Worldwide, approximately 90,000 first HSCTs-53% autologous and 47% allogeneic-are performed every year, according to the World Wide Network of Blood and Marrow Transplantation. (medscape.com)
This, along with the development of unrelated cord blood transplantation and familial haploidentical transplantation methods, have improved the likelihood of finding an appropriate HSCT source in a timely manner. (medscape.com)
2003). After the early success of transplantation of cord blood from related donors, cord blood banks were established to provide rapidly accessible, human leukocyte antigen (HLA)-typed units predominantly for transplantation of HPCs from unrelated donors. (nationalacademies.org)
Blood and Marrow Transplant Research [CIBMTR] in 2004), the European Research Project on Cord Blood Transplantation (Eurocord) in 1993, and the Japanese Cord Blood Banking Network in 1996-expedited the clinical evaluation of the efficacy and safety of transplantation of cord blood from unrelated donors. (nationalacademies.org)
Abstract Introduction: Graft-versus-host disease (GVHD) is a serious complication in allogeneic transplantation. (scielo.org)
There is currently no cure for MM. However, advances in therapy, such as autologous stem cell transplantation, radiation, and surgical care in certain cases, have helped to lessen the occurrence and severity of adverse effects of this disease and to manage associated complications. (medscape.com)
Several drug therapies are valuable in the treatment of symptomatic MM. Clinicians treat many patients with high-dose therapy and peripheral blood or bone marrow stem cell transplantation. (medscape.com)
Bone marrow2
The National Marrow Donor Program (NMDP), founded in 1986, and the World Marrow Donor Association (WMDA), founded in 1988, were established to (1) locate and secure appropriate unrelated-donor HSCT sources for patients by promoting volunteer donation of bone marrow and peripheral blood stem cells in the community and (2) promote ethical practices of sharing stem cell sources by need, rather than by geographic location of the donor. (medscape.com)
They are found primarily in the bone marrow and also in small numbers in the peripheral blood. (lecturio.com)
Umbilical cord1
Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
Transplants2
[ 1 ] More than half of autologous transplantations are performed for multiple myeloma and non-Hodgkin lymphoma , and the vast majority of allogeneic transplants are performed for hematologic and lymphoid cancers. (medscape.com)
With more than 6,000 transplants of cord blood from related and unrelated donors performed thus far, cord blood has emerged as an acceptable, alternative source of HPCs that has some advantages over adult sources of HPCs and the availability of which represents an important development in the field. (nationalacademies.org)
Pluripotent stem2
The present invention provides methods to promote the differentiation of pluripotent stem cells. (patsnap.com)
The present invention also provides methods to promote the differentiation of pluripotent stem cells without the use of a feeder cell layer. (patsnap.com)
Transplantations1
In the last decade, the number of transplantations of HPCs derived from cord blood has increased, particularly for children. (nationalacademies.org)
Tissue2
Progenitor cell therapy describes the use of multipotent cells of various cell lineages (autologous or allogeneic) for tissue repair and/or regeneration. (southcarolinablues.com)
An immune response with both cellular and humoral components, directed against an allogeneic transplant, whose tissue antigens are not compatible with those of the recipient. (lookformedical.com)
These committed progenitor cells are difficult to discern from the original multipotent cells but can be cultured to form colonies of specific types of blood cells (Guyton and Hall, 2000). (nationalacademies.org)
Progenitor cells1
1 Treatment with progenitor cells (i.e., stem cells) offers potential benefits beyond those of standard medical care, including the potential for repair and/or regeneration of damaged myocardium. (southcarolinablues.com)
Donor2
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
Donor and recipient pairs should be of identical ABO blood group, and in addition should be matched as closely as possible for HISTOCOMPATIBILITY ANTIGENS in order to minimize the likelihood of allograft rejection. (lookformedical.com)
Cancers2
While CAR-T cell therapy has had remarkable success against most types of blood cancers, its application to T cell cancers is limited. (cartherics.com)
The use of CAR-T cells for the treatment of blood cancers has been revolutionary with unparalleled responses observed in some patients. (cartherics.com)
Topics have included the effects of non-steroidal anti-inflammatory drugs on skeletal stem cells in fractures. (stanford.edu)
Radiation1
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Cells4
CTCL is a blood cancer caused by malignant T cells. (cartherics.com)
Cancer cells can also reduce their expression of the target, which may lead to therapy resistance, and during the manufacture of CAR-T cells from patient blood, the therapy may become contaminated with cancerous cells. (cartherics.com)
Dr. Goodnough has conducted research on the role of skeletal stem cells in fracture healing. (stanford.edu)
Yellow marrow is found in the large cavities of large bones and consists mostly of fat cells and a few primitive blood cells. (lecturio.com)
Cell1
Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
Transplant16
Cells for HSCT may be obtained from the patient himself or herself (autologous transplant) or from another person, such as a sibling or unrelated donor (allogeneic transplant) or an identical twin (syngeneic transplant). (medscape.com)
15. Treatment of severe Evans syndrome with an allogeneic cord blood transplant. (nih.gov)
X-linked Severe Combined Immunodeficiency (SCID-X1) due to IL2RG mutations is potentially fatal in infancy where 'emergency' life-saving stem cell transplant may only achieve incomplete immune reconstitution following transplant. (bvsalud.org)
An allogeneic stem cell transplant kurapwa kwakasimba uko kwaunogamuchira kuisirwa donor (mumwe munhu) stem cell. (lymphoma.org.au)
Izvi zvakasiyana apo murwere anogamuchira masero avo kumashure, anonzi an autologous stem cell transplant . (lymphoma.org.au)
An allogeneic stem cell transplant ay isang masinsinang paggamot kung saan makakatanggap ka ng transplant ng mga stem cell ng donor (ng ibang tao). (lymphoma.org.au)
Ito ay iba sa kapag ang isang pasyente ay tumatanggap ng kanilang sariling mga cell pabalik, na tinatawag na an autologous stem cell transplant . (lymphoma.org.au)
Karamihan sa mga taong may lymphoma ay hindi nangangailangan ng stem cell transplant. (lymphoma.org.au)
Sa lymphoma, ang mga allogeneic (donor) transplant ay mas bihira kaysa sa autologous ( sarili) mga transplant. (lymphoma.org.au)
Ang lymphoma ay maaaring lumalaban sa mga donor stem cell, o ang katawan ng tatanggap (tinatawag na host) ay maaaring lumaban sa mga donor cell (tinatawag na graft) na nagreresulta sa graft kumpara sa host disease (isang komplikasyon ng allogeneic transplant). (lymphoma.org.au)
ito ang proseso ng pag-aani ng mga stem cell, dahil ang isang allogenic transplant ay mula sa isang donor, ang pangkat ng medikal ay kailangang makahanap ng katugma para sa transplant. (lymphoma.org.au)
2.2.1 Autologous Bone Marrow Transplant (ABMT), where the patient is both donor and recipient of stem cells harvested from the bone marrow. (health.mil)
Progenitor cell1
9. Intense immunosuppressive therapy followed by autologous peripheral blood selected progenitor cell reinfusion for severe autoimmune disease. (nih.gov)
Graft3
Apa ndipo apo donor stem masero (anonzi graft) anoziva chero akasara lymphoma masero uye anoarwisa, achiparadza lymphoma. (lymphoma.org.au)
Ito ay kapag nakilala ng mga donor stem cell (tinatawag na graft) ang anumang natitirang mga selula ng lymphoma at inaatake sila, na sinisira ang lymphoma. (lymphoma.org.au)
Cov qog ntshav qog tuaj yeem tiv taus cov kab mob pub dawb, lossis tus neeg txais lub cev (hu ua tus tswv tsev) tuaj yeem tawm tsam cov hlwb pub dawb (hu ua graft) ua rau graft tiv thaiv tus kab mob (ib qho teeb meem ntawm kev hloov pauv allogeneic). (lymphoma.org.au)
Umbilical1
Umbilical cord blood is a rich source of these committed progenitor cells and, presumably, multipotent HPCs (Knudtzon, 1974). (nationalacademies.org)
Clinical2
X-linked adrenoleukodystrophy now became a distinct clinical entity with an associated biochemical marker that could be used to confirm the diagnosis in readily accessible materials like blood cells and plasma [ 3 ]. (biomedcentral.com)
Salvage therapy SCID-X1 patients over 2 years old (NCT01306019) is a non-randomized, open-label, phase I/II clinical trial for administration of lentiviral-transduced autologous hematopoietic stem cells following busulfan (6 mg/kg total) conditioning. (bvsalud.org)
Chemotherapy3
The purpose is to deliver chemotherapy, immunotherapy, and/or radiation to eliminate malignancy, prevent rejection of new stem cells, and create space for the new cells. (medscape.com)
Chinangwa che chemotherapy ndeyekubvisa masero e-lymphoma uye ese maseru stem anogona kukura kuita lymphoma. (lymphoma.org.au)
Ang layunin ng chemotherapy ay upang lipulin ang mga lymphoma cell at lahat ng stem cell na posibleng lumaki sa lymphoma. (lymphoma.org.au)
Infusion2
Stem cell infusion is a relatively simple process that is performed at the bedside. (medscape.com)
11. Immunoablation followed by autologous hematopoietic stem cell infusion for the treatment of severe autoimmune disease. (nih.gov)
Lymphocytes1
Ang mga lymphocytes ay isang uri ng white blood cell na nabubuo mula sa mga stem cell. (lymphoma.org.au)
Treatment1
3.2 HDC with ABMT or autologous PSCT is covered in the treatment of the following malignancies. (health.mil)
Immune system1
Naizvozvo, kubvisa masero emushonga ane madosi akanyanya ekemotherapy, wobva watsiva masero emunhu iyeye neomumwe munhu zvinogona kukonzera immune system nyowani uko madonor stem masero anotora basa rekugadzira masero eropa asingashanduke kuita lymphoma. (lymphoma.org.au)
Patients1
6. Allogeneic hematopoietic SCT for patients with autoimmune diseases. (nih.gov)
White1
Consequently, there is an accumulation of VLCFA in plasma and all tissues, including the white matter of the brain, the spinal cord and adrenal cortex. (biomedcentral.com)