more marked decrease in AD group compared to VD group. (biomedcentral.com)
Peroxisome Proliferator-Activated Receptors gamma-2 (PPARγ2) and estrogen receptor alpha (ERα) mRNA expression levels in adipose tissue were decreased up to 70% in HFD-fed mice but were more markedly reduced in male mice as compared with female mice. (biomedcentral.com)
The mRNA expression levels of peroxisome proliferator-activated receptor (PPAR)-γ and lipocalin-2 in white adipose tissue were, respectively, down- and up-regulated. (biomedcentral.com)
The three aims explored different facets of visceral adipose tissue, as it relates to internal exposure to POPs and metabolic health. (cdc.gov)
The cumulative loss of fat leads to a decrease in adipose-derived adiponectin and leptin. (medscape.com)

Activation of adiponectin receptors (AdipoRs) by its natural ligand, adiponectin has been known to be involved in modulating critical metabolic processes such as glucose metabolism and fatty acid oxidation as demonstrated by a number of in vitro and in vivo studies over last two decades. (phoenixpeptide.com)
There are three known receptors for adiponectin: adiponectin receptor 1 (AdipoR1), adiponectin receptor 2 (AdipoR2), and T-cadherin. (encyclopedia.pub)
Overweight youth are more susceptible to metabolic disorders, since the accumulation of body fat, especially in the abdominal region, generates an increase in fatty acids circulating in the bloodstream, which consequently impairs insulin signaling and leads to a reduction in sensitivity of receptors and tissue response to cellular actions that are mediated by this hormone 1,3,4 . (bvsalud.org)

The spearman correlation analysis revealed that UPF supplementation reduced the relative abundance of Parasutterella and possibly decreased the blood sugar levels, leading to a decrease in the relative abundances of Blautia and Fusicatenibacter and a subsequent decrease in insulin levels. (frontiersin.org)
Correlation studies have shown that visceral fat increases with age, with an inverse correlation between the amount of visceral fat and plasma insulin with levels of testosterone and sex[1]hormone binding globulin (SHBG) (Kupelian et al, 2006). (bhma.org)
Correlation studies cannot distinguish between cause and effect relationships between whether low testosterone induces visceral fat deposition or whether a large visceral fat deposit leads to low testosterone levels. (bhma.org)
Univariate correlation analysis showed an inverse weak correlation between adiponectin and testosterone concentrations in male diabetic patients (r = -0.27, P = 0.009). (biochemia-medica.com)
However, few studies have investigated the correlation between FGF21 levels and metabolic parameters in children. (jomes.org)
Independent t -test and multivariate correlation analysis were used to evaluate the relationship between FGF21 and metabolic parameters. (jomes.org)
After adjustment for body mass index, triglycerides, HDL cholesterol and adiponectin, FGF21 levels showed a significant correlation with only HOMA-IR on multivariate linear regression analysis. (jomes.org)
Data from large cross-sectional and cohort studies showed a positive correlation between serum adiponectin and mortality in chronic kidney disease. (encyclopedia.pub)

Because of limitations in production of biologically active adiponectin, adiponectin-mimetic AdipoRs' agonists have been suggested as alternative ways to expand the opportunity to develop anti-diabetic agents. (phoenixpeptide.com)
We investigated the relationship between serum concentrations of POPs measured in 1999/2000, individually and as mixtures, and serum levels of leptin and high molecular weight (HMW) adiponectin, a biologically active form of adiponectin, measured in 2002/2003 among 1,400 women. (cdc.gov)

ABSTRACT This study aimed to estimate the frequency of the SNPs (+45T>G and +276G>T) genotypes and investigate the association between the two SNPs and adiponectin concentration, metabolic parameters and risk of T2DM in the Bahraini population. (who.int)
T2DM patients had reduced adiponectin levels compared with controls. (who.int)

Adjustment of circulating SHBG for liver fat abolished the relationships of SHBG with insulin sensitivity. (medscape.com)
[ 20 ] This is in agreement with human studies showing that low circulating SHBG was not associated with elevated insulin levels [ 21 ] but was associated with obesity and dyslipidemia, conditions that are strongly associated with fatty liver in humans. (medscape.com)
Increased circulating adiponectin and insulin sensitivity are usually observed after body fat loss induced by a weight‑loss diet. (hmamedicalclinic.com)
Therefore, the purpose of this study was to ascertain the effects of combined 16‑week PRT and weight‑loss diet on circulating adiponectin and insulin sensitivity index. (hmamedicalclinic.com)
WL resulted in an expected increase in circulating levels of adiponectin ( P = 0.07) and insulin sensitivity. (hmamedicalclinic.com)
This could yield highly favorable changes in circulating anthropometric variables adiponectin and, as a result, to the metabolic and cardio- Height of the barefoot subjects was measured to the nearest 0.1 cm. vascular risk. (hmamedicalclinic.com)
Increased adiposity, with its associated hyperinsulinism, suppresses SHBG synthesis, and reduces levels of circulating FT (Eckel et al, 2005). (bhma.org)
We know obese people have high circulating levels of the proinflammatory hormone and thus inflammation and we have also seen that obese people are doing very poorly with COVID. (debuglies.com)
Testosterone is another factor that influences concentration of circulating adiponectin. (biochemia-medica.com)
To date, there is little information about the association between circulating testosterone and adiponectin in adult diabetic patients. (biochemia-medica.com)
Another circulating, active form is globular adiponectin. (encyclopedia.pub)
We evaluated the relationship between changes in central adiposity and changes in circulating concentrations of PCBs and OCPs in 75 women over a twelve-year period (1999-2011). (cdc.gov)

Studies indicated that high insulin levels decrease the release of SHBG from hepatocytes, [ 16 , 17 ] which represent the major source of SHBG biosynthesis. (medscape.com)
Training intervention leads to a decrease in leptin level of middle-aged or older, overweight or obese male and female groups, even without major weight loss, indicated by unchanged serum adiponectin levels. (plos.org)
Many studies emphasise legume consumption advantages contributing to a decrease of a cluster of metabolic risk factors. (umk.pl)
Alpha-lipoic acid can decrease blood sugar levels. (medlineplus.gov)

Legume intake seems to be a valuable predictor of decreasing BMI and abdominal adiposity because of high fibre levels and regulation of adiponectin and 8-epi-PGF2α in obese subjects. (umk.pl)

We aim to generate county-level prevalence estimates, masked by national and state estimates, to identify counties with high PSA screening prevalence. (cdc.gov)

Prospective studies have confirmed that lower endogenous androgens predict central adiposity in men (Rosmond et al, 2003) and that these low testosterone levels are significantly inversely associated with levels of blood pressure, fasting plasma glucose, triglycerides, and body mass index and positively correlated with HDL-cholesterol (Zmuda et al, 1997). (bhma.org)
Serum FGF21 levels were higher in obese children and significantly correlated with HOMA-IR. (jomes.org)
SBP, PP, cfPWV were significantly higher in subjects with high leptin and low adiponectin (group 2). (dovepress.com)
After 8 weeks of combined station training, the levels of adiponectin in experimental group increased significantly ( P =0.001) while the levels of hs-CRP decreased ( P =0.001). (ac.ir)
After adjustment , HOMA-IR was also significantly inversely correlated with 25-hydroxyvitamin D levels, although associations with bone turnover markers no longer remained significant. (medscape.com)

ADPQ is exclusively secreted by adipocytes, and abundant levels in the circulation are eliminated by liver. (frontiersin.org)
Adiponectin is a protein exclusivelysecreted by mature adipocytes, which circulates in high concentrationsin the blood (1,2). (biochemia-medica.com)

There was no association between both SNPs and metabolic parameters. (who.int)
Serum betatrophin level in cord blood,maternal blood and amniotic fluid was tested,and the relationships among betatrophin in cord blood,indexes of fetal growth and development,glucose and lipid metabolic parameters,insulin resistance,leptin and serum adiponectin were analyzed. (magtech.com.cn)
This study sought to evaluate the relationship between FGF21 and metabolic parameters in obese Korean children and adolescents. (jomes.org)

This ARC will coordinate activities of basic science labs and clinical research labs to assess the interrelationship between metabolic dysfunction and vascular disease. (bu.edu)
The ARC takes a well integrated approach to understand the functional interrelationships between metabolic disease and vascular dysfunction. (bu.edu)
[ 1 , 2 ] A study by Stuebe et al found this condition to be associated with persistent metabolic dysfunction in women at 3 years after delivery, separate from other clinical risk factors. (medscape.com)

This would be consistent with possible beneficial metabolic effects as a consequence of the lower and prolonged glycaemic response and lower insulinaemic burden. (cambridge.org)
According to a randomized, placebo-controlled study of pregnant women with GDM, supplemental calcium plus vitamin D at 24 to 28 weeks' gestation may have beneficial effects on metabolic profile. (medscape.com)

On the other hand, insulin levels were only increased in AD-fed group in both sexes associated with increased resistin levels. (biomedcentral.com)

Adiponectin concentrations are gender specific, with higher levels in females [ 2 ] [ 3 ] . (encyclopedia.pub)

Adiponectin (ADPQ), which is encoded by the AdipoQ gene located on chromosome 3q27.3, is a 244-amino acid pleiotropic hormone with a molecular weight of approximately 30 kDa for its basic subunit. (frontiersin.org)
Taken together, our findings suggested that the anti-obesity properties of UPF could be achieved by decreasing the insulin levels, positive-regulating of the gut microbiota composition as well as altering gene expression related to glucolipid metabolism. (frontiersin.org)
Similar to adiponectin, ADP-1 increased the expression of the adiponectin receptor 1 gene. (phoenixpeptide.com)
The prostaglandin E2 (PGE2) level, brain-derived neurotrophic factor (BDNF), interleukin-10 (IL-10), and IL-1β gene expression were evaluated in the cortex. (researchgate.net)
In the same experimental system, IL-10 and BDNF gene expressions increased, and in HypoE22 cells, the extract decreased the extracellular dopamine level and increased the DAT gene expression due to the direct interaction of parthenolide with the DAT. (researchgate.net)

Accordingly, adiponectin-mimetic molecules possess significant pharmacological potential. (phoenixpeptide.com)

There are several reasons to believe that adiposity is a significant factor in lowering levels of testosterone, which can be seen in men as young as 40 (Goncharov et al, 2009). (bhma.org)
The team suggests several direct and indirect pathways by which insulin resistance could affect bone size, such as impaired insulin signaling, fat-mass- or adiposity-associated pathways, and modulation of the muscle-bone relationship at weight-bearing sites. (medscape.com)

The relationship between adiponectin levels and metabolic status in centenarian, early elderly, young and obese women. (nel.edu)

Overweight children and adolescents are more susceptible to metabolic disorders. (bvsalud.org)

Hence, a metabolic signature at birth may help elucidate the mechanisms involved in metabolic health later in life. (nature.com)
However more data and further research on the long-term effects of legumes on metabolic alterations are required to elucidate their effective health implications. (umk.pl)
Turning to the proteome to elucidate the complex potential relationship between sugar intake and T2D incidence did not provide a clear enlightenment, but despite the fact that no significant associations were observed between added sugar and SSB intake with levels of CRP, the data suggests that SSB intake is related to a T2D-pathological proteomic signature, while this was not observed for added sugar intake. (lu.se)

A goal is to foster cross-talk between basic and clinical labs by establishing an environment where techniques employed in mouse studies are used to characterize clinical specimens at a deeper mechanistic level. (bu.edu)

How do high neutrophil elastase levels increase inflammation and cause weight gain and other metabolic problems? (medindia.net)

Physical inactivity is considered a case of public health, and other behavioral and metabolic risk factors, according to WHO (2011), such as smoking, increased blood pressure, increased blood glucose, hypercholesterolemia, overweight and obesity. (scirp.org)
Of note, ADP-1 decreased blood glucose levels and enhanced insulin production in pancreatic β cells in db/db mice. (phoenixpeptide.com)

There are few studies about the relationship between risk factors, NCDs and NAFLD. (scirp.org)
Oxidation of low-density lipoprotein (LDL) cholesterol is crucial in the development of atherosclerosis, and low LDL levels reduce the risk of major events in patients with CVD [ 6 ]. (hindawi.com)
Many environmental chemicals are known or suspected risk factors for metabolic disease, including persistent organic pollutants (POPs) such as polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), and organochlorine pesticides (OCPs). (cdc.gov)
Nevertheless, a significant positive interaction effect between added sugar intake and CRP on the risk of T2D was observed ( p = 0.01), where increased T2D risk from high added sugar intake could only be observed at higher CRP levels. (lu.se)

Testosterone was determined by the radio-immunoassay , whereas adiponectin levels weredetermined by enzyme-linked immunosorbent assay (ELISA). (biochemia-medica.com)

Conclusion s Betatrophin level of cord blood is related to the adjustment of fetal growth. (magtech.com.cn)

Compared with other types of lipodystrophy, acquired partial lipodystrophy is seldom associated with insulin resistance and its related metabolic derangements. (medscape.com)

Nous avons génotypé les deux polymorphismes mononucléotidiques du gène ADIPOQ chez 140 patients atteints de DNID sans lien de parenté et 66 témoins non diabétiques en recourant à l'analyse du polymorphisme de longueur des fragments de restriction par réaction en chaîne de polymérase. (who.int)

Current biochemical and physiological evidence suggest that low adiponectin levels may be a consequence of insulin resistance with compensatory hyperinsulinemia (1). (biochemia-medica.com)

A collagen domain-derived short adiponectin peptide activates APPL1 and AMPK signaling pathways and improves glucose and fatty acid metabolisms. (phoenixpeptide.com)
They discovered that neutrophil elastase-deficient mice have increased levels of several factors, including adiponectin, AMPK, and fatty acid oxidation. (medindia.net)

In this study, we have investigated the cord blood metabolic signatures of rapid growth in infancy and overweight in early childhood in four European birth cohorts. (nature.com)
Lower levels of the branched-chain amino acid (BCAA) valine ( p = 8.6 × 10 −6 ) were predictive of overweight in childhood. (nature.com)
The aim of this study was to evaluate the effect of 8 weeks of combined station training on the adiponectin and hs-CRP in overweight women. (ac.ir)
The intervention program proved to be efficient in reducing waist circumference, HOMA-IR and uric acid levels of overweight adolescents. (bvsalud.org)

MANTZOROS, C.S. Adiponectin and cancer: a systematic review. (scielo.br)

Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
To our knowledge this is the first report on identification of a short peptidefrom adiponectin with positive effects on glucose or fatty acid metabolism. (phoenixpeptide.com)
Our data suggest gender specific interactions between the diet's fatty acid source, the adipocyte-secreted proteins and metabolic disorders. (biomedcentral.com)
Interestingly, animal studies have shown that adiponectin ameliorates the proinflammatory effect of saturated free fatty acid rich diet in hypothalamus. (encyclopedia.pub)

Early atherosclerosis in obese juveniles is associated with low serum levels of adiponectin. (medigraphic.com)

Anatomy7

Organisms3

Diseases23

Chemicals and Drugs30

Analytical, Diagnostic and Therapeutic Techniques and Equipment27

Psychiatry and Psychology1

Phenomena and Processes23

Technology, Industry, Agriculture1

Named Groups2

Health Care13

Geographicals2

Syndrome53

Adipokine4

Plasma adiponectin2

Leptin levels2

Adipokines7

MetS1

Lower serum adiponectin2

Anti-inflammatory4

Serum adiponectin level1

Abnormalities5

Role of leptin1

Type 2 diabet16

Expression of adiponectin4

Cardiovascular8

Diabetes6

0.052

Total adiponectin2

Adipose13

Receptors3

Correlation8

Biologically active2

T2DM2

Circulating12

Decrease4

Abdominal1

Prevalence1

Significantly5

Adipocytes2

Parameters3

Dysfunction3

Beneficial2

Resistin1

Concentrations1

Gene5

Molecules1

Adiposity2

Obese women1

Children and adolescents1

Elucidate3

Mechanistic1

Inflammation1

Blood Glucose2

Risk4

ELISA1

Conclusion1

Associated with insulin1

AdipoQ1

Physiological1

AMPK2

Overweight4

Systematic1

Fatty4

Atherosclerosis1