Regulatory target sequences amino homeodomain sequences. Medical search. Frequent questions

They contain a specific DNA sequence with the aim of providing instructions for making a string of 60 protein building blocks - amino acids- which are referred to as the homeodomain. (wikipedia.org)
The sequence of PURINES and PYRIMIDINES in nucleic acids and polynucleotides. (lookformedical.com)
The order of amino acids as they occur in a polypeptide chain. (lookformedical.com)
In this work, a computational study is described to identify novel potential peptides designed by employing a database of non-natural amino acids. (mdpi.com)
The human SCGB3A2 gene encodes a protein of molecular weight 10.2 kDa consisting of 93 amino acids, of which the N-terminal 21 amino acid residues exhibit a characteristic signal sequence that may function to target the protein to a secretory pathway. (biovendor.com)
The homeodomain domain is generally composed of about 60 amino acids encoded homeobox, which form three alpha helices. (biomedcentral.com)
Members of this subgroup share a conserved motif of 19 amino acids in the putative transcription activation domain at the C-terminal end. (gao-lab.org)
The C-terminal sequence of 220 amino acids is named the Mage homology domain (MHD) and contains 25 repeats of a WQXPXX sequence in the middle region 7 - 10 . (researchsquare.com)

Most homeodomain-containing proteins function as transcription factors and fundamentally bind and regulate the activity of different genes. (wikipedia.org)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
The others are the site-specific TFs or the DNA sequence-specific binding proteins. (intechopen.com)
A ubiquitously expressed sequence-specific transcriptional repressor that is normally the target of signaling by NOTCH PROTEINS. (harvard.edu)
All genes in the ANTP-C and BX-C code for homeodomain proteins. (sdbonline.org)
In Drosophila, the majority of Notch target genes known so far is located in the Enhancer of split complex , encoding small basic helix-loop-helix (bHLH) proteins that presumably act as transcriptional repressors. (sdbonline.org)
To evaluate the capacity of the UPS to degrade disease related proteins, polyglutamine (polyGln) proteins were targeted for proteasomal degradation. (5dok.org)
Hox proteins finely coordinate antero-posterior axis during embryonic development and through their action specific target genes are expressed at the right time and space to determine the embryo body plan. (biomedcentral.com)
As master transcriptional regulators, Hox proteins recognize DNA through the homeodomain (HD) and interact with a multitude of proteins, including general transcription factors and other cofactors. (biomedcentral.com)
Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)

Studies suggest that the regulation and other target genes in different species are actually what causes such a great difference in phenotypic difference between species. (wikipedia.org)
Hox genes contain a DNA sequence known as the homeobox that are involved in the regulation of patterns of anatomical development. (wikipedia.org)
The homeodomain is the segment of the protein that binds to precise regulatory regions of the target genes. (wikipedia.org)
Their sequences contain a 180 nucleotide sequence designated the homeobox, so called because mutations of these genes often results in homeotic transformations, in which one body structure replaces another. (lookformedical.com)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
We then surveyed the distribution of stress-related cis -regulatory elements in the −1.5 kb promoter regions of ZmCAMTA genes. (frontiersin.org)
CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
In contrast, the Fushi Tarazu homeodomain protein is an activator, both in cultured cells and in Drosophila embryos, where it activates several known target genes, including its own gene. (biologists.com)
Normal Fushi Tarazu target genes are affected as they are in fushi tarazu mutants. (biologists.com)
Polycomb repressive complex 1 (PRC1) undergoes phase separation to form Polycomb condensates that are multi-component hubs for silencing Polycomb target genes. (bvsalud.org)
Developmental signals received by the Notch receptor cause Suppressor of Hairless (Su[H]) to mediate transcription of target genes. (sdbonline.org)
The expression patterns suggest that both genes are under the same regulatory control as are the E(spl) bHLH genes and thus, might play a part in Notch mediated cell differentiation. (sdbonline.org)
By comparing the transcriptome of mict-L130F vs WD1 and 06-2 ( mict ) vs 06-1 (wildtype, near-isogenic line of 06-2), several potential target genes that may be related to trichome development were identified. (biomedcentral.com)
Eighty known hearing loss genes were selected and simultaneously sequenced by targeted next-generation sequencing (NGS) in 8 Korean families with autosomal dominant non-syndromic sensorineural hearing loss. (biomedcentral.com)
Due to the limitation of the Sanger sequencing method, which is highly expensive and time-consuming, it has been difficult to sequence the hundreds of genes in these candidate chromosomal loci. (biomedcentral.com)
The capacity to simultaneously screen thousands of target genes makes this technique an especially powerful tool for detecting pathogenic mutations that cause heterogeneous disorders such as hereditary hearing loss. (biomedcentral.com)
Therefore, based on the hypothesis that causative mutations of hearing loss are more likely to exist in known hearing loss associated-genes than in novel genes, we performed exon capture and resequencing using Illumina library generation and Solexa sequencing methods. (biomedcentral.com)
HD binding specificity increases by protein-protein interactions with a diversity of cofactors that outline the Hox interactome and determine the transcriptional landscape of the selected target genes. (biomedcentral.com)
This plethora of Hox protein-protein interactions clearly points to a Hox-driven transcription process in which every Hox homeoprotein could selectively recruit GTFs to achieve specificity and activate or repress target genes during Drosophila development, although the precise molecular mechanisms remain elusive [ 25 ]. (biomedcentral.com)
Subsequently, phosphorylation of the retinoblastoma (Rb) family members leads to the release of E2F-containing repressor complexes from E2F-regulated promoters and upregulates the expression of E2F downstream target genes [ 4 ]. (biomedcentral.com)
Large tumor genome sequencing projects have now uncovered a few hundred genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies. (biomedcentral.com)
Furthermore, I am able to identify other driver genes that cause tumorigenesis through the alteration of very similar sets of targets. (biomedcentral.com)
Exploiting the aforementioned catalogs of driver genes, for example, we recently revealed the mutational landscape of chromatin regulatory factors (CRFs) in cancer [ 5 ]. (biomedcentral.com)
Based on previous phylogenetic analyses in arabidopsis ( Arabidopsis thaliana ), our results showed that some tomato SL-ZH ( S. lycopersicum zinc-finger homeodomain) genes cluster into the same neighbor-joining (NJ) branch as arabidopsis, indicating that these genes may share similar structures and functions in these plants. (ashs.org)
TFs contain motifs for activation or repression of target genes through direct binding to gene regulatory elements or motifs. (ashs.org)
It attempts to understand the mechanism by which the expression of particular genes is being modulated by some means other than the DNA sequence. (activemotif.com.cn)
Thirty-four known candidate genes for congenital cataracts were analyzed in the probands of 21 families with targeted next-generation sequencing (NGS). (molvis.org)
Previous studies regarding gene mutations in congenital cataracts have used Sanger sequencing in known disease-causing genes. (molvis.org)
Plants respond to various stimuli under abiotic or biotic stress condition and express certain genes either structural or regulatory genes which maintain the plant integrity. (scielo.br)
The regulatory genes primarily the transcription factors that exert their activity by binding to certain cis DNA elements and consequently either up regulated or down regulate to target expression. (scielo.br)
Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)

pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
WUS is a homeodomain transcription factor (TF) produced in the organizing center (OC) domain of apical meristems and is transported via plasmodesmata into the apical domain (called central zone, CZ) to promote proliferation of stem cells 3 . (nature.com)
The dynamic cytoskeletal localization of Csl and its dominant effects on cell shape and behavior and transcription factor activity suggest that Csl plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. (ox.ac.uk)
HD-Zip transcription factors belong to the Homeodomain (HD) transcription factor superfamily and are only found in plants. (biomedcentral.com)
As a unique transcription factor in plants, HD-Zip plays an important regulatory role in plant growth and development, environmental response, cell cycle and cell metabolism [ 9 ]. (biomedcentral.com)
These novel interactions open the possibility to analyze promoter function and gene expression to measure transcription factor binding dynamics at target sites throughout the genome. (biomedcentral.com)
MNX1 (motor neuron and pancreas homeobox 1), also known as HLXB9, is a homeodomain-containing transcription factor [ 13 ]. (biomedcentral.com)
Direct evidence for this model comes from the identification of heterozygous germline mutations in the homeodomain transcription factor PHOX2B , a regulator of sympathetic neuronal differentiation [3] - [8] . (prolekarniky.cz)

Antennapedia homeodomain protein. (lookformedical.com)
Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl-heidelberg.de)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
The Engrailed homeodomain protein is an 'active' or dominant transcriptional repressor in cultured cells. (biologists.com)
Immunoglobulin J Recombination Signal Sequence-Binding Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (harvard.edu)
This graph shows the total number of publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Harvard Catalyst Profiles by year, and whether "Immunoglobulin J Recombination Signal Sequence-Binding Protein" was a major or minor topic of these publication. (harvard.edu)
Below are the most recent publications written about "Immunoglobulin J Recombination Signal Sequence-Binding Protein" by people in Profiles. (harvard.edu)
We have isolated a murine cDNA encoding a 9-kD protein, Chisel (Csl), in a screen for transcriptional targets of the cardiac homeodomain factor Nkx2-5. (ox.ac.uk)
HD-Zip protein usually contain two highly conserved domains: homeodomain (HD) and leucine zipper (LZ) [ 1 ]. (biomedcentral.com)
And 4 from 207 independent Tol2 focusing on occasions occurred at the identical place positioned inside of the intron of signal regulatory protein delta. (plksignaling.com)
Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)

Epigenetics is the study of how the environment, behavior, and other mechanisms cause changes to the genome that can contribute to the regulation of gene expression and other biological processes without changing to the underlying primary DNA sequences. (activemotif.com.cn)
Because these processes can't be explained solely by the primary DNA sequence of the genome there must be a second level of regulation at play. (activemotif.com.cn)
By conducting a Blat search against the UCSC genome browser database, we recognized 16 piggyBac and twelve Tol2 targeting sequences which have a minimum of the very first 100 bp nucleotides 3 to the target website share greater than 97% sequence identity with other sequences from the gen ome. (plksignaling.com)
A different example, B87 4, was identified to share at the least 97% sequence identity with 510 sequences elsewhere while in the human genome, yet none of these remarkably similar sequences had been targeted by piggyBac. (plksignaling.com)

Screening for sequence variations in the exons and the 5´ promoter region of the SCGB3A2 gene among patients with asthma and healthy control individuals revealed the presence of a point mutation, in the promoter region, that appears to be responsible for reduced transcriptional activity of the gene and is associated with an increased risk of asthma. (biovendor.com)

Members of the zinc-finger homeodomain (ZF-HD) family play a key role in the control of plant growth and development, which are involved in plant responses to stress. (ashs.org)

Descriptions of specific amino acid, carbohydrate, or nucleotide sequences which have appeared in the published literature and/or are deposited in and maintained by databanks such as GENBANK, European Molecular Biology Laboratory (EMBL), National Biomedical Research Foundation (NBRF), or other sequence repositories. (lookformedical.com)
It is also called nucleotide sequence. (lookformedical.com)
Sequence analysis showed that only one single nucleotide mutation (C → T) between 9930 and nps was found in the second exon of Csa3G748220 , a plant-specific class I HD-Zip gene. (biomedcentral.com)
Transcription factors (TFs), which bind to specific nucleotide sequences, have been shown to play important roles in the regulatory networks of numerous developmental processes in plants. (ashs.org)

Targeted NGS allowed for the detection of pathogenic mutations in affected individuals who were not candidates for classical genetic studies. (biomedcentral.com)
Therefore, it has been nearly impossible to identify the precise pathogenic mutations in affected individuals from small families who cannot be examined either through linkage analysis or standard capillary sequencing analysis. (biomedcentral.com)

Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. (embl-heidelberg.de)

Sanger sequencing was used to perform the cosegregation analysis. (molvis.org)
Compared with traditional Sanger sequencing, targeted NGS for genetic testing of congenital cataracts markedly increases the mutation detection rate and is cost-effective. (molvis.org)

There are many superfamilies of Znf motifs, varying in both sequence and structure. (embl-heidelberg.de)
Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target. (embl-heidelberg.de)
Furthermore, in transcripts of both Brd and m4 there are three common regulatory sequence motifs within the 3' UTR. (sdbonline.org)

Plant/ crop productivity effected by the environmental strains such as water deficit condition (drought), Low temperature (cold), salt and High temperature (heat) these stresses disturb the signal transduction of gene regulatory systems of plants. (scielo.br)

To examine the nature of piggyBac target specificity, we subsequent examined the neighboring sequences close to five piggyBac hotspots. (plksignaling.com)

These findings establish ZmWUS1 as an essential meristem size regulator in maize and highlight the striking effect of cis-regulatory variation on a key developmental program. (nature.com)
The differential regulation of aos and btd domains by dri occurs at a time when Dri is found in all somatic nuclei of the embryo, so that Dri must be acting to permit the proper function of other developmental regulatory factors. (sdbonline.org)

[ 5 ] Targeted disruption of TP53 in the mouse leads to the development of various tumors. (medscape.com)
Direct evidence linking the INK4A locus to tumorigenesis was provided by the targeted disruption of exon 2 of INK4A in mice. (medscape.com)
Targeted disruption of Csl showed no overt muscle phenotype. (ox.ac.uk)

As in m4 , the sequence motif of the Brd box is found twice in the 3'-UTR of malpha mRNA at similar positions but without a GY box. (sdbonline.org)

MLL4 contains the catalytic SET domain that catalyzes mono methylation of lysine 4 of histone H3 (H3K4me1) and seven plant homeodomain (PHD) fingers, six of which have not been structurally and functionally characterized. (bvsalud.org)
Plant homeodomain (PHD) fingers comprise a large and well-established family of epigenetic readers that recognize histone H3. (bvsalud.org)
HD-Zips (Homeodomain-Leucine Zippers) are a class of plant-specific transcription factors that play multiple roles in plant growth and development. (biomedcentral.com)

Then, I collect a list of downstream targets of the all driver transcription factors (TFs), and identify which of them exhibit a differential expression upon alterations of driver transcription factors. (biomedcentral.com)

For the occurrence of floral transition at an opportune time, these regulatory mechanisms integrate varied environmental cues with the endogenous physiological ones. (jabonline.in)

LIM-homeodomain component responses LHX2, LHX3, LHX4, LHX9 and ISL1 encode previously then reduced established in a host polymerase SLC17 cytokine of ROBO1, ROBO2, ROBO3 and SLIT2( Wilson et al. (erik-mill.de)

Here, we review the complex regulation of Wnt/β-catenin signaling by SUMOylation and discuss the potential targets of SUMOylation therapy. (frontiersin.org)

microRNAs such as miR156 and miR172 and their corresponding targets are the key regulators of the phase changes in the floral transition [ 4 ]. (jabonline.in)
These different actions must depend on the combination of regulators acting on the respective position-specific cis-regulatory sequences. (sdbonline.org)

Next-generation sequencing (NGS) can overcome these limitations through its ability to perform parallel sequencing of billions of nucleotides at a low cost and high speed[ 1 - 4 ]. (biomedcentral.com)

Most people now agree that epigenetics is the study of heritable differences in genetic expression passed down through successive generations of cells or organisms, without any change in the primary DNA sequence. (activemotif.com.cn)

This auto-activation has been shown to depend on targeting to a fushi tarazu enhancer by the Fushi Tarazu homeodomain. (biologists.com)

However, since all cells of the human body originate from this single-celled ancestor (except germ and immune cells), they have the same primary DNA sequence. (activemotif.com.cn)
The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)

Our understanding of the landscape of pediatric cancer genomics has improved markedly in the past 20 years with the advent of next generation sequencing and other high throughput genetic sequencing. (medscape.com)

Structurally, Mage-D1 possesses the N-terminal sequence Mage homology domain 2 (MHD2), which is a highly conserved structure of the type II Mage gene family. (researchsquare.com)

In the study of genomic cis -regulatory elements, generation of mice featuring transgenic reporters or cis -regulatory element knockout remains the standard approach. (mdpi.com)

Therefore, there is an urgent need to determine the underlying molecular mechanisms of bladder cancer tumorigenesis and to develop effective, molecular targeted bladder cancer therapies. (biomedcentral.com)
The heterogeneity of driver alterations in a tumor type presents a major challenge to the efforts to develop a comprehensive toolbox of targeted therapies to extend personalized cancer medicine driven by genomics information. (biomedcentral.com)

Our results suggest that ERKi, including current clinical candidates, act as 'kinase degraders', driving the proteasome-dependent turnover of their major target, ERK2. (babraham.ac.uk)
She is currently engaged in efforts to identify allosteric inhibitors of ITK that could be used in combination with active site kinase inhibitors to target ITK and thereby interfere with autoimmune T cell infiltration. (cuanschutz.edu)
2005 ). They act by stimulating specific membrane serine/threonine receptor complexes, the activin-like kinase receptors, resulting in the phosphorylation and activation of regulatory Smads (R-Smads). (biomedcentral.com)

Constant with pre vious reports, the characteristic TTAA tetranucleotide was exclusively identified in the piggyBac target sites. (plksignaling.com)

performed whole-exome sequencing in a Palestinian family with hereditary hearing loss and identified a novel mutation in the gene, GPSM2 , which had been hidden in the autosomal recessive hearing loss locus (DFNB32) first identified by Masmoudi et al. (biomedcentral.com)

One such target gene is repressed by EFE even where Fushi Tarazu is not expressed, suggesting that the repression is active. (biologists.com)

These findings reveal an oncogenic role and novel regulatory mechanism of MNX1 in bladder cancer progression and suggest that MNX1 is a potential prognostic biomarker and therapeutic target. (biomedcentral.com)

And the arrangement of the three helices determines the difference in the specific binding of homeodomain to DNA. (biomedcentral.com)
Recent studies have shown that Mage-D1 is closely related to tooth development, but its specific regulatory mechanism is unclear. (researchsquare.com)

Indeed, in the absence of PRDM9, meiotic DSBs occur at transcription regulatory regions, such as promoters and enhancers (Brick et al. (springer.com)

Though no precise signature may very well be detected at Tol2 target web sites, a weak but important preference was observed from the initial ten 11 bp three flanking the target site. (plksignaling.com)

In this disturbance the maintenance involve the gene expression under the stress either in the form of structural gene or regulatory. (scielo.br)

The truth that piggyBac targeted repeatedly on the very same TTAA but not the adjacent TTAA tetranucleotides or for the TTAA website on yet another highly identical sequence close by raise the likelihood the real TTAA pig gyBac targets could possibly be determined by some intrinsic sequence constraints flanking the target internet site. (plksignaling.com)

By applying this sequence constrain, the frequency of targeting repeats lessen way more dramatically in piggyBac than in Tol2 to the bulk of repeat styles suggesting that piggyBac might display a greater degree of sequence constrains than Tol2 in selecting their target internet sites. (plksignaling.com)
Surprisingly, 11 on the 12 Tol2 targets had been located inside of repeats, but none from the sixteen piggyBac targets was. (plksignaling.com)

In this study, by characterization of the dominant maize mutant Barren inflorescence3 ( Bif3 ) we identified a tandem-duplicated copy of ZmWUS1 whose expression is dramatically enhanced by the insertion of a short stretch of chimeric proximal promoter sequence. (nature.com)

Bioinformatics analysis of the sequence variants was performed through computational predictive programs. (molvis.org)

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