• Therefore, it has been proposed that immunization with heat-shock protein peptides could prevent the development of certain diseases. (oatext.com)
  • Eukayotic protein kinases evolved as a family of highly dynamic molecules with strictly organized internal architecture. (nih.gov)
  • If the duplex contains single stranded regions, recA protein binds cooperatively and loads the duplex molecules, covering the duplex as well as the single stranded regions. (springer.com)
  • Proteins that associate with the core dimer include three families of regulatory subunits B (the R2/B/PR55/B55, R3/B''/PR72/PR130/PR59 and R5/B'/B56 families), the 48 kDa variable regulatory subunit, viral proteins, and cell signaling molecules. (atlasgeneticsoncology.org)
  • Heat shock proteins (HSPs) are important molecules required for ideal protein function. (edu.au)
  • 000261358 001__ 261358 000261358 005__ 20190619220056.0 000261358 037__ $$aPOST_TALK 000261358 245__ $$aExplore RdhK based regulatory network of organohalide respiration using a hybrid proteins strategy 000261358 260__ $$c2019-03-14 000261358 269__ $$a2019-03-14 000261358 300__ $$a1 000261358 336__ $$aPosters 000261358 513__ $$aPosters 000261358 520__ $$aReductive dehalogenase (rdh) gene clusters are encoding proteins that enable organohalide respiring bacteria (OHRB) to couple the degradation of halogenated molecules to energy conservation. (epfl.ch)
  • Protein replacement therapies for rare monogenic diseases have a higher probability of regulatory approval compared with biologics, small molecules, and grant-funded orphan drugs. (sciencemag.org)
  • We identified about 20 regulatory molecules known as cytokines and chemokines that are themselves directly regulated by NFATc2," Yu adds. (medicalxpress.com)
  • A crucial step in the production of proteins is the translation of messenger RNA molecules. (elifesciences.org)
  • Other RNA molecules called small RNAs are also involved in this process: these small RNAs bind to the messenger RNA molecules to either increase or decrease the production of proteins. (elifesciences.org)
  • Many small RNA molecules use a protein called Hfq to help them interact with their target messenger RNAs. (elifesciences.org)
  • In some cases this protein protects the small RNA molecules when they are not bound to their targets. (elifesciences.org)
  • Newswise - March 7, 2014, Phoenix, AZ -- Researchers found initial confirmation that a novel scaffold protein previously unassociated with the mu opioid receptor (MOR) regulates MOR-induced signaling activation. (newswise.com)
  • The most surprising result of this study was that we were able to find a novel regulatory protein that no one had ever associated with the MOR or pain, and show in cells that this protein regulates MOR signaling," said senior study author John Streicher, PhD, assistant professor at the University of New England, College of Osteopathic Medicine, in Biddeford, Maine. (newswise.com)
  • And Pin1 regulates many proteins, not just tau and APP. (innovations-report.com)
  • Previous studies have shown that B. burgdorferi regulates synthesis of Erp proteins ( 1 , 6 , 29 , 43 , 45 , 48 ). (asm.org)
  • Research funded in part by the NIH's National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has revealed a new role for A20, a protein that regulates a key immune response pathway, in certain early-onset autoinflammatory diseases. (nih.gov)
  • It binds to iron regulatory elements found on mRNAs involved in iron metabolism and regulates their translation. (umassmed.edu)
  • p>When browsing through different UniProt proteins, you can use the 'basket' to save them, so that you can back to find or analyse them later. (uniprot.org)
  • The regulation occurs through an interaction of Fe 2+ and a metal-dependent regulatory protein. (pnas.org)
  • I'm sure there's an easier way to explain this, but the take-home message is that a protein-coding change in AMN1 leads, indirectly, to it's own regulation. (gnxp.com)
  • Insulin enhances the biogenesis of nuclear sterol regulatory element-binding protein (SREBP)-1c by posttranscriptional down-regulation of Insig-2A and its dissociation from SREBP cleavage-activating protein (SCAP).SREBP-1c complex. (wikipathways.org)
  • Bacterial TCSs are common components of complex regulatory networks and cascades, often associated with global regulation as well as with regulation of virulence. (pubmedcentralcanada.ca)
  • The regulation of activity by dual phosphorylations at closely spaced threonyl and tyrosyl residues has a functional correlate in p34cdc2, and may be characteristic of a family of protein kinases regulating cell cycle transitions. (nih.gov)
  • Role of membrane cofactor protein (CD46) in regulation of C4b and C3b deposited on cells. (springer.com)
  • Results from new research conducted at the La Jolla Institute for Allergy & Immunology (LJI) have identified the mechanism by which the protein Sharpin contributes to the regulation of immunosuppressive T cells or Tregs that are essential to the prevention of autoimmune disorders. (painweek.org)
  • Even though their protein sequences are strongly conserved, their mechanism of regulation is not conserved across yeast, Drosophila , and vertebrates. (biomedcentral.com)
  • The key to understanding these fundamental processes of sRNA-based regulation is to determine how RNAs are bound and presented by Hfq and other effector proteins. (elifesciences.org)
  • The first method (proteomic screen) involved pulling out the receptor and proteins bound to the receptor after drug activation using a technique called co-immunoprecipitation. (newswise.com)
  • Once isolated, the receptor and the proteins bound to it may be identified by mass spectrometry. (newswise.com)
  • tumor necrosis factor (zeige TNF Antikörper ) receptor superfamily, member 14 ( TNFRSF14 (zeige TNFRSF14 Antikörper )) and signal regulatory protein , gamma ( SIRPG ) appear to contribute to gender difference in incidence of systemic lupus erythematosus. (antikoerper-online.de)
  • It is proximal to LRP5 (LDL receptor related protein 5) gene. (atlasgeneticsoncology.org)
  • Neisseria meningitidis, the causative agent of bacterial meningitis, acquires the essential element iron from the host glycoprotein transferrin during infection through a surface transferrin receptor system composed of proteins TbpA and TbpB. (ebscohost.com)
  • sought to identify the proteins in the epidermal growth factor receptor (EGFR) signaling network that serve as the conductors or directors of the EGF signal. (sciencemag.org)
  • Regulator of G-protein signaling-GAIP-interacting protein COOH terminus (GIPC) is involved in protein trafficking, endocytosis, and receptor clustering and is associated with insulin-like growth factor I receptor (IGF-IR), a receptor important for proliferation and anchorage-independent growth. (aacrjournals.org)
  • Transferrin receptor (TfR1) and divalent metal transporter 1 (DMT1) are important proteins for cellular iron uptake, and both are regulated transcriptionally through the binding of hypoxia-inducible factor 1 (HIF-1) to hypoxia-responsive elements (HREs) under hypoxic conditions. (sigmaaldrich.com)
  • T cell receptor (TCR)-dependent regulatory T cell (T reg ) activity controls effector T cell (T eff ) function and is inhibited by the inflammatory cytokine tumor necrosis factor-α (TNF-α). (sciencemag.org)
  • The dendritic cells themselves are stimulated by antigens binding to a protein receptor called dectin-1 that protrudes from the dendritic cell surface. (medicalxpress.com)
  • 11 12 In addition, a unique rodent transmembrane protein known as Crry (complement-receptor 1-related gene/protein y) has both CD46 and CD55 activities and is considered a functional homologue of human CD46. (arvojournals.org)
  • RdhK effector-binding domain binds to organohalides which triggers protein conformational change and allows the interaction with specific DNA motifs (dehalobox, DB) upstream of rdh gene clusters3,4. (epfl.ch)
  • Brooke, Holbrook, Brown, Barclay: Human lymphocytes interact directly with CD47 through a novel member of the signal regulatory protein (SIRP) family. (antikoerper-online.de)
  • Signal-regulatory proteins (SIRP) are transmembrane glycoproteins with three extracellular Ig-like domains, closely related to Ag receptors Ig, TCR, and MHC, and a cytoplasmic domain with two immunoreceptor with tyrosine-based inhibition motifs that can interact with src homology 2 domain-containing phosphatases. (jimmunol.org)
  • In this regard, we observed that one or more DNA-binding proteins interact specifically with erp promoter DNA but not with the ospC promoter. (prohealth.com)
  • These findings confirm the importance of A20 in dampening inflammatory responses, and show that failure of other proteins to interact with it can be as damaging as mutations that affect A20 itself. (nih.gov)
  • In this paper, we reconstruct the regulatory network around E2F, a family of transcription factors whose deregulation has been associated to cancer progression, chemoresistance, invasiveness, and metastasis. (nature.com)
  • Deciphering the mechanisms by which Borrelia burgdorferi controls the synthesis of proteins associated with mammalian infection will be an important step toward understanding the pathogenic properties of Lyme disease -causing bacteria. (prohealth.com)
  • Among the B. burgdorferi proteins synthesized during mammalian infection are members of the Erp (OspE/F-related) protein family ( 3 , 32 , 42 , 46 , 48 ). (asm.org)
  • In studies to investigate the in vivo functions of mCRP proteins, corresponding CD46, CD55, and CD59 orthologues have been identified in the mouse. (arvojournals.org)
  • 14 Although there are several noticeable differences between human and mouse mCRPs, the generation of CD55/59 double-deficient (CD55 −/− CD59 −/− ) mice has provided insight into the function of these proteins in vivo. (arvojournals.org)
  • Postreplication gaps or other damage that produced single stranded regions in the bacterial DNA, may cause recA protein to bind to the DNA. (springer.com)
  • Furthermore, a DNA-binding protein was recently observed to bind specifically to all tested erp promoter DNAs ( 6 ). (asm.org)
  • Recently, GIPC, an regulator of G-protein signaling (RGS)-GAIP binding protein, was found to bind IGF-IR ( 3 , 4 ). (aacrjournals.org)
  • which allowed us to unravel which AKAPs bind preferentially to the RI or RII regulatory domains of PKA. (mcponline.org)
  • Several other proteins such as cyclic nucleotide gated ion channels ( 1 ), phosphodiesterases (PDE) ( 2 ), and guanine nucleotide exchange factors (Epac) ( 3 ) bind cAMP. (mcponline.org)
  • Iron regulatory proteins (IRPs) 1 and 2 are key regulators of vertebrate iron metabolism. (nih.gov)
  • A generic mammalian cell depicting the various roles of mammalian proteins encoded by IRE-containing mRNAs ( red lettering ). (nih.gov)
  • In this article we review the basics of the stress response, summarize current controversies over the role of extracellular chaperones in inflammatory reactions and autoimmunity, and discuss the cytoprotective and immunoregulatory roles of heat-shock proteins, a challenging subject that may open a new avenue for the drug discovery and treatment of diseases related to autoimmune disturbs. (oatext.com)
  • The precursor has a hairpin orientation in the membrane, so that both the amino-terminal transcription factor domain and the COOH-terminal regulatory domain face the cytoplasm . (wikipedia.org)
  • GKRP is a 68 kD protein of 626 amino acids. (wikipedia.org)
  • Semiquantitative biochemical analysis of the corresponding mutant proteins revealed that each of the 21 amino acid alterations caused simultaneous defects in every single protein-protein interaction and in Gal80's structural integrity. (genetics.org)
  • cdk8 and cycC mutants are sensitive to the levels of dietary proteins and seven amino acids (arginine, glutamine, isoleucine, leucine, methionine, threonine, and valine). (sdbonline.org)
  • The 1150-amino acid protein has a reported mass of 130,278 daltons. (biocompare.com)
  • Erp proteins are located on the bacterial outer surface, and those encoded by an individual bacterium may share anywhere between 16 and 100% identical amino acid sequences among themselves ( 2 , 15 , 25 , 42 , 43 , 47 ). (asm.org)
  • Export of iron is coupled to the oxidation of iron possibly by the membrane bound protein hephaestin (HP) or the serum multicopper oxidase ceruloplasmin (CP). (nih.gov)
  • We present results of studies indicating that B. burgdorferi senses a wide variety of environmental stimuli, including soluble chemicals, which enables it to independently control synthesis of the Erp and OspC proteins. (prohealth.com)
  • The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. (antikoerper-online.de)
  • The generation of a new proteostasis network implies an immediate role in protein synthesis, folding, disaggregation, or degradation, processes that encompass the translational machinery, molecular chaperones and their associated cochaperones, the ubiquitin-proteasome machinery, and the autophagy system. (oatext.com)
  • Protein kinases thus represent a unique, highly dynamic, and precisely regulated set of switches that control most biological events in eukaryotic cells. (nih.gov)
  • The glucokinase regulatory protein (GKRP) also known as glucokinase (hexokinase 4) regulator (GCKR) is a protein produced in hepatocytes (liver cells). (wikipedia.org)
  • Molecular signals are released that recruit certain cells and proteins to aid in the healing process. (bu.edu)
  • Blood vessel with no RhoA protein activity keeps its barrier function (left), but when the researchers activated RhoA only in the mural cells, barrier function was lost (right). (bu.edu)
  • Chen was able to show that a specific balance of these three proteins-RhoA, Rac 1 and N -cadherin-must be sustained in order to preserve the junction between endothelial cells and mural cells. (bu.edu)
  • Once identified, candidate proteins can be manipulated in cells and the effects on MOR signaling determined, as was done with one candidate protein in this study, Dr. Streicher explained. (newswise.com)
  • In Alzheimer's disease, amyloid precursor protein (APP) and tau form aggregated tangles in the brain: APP outside and between cells, tau within the neurons. (innovations-report.com)
  • 5 More than 30 proteins act synergically to provide host defense against cells, microorganisms, and tissues identified as abnormal by a specific antibody. (scielo.br)
  • All mAbs were purified from supernatants from hybridoma cells cultured in RPMI 1640 containing 5% low IgG FCS (Life Technologies, Gaithersberg, MD) on protein A-Sepharose (Pharmacia, Uppsala, Sweden). (jimmunol.org)
  • Iron homeostasis of cells is regulated posttranscriptionally by the binding of iron-regulatory proteins (IRP)-1 and -2 with iron-responsive elements (IREs). (hindawi.com)
  • Although cardiac tumorigenesis may require a second somatic mutation, DNA and protein analyses of an atrial myxoma resected from a Carney complex patient with a PRKAR1α deletion revealed that the myxoma cells retain both the wild-type and the mutant PRKAR1α alleles and that wild-type R1α protein is stably expressed. (jci.org)
  • Heat shock proteins and regulatory T cells" by Ekua Brenu, Don Staines et al. (edu.au)
  • Regulatory T cells (Tregs) are important T cells with suppressive functions and impairments in their function have been associated with a number of autoimmune disorders. (edu.au)
  • The interrelationship between cells and proteins may be important in cellular functions necessary for cell survival and expansion during diseased state. (edu.au)
  • They found that the abundance of most core pathway proteins was very similar between cells and rather that the very low abundance of the adaptor proteins made them rate-limiting for EGFR-MAPK pathway signaling in normal and malignant cells. (sciencemag.org)
  • Germinal center B cells and follicular helper T cells spontaneously accumulated in unimmunized mice, and CD8 + CD44 + CD122 + Ly49 + regulatory T (CD8 + Tregs) cells, which inhibit the expansion of follicular helper T cells, were severely reduced in these mice. (jimmunol.org)
  • With the purpose to protect proteins from misfolding, denaturation and/or aggregation, cells trigger a fast response characterized by a number of events able to protect them from the hostile environment, and restore a balanced and safe new steady-state of protein homeostasis commonly referred to as 'proteostasis' [ 1 , 2 ]. (oatext.com)
  • A team of A*STAR scientists has now discovered a regulatory protein that helps to coax human pluripotent stem cells to form more specialized types of cells. (phys.org)
  • CD46 protein polymorphisms were observed in cultured hRPE cells. (arvojournals.org)
  • The role of iron regulatory proteins in mammalian iron homeostasis and disease. (ebi.ac.uk)
  • Proteins responsible for controlling levels of iron in the body also play an important role in combatting infection, according to a study published today in Cell Host & Microbe. (medicalxpress.com)
  • Each one of these proteins plays a different role in maintaining vessel barrier function. (bu.edu)
  • To investigate the role of segments of the membrane-associated UhpB and UhpC regulatory proteins, a series of mutations were constructed in vitro by insertion of a 12- or 24-bp oligonucleotide linker at 44 sites within the uhpABCT locus. (asm.org)
  • A multi-institutional team of scientists has gained important new knowledge about the regulatory role played in Alzheimer's disease by Pin1, a protein that coaxes other proteins into untwisting. (innovations-report.com)
  • The article presents abstracts on molecular biosciences topics discussed at the Canadian Society for Molecular Biosciences 57th Annual Meeting, including role of membrane proteins in disease, structural analysis of Neisseria meningitidis porin, and screening of membrane protein crystals. (ebscohost.com)
  • The regulatory beta-subunit of CK2 exerts a central role not only in mediating formation of tetrameric CK2 complexes but also as a docking partner for several protein kinases. (nih.gov)
  • In vitro experiments indicated that GKRP was able to increase both GK protein and enzymatic activity levels, suggesting that another role for GKRP is to stabilize and/or protect GK. (diabetesjournals.org)
  • Domain-swapping experiments have shown that, in some cases, the HD plays a central role in dictating the functional specificity of the protein ( Chan and Mann, 1993 ). (biologists.org)
  • We investigated the role of specific protein oxidation in oxidant-induced apoptosis. (aacrjournals.org)
  • use of publicly available protein therapeutic standards and their role in biosimilars development. (bioprocessintl.com)
  • Part 2 will focus on potency assignment for bioassay reference standards and the role of public reference standards in global harmonization of protein therapeutics. (bioprocessintl.com)
  • When the body sends out a signal that triggers inflammation, certain proteins are released that cause the blood vessel to lose its ability to act as a barrier. (bu.edu)
  • The aqueous phase between these two membranes cannot be crossed by the lipophilic cholesterol, unless certain proteins assist in this process. (thefullwiki.org)
  • The Canadian Society for Molecular Biosciences 57th Annual Meeting - Membrane Proteins in Health and Disease, Banff, Alberta, 9-13 April 2014. (ebscohost.com)
  • Then they could measure activity levels of specific proteins along with how penetrable the vessel became under inflammatory conditions. (bu.edu)
  • In addition to numerous components in immune responses, chaperone proteins are also detected in the extracellular fluids and have been implicated in autoimmune and inflammatory diseases acting as pro- and anti-inflammatory factors. (oatext.com)
  • These extracellular chaperones are capable to stimulate anti-inflammatory regulatory T cell responses, thereby inducing the negative feedback control of inflammation. (oatext.com)
  • A notable feature of this regulatory feedback machinery was first observed for the SREBP pathway - regulated intramembrane proteolysis (RIP). (wikipedia.org)
  • This study reports that dietary nutrients, particularly proteins and carbohydrates, modulate the developmental timing through the CDK8/CycC/EcR pathway. (sdbonline.org)
  • We found that core pathway proteins were present at very similar concentrations across all cell types, with a variance similar to that of proteins previously shown to display conserved abundances across species. (sciencemag.org)
  • However, because both proteins contain this motif, some other pathway must be responsible for the rapid turnover of MCIP1.4. (ahajournals.org)
  • The researchers plan to begin studies of this sort in genetically manipulated mice within the next few months with the regulatory protein they have already identified. (newswise.com)
  • Because genetic experiments in mice demonstrated that Hox10 proteins are strongly redundant in this function, we first searched for common motifs among the group members. (biologists.org)
  • The lack of in vitro culture techniques and genetic systems for Treponema pallidum has made it extremely difficult to identify virulence or regulatory factors involved in the pathogenesis of syphilis. (pnas.org)