• miRNAs are numbered based on the sequence of the mature RNA. (wikipedia.org)
  • miRNAs are thought to have regulatory roles through complementarity to mRNA. (wikipedia.org)
  • The miRNAs regulate root elongation, lateral root (LR) formation and adventitious root (AR) development in response to hormone signaling, nutrient uptake and biotic/abiotic stress. (chinaagrisci.com)
  • This review provides multiple perspectives on the involvement of miRNAs in regulating root growth and development in plants. (chinaagrisci.com)
  • microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
  • miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. (cancerindex.org)
  • MicroRNAs (miRNAs) are 21-24 nt long non-coding RNAs that regulate gene expression at the post-transcriptional level. (researchsquare.com)
  • Research advances have demonstrated the crucial regulatory roles of miRNAs in many diseases, including COPD [ 13 , 14 ]. (researchsquare.com)
  • Recently, an increasing number of reports have implicated a new class of small regulatory RNA molecules, termed microRNAs (miRNAs), in HCC progression. (spandidos-publications.com)
  • miRNAs are highly conserved, small, non-coding RNAs that negatively regulate gene expression in vertebrates through multiple mechanisms, such as complimentary base pairing with the 3′-UTR of their target mRNAs, resulting in translational repression, mRNA cleavage and mRNA decay initiated by miRNA-guided rapid deadenylation ( 10 ). (spandidos-publications.com)
  • Finally, we identified 76 therapeutic agents, 152 miRNAs targets, and 91 TFs regulatory networks. (nature.com)
  • MicroRNAs (miRNAs) are short non-coding RNAs that regulate gene expression via mRNA targeting, playing important roles in the pancreatic islets. (lu.se)
  • MicroRNAs (miRNAs) are small noncoding RNAs (~22 nucleotides in length) that regulate gene expression post-transcriptionally by imperfect binding to the 3′ untranslated region of target mRNAs in a wide variety of cell types. (biomedcentral.com)
  • The recent publication by Wagh and colleagues sought to identify the novel miRNAs regulating cardiac-specific transcription factors that determine left versus right ventricular determination [ 1 ]. (biomedcentral.com)
  • Taking into account the important regulatory roles that miRNAs have in cancer development, by acting either as oncogenes or as tumor-suppressor genes, they represent potential biomarkers in ovarian cancer [ 5 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs or miRs) refer to a group of small noncoding RNA molecules, typically 18~25 nucleotides in length, that function in RNA silencing and post-transcriptional regulation of gene expression [ 9 ]. (ijbs.com)
  • In the case of RNA molecules that bind target RNA segments, such as microRNAs (miRNAs), the altered base pairing can change binding specificities. (biomedcentral.com)
  • Emerging evidence indicates that Long non-coding RNAs (LncRNAs) and microRNAs (miRNAs) play crucial roles in tumor progression, including hepatocellular carcinoma (HCC). (biomedcentral.com)
  • A series of studies indicate that lncRNAs serve as competing endogenous RNAs (ceRNA) by sponging miRNAs, and modulate the targets of miRNAs [ 15 , 16 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) represent a class of small non-coding regulatory RNAs that play important roles in normal hematopoiesis, including erythropoiesis. (molcells.org)
  • Although studies have identified several miRNAs that regulate erythroid commitment and differentiation, we do not understand the mechanism by which the crucial erythroid transcription factors, GATA-1and NF-E2 directly regulate and control differentiation via miRNA pathways. (molcells.org)
  • MicroRNAs (miRNAs, miRs) are endogenously expressed small non-coding RNAs that generally regulate gene expression by binding to the 3ʹ untranslated region (3ʹ-UTR) of their targets, resulting in silencing [ 13 ]. (biomedcentral.com)
  • MicroRNAs (miRNAs) are endogenous small noncoding RNAs that negatively regulate the expression of target genes through mRNA cleavage, translational repression and DNA methylation. (plantae.org)
  • however, the cell-autonomous roles for endothelial-expressing microRNAs (miRNAs) are poorly understood in this process. (unl.edu)
  • Among them, micro RNAs (miRNAs) and small interfering RNAs (siRNAs) are found to be very important riboregulators in plants. (csircentral.net)
  • Accumulating evidence suggests that microRNAs (miRNAs) are key regulators of this network, with the capacity to target multiple messenger RNAs involved in the EndMT process as well as in the regulation of disease progression. (bmbreports.org)
  • This review highlights the current fund of knowledge regarding the known links between miRNAs and the EndMT process, with a focus on the mechanism that regulates associated signaling pathways and discusses the potential for the EndMT as a therapeutic target to treat many diseases. (bmbreports.org)
  • MicroRNAs (miRNAs) are the most altered subset of ncRNAs, followed by long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs). (ersjournals.com)
  • We summarise the pathophysiological regulatory processes of ncRNAs, especially miRNAs, lncRNAs and circRNAs, in hyperplasia, hypertrophy, ECM production and cytokine production in asthmatic ASMCs. (ersjournals.com)
  • that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)
  • Understanding the roles of Asthma is a worldwide problem, the prevalence of miRNAs in asthma pathogenesis may also aid to asthma ranged from 1% to 18% of the population in explore new therapeutic targets. (cdc.gov)
  • MiRNAs are approximately 19- to 25-nucleotide estimated about 250,000 and mortality does not appear single-stranded, noncoding RNAs that exist in both to correlate well with prevalence. (cdc.gov)
  • Th)1 cells.5 Meanwhile, the function and immunity of with genetic predisposition, involving multiple cells, DCs are closely regulated by miRNAs. (cdc.gov)
  • Among the miRNAs up-regulated in H1299-MTp53 cells and these cell lines expressing p53shRNAs, was the oncogenic miRNA miR-155, a recently discovered target of MTp53. (thegomap.org)
  • MicroRNAs (miRNAs) are a kind of small noncoding RNAs that regulate the expression of protein through targeting the 3′UTR of messenger RNA (mRNA), resulting in mRNA degradation or suppression of translation [ 5 ]. (degruyter.com)
  • The Keane lab will explore how the structural configurations of large RNAs control the production of smaller regulatory RNA molecules. (pewtrusts.org)
  • The full sequencing of the human genome revealed the surprising existence of a vast assortment of small RNA molecules that have the ability to regulate the activity of genes. (pewtrusts.org)
  • These microRNAs are encoded in larger RNA transcripts that must be trimmed to produce the active regulatory molecules. (pewtrusts.org)
  • Using techniques in molecular and structural biology combined with a method I developed for monitoring the structure of large RNA molecules, my lab will elucidate the conformational "switch" that directs the processing of microRNAs encoded on large primary transcripts. (pewtrusts.org)
  • I will present the current knowledge on the many functions RNA molecules have in controlling cellular metabolism. (videolectures.net)
  • A potent method, called SELEX, enables the isolation and selection of RNA molecules with desired functions and opens the potential for design of therapeutic molecules. (videolectures.net)
  • MicroRNAs are an abundant class of small regulatory RNA molecules about 19-22 nucleotides (nt) in length. (mirtar2go.org)
  • These RNA molecules are transcribed from the genome but do not encode proteins, and they have diverse roles in plant growth, development, stress responses, and other biological processes. (mdpi.com)
  • Circular RNAs (circRNAs) belong to a class of non‐coding RNAs that are widespread in the cytoplasm of eukaryotic cells and are structurally and functionally different from linear RNA molecules [ 1 ]. (biomedcentral.com)
  • They are covalently closed-loop RNA molecules that are formed by back-splicing of the 5′ and 3′ ends of the primary transcript. (biomedcentral.com)
  • As novel regulatory molecules, circRNAs mediate the regulation of viral infections and the cellular immune response, which provide a new perspective for understanding virus-cell interactions. (biomedcentral.com)
  • Although some key flowering responsive genes have been identified in spinach, non-coding RNA molecules like long non-coding RNAs (lncRNAs) were not investigated yet. (biomedcentral.com)
  • A growing body of evidence indicates that epigenetic regulators rely, amongst other factors, on their interaction with untranslated RNA molecules for guidance to particular targets on DNA. (frontiersin.org)
  • Non (protein)-coding RNAs are the most abundant transcriptional products of the coding genome, and comprise several different classes of molecules with unique lengths, conformations and targets. (frontiersin.org)
  • Bits of the transcriptome once believed to function as RNA molecules are in fact translated into small proteins. (the-scientist.com)
  • Circular RNAs (circRNAs) are a new type of endogenous noncoding RNA that exhibit a variety of biological functions. (biomedcentral.com)
  • Mechanistically, PTTG3P upregulated the expression of miR-383 targets Cyclin D1 (CCND1) and poly ADP-ribose polymerase 2 (PARP2) by sponging miR-383, acting as a competing endogenous RNA (ceRNA). (biomedcentral.com)
  • In addition, we have shown that FENDRR is a competing endogenous RNA (ceRNA) that functions as a sponge for miR-214. (grantome.com)
  • To further establish the role of MTp53 in regulating microRNAs expression, we will knockdown endogenous MTp53 in lung, breast and colorectal cancer cell lines and perform deep sequencing. (thegomap.org)
  • Bioinformatic predictions suggest that the human EGFR mRNA 3'-untranslated region contains three microRNA-7 (miR-7) target sites, which are not conserved across mammals. (wikipedia.org)
  • CircRNAs are newly discovered noncoding RNAs formed through the alternative splicing of premessenger RNA (mRNA). (hindawi.com)
  • The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. (cancerindex.org)
  • Incorporated into one member of the Argonaute (AGO) protein family in the RNA induced silencing complex (RISC), a mature miRNA binds typically to the 3' untranslated region (3' UTR) of the targeted messenger RNA (mRNA) and inhibits its translation via various mechanisms. (mirtar2go.org)
  • MiRNA usually binds directly to the 3′-untranslated region (3′-UTR) of target gene mRNA through the RNA-induced silencing complex (RISC) [ 15 , 16 ]. (ersjournals.com)
  • Each microRNA can regulate the expression of hundreds of genes by blocking mRNA translation and/or inducing mRNA decay. (thegomap.org)
  • These vesicles are carriers of active or non-autonomous function biomolecules, such as proteins, lipids, DNA, mRNA and non-coding regulatory RNA. (spandidos-publications.com)
  • Previous findings indicate that circRNAs mainly function as microRNA (miRNA) sponges to regulate the transcription and posttranscription of miRNA-targeted genes. (hindawi.com)
  • In general, microRNAs, a class of small (~21 nucleotide) non-coding RNAs, negatively regulate the expression of their target genes. (spandidos-publications.com)
  • Chromatin immunoprecipitation and sequencing (ChIP-seq) analysis and RNA-seq analysis of suvh5 and suvh6 single mutants revealed novel functions for SUVH5 and SUVH6 in affecting many genes with development- and defense-related functions under nematode-infected conditions. (tennessee.edu)
  • Finally, we constructed the drug, transcription factors (TFs), and microRNA network of the diagnostic genes. (nature.com)
  • They have been predicted to regulate the expression of more than 60% of mammalian genes and play fundamental roles in most biological processes including diseases. (mirtar2go.org)
  • ADARs have been shown to contribute to disease pathologies by editing of glutamate receptors, editing of serotonin receptors, mutations in ADAR genes, and by other mechanisms, including recently identified regulatory roles in microRNA processing. (biomedcentral.com)
  • To achieve this, p53 mainly functions as a transcription factor (TF) targeting hundreds of genes, but it also has TF-independent roles in the nucleus and cytoplasm [ 6 ]. (nature.com)
  • This study is the first report on identifying bolting and flowering-related lncRNAs based on transcriptome sequencing in spinach, which provides a useful resource for future functional genomics studies, genes expression researches, evaluating genes regulatory networks and molecular breeding programs in the regulation of the genetic mechanisms related to bolting in spinach. (biomedcentral.com)
  • MicroRNA genes reside in regions of the genome as distinct transcriptional units as well as in clusters of polycistronic units. (thegomap.org)
  • RNA polymerase II transcribes microRNA genes, generating long primary transcripts. (thegomap.org)
  • Among the most pressing questions regarding this unusual class of regulatory microRNA-encoding genes is how their expression is regulated. (thegomap.org)
  • Since the mechanism of transcription of microRNA genes is similar to mRNAs, we hypothesize that in cancer cells, MTp53 alters the abundance of a subset of cellular microRNAs by regulating the activity of the above-mentioned transcription factors. (thegomap.org)
  • Having identified the common set of microRNAs regulated by MTp53, we will next investigate (1) whether candidate microRNAs are also regulated by other aggressive mutants of p53 (such as R175H) (2) changes in transcription and regulation of candidate microRNA genes by MTp53 and MTp53-interacting transcription factors such as E2F1, ETS1 and p63/p73. (thegomap.org)
  • Identification of miRNA-regulated targeting genes is important for understanding their specific biological functions [ 11 ]. (degruyter.com)
  • The non-specific lethal complex regulates genes and pathways genetically linked to Parkinson's disease. (medscape.com)
  • Although carcinogenic roles for the INK4B, INK4C, INK4D, CIP1, KIP1, and KIP2 genes appear to be limited, INK4A is among the most commonly mutated genes in human tumors. (medscape.com)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • We aimed to identify molecular pathways and genomic regulatory regions associated with altered miRNA expression due to glycemic status, which could contribute to the development of type 2 diabetes (T2D). (lu.se)
  • Endothelial miR-181a2b2 deficiency regulates multiple key pathways related to endothelial inflammation, cell adhesion, cell cycle, and immune response involved in the development of atherosclerosis. (unl.edu)
  • Our research focuses on developmental pathways that regulate hematopoietic cell growth and differentiation and are disrupted in the course of neoplastic transformation, particularly in leukemias and lymphomas. (stanford.edu)
  • The identification of microRNAs regulated by multiple p53 mutants in a panel of cell lines will be indicative of key pathways relevant to mutant p53-mediated tumorigenesis. (thegomap.org)
  • Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
  • to other RNAs may initiate epige- cleus pathways. (who.int)
  • This family represents the microRNA (miRNA) precursor mir-7. (wikipedia.org)
  • The involvement of Dicer in miRNA processing suggests a relationship with the phenomenon of RNA interference. (wikipedia.org)
  • Mature miRNA-7 is derived from three microRNA precursors in the human genome, miR-7-1, miR-7-2 and miR-7-3. (wikipedia.org)
  • Pax6 translation in the lateral wall of the subventricular zone of developed mice is post-transcriptionally regulated by miRNA-7a mediated gene silencing, which is necessary to control the rate of dopaminergic neuron production in the olfactory bulb. (wikipedia.org)
  • The aim of this study is to investigate the key regulatory miRNA-486-5p and underlying molecular mechanisms in chronic obstructive pulmonary disease (COPD) progression. (researchsquare.com)
  • However, the relationship between BDNF and microRNA (miRNA) in cardiomyocytes are unclear. (ijbs.com)
  • We also found that the tumor suppressor miRNA, let-7, was significantly down-regulated by mutant p53 in all the cell lines that tested. (thegomap.org)
  • We are studying the expressions, targets, mechanisms of action and functions of microRNAs, TUCRs and lncRNAs in gliomas and brain metastasis. (virginia.edu)
  • Long noncoding RNAs (lncRNAs) have been identified as important regulators of gene expression in plants. (mdpi.com)
  • The study of lncRNAs in plants is a relatively new area of research, but it has already revealed several important insights into their roles in gene regulation. (mdpi.com)
  • Pseudogene, a subclass of long non-coding RNAs (lncRNAs), are considered as genomic loci that resemble real gene, but lost some functionality because they are lack of protein-coding ability because of disabling mutation, lack of transcription, or their inability to encode RNA [ 3 ]. (biomedcentral.com)
  • The objective of the current application is to understand how long non-coding RNAs (lncRNAs) regulate pulmonary fibroblast activation in IPF. (grantome.com)
  • Although small non-coding RNAs, such as microRNAs, have been extensively studied in IPF, very little is known regarding the roles of lncRNAs in the pathogenesis of pulmonary diseases, such as IPF. (grantome.com)
  • The aim of this mini-review is to discuss emerging epigenetic roles of long non-coding RNAs (lncRNAs) in Acute Myeloid Leukemia (AML). (frontiersin.org)
  • In particular, there are incremental examples of the participation of the distinct class of long non-coding RNAs (lncRNAs) in AML epigenetic regulation, some of which have translational potential. (frontiersin.org)
  • We define lncRNAs and highlight their general roles of in normal development and in cancer. (frontiersin.org)
  • We will also identify proteins that specifically interact with and alter the structure of the large primary microRNA, differentially altering access to the enzymes that process and release its individual microRNAs. (pewtrusts.org)
  • The central dogma of molecular biology suggests that biological information is stored in DNA then flows via RNA into proteins, which execute the functions dictated by DNA. (videolectures.net)
  • The RNA world theory proposes that an RNA-based life predated today's DNA and proteins dominated cellular metabolism. (videolectures.net)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
  • The recently discovered long noncoding RNAs seem to boost the production of specific proteins in the cell by interacting with RNA-binding proteins, researchers find. (the-scientist.com)
  • Scientists discover transcripts from the same gene that can express both proteins and noncoding RNA. (the-scientist.com)
  • We found 1100 differentially expressed circRNAs (675 downregulated and 425 upregulated) which were involved in various biological processes such as protein ubiquitination modification, cell cycle regulation, RNA transport, and autophagy. (biomedcentral.com)
  • Although more and animals and plants and regulate gene/protein expression more progressions have been made about the through direct complementarity between their 5' region pathogenesis of asthma in recent years, the increasing and the 3' untranslated region of target mRNAs. (cdc.gov)
  • However, a growing body of evidence suggests that recruitment, stability, and function of epigenetic factors can be mediated by non-protein-coding RNAs. (frontiersin.org)
  • Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)
  • An RNA thought to be noncoding in fact encodes a small protein that regulates calcium uptake in muscle. (the-scientist.com)
  • After 4 weeks of conversion, we performed global analyses of RNA and protein levels by RNA-sequencing and mass spectrometry. (lu.se)
  • Multiple roles and targets of miR-7 as well as its expression pattern were linked to regulatory mechanisms and pathogenesis in glioblastoma, breast cancer and other types of cancers, as well as in schizophrenia and visual abnormalities. (wikipedia.org)
  • Oxidative stress and neuroinflammation play important roles in the pathogenesis of AD. (nature.com)
  • MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
  • This review summarizes the physiological and pathological roles of alpha-synuclein and its implication in Parkinson's disease pathogenesis. (medscape.com)
  • Epigenetic mechanisms, including histone and DNA methylation and microRNAs, play key roles in mediating transcriptional changes during plant development and stress responses. (tennessee.edu)
  • Additionally, promoter activities suggest hormone-linked methylome regulatory mechanisms facilitate tissue differentiation. (tennessee.edu)
  • These results suggest methylation-dependent mechanisms similarly and differentially regulate plant responses to infection by two distinct nematode species. (tennessee.edu)
  • However, the literature elucidating their functional roles and their mechanisms of action in cancer is very sparse, with the literature on their role in glioblastoma being inexistent. (virginia.edu)
  • The underlying regulatory mechanisms of TGF-β-induced EMT in NPC remain unclear. (biomedcentral.com)
  • Aim II will define the functional roles and molecular mechanisms of FENDRR in fibroblast activation. (grantome.com)
  • Previous Cold Spring Harbor Symposia have addressed many different aspects of RNA biology such as Mechanisms of Transcription (1998), The Ribosome (2001), Epigenetics (2004) and Regulatory RNAs (2006). (cshlpress.com)
  • ADAR3 contains an arginine-rich domain, shown in pink, which binds single-stranded RNA. (biomedcentral.com)
  • Exosomes secreted by the umbilical cord mesenchymal stromal cells (UMSCs) and circular RNAs (circRNAs) derived from exosomes have been shown to be associated with the progression of GDM-related complications. (hindawi.com)
  • Noncoding RNAs and microproteins, once considered genomic noise, are turning out to be critical to the progression of some types of cancer. (the-scientist.com)
  • The 84th Cold Spring Harbor Symposium focused on RNA Control & Regulation and provided a current synthesis of the enormous progress in our understanding of RNA's influence on cells and organisms and how, when aberrant, its effects may contribute to the progression of disease. (cshlpress.com)
  • Over millions of years of evolution, p53 has been highly conserved across species, thus suggesting its critical roles [ 3 ]. (nature.com)
  • miR-34a was found to be up-regulated in small airway fibroblasts in COPD patients compared to non-smokers, and miR-34a could promote cellular senescence in small airway fibroblasts in COPD patients [ 15 ]. (researchsquare.com)
  • Small RNAs (sRNAs) are 18-30 nt non-coding regulatory elements found in diverse organisms, which were initially identified as small double-stranded RNAs in Caenorhabditis elegans. (csircentral.net)
  • In this regards, they can be separated into small non-coding RNA (small ncRNA) and lncRNA. (biomedcentral.com)
  • MicroRNAs are an abundant class of small non-coding RNAs that play key roles in gene regulation. (thegomap.org)
  • and autophagy, timing and small RNAs. (cshlpress.com)
  • Hang P, Sun C, Guo J, Zhao J, Du Z. BDNF-mediates Down-regulation of MicroRNA-195 Inhibits Ischemic Cardiac Apoptosis in Rats. (ijbs.com)
  • Since then, they have been found to be involved in the regulation of cell proliferation, migration and apoptosis as important post-transcriptional regulatory factors [ 15 ]. (ersjournals.com)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)
  • Our findings suggest that the increased invasiveness of MTp53 cells could be partly mediated by increased levels of oncogenic microRNAs and down-regulation of tumor suppressor microRNAs. (thegomap.org)
  • Because of their expanding roles in the endocrine regulation of homeostasis and stress, and their involvement in human pathophysiology, exosomes are now the epicenter of a new field, termed 'exosomics' ( 3 ). (spandidos-publications.com)
  • More so, our results show that the epigenetic regulation of TE transcription is dynamically regulated throughout life (Paper II), upon the beginning of neuroinflammation (Paper III), and in a disease-driving polymorphic TE insertion (Paper IV). (lu.se)
  • Finally, the regulatory mechanism through which miR778 induces histone modifications, DNA methylation, and transcriptome reprogramming during H. schachtii parasitism of Arabidopsis was investigated. (tennessee.edu)
  • A-to-I editing is a mechanism that regulates and diversifies the transcriptome, but the full biological significance of ADARs is not understood. (biomedcentral.com)
  • Eukaryotic RNA transcripts can undergo a range of post-transcriptional modifications, which increase the diversity of the transcriptome without requiring increases in genome size. (biomedcentral.com)
  • MicroRNAs regulate target gene expression post-transcriptionally in a myriad of cell types and play critical roles in diverse physiological and pathological processes, including cardiomyocyte development, differentiation, and regeneration. (biomedcentral.com)
  • In this study, we identified miR-199b-5p as a key regulator of human erythropoiesis, and its expression was up-regulated during the erythroid differentiation of K562 cells. (molcells.org)
  • Transforming growth factor-β (TGF-β) signaling pathway is a multifunctional cytokine and plays important roles in regulating cell proliferation, cell cycle, differentiation, migration, and apoptosis in a broad spectrum of tissues [ 12 ]. (degruyter.com)
  • One of the earliest discoveries was the identification of COOLAIR, an lncRNA that regulates the flowering time gene FLOWERING LOCUS C (FLC) in Arabidopsis thaliana. (mdpi.com)
  • Luciferase reporter assay and RNA pull-down assay were carried out to detect the interaction between miR-383 and LncRNA PTTG3P. (biomedcentral.com)
  • Through the analyses of RNA_seq datasets, we have identified human fetal-lethal non-coding developmental regulatory RNA (FENDRR) as an lncRNA that is down-regulated in the fibrotic lungs of patients with IPF. (grantome.com)
  • RNA might be at the centre of life, at its origin, driving evolution and regulating cellular activities until today. (videolectures.net)
  • The multi‑dimensional nature of their roles in cellular homeostasis, cell‑to‑cell and tissue‑to‑tissue communication at the level of the organism, as well as their actions on the holobiome (intra‑/interspecies interaction), have garnered the interest of a large number of researchers. (spandidos-publications.com)
  • 200 nucleotides that have been increasingly recognized for their importance in regulating various biological processes. (grantome.com)
  • Recent studies have shown that microRNAs regulate several cancer-related biological processes, including enhanced proliferation, tumor angiogenesis and metastasis. (thegomap.org)
  • By employing microRNA expression profiling and functional knockdown studies on human embryonic stem cell-derived cardiomyocytes, the authors identified miR-363 as an upstream negative regulator of left ventricular specification transcription factor HAND1 . (biomedcentral.com)
  • As a result, circRNAs exert important roles in numerous physiological and pathological processes [ 9 , 10 ]. (hindawi.com)
  • The profound roles of exosomes in homeostasis, stress and several pathological conditions, in conjunction with their selective and cell‑specific composition/function, allude to their use as promising circulating clinical biomarkers of systemic stress and specific pathologic states, and as biocompatible vehicles of therapeutic cargo. (spandidos-publications.com)
  • A-to-I RNA editing is a post-transcriptional modification that converts adenosines to inosines in both coding and noncoding RNA transcripts. (biomedcentral.com)
  • RNA editing refers to post-transcriptional processes that alter the nucleotide sequence of an RNA transcript by insertion, deletion or nucleotide conversion. (biomedcentral.com)
  • Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)
  • The binding sites of miR-128-3p and TGFBR2 were predicted by Targetscan online software and confirmed by dual-luciferase reporter assay and RNA immunoprecipitation (RIP) assay. (degruyter.com)
  • Because many of the microRNA targets we are studying are enriched in various cancers, our work could lead to novel forms of chemotherapy. (pewtrusts.org)
  • Project 1: To study the role of non-coding RNAs in brain tumor and brain metastasis malignancy and uncover new therapeutic targets: Non-coding RNAs are regulatory RNAs that play important roles in regulating normal and cancer biology. (virginia.edu)
  • NEW: Analysis of the user's personal CLIP-Seq to find microRNA targets is also provided upon request (more in documentation page). (mirtar2go.org)
  • Furthermore, microRNAs are also shown to be targets for asthma therapy in the future. (cdc.gov)
  • Scientists discover a novel antibacterial molecule that targets a vital RNA regulatory element. (the-scientist.com)
  • As a result, ADAR-mediated editing can post-transcriptionally alter codons, introduce or remove splice sites, or affect the base pairing of the RNA molecule with itself or with other RNAs. (biomedcentral.com)
  • Since RA signalling is highly dose-dependent, a fine-tuning regulatory mechanism is required. (mdpi.com)
  • This study revealed a novel mechanism by which miR-296-5p regulates the EMT and metastasis of NPC cells, indicating that it could be a new target for the treatment of NPC. (biomedcentral.com)
  • The double-stranded (ds)RNA-binding domains, shown in purple, determine substrate specificity. (biomedcentral.com)
  • The expression levels of RNA of hsa_circ_0046060, mmu_circ_0002819, and miR-338-3p were determined by quantitative real-time polymerase chain reaction (RT-qPCR). (hindawi.com)
  • Studies report that circular RNAs (circRNAs) derived from exosomes may play a key role in GDM development. (hindawi.com)
  • In recent years, noncoding RNAs (ncRNAs), especially microRNAs, long noncoding RNAs and circular RNAs, have been found to be associated with abnormalities of the ASMCs. (ersjournals.com)
  • Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)
  • Using this strategy, we found that MTp53 expressing H1299 cells had significantly increased expression of several oncogenic microRNAs and decreased abundance of select tumor suppressor microRNAs. (thegomap.org)
  • In this study, we found that PTTG3P was up-regulated in HCC tissues and cells. (biomedcentral.com)
  • In this study, we established that miR-296-5p has a significantly lower expression in NPC tissues and cells and was involved in regulating the EMT and metastasis of NPC cells in vitro. (biomedcentral.com)
  • however, with the rapid development of high-throughput sequencing technologies and bioinformatics, there is growing evidence that circRNAs are involved in regulating a variety of important physiological functions [ 8 ]. (biomedcentral.com)
  • The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)
  • Neurologically important noncoding RNAs come in many shapes and sizes. (the-scientist.com)
  • The expression of TUCRs is commonly deregulated in cancer, where they might exert crucial regulatory roles. (virginia.edu)
  • p53 has a crucial but complex role in regulating ferroptosis. (nature.com)
  • However, how these interconnected epigenetic components regulate gene expression in a spatiotemporal fashion remains partially known. (tennessee.edu)
  • miR-195 level was dynamically regulated in response to MI and significantly increased in ischemic regions 24 h post-MI as well as in hypoxic or H 2 O 2 -treated cardiomyocytes. (ijbs.com)
  • Although RNA editing has long been considered a relatively rare processing event, more recent research suggests that the vast majority of pre-mRNAs are edited [ 6 ]. (biomedcentral.com)
  • A long noncoding RNA from humans appeared to help the enzyme phenylalanine hydroxylase work better in a mouse model of phenylketonuria, the disorder characterized by reduced activity of that enzyme. (the-scientist.com)
  • With the discovery that ribonucleic acid (RNA) can store genetic information and execute catalytic and regulatory functions, the central dogma is now being challenged. (videolectures.net)
  • In the present study, we identified miR-199b-5p as a positive erythroid regulator, that was regulated by the key erythroid transcription factors GATA-1 and NF-E2. (molcells.org)
  • In normal cells, wild-type p53 has been shown to enhance the biogenesis of some microRNAs during DNA damage. (thegomap.org)
  • We are investigating the roles of microRNAs in priming the brain microenvironment for metastasis from primary lung, breast and melanoma tumors using paired human tumors and metastasis animal models. (virginia.edu)