AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesNamed GroupsHealth Care
Corneal TransplantationGraft RejectionEye BanksDescemet Stripping Endothelial KeratoplastyTissue DonorsFetal Tissue TransplantationEpikeratophakiaBrain Tissue TransplantationTissue PreservationGraft SurvivalTransplantation, HomologousCorneaRejection (Psychology)Corneal DiseasesEndothelium, CornealTransplantation, HeterologousLiving DonorsKidney TransplantationBlood DonorsHeart TransplantationSkin TransplantationImmunosuppressive AgentsLiver TransplantationTransplantation ImmunologyLung TransplantationIsoantibodiesImmunosuppressionCyclosporineAcute DiseaseHistocompatibility TestingTransplantation ToleranceTacrolimusTransplantation, HeterotopicRats, Inbred Lew
TransplantationKeratoconusPenetrating keratoplastyEndotheliumNeed a corneal transplantPartial thickness cornealRequire a cornealDeep anterior lamellar keratoplastyGraft rejectionOrgan DonorTransplantsStromaIrregular astigmatismAstigmatismCorneasThicknessTransplant surgeryReplacing the damaged corneaOrgans and tissuesDystrophyBlindnessInvolvesEndothelial keratoplastyDALKMicroscopyRegenerationPatientPatientsStromal cellsRecipientsViabilityDonor'sReplacesCornea transplantCollagenProcedureTreatmentsBlood vesselsInfectiousInfectionAntigensKidneysHumanDonationVisionCommonPurposeTypesSurgeryPreventRetainHealthyRecovery
Transplantation14
  • Although described for more than 100 years, corneal transplantation has become increasingly common since the 1960s. (medscape.com)
  • Corneal transplantation has a high success rate in part because of the relative immune privilege of the cornea. (medscape.com)
  • [ 2 ] The incidence of graft rejection varies widely depending on the study design, type of transplantation, and risk factors for rejection. (medscape.com)
  • The reported incidence of graft rejection is lower in partial thickness corneal transplantation. (medscape.com)
  • Experimental mice, i.e., wild-type, Col5a1 f/f and Kera-Cre/Col5a1 f/f ( Col5a1 ∆st/∆st , collagen V null in the corneal stroma) mice in a C57BL/6J genetic background, were subjected to a lamellar keratectomy, and treated with or without UMSC (10 4 cells/cornea) transplantation via an intrastromal injection or a fibrin plug. (molvis.org)
  • UMSC transplantation was successful in recovering some corneal transparency in injured corneas of wild-type, Col5a1 f/f and Col5a1 ∆st/∆st mice. (molvis.org)
  • Replacing a damaged cornea portion with healthy donor tissues (transplantation) is a common surgical procedure. (eyepatient.net)
  • One attractive strategy to prevent or control allograft rejection is to genetically modify the donor tissue before transplantation. (ox.ac.uk)
  • This study suggests that genetic alteration of donor cornea before transplantation is a feasible approach for preventing or controlling allograft rejection. (ox.ac.uk)
  • Corneal transplantation is currently the only therapy for severe corneal disorders. (lww.com)
  • Although previous recommendations for preventing transmission of human immunodeficiency virus (HIV) through transplantation of human tissue and organs have markedly reduced the risk for this type of transmission, a case of HIV transmission from a screened, antibody-negative donor to several recipients raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • A working group formed by the Public Health Service (PHS) in 1991 to address these issues concluded that further recommendations should be made to reduce the already low risk of HIV transmission by transplantation of organs and tissues. (cdc.gov)
  • This occurrence raised questions about the need for additional federal oversight of transplantation of organs and tissues. (cdc.gov)
  • The working group concluded that, although existing recommendations are largely sufficient, revisions should be made to reduce the already low risk of HIV transmission via transplantation of organs and tissues. (cdc.gov)
Keratoconus9
  • It is indicated for keratoconus where there's corneal thinning. (eyepatient.net)
  • There are several conditions like Keratoconus, corneal clouding, corneal infection, corneal dystrophy and corneal injury that leave your cornea damaged. (dishaeye.org)
  • Compared with penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK) presents several advantages that make it currently considered by many corneal surgeons as the first-choice surgical procedure in patients with keratoconus. (bmj.com)
  • Rings have recently been used with success in treating corneal disorders such as keratoconus, irregular astigmatism, and progressive corneal thinning that follows other corneal refractive procedures. (themedicaleyecenter.com)
  • DALK is our treatment of choice for keratoconus or corneal scars, as long as the inner cell layer of the cornea (the endothelium) is healthy. (cornea.org)
  • Corneal crosslinking is a procedure used to treat patients suffering from keratoconus , a disorder of the eye in which the cornea thins, weakens, and becomes distorted and cone-shaped. (modern-optometry.com)
  • Corneal crosslinking is never required, but is an effective treatment alternative to corneal transplant surgery, uncomfortable contact lenses, and LASIK surgery for patients suffering from keratoconus. (modern-optometry.com)
  • These problems include keratoconus (a cone-like malformation in the cornea's shape), thinning of the corneal tissue, scarring from infections or injuries, ulceration or the clouding of the corneal surface, and a disorder known as Fuchs' dystrophy . (modern-optometry.com)
  • Kocaba V. Bowman layer onlay grafting as a minimally invasive technique to flatten the corneal curvature and reduce progression in eyes with advanced keratoconus. (niios.com)
Penetrating keratoplasty6
  • This severely vascularized cornea would be at high risk for graft rejection following a penetrating keratoplasty. (medscape.com)
  • If the inner and outer layers of the cornea are damaged, then you might be recommended to undergo a full-thickness corneal transplant, also known as penetrating keratoplasty. (dishaeye.org)
  • One type of corneal transplant called a penetrating keratoplasty (PKP), replaces your central corneal tissue with donor tissue. (themedicaleyecenter.com)
  • Although this is a more technically challenging procedure than penetrating keratoplasty, it may reduce the risk that your body will reject the donor tissue and is a good option for some patients. (themedicaleyecenter.com)
  • Penetrating Keratoplasty (PK), is the traditional full thickness transplant where all three main layers of the cornea--the epithelium, stroma and endothelium--are removed and replaced with donor tissue. (cornea.org)
  • The traditional kind, known as penetrating keratoplasty or PK, involves removing and replacing the full thickness of the corneal tissue. (modern-optometry.com)
Endothelium4
  • The cornea does so by having an organization consisting of three tissue layers: the epithelium, stroma, and endothelium. (molvis.org)
  • In this study, we have examined the feasibility of gene transfer to human corneal endothelium, using a number of recombinant adenovirus constructs. (ox.ac.uk)
  • With ALK and DALK, patients retain their own endothelium so the risk of a patient's immune system rejecting the tissue is dramatically reduced, which means patients can discontinue use of the corticosteroid eye drops used to prevent rejection sooner. (cornea.org)
  • The most important function of the corneal endothelium (CE) is maintenance of corneal transparency by regulating water content of the corneal stroma. (lww.com)
Need a corneal transplant1
Partial thickness corneal1
  • If your cornea is not completely damaged, and only partly affected (the front and middle layers), a partial-thickness corneal transplant is recommended. (dishaeye.org)
Require a corneal1
Deep anterior lamellar keratoplasty1
  • btained with a type of ALK known as Deep Anterior Lamellar Keratoplasty (DALK) , in which the surgeon only leaves behind 5% or less of your original corneal thickness and replaces the rest with donor tissue. (cornea.org)
Graft rejection7
Organ Donor3
  • Become an Organ Donor! (organindia.org)
  • During July 2015, physicians at a hospital in Beijing, China, diagnosed rabies in 2 patients who had each received a kidney from a common organ donor who had died from acute progressive encephalitis of unknown cause. (cdc.gov)
  • In July 2015, physicians at a hospital in Beijing, China, diagnosed rabies in 2 recipients of kidneys from a common organ donor. (cdc.gov)
Transplants5
  • There are three types of corneal transplants that are done depending on cases. (dishaeye.org)
  • Corneal transplants, which usually involve replacing the damaged cornea with one from a human donor, are not always accepted by the body and may require lengthy recovery times, but in most cases they can restore vision to the affected eye. (modern-optometry.com)
  • There are two primary types of corneal transplants. (modern-optometry.com)
  • Lungs: Single or double-lung transplants can be performed from deceased donors. (organindia.org)
  • We reviewed medical records for the donor and recipients to determine if the kidney recipients acquired rabies virus through the transplanted organs and to identify other potentially infected recipients of transplants from the same donor. (cdc.gov)
Stroma2
  • Maintenance of a transparent corneal stroma is imperative for proper vision. (molvis.org)
  • The corneal stroma is composed of primarily collagen fibrils, small leucine-rich proteoglycans (SLRPs), as well as sparsely distributed cells called keratocytes. (molvis.org)
Irregular astigmatism1
  • Kocaba V. Customized transepithelial phototherapeutic keratectomy for the treatment of irregular astigmatism and corneal opacities. (niios.com)
Astigmatism1
  • By increasing the amount of crosslinks within the cornea's collagen fibers, corneal crosslinking strengthens the cornea and allows it to maintain its shape, correcting astigmatism and improving visual acuity. (modern-optometry.com)
Corneas5
  • She also established two corneal disease models in rodents and large animals with surgical tool-inner stopper trephines, which she invented to create consistent corneal defects in animal corneas. (stanford.edu)
  • In vivo Heidelberg retinal tomograph (HRT II) confocal microscopy, second harmonic generated (SHG) confocal microscopy, histology, and immunofluorescence microscopy were used to assess the corneal transparency of the regenerated corneas. (molvis.org)
  • Following infection of human corneas with adenoviral vectors encoding CTLA-4 Ig protein, high levels of the fusion protein were detected in corneal culture supernatants for up to 28 days. (ox.ac.uk)
  • The principal advantages of the interlocking zigzag incision over the straight incision are that the zigzag helps align the front surfaces of the donor and recipient corneas, much like a boat floating in a boat dock. (cornea.org)
  • Clinical course of a transplant donor, 2 recipients of kidneys, and 2 recipients of corneas in investigation of probable transplant-associated transmission of rabies virus, China, 2015. (cdc.gov)
Thickness1
  • An eye care professional can measure the thickness of the cornea, and help a patient decide whether corneal crosslinking is the right treatment option. (modern-optometry.com)
Transplant surgery2
  • Your body can reject the donated cornea after years of transplant surgery and, thus, it is crucial to know the signs of rejection. (dishaeye.org)
  • After corneal transplant surgery, you will wear a plastic shield or eyeglasses to protect your eye, and you will use eyedrops to prevent infection and rejection of the donor tissue. (themedicaleyecenter.com)
Replacing the damaged cornea1
  • If your cornea is damaged or unhealthy, your eye specialist may recommend a corneal transplant which involves replacing the damaged cornea with a healthy cornea from a deceased donor. (dishaeye.org)
Organs and tissues1
  • any remaining organs and tissues must be quarantined and not transplanted. (cdc.gov)
Dystrophy2
  • This treats several conditions such as Fuch's Dystrophy or other causes of corneal edema (swelling) such as bullous keratopathy. (themedicaleyecenter.com)
  • Oellerich S. Impact of Fuchs endothelial corneal dystrophy severity on Scheimpflug-derived parameters after DMEK. (niios.com)
Blindness2
  • Recipients who suffer from corneal blindness can gain their sight again after a corneal transplant. (organindia.org)
  • Loss of corneal endothelial cells (CECs) bears disastrous consequences for the patient, including corneal clouding and blindness. (lww.com)
Involves3
  • It involves removal of the outer layer of tissue from the cornea. (eyepatient.net)
  • A corneal transplant is a fairly safe procedure but like any other surgery, it involves a couple of risks. (dishaeye.org)
  • When scarring or corneal disease involves the front (anterior) part of the cornea, there are two surgical options to consider. (cornea.org)
Endothelial keratoplasty2
  • The more recent type of transplant, known as endothelial keratoplasty or EK, removes and replaces only inner tissue at the rear of the cornea. (modern-optometry.com)
  • Vasanthananthan K. Corneal guttae after Descemet membrane endothelial keratoplasty (DMEK) (ePoster). (niios.com)
DALK1
  • DALK surgery can be done with a manual or hand dissection of donor tissue or by using air to detach the inner layer of your cornea with a technique called the "big bubble" developed by Dr. Anwar of Saudi Arabia which has since been adopted around the world. (cornea.org)
Microscopy1
  • Visual acuity, specular microscopy, corneal topography and optical coherence tomography findings were recorded. (bmj.com)
Regeneration1
  • The production of collagen V by transplanted UMSCs may account for the regeneration of corneal transparency, as exemplified by better collagen fiber organization, as revealed with SHG signals. (molvis.org)
Patient2
  • The patient should consult with the doctor on how to prepare for a corneal surgery. (eyepatient.net)
  • Pancreas: A deceased donor pancreas can be transplanted into an ailing patient. (organindia.org)
Patients3
  • It is an alternative approach in patients with severe ocular and corneal disease. (eyepatient.net)
  • While medical science offers several conservative methods of correcting poor vision caused by corneal issues, some patients may opt for a cornea transplant when these other options can't help them. (modern-optometry.com)
  • Usually a human cornea from a donor is used, but patients with a history of organ rejection may receive a synthetic cornea instead. (modern-optometry.com)
Stromal cells1
  • The purpose of this study is to examine the therapeutic efficacy of human umbilical cord mesenchymal stem/stromal cells (UMSCs) in treating congenital and acquired corneal opacity associated with the loss of collagen V. (molvis.org)
Recipients2
  • We also interviewed family members of the donor and the deceased kidney recipients. (cdc.gov)
  • A 1991 investigation determined that several recipients had been infected with HIV by an organ/tissue donor who had tested negative for HIV antibody at the time of donation (4). (cdc.gov)
Viability1
  • It is important to inform your eye doctor if you have pain, irritation, or redness of the eye following PKP, as this could be the earliest sign of infection or rejection, and early treatment of these conditions is critical to the viability of your graft. (themedicaleyecenter.com)
Donor's1
  • Most Tissues should be donated within 6 hours of the donor's death. (organindia.org)
Replaces1
  • This is an advanced technique that replaces only the superficial layers of your cornea using donor tissue, leaving the lower layers of tissue intact. (themedicaleyecenter.com)
Cornea transplant1
  • A cornea transplant usually lasts for a lifetime if the body does not reject the donated tissue. (dishaeye.org)
Collagen2
  • Collagen V is a quantitatively minor component of predominantly type I collagen fibrils in most non-cartilaginous tissues. (molvis.org)
  • Corneal crosslinking is a procedure which increases the amount of crosslinking or binding fibers within the cornea's collagen, strengthening the cornea and helping it to better retain its shape. (modern-optometry.com)
Procedure2
  • This minor surgical procedure uses a laser to treat ocular diseases that affect the corneal surface. (eyepatient.net)
  • In a traditional procedure, the epithelial, a thin piece protective tissue covering the cornea, is removed prior to the procedure. (modern-optometry.com)
Treatments1
  • But those who cannot benefit from these treatments may need to consider the possibility of having a corneal transplant. (modern-optometry.com)
Blood vessels2
Infectious1
  • An effective regulatory system for testing donors should be implemented to decrease the occurrence of donor-derived infectious diseases. (cdc.gov)
Infection1
  • Exclusion of prospective blood donors based on their acknowledged risk behaviors for human immunodeficiency virus (HIV) infection began in 1983 (1). (cdc.gov)
Antigens1
  • The cornea expresses MHC antigens to a lesser extent than other tissues, contributing to immune privilege. (medscape.com)
Kidneys1
  • Kidneys: Both kidneys can be donated by a deceased donor. (organindia.org)
Human2
  • Synthetic or bioengineered alternatives to human corneal tissue are being researched to reduce the risk for rejection. (medscape.com)
  • Organ donation is the entire practice of retrieving a human organ from a living or deceased person, who is referred to as a Donor, and transplanting it into a recipient. (organindia.org)
Donation4
  • What is Tissue Donation? (organindia.org)
  • Tissue Donation is the process of Retrieving or Procuring tissues from a living or deceased persons, called a Donor, and transplanted into the Recipient who needs it. (organindia.org)
  • Cornea: Cornea donation or eye donation is the most common tissue donation. (organindia.org)
  • and recall of stored tissues from donors found after donation to have been infected. (cdc.gov)
Vision4
  • Corneal surgeries are aimed at restoring proper vision. (eyepatient.net)
  • How does corneal crosslinking improve vision? (modern-optometry.com)
  • You will be asked not to overexert yourself for a few weeks, and your vision in the treated eye may remain as least as bad as before for several months as the tissues heal and the eye becomes accustomed to its new cornea. (modern-optometry.com)
  • 1 If the number of corneal endothelial cells (CECs) falls below a certain threshold because of traumatic injury, disease, or normal aging processes, functionality of the CE is decreased, and the cornea swells and becomes milky, leading to eventual vision loss. (lww.com)
Common1
  • Corneal operations are common and can be performed on individuals of all ages. (eyepatient.net)
Purpose1
  • Layers of cells that function together to serve a specific purpose are called Tissues. (organindia.org)
Types1
  • Two types of corneal crosslinking exist: traditional corneal crosslinking and transepithelial CXL technique. (modern-optometry.com)
Surgery1
  • Corneal surgery is any medical operation carried out on the cornea, the clear jelly-like part at the front of the eye. (eyepatient.net)
Prevent1
  • Similar gene-based strategies might also be feasible to prevent rejection of other transplanted tissues or organs. (ox.ac.uk)
Retain1
  • A living donor can also donate a portion of the pancreas and still retain pancreas functionality. (organindia.org)
Healthy1
  • A matching area of healthy tissue from a donor cornea is then used to replace the area that was removed. (cornea.org)
Recovery1