• Here, the techniques used to transfect synthetic microRNAs into host erythrocytes and isolate all RNAs from P. falciparum are described. (jove.com)
  • MicroRNAs, as their name implies, are small RNAs that provide an essential regulation of gene expression by controlling translation of protein expressing messenger RNAs. (rvc.ac.uk)
  • Previously it was known that microRNAs were important for the development of a subset of helper T cells called regulatory T cells, which are required to regulate the immune response and prevent attacks against host tissue that lead to autoimmunity. (rvc.ac.uk)
  • In this article the researchers describe their identification of important individual microRNAs and relevant genes they regulate to control regulatory T cell development. (rvc.ac.uk)
  • MicroRNAs (miRNAs) are small noncoding RNAs that posttranscriptionally regulate gene expression by imperfect matching of mRNA [ 6 ]. (hindawi.com)
  • Still other RNA molecules, such as tiny microRNAs ( miRNAs ), act as regulators of other genes, and new types of non-protein-coding RNAs are being discovered all the time. (khanacademy.org)
  • Among these regulatory RNAs, microRNAs play critical roles in the control of gene expression. (pewtrusts.org)
  • These microRNAs are encoded in larger RNA transcripts that must be trimmed to produce the active regulatory molecules. (pewtrusts.org)
  • Using techniques in molecular and structural biology combined with a method I developed for monitoring the structure of large RNA molecules, my lab will elucidate the conformational "switch" that directs the processing of microRNAs encoded on large primary transcripts. (pewtrusts.org)
  • MicroRNAs, or miRNAs, are small RNA molecules that do not encode proteins but perform a regulatory role in several intracellular processes. (eurekalert.org)
  • MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
  • MicroRNAs are small, noncoding RNAs that exhibit profound functional significance through the inhibition of gene expression of mRNA targets. (cdc.gov)
  • Sofia Elmroth and her research team primarily study microRNAs, which are molecules that influence protein levels in the cells of the body indirectly by binding to messenger RNA. (lu.se)
  • There are many different types of microRNAs involved in the regulation of different proteins and of other RNA molecules. (lu.se)
  • If these microRNAs are over or under expressed (increase or decrease in quantity) - for example owing to epigenetic changes to the DNA - this will have an impact on many other regulatory processes. (lu.se)
  • Adaptive responses to various environmental stresses and stimuli are often regulated by small regulatory RNAs (sRNA). (nih.gov)
  • Antisense small RNAs (abbreviated anti small RNA or anti-sRNA) are short RNA sequences (about 50-500 nucleotides long) that are complementary to other small RNA (sRNA) in the cell. (wikipedia.org)
  • While the mRNA-regulating small RNAs were discovered in 1984, the first natural anti-sRNA was only discovered in 2014 in an Escherichia coli model. (wikipedia.org)
  • RNA-Seq has emerged as a popular method for the identification of small RNA, since its ability to distinguish between messenger and structural RNA allows for increased sensitivity in sRNA analysis. (wikipedia.org)
  • Strand-specific RNA-Seq provides further characterization of sRNA by predicting transcript structures with enhanced accuracy. (wikipedia.org)
  • One example of this is established in bacterial trans-encoded sRNA, which demonstrate only partial complementarity to the target RNA. (wikipedia.org)
  • Despite their critical implication in worldwide public healthcare, essential and available resources such as deep transcriptome annotations remain poor, which also limits our understanding of post-transcriptional control small regulatory RNA (sRNA) functions in these bacteria. (frontiersin.org)
  • We report here that a small regulatory RNA (sRNA), Esr41, mediates LEE repression and flagellar gene activation. (nih.gov)
  • Esr41-mediated ler and pch repression was not observed in cells lacking hfq, which encodes an RNA-binding protein essential for most sRNA functions, indicating that Esr41 acts in an Hfq-dependent manner. (nih.gov)
  • In this review, we summarize the current knowledge on the regulation and function of P. aeruginosa sRNAs that titrate regulatory proteins, base-pair with target mRNAs, and which are derived from CRISPR elements. (nih.gov)
  • RsmA and RsmF are both members of the CsrA family of RNA-binding proteins and regulate protein synthesis at the posttranscriptional level. (bvsalud.org)
  • Gene Ontology and pathway enrichment analyses and assessment of RNA binding proteins were performed by R software, circlncRNAnet and Encyclopedia of RNA Interactomes (ENCORI). (xiahepublishing.com)
  • Holmqvist, E. & Vogel, J. RNA-binding proteins in bacteria. (nature.com)
  • Like proteins, RNA molecules twist and fold into intricate 3D shapes that allow them to perform a wide range of cellular functions, including catalyzing reactions, regulating gene expression, modulating innate immunity, and sensing small molecules. (scienceboard.net)
  • However, while scientists' understanding of protein structure has made great strides in the last decade, their knowledge of RNA structure lags far behind, despite the fact that the fraction of the human genome transcribed to RNA is approximately 30 times as large as the fraction that codes for proteins. (scienceboard.net)
  • This is partly because RNA structures are currently not well understood and because RNA sequence information provides less information about 3D RNA structures than is the case for proteins. (scienceboard.net)
  • Mechanically, m6A can be recognized by "reader" proteins or can directly modify RNA conformation, and it widely affects gene expression by mediating RNA stability, translation, splicing and export. (scienceopen.com)
  • Fast Fenton footprinting: a laboratory-based method for the time-resolved analysis of DNA, RNA and proteins. (nyu.edu)
  • This type of RNA is called a messenger RNA ( mRNA ), as it serves as a messenger between DNA and the ribosomes, molecular machines that read mRNA sequences and use them to build proteins. (khanacademy.org)
  • MiRNAs have complementary nucleotide sequences, so they can bind to messenger RNAs and break them down or prevent their translation into proteins. (eurekalert.org)
  • Research has long focused on transcription from our genes that uses RNA messengers to code for the formation of proteins, the building blocks of the body. (lu.se)
  • Around ten years ago, it was discovered that these areas code for a number of small RNA molecules that are now called non-coding RNAs because they don't code for proteins. (lu.se)
  • Transfer RNA (tRNA) molecules contain various post-transcriptional modifications that are crucial for tRNA stability, translation efficiency, and fidelity. (mdpi.com)
  • Unlike AlphaFold, which was trained on thousands of known protein structures, the ARES training data was limited to 18 RNA molecules for which experimentally determined structures were published between 1994 and 2006. (scienceboard.net)
  • Mechanisms of regulation of gene expression by structured RNA molecules and RNA-protein complexes. (nyu.edu)
  • Testing regulatory RNAs and small-molecules as novel therapeutic agents. (nyu.edu)
  • RNA molecules with conserved catalytic cores but variable peripheries fold along unique energetically optimized pathways. (nyu.edu)
  • Using Analytical Ultra Centrifugation to measure global structural changes during equilibrium folding of RNA molecules. (nyu.edu)
  • For instance, some genes specify ribosomal RNAs ( rRNAs ), which serve as structural components of ribosomes, or transfer RNAs ( tRNAs ), cloverleaf-shaped RNA molecules that bring amino acids to the ribosome for protein synthesis. (khanacademy.org)
  • The Keane lab will explore how the structural configurations of large RNAs control the production of smaller regulatory RNA molecules. (pewtrusts.org)
  • The full sequencing of the human genome revealed the surprising existence of a vast assortment of small RNA molecules that have the ability to regulate the activity of genes. (pewtrusts.org)
  • Because alternative RNA splicing allows different types of mRNA molecules to be created from a single gene, it generates the diversity of protein function and structure that is essential to complex organisms. (genomicglossaries.com)
  • RNA molecules which hybridize to complementary sequences in either RNA or DNA altering the function of the latter. (genomicglossaries.com)
  • More specifically, antisense oligonucleotides that are useful as reagents for target validation , or as drugs, are engineered molecules that differ from natural RNA but that have a base sequence that is recognized as being complementary to a very specific mRNA sequence. (genomicglossaries.com)
  • What we used to call 'junk DNA' has proved to be made up of areas that produce small molecules known as non-coding RNAs. (lu.se)
  • Sponge RNA is another term used to describe anti-sRNAs. (wikipedia.org)
  • A major contributor to this approach is the Hfq protein, a conserved RNA-binding protein that is known to attach various sRNAs. (wikipedia.org)
  • However, cross-linking immunoprecipitation fails to provide information on which two RNAs are interacting with each other, which is critical to identify the regulatory role of sRNAs. (wikipedia.org)
  • This shortcoming has been remedied by utilizing an RNA ligase to join the ends of the two RNAs that are interacting, allowing the mapping of sRNAs that are interacting with each other using RNA-Seq. (wikipedia.org)
  • Many anti-sRNAs are involved in regulatory activities to modulate gene expression, with the bulk of research exploring specific interactions within the bacterial domain. (wikipedia.org)
  • The goal of this study was to understand the differential binding properties of RsmA and RsmF by using the RsmY and RsmZ regulatory small RNAs (sRNAs) as a model. (bvsalud.org)
  • A Korean research team led by Distinguished Professor Sang Yup Lee at the Department of Chemical and Biomolecular Engineering from the Korea Advanced Institute of Science and Technology (KAIST), a science and engineering university in Korea, reported the development of a strategy for efficiently developing microbial cell factories by employing synthetic small RNAs (sRNAs). (sciencedaily.com)
  • In order to confirm that the sRNAs suppressed their targets using their host's RNAi pathways, the investigators immunoprecipitated Argonaute 1 - the primary component of the RNA-induced silencing complex that enables RNAi - from Arabidopsis and identified the three sRNAs they have been studying in Ago1-associated fraction pulled from B. cinerea -infected plant samples but not controls. (genomeweb.com)
  • One aspect of their research is the hundreds of regulatory and small RNAs (sRNAs) that are potential targets for antimicrobial therapy. (ohio.edu)
  • A better understanding of how these species cause disease and spread antibiotic resistance requires a knowledge of how its genes are controlled, on both the DNA and the RNA level. (frontiersin.org)
  • Long non-coding RNA small nucleolar RNA host genes (SNHGs) play a critical role in the occurrence and development of tumors. (xiahepublishing.com)
  • Synthetic antisense RNAs are used to effect the functioning of specific genes for investigative or therapeutic purposes. (genomicglossaries.com)
  • After summarizing the latest mechanisms of tsRNAs, including transcriptional gene silencing, post-transcriptional gene silencing , nascent RNA silencing , translation regulation , rRNA regulation , and reverse transcription regulation , we explored the representative biological functions of tsRNAs in tumors . (bvsalud.org)
  • Characterizing post-transcriptional regulatory pathways implicated in oncogenesis. (nyu.edu)
  • The C-terminal domain of YTHDF2 selectively binds to m6A-containing mRNA whereas the N-terminal domain is responsible for the localization of the YTHDF2-mRNA complex to cellular RNA decay sites. (scienceopen.com)
  • RNA-like oligonucleotides that are complementary to a portion of a target mRNA molecule. (genomicglossaries.com)
  • A complementary RNA sequence that binds to a naturally occurring (sense) mRNA molecule, thus blocking its translation. (genomicglossaries.com)
  • In 2019, a new algorithm called APERO was established which allows accurate genome-wide detection of small transcripts from paired-end bacterial RNA-Seq data. (wikipedia.org)
  • Our study reveals a novel pathway of small guide RNA maturation and the first example of a host factor (RNase III) required for bacterial RNA-mediated immunity against invaders. (nature.com)
  • Carrier, M.-C., Lalaouna, D. & Massé, E. Broadening the definition of bacterial small RNAs: characteristics and mechanisms of action. (nature.com)
  • Meister, G. & Tuschl, T. Mechanisms of gene silencing by double-stranded RNA. (nature.com)
  • Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). (cshlpress.com)
  • Endogenous antisense RNAs function as regulators of gene expression by a variety of mechanisms. (genomicglossaries.com)
  • The analysis of epigenetics patterns or regulatory elements have been an increasing focus of research in many contexts, such as development biology or characterization of molecular mechanisms in complex diseases ( Schübeler, 2015 ). (biorxiv.org)
  • Recently, the molecular mechanisms of miRNA in host-pathogen interaction networks have been extensively studied in mammals, whereas the underlying regulatory mechanisms in fish are still poorly understood. (frontiersin.org)
  • 3DFAACTS-SNP: using regulatory T cell-specific epigenomics data to uncover candidate mechanisms of type 1 diabetes (T1D) risk. (cdc.gov)
  • We have determined the transcriptional landscape of R. conorii during infection of Human Microvascular Endothelial Cells (HMECs) by strand-specific RNA sequencing to identify 4 riboswitches, 13 trans-acting (intergenic), and 22 cis-acting (antisense) small RNAs (termed Rc-sR's). (utmb.edu)
  • The initial characterization of antisense small RNA within E. coli models were demonstrated through microarrays and computational predictions. (wikipedia.org)
  • Antisense small RNA are found in all domains of life, including Eukaryotes, Bacteria and Archaea. (wikipedia.org)
  • Antisense small RNA can also be engineered and utilized by scientists to perform experimental functions. (wikipedia.org)
  • In synthetic biology, employing non-coding RNA such as antisense small RNA has advantages for creating regulatory architecture within engineering systems, provided the ability to predict function using the strand sequence. (wikipedia.org)
  • Development of RNA array-based interaction assays that allow for screening in vitro have further advanced platforms targeting gene expression with antisense small RNAs. (wikipedia.org)
  • RNA-array based interaction assays screen for synthetic antisense small RNA interactions in vitro, through a surface-capture technique. (wikipedia.org)
  • An array of immobilized double-stranded DNA template for antisense small RNA sits opposite to an RNA-capture surface composed of possible antisense small RNA targets, separated by a solution of transcription reagents. (wikipedia.org)
  • Captured RNA are visualized using fluorescent staining, which can indicate whether a prospective antisense small RNA has been bound to its target. (wikipedia.org)
  • This has been achieved by utilizing antisense small RNAs designed through the RNA array pipeline, opening the possibilities for future antimicrobial or therapeutic applications. (wikipedia.org)
  • Functional enrichment analysis revealed SNHG4 involvement with regulation of ribosomal RNA synthesis and the RNA processing and surveillance pathway. (xiahepublishing.com)
  • University of California, Riverside researchers this month reported the discovery that a fungal pathogen known to infect a wide variety of vegetable and fruit crops is capable of hijacking a plant's RNA interference pathway to suppress host immunity, thereby enhancing its virulence. (genomeweb.com)
  • The collective findings indicate that miR-21 plays a regulatory role in host-pathogen interactions through IRAK4-mediated NF-κB signaling pathway. (frontiersin.org)
  • Allosteric inhibitors of Coxsackie virus A24 RNA polymerase. (utmb.edu)
  • ELL facilitates RNA polymerase II pause site entry and release. (zymoresearch.com)
  • 87(5): 1663-1667] Specifically, the investigators started by priming whole cerebellar RNA with a synthetic oligonucleotide containing a T7 RNA polymerase promoter sequence. (genomicglossaries.com)
  • After second- strand cDNA synthesis, T7 RNA polymerase was used to generate aRNA. (genomicglossaries.com)
  • miRNAs are small non-coding RNAs that regulate gene expression post-transcriptionally. (biomedcentral.com)
  • miRNAs are small noncoding RNAs that have broad regulatory functions on gene expression. (lu.se)
  • Jinek, M. & Doudna, J. A. A three-dimensional view of the molecular machinery of RNA interference. (nature.com)
  • Marraffini, L. A. & Sontheimer, E. J. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. (nature.com)
  • SLN360 is designed to lower Lp(a) production by using RNA interference to silence messenger RNA transcribed from the LPA gene in liver cells. (medscape.com)
  • RNA interference is an evolutionary conserved gene regulatory mechanism that can be used by introducing exogenous synthetic double-stranded RNAs, so called small interfering RNA (siRNA). (lu.se)
  • However, a key challenge in translating siRNA into the clinic is the inefficacy to deliver siRNA across the plasma membrane, but most importantly, to escape the endosomal system and reach the cytosol where they can interact with the RNA interference machinery. (lu.se)
  • Malone, C. D. & Hannon, G. J. Small RNAs as guardians of the genome. (nature.com)
  • Dr. Zhang has made unique and significant contributions to cotton biotechnology using genome editing and small regulatory RNAs. (cottoninc.com)
  • Advances in molecular biology and genome analysis now also allow for detailed descriptions of DNA-binding transcription factors and transcriptional regulatory networks. (medscape.com)
  • Scientists have reported the development of a strategy for efficiently developing microbial cell factories by employing synthetic small RNAs. (sciencedaily.com)
  • DNA and RNA are polymers (in the case of DNA, often very long polymers), and are made up of monomers known as nucleotides . (khanacademy.org)
  • They are non-coding RNA sequences involved in regulatory processes, such as metabolism and aiding in transcription. (wikipedia.org)
  • However, it is not trivial to engineer the cellular metabolism and regulatory circuits in the cell due to their high complexity. (sciencedaily.com)
  • With the development of sequencing technology , transfer RNA ( tRNA )-derived small RNAs (tsRNAs) have received extensive attention as a new type of small noncoding RNAs. (bvsalud.org)
  • Besides their canonical roles in translation, tRNAs also originate tRNA-derived small RNAs (tsRNAs), a class of small non-coding RNAs with regulatory functions ranging from translation regulation to gene expression control and cellular stress response. (mdpi.com)
  • An extensive repertoire of modifications is known to underlie the versatile coding, structural and catalytic functions of RNA, but it remains largely uncharted territory. (scienceopen.com)
  • RNA which contains an intron sequence that has an enzyme- like catalytic activity. (genomicglossaries.com)
  • The ARES deep neural network accepts as input a structural model of the 3D coordinates and chemical element type of each atom and then predicts the model's root mean square deviation from the unknown true 3D RNA structure. (scienceboard.net)
  • To assess the ability of ARES to identify accurate structural models of previously unseen RNAs, the Stanford researchers compiled a benchmark data set of seven years' worth of winning entries in the RNA-Puzzles contest, a long-running challenge organized by the RNA scientific community. (scienceboard.net)
  • According to the rules of RNA-Puzzles, when scientists in the community discover a new RNA structure experimentally, they withhold publication of the details until other RNA-Puzzles participants have submitted their structural predictions, which are then judged based on how closely they match the experimentally determined structure. (scienceboard.net)
  • For each RNA structure in the RNA-Puzzles data set, the researchers generated a minimum of 1,500 structural models using the Rosetta FARFAR2 sampling software. (scienceboard.net)
  • For all four RNAs, ARES "won" the challenge, producing the most accurate structural model of any method. (scienceboard.net)
  • Researchers are finding new RNA all the time because sequencing is now so quick and cheap", says Sofi Elmroth, professor at the Division of Biochemistry and Structural Biology at Lund University. (lu.se)
  • Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)
  • Small regulatory RNAs comprise critically important modulators of gene expression in bacteria, yet very little is known about their prevalence and functions in Rickettsia species. (utmb.edu)
  • Identification and Characterization of Novel Small RNAs in Rickettsia prowazekii. (utmb.edu)
  • In vitro transcribed short hairpin RNA constructs were recovered from 20% denaturing polyacrylamide gels using the ZR small-RNA PAGE Recovery kit. (zymoresearch.com)
  • Aliyari, R. & Ding, S. W. RNA-based viral immunity initiated by the Dicer family of host immune receptors. (nature.com)
  • Low molecular weight RNA was separated by gel electrophoresis and the 18 to 26 nt fraction was isolated using the ZR Small-RNA PAGE Recovery kit for Northern blot analysis of viral small RNAs. (zymoresearch.com)
  • Over the past year, methods for sewer system contains biological waste from the hu- detection and quantifi cation of SARS-CoV-2 viral RNA in man population it serves. (cdc.gov)
  • Multiple regulatory roles of the transfer RNA-derived small RNAs in cancers. (bvsalud.org)
  • The provided "Sequence" is that of the RNA strand, i.e. (unam.mx)
  • Functional Analyses of the RsmY and RsmZ Small Noncoding Regulatory RNAs in Pseudomonas aeruginosa. (bvsalud.org)
  • Here, differential RNA sequencing of the human pathogen Streptococcus pyogenes uncovered tracrRNA, a trans -encoded small RNA with 24-nucleotide complementarity to the repeat regions of crRNA precursor transcripts. (nature.com)
  • Uncleaved RNA transcripts were extracted from denaturing (8.3M ura) 10% polyacrylamide gel using the ZR small-RNA PAGE Recovery kit. (zymoresearch.com)
  • The short interfering RNA (siRNA) agent SLN360 was well tolerated and lowered lipoprotein(a) by up to 98% in volunteers without cardiovascular disease but with elevated Lp(a) in the small dose-ranging APOLLO trial. (medscape.com)
  • The reclassification is based on the degree of homology of RNA oligonucleotides between groups. (medscape.com)
  • Yes, the kit is compatible with both single- or double-stranded RNA (and DNA) fragments. (zymoresearch.com)
  • Differential Inductions of RNA Silencing among Encapsidated Double-Stranded RNA Mycoviruses in the White Root Rot Fungus Rosellinia necatrix. (zymoresearch.com)
  • Before this information can be used for protein synthesis, however, an RNA copy (transcript) of the gene must first be made. (khanacademy.org)
  • Their study in humans, however, has been hampered by the unavailability of inner ear RNA from human subjects, making the mouse an invaluable model for studying miRNA development and regulation in the inner ear [ 8 ]. (biomedcentral.com)
  • A single miRNA may be able to bind to hundreds or thousands of messenger RNAs. (eurekalert.org)
  • microRNA (miRNA) is a small molecule RNA that can be stably expressed in body fluids such as serum, plasma, saliva and can be sensitively detected. (researchsquare.com)
  • Exploring the role of miRNA 210 and regulatory T cells during TDI sensitization (HYP6P.270). (cdc.gov)
  • This data indicates that miRNA 210 has a functional role in TDI sensitization which may be related to regulatory T cell differentiation and function. (cdc.gov)
  • As seen with many other bacteria, RNA-seq technology has now become the method of choice for transcriptome analysis in the enterococcus. (frontiersin.org)
  • Due to the development of RNA sequencing technology, the distribution pattern of m6A in the transcriptome has been uncovered. (scienceopen.com)
  • This comprehensive global TSS mapping atlas provides a valuable resource for RNA biology and gene expression analysis in the Enterococci. (frontiersin.org)
  • Mitra, S. ( 2014 ) Methods in Molecular Biology, Vol. 1086 (RNA Folding - Methods and Protocols), Chapter 16: 265-288. (nyu.edu)
  • This progression from DNA to RNA to protein is called the " central dogma " of molecular biology. (khanacademy.org)
  • In experiments, engineered riboregulators, which are specific RNA that respond to signal RNA through complementary base pairing utilizing anti-small RNA, have been found to be capable of activating independent gene expression. (wikipedia.org)
  • After 4 weeks of conversion, we performed global analyses of RNA and protein levels by RNA-sequencing and mass spectrometry. (lu.se)
  • The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA's influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. (cshlpress.com)
  • Our findings therefore suggest that RNA decoration by m(6)A has a fundamental role in regulation of gene expression. (scienceopen.com)
  • To address this issue, the researchers, led by Raphael Townshend, a Stanford doctoral graduate and founder and CEO of Atomic AI, designed ARES to make its RNA structure predictions based on minimal assumptions. (scienceboard.net)
  • Next, the researchers entered ARES' predictions into four new rounds of the RNA-Puzzles blind structure prediction challenge. (scienceboard.net)
  • Researchers at Stanford University used such a method to produce amplified heterogeneous populations of RNA from limited quantities of cDNA. (genomicglossaries.com)
  • More recently, another group of researchers reported that they had developed a process for optimizing low- abundance RNA, by combining aRNA amplification with template- switching. (genomicglossaries.com)
  • Given that SARS-CoV-2 RNA is shed in knowledge gaps between researchers and public health feces of persons with asymptomatic and symptomatic responders is needed. (cdc.gov)
  • The results provide further support of the essential regulatory role of miRNAs in inner ear sensory epithelia and in regulating pathways that define development and growth of these cells. (biomedcentral.com)
  • miRNAs are a family of small non-coding RNAs that emerged as significant and versatile regulators involved in regulation of immune responses. (frontiersin.org)
  • MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. (rvc.ac.uk)
  • Although biochemical studies indicate that N(6)-methyladenosine (m(6)A) is the most prevalent internal modification in messenger RNA, an in-depth study of its distribution and functions has been impeded by a lack of robust analytical methods. (scienceopen.com)
  • Overall, our findings highlight the importance of TEs as regulatory agents and their dynamic activity during development, adult life, and disease in the human brain. (lu.se)
  • The development of therapies targeting messenger RNA has made possible significant lowering of lipoprotein(a). (medscape.com)
  • We hope to be able to contribute to the development of a whole new type of drug that, because of its resemblance to the cell's own RNA, can effectively influence cell processes that have not previously been exploited in treatment. (lu.se)
  • This facilitates the generation of ribozyme-based control devices for gene regulatory activities. (zymoresearch.com)
  • N6-methyladenosine (m6A) is the most abundant inner RNA modification in eukaryotes. (scienceopen.com)
  • In eukaryotes, DNA is typically broken up into a number of very long, linear pieces called chromosomes , while in prokaryotes such as bacteria, chromosomes are much smaller and often circular (ring-shaped). (khanacademy.org)
  • My focus has been on the data analysis side of things, employing different computational methods to deal with mapping ambiguity and adapting new technologies such as single-cell RNA sequencing to better understand three families of transposable elements. (lu.se)