AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesInformation Science
RegulonGene Expression Regulation, BacterialBacterial ProteinsSigma FactorOperonGenes, BacterialEscherichia coli ProteinsEscherichia coliGenes, RegulatorRepressor ProteinsTranscription FactorsTranscription, GeneticMolecular Sequence DataPromoter Regions, GeneticBase SequenceBacillus subtilisMutationVirulenceArtificial Gene FusionDNA, BacterialOligonucleotide Array Sequence AnalysisGene Expression ProfilingGene DeletionTrans-ActivatorsMaltoseRNA, BacterialCyclic AMP Receptor ProteinSOS Response (Genetics)Salmonella typhimuriumbeta-GalactosidaseGenome, BacterialDNA-Binding ProteinsElectrophoretic Mobility Shift AssayPhosphatesOperator Regions, GeneticPlasmidsRNA Polymerase Sigma 54Heat-Shock ResponseGenetic Complementation TestBinding SitesFlagellaPhosphate-Binding ProteinsQuorum Sensing
GenesGenomesOperonsPhosphate regulonBacterialColiGeneBacteriaSubtilisRegulatorsEnriched hallmarksPathwayGrowthFrameworkStudyStressEffectClassActivityFormHighlyEscherichiaOxidative stressSignalling pathwayRepressionCharacterizationEncodesPromoterRpoNInduceOperonRegulationExpressionProteinConservationRolesCellularInductionResistanceExperimentalFunction
Genes13
  • In molecular genetics, a regulon is a group of genes that are regulated as a unit, generally controlled by the same regulatory gene that expresses a protein acting as a repressor or activator. (wikipedia.org)
  • the genes contained within a regulon are usually organized into more than one operon at disparate locations on the chromosome. (wikipedia.org)
  • The Ada regulon in E. coli is a well-characterized example of a group of genes involved in the adaptive response form of DNA repair. (wikipedia.org)
  • List of genes that are included in the regulon. (systemsbiology.net)
  • All the genes whose transcription is regulated by PhoB in a bacterium are collectively called a Pho regulon . (biomedcentral.com)
  • The SCENIC algorithm infers the TFs and their potential target genes, which are jointly named a regulon. (biomedcentral.com)
  • Sigma factor B (SigB) is the central regulator of the general stress response in Bacillus subtilis and regulates a group of genes in response to various stressors, known as the SigB regulon members. (biomedcentral.com)
  • Additionally, genes involved in the integration of stress signals to activate SigB were predicted in these genomes, indicating that SigB signaling and regulon genes are species-specific. (biomedcentral.com)
  • The genes/proteins with SigB-dependent expression are defined as the SigB regulon members. (biomedcentral.com)
  • Since the expression of genes defining discrete phenotypes is highly coordinated, application of reverse engineering algorithms to transcriptome datasets allows interpreting transcriptional networks by defining MRs and their associated regulons and gene circuits. (aging-us.com)
  • Streamlining Regulon Identification in Bacteria Regulons are a group of genes that can be turned on or off by the same regulatory protein. (doe.gov)
  • This regulon comprises several protein chaperone genes, including clpC, clpE and clpX, and is controlled by transcriptional repression. (bvsalud.org)
  • The regulatory relationship between transcription factors (TFs), key regulators of gene expression, and their target genes, the so called TF regulons, can be coupled with computational algorithms to estimate the activity of TFs. (bvsalud.org)
Genomes4
  • We have predicted and analyzed the Pho regulons in 19 sequenced cyanobacterial genomes using a highly effective scanning algorithm that we have previously developed. (biomedcentral.com)
  • Genomic Arrangement of Regulons in Bacterial Genomes" by Yanbin Yin, Han Zhang et al. (niu.edu)
  • Zhang H, Yin Y, Olman V, Xu Y (2012) Genomic Arrangement of Regulons in Bacterial Genomes. (niu.edu)
  • Orthologs of SigB regulon candidates with SigB PBMs were identified in other Bacillales genomes, but not all showed a SigB PBM. (biomedcentral.com)
Operons3
  • A modulon is a set of regulons or operons that are collectively regulated in response to changes in overall conditions or stresses, but may be under the control of different or overlapping regulatory molecules. (wikipedia.org)
  • Regulons, as groups of transcriptionally co-regulated operons, are the basic units of cellular response systems in bacterial cells. (niu.edu)
  • and (3) the global arrangement of the component operons of all the regulons in a genome tends to minimize a simple scoring function, indicating that the global arrangement of regulons follows simple organizational principles. (niu.edu)
Phosphate regulon1
  • an often-studied example is the phosphate regulon in E. coli, which couples phosphate homeostasis to pathogenicity through a two-component system. (wikipedia.org)
Bacterial2
  • We present a computational study to elucidate of the organizational principles of regulons in a bacterial genome, based on the experimentally validated regulons of E. coli and B. subtilis. (niu.edu)
  • Crosstalk between bacterial chemotaxis signal transduction proteins and regulators of transcription of the Ntr regulon: evidence that nitrogen assimilation and chemotaxis are controlled by a common phosphotransfer mechanism. (princeton.edu)
Coli1
  • The heat shock response in E. coli is regulated by the sigma factor σ32 (RpoH), whose regulon has been characterized as containing at least 89 open reading frames. (wikipedia.org)
Gene3
  • These transcription factors are known as masters regulators because its single transcript regulate more than one gene, in this context the regulon word is fascinating more in compass of transcription factors. (scielo.br)
  • RESULTS: Using the novel gene-set analysis tool GINtool, we found a reduced activity of the CtsR regulon when XynA was overproduced. (bvsalud.org)
  • In this study, we present and evaluate a collection of regulons created using the CollecTRI meta-resource containing signed TF-gene interactions for 1186 TFs. (bvsalud.org)
Bacteria2
  • Commonly studied regulons in bacteria are those involved in response to stress such as heat shock. (wikipedia.org)
  • He received his Ph.D. degree in the laboratory of Dr. En-Duo Wang in Biochemistry and Molecular Biology from Shanghai Institute of Biochemistry and Cell Biology of Chinese Academy of Science in 2008, where he studied the structural and functional interplay of transfer RNA (tRNA) and tRNA synthetase in bacteria, yeast and human. (rochester.edu)
Subtilis1
  • The identified extended SigB regulon candidates in B. subtilis are mainly involved in coping with stress but are also engaged in other cellular processes. (biomedcentral.com)
Regulators1
  • are statistically significant links between putative causal events (somatic mutations, copy number variations, chromosomal translocations, etc.) and the activity levels of regulators and regulons. (systemsbiology.net)
Enriched hallmarks1
  • that includes the regulon, Drugs that are associated with members of the regulon, together with mechanism of action and class, and enriched hallmarks of cancer if any. (systemsbiology.net)
Pathway2
  • However, a systematic study of the Pho regulon, the core of the phosphorus assimilation pathway in a cyanobacterium, is hitherto lacking. (biomedcentral.com)
  • Figure illustrates Cpx regulon activation pathway. (igem.org)
Growth1
  • Therefore, our work aims at developing a regulon (genome-wide regulatory infrastructure) to enhance the growth and biocatalytic fitness of this yeast for enhanced respiratory growth and advanced biofuel (non-ethanolic) production using xylose. (confex.com)
Framework1
  • We next introduce LPRI (Lung Cancer Prognostic Regulon Index), a precision oncology framework to identify new biomarkers associated with prognosis by leveraging the single cell regulon atlas and bulk RNA sequencing or microarray datasets. (biomedcentral.com)
Study3
  • In this study, the AlgU regulon was dissected by a proteomic approach under vegetative growing conditions and upon encystment induction. (sciety.org)
  • Our study provides a comprehensive chart of regulons in LUAD. (biomedcentral.com)
  • Eight classical TB vaccine candidate antigens, 51 DosR regulon encoded antigens, 23 TB reactivation antigens, 5 TB resuscitation promoting factors (rpfs), 6 starvation and 24 other stress response-associated TB antigens were evaluated in the study. (biomedcentral.com)
Stress1
  • Progress has been made to better understand about effect of regulons (AREB/ABF, DREB, MYB, and NAC) under abiotic stresses and a number of regulons reported for stress responsive and used as a better transgenic tool of Arabidopsis and Rice. (scielo.br)
Effect1
  • However, studies confirm that in addition to the contraceptive effect, Regulon is also characterized by the presence of a therapeutic effect. (farmacy-houses.com)
Class1
  • Related to regulon-class in chrischen1/viper_copy . (rdrr.io)
Activity1
  • Furthermore, we showcase the value of the regulons by examining TF activity profiles in three different cancer types and exploring TF activities at the level of single-cells. (bvsalud.org)
Form1
Highly1
  • The Pho regulons in cyanobacteria are highly diversified to accommodate to their respective living environments. (biomedcentral.com)
Escherichia3
  • Regulation of the multiple antibiotic resistance (mar) regulon by marORA sequences in Escherichia coli. (nih.gov)
  • Induction of the manganese-containing superoxide dismutase in Escherichia coli is independent of the oxidative stress (oxyR-controlled) regulon. (ncsu.edu)
  • By microscopic analysis of fluorescent-labeled GalR, a regulon-specific transcription factor in Escherichia coli, we observed that GalR is present in the cell as aggregates (one to three fluorescent foci per cell) in nongrowing cells. (nih.gov)
Oxidative stress1
  • Paraquat induced this enzyme in a strain compromised in its ability to induce the defense response against oxidative stress (oxyR deletion) as well as in a strain that is constitutive and overexpresses the oxyR regulon. (ncsu.edu)
Signalling pathway1
  • The CBF1-dependent low temperature signalling pathway, regulon and increase in freeze tolerance are conserved in Populus spp. (oregonstate.edu)
Repression1
  • MIG1 is required for full glucose repression of the regulon, but there must be a KIMIG1-independent repression pathway also. (uky.edu)
Characterization1
  • In this work, we assess the ability of a promiscuous, constitutively-active bEBP-the AAA+ ATPase domain of DctD from Sinorhizobium meliloti -to activate transcription from all σ 54 -dependent promoters for the characterization of the σ 54 regulon of Salmonella Typhimurium LT2. (biomedcentral.com)
Encodes2
  • [ 29 ] Physiological analyses of a M. tuberculosis dosR- knockout strain demonstrated that the massive loss of viability correlates with a collapse of energy and redox homeostasis, thus suggesting that the DosR regulon encodes critical functions required for adaptation to the reduced metabolic state, which is characteristic of nonreplicating tubercle bacilli. (medscape.com)
  • The tbu regulon of Ralstonia pickettii PKO1 encodes enzymes involved in the catabolism of toluene, benzene, and related alkylaromatic hydrocarbons. (nih.gov)
Promoter2
  • In order to investigate the regulon of the G. sulfurreducens RpoN, an RpoN over-expression strain was made in which an extra copy of the rpoN gene was under the control of a taclac promoter. (umass.edu)
  • Based on a unique expression factor, we describe regulons and relevant promoter sequences at single-nucleotide resolution. (nih.gov)
RpoN1
  • Genome-wide analysis of the RpoN regulon in Geobacter sulfurreducens. (umass.edu)
Induce2
  • Hydrogen peroxide treatment did not induce manganese-superoxide dismutase, but did induce the oxyR regulon. (ncsu.edu)
  • Stresses that induce the psp regulon include phage secretin overexpression, ethanol, heat shock, and protein export defects. (nih.gov)
Operon1
  • The S . Typhimurium σ 54 regulon included a high number of intragenic σ 54 binding sites/promoters, suggesting that σ 54 may have multiple regulatory roles beyond the initiation of transcription at the start of an operon. (biomedcentral.com)
Regulation2
  • In this study, we classified the bladder cancer cell lines according to the activities of regulons implicated in the regulation of primary bladder tumors. (tubitak.gov.tr)
  • The HrpG/HrpX regulon is activated in planta and subjected to tight metabolic and genetic regulation. (agri.gov.il)
Expression5
  • Expression of katE was unaffected by the addition of hydrogen peroxide or by the presence of additional lesions in oxyR or sodA, indicating that it is not part of the oxyR regulon. (ncsu.edu)
  • Expression of the lactose-galactose regulon in Kluyveromyces lactis is induced by lactose or galactose and repressed by glucose. (uky.edu)
  • Regulating KIGAL1 expression in this manner enables the cell to switch the regulon off in the presence of glucose. (uky.edu)
  • Protein expression of targets of the FMRP regulon is altered in brains of subjects with schizophrenia and mood disorders. (cdc.gov)
  • This demonstrated the differential expression of various regulons. (nih.gov)
Protein3
  • [ 3 , 18-24 ] More recent work linked DosR and its regulon to additional signaling networks involving Ser/Thr protein kinases. (medscape.com)
  • [ 25 ] The precise functions of all the members of the DosR (protein-coding) regulon still remain to be determined (see [ 7 , 26-28 ] ). (medscape.com)
  • [ 36 ] Regarding the functional role of the original members of the DosR regulon, [ 10 ] it is interesting to note that the ATP-binding, USP domain-containing dormancy protein Rv2623 has the ability to regulate growth in vitro and in vivo , and is required for the establishment of a persistent infection. (medscape.com)
Conservation1
  • In this review, we cover the advances made in understanding the regulatory networks that control and are controlled by the HrpG/HrpX regulon and their conservation between different Xanthomonas spp. (agri.gov.il)
Roles1
  • Overall, our data show that, while the Snf1 and Mig1 proteins play similar roles in regulating the galactose regulon in Saccharomyces cerevisiae and K. lactis, the way in which these proteins are integrated into the regulatory circuits are unique to each regulon, as is the degree to which each regulon is controlled by the two proteins. (uky.edu)
Cellular1
  • 2. eIF4E is a central node of an RNA regulon that governs cellular proliferation. (nih.gov)
Induction1
  • The data clearly demonstrate that the induction of manganese-superoxide dismutase is independent of the oxyR-controlled regulon. (ncsu.edu)
Resistance2
  • The mar regulon: multiple resistance to antibiotics and other toxic chemicals. (nih.gov)
  • This more comprehensive understanding of the Upc2A regulon in C. glabrata may eventually lead to strategies to overcome FLU resistance and enhance fluconazole activity against this important fungal pathogen. (uthsc.edu)
Experimental2
  • Collectively, our results and classifications may serve as an important guide for the selection and use of bladder cancer cell lines for experimental strategies, which aim to manipulate regulons critical for bladder cancer development. (tubitak.gov.tr)
  • Desarrollo experimental de procesos de transformaci n de biomasal gnocelulosica y otras fuentes de carbono en diversos bioproductos en Andaluc a sostenible. (us.es)
Function1
  • Can Occur via Loss of Function and Regulon Modulation. (uzh.ch)