Regulatory microrna. Medical search. Frequent questions

MicroRNAs (miRNAs) are potent effectors in gene regulatory networks where aberrant miRNA expression can contribute to human diseases such as cancer. (hindawi.com)
For a better understanding of the regulatory role of miRNAs in coordinating gene expression, we here present a systems biology approach combining data-driven modeling and model-driven experiments. (hindawi.com)
Although microRNAs (miRNAs) are physically small, they have been shown to play an important role in gene regulation [ 1 ]. (hindawi.com)
The systems biology approach, combining data-driven modeling and model-driven experiments, provides a systematic and comprehensive perspective on the regulatory roles of miRNAs in gene regulatory networks [ 3 - 5 ]. (hindawi.com)
The application of the systems biology approach to the analysis of a gene regulatory network is demonstrated with a case study of the regulation of p21 by multiple miRNAs [ 4 ]. (hindawi.com)
This study aimed to investigate the potential regulatory role of miRNAs in the development of gastrointestinal tract (GIT) during the early life of dairy calves. (figshare.com)
Here, we have executed an in-silico integrative analysis of GEO/TCGA-LIHC of genes/microRNAs expression analysis in HCC, including (446 HCC vs. 146 normal specimens for miRNAs expression) ad 488 specimens for genes expression. (medrxiv.org)
MicroRNAs (miRNAs) constitute a class of short noncoding RNAs which regulate gene expression by targeting messenger RNA, inducing translational repression and messenger RNA degradation. (aston.ac.uk)
Therefore, this review presents an up-to-date comprehensive overview of the role of key regulatory miRNAs in BAT, brite AT, and WAT. (aston.ac.uk)
It has been found that microRNAs (miRNAs) can function as a regulatory factor across species. (biomedcentral.com)
In this study, we investigate the possibility that post-transcriptional gene regulation by microRNAs (miRNAs) has contributed to the adaptive evolution of diving capacities in the Weddell Seal. (uea.ac.uk)
MicroRNAs (miRNAs) are small non-coding RNAs that bind complementary messenger RNAs (mRNAs) to repress gene expression and regulate essentially all cellular processes 19 . (nature.com)
This study explored whether serum miRNAs are associated with both altered innate immune responses and changes in mitochondrial respiration as a link of regulatory mechanisms for these two common abnormalities in ASD subjects. (frontiersin.org)
MicroRNAs (miRNAs) are commonly used to identify novel OA genes and their related inflammatory network [ 4 ]. (biomedcentral.com)
Then, the miRNAs-mRNAs relations were explored, followed by the miRNAs-mRNAs regulatory network investigation. (biomedcentral.com)
MicroRNAs (miRNAs) negatively regulate the expression of the target genes by binding to ʻseed sequences' in the 3'‑untranslated region (3'‑UTR) mRNA transcripts, and the variants within or nearby ʻseed sequences' may compromise or enhance miRNA/mRNA interaction leading to either ʻloss‑of‑function' or ʻgain‑of‑function' effects. (spandidos-publications.com)
MicroRNAs (miRNAs), a class of endogenous small non-coding RNAs of 20-25 nucleotides, modulate the expression of genes at the post-transcriptional level ( 7 ). (spandidos-publications.com)
MicroRNAs (miRNAs) are small endogenous RNAs that are associated with tumourigenesis, cell proliferation and apoptosis ( 4 , 5 ). (spandidos-publications.com)
The development, cell fate, patterning, and innervation of both the sensory and nonsensory regions of the inner ear are governed by tight regulation involving, among others, transcription factors and microRNAs (miRNAs). (biomedcentral.com)
The results provide further support of the essential regulatory role of miRNAs in inner ear sensory epithelia and in regulating pathways that define development and growth of these cells. (biomedcentral.com)
A large number of studies have demonstrated that the synergistic collaboration of a number of microRNAs (miRNAs), their growth factors and their downstream agents is required for the initiation and completion of pathogenesis in the liver. (wjgnet.com)
In a previous work, increased expression of multiple miRNAs during TDI sensitization was observed and several putative mRNA targets identified for these miRNAs were directly related to regulatory T-cell (Treg) differentiation and function including Foxp3 and Runx3. (cdc.gov)
MicroRNAs (miRNAs) are highly conserved, single-stranded, small non-coding RNAs that have been shown to act as essential regulators of gene expression at the posttranscriptional level. (frontiersin.org)
microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. (cancerindex.org)
MicroRNAs (miRNAs) play an important role in the regulati. (researchgate.net)
It is widely accepted that microRNAs (miRNAs) play an imp. (researchgate.net)
Here we present GeneCodis 4, a new release that expands the functional analysis provided by the application, to accept regulatory elements, including lists of, transcription factors, CpG sites and miRNAs. (biorxiv.org)
Since microRNAs (miRNAs) are developmentally regulated and required for CD8+ T cell function, we hypothesized that defective CD8+ T cell memory formation in early life may be due to differences in miRNA expression patterns between neonatal and adult CD8+ T cells. (cornell.edu)
that asthma is intensively regulated by a variety of microRNAs (miRNAs). (cdc.gov)

Currently, an increasing number of studies are being carried out to deepen our understanding of miRNA regulatory mechanisms and functions. (hindawi.com)
It virtually shows that microRNAs could have an ability to target both oncogenes and tumor suppressor genes that contribute to its dual activity role as a tumor suppressor and oncomirs via miRNA-lncRNA-TFs-PPI Crosstalk. (medrxiv.org)
We find that the core microRNA (miRNA) biogenesis and targeting machinery maintains the sensitivity of cancer cells to PD-1-independent T cell-mediated cytotoxicity. (nature.com)
MicroRNA (miRNA) are small, single-stranded, non-coding RNA molecules containing 21 to 23 nucleotides. (wikipedia.org)
However, only about 500 human microRNAs represent bona fide miRNA in the manually curated miRNA gene database MirGeneDB. (wikipedia.org)
We also found, in separate studies, that microRNA (miRNA) expression in PBMo and mitochondrial respiration in peripheral blood mononuclear cells (PBMCs) differed in the IL-1ß/IL-10-based ASD subgroups. (frontiersin.org)
Treg cells transferred microRNAs ( miRNA ) to various immune cells , including T helper 1 (Th1) cells , suppressing Th1 cell proliferation and cytokine secretion . (bvsalud.org)
Individuals affected with PTSD (Post-Traumatic Stress Disorder) demonstrate changes in microRNA (miRNA) molecules associated with gene regulation. (news-medical.net)
Potential inhibitory influence of miRNA 210 on regulatory T cells during epicutaneous chemical sensitization. (cdc.gov)
Recently, the molecular mechanisms of miRNA in host-pathogen interaction networks have been extensively studied in mammals, whereas the underlying regulatory mechanisms in fish are still poorly understood. (frontiersin.org)
microRNA (miRNA) is a small molecule RNA that can be stably expressed in body fluids such as serum, plasma, saliva and can be sensitively detected. (researchsquare.com)

MicroRNAs are well known as short RNAs bases, 22 nucleotides, binding directly to 3'untranslated region (3'UTR) of the messenger RNA to repress their functions. (medrxiv.org)
At this point, researchers started using the term "microRNA" to refer to this class of small regulatory RNAs. (wikipedia.org)
Background MicroRNAs are brief (～22 nt) non-coding regulatory RNAs that control gene appearance on the post-transcriptional level. (techblessing.com)
He, L. & Hannon, G. J. MicroRNAs: small RNAs with a big role in gene regulation. (nature.com)
MicroRNAs, as their name implies, are small RNAs that provide an essential regulation of gene expression by controlling translation of protein expressing messenger RNAs. (rvc.ac.uk)

It enhances our concluded suggestion of using combination therapy of tumor suppressor genes activators with microRNAs. (medrxiv.org)
We previously observed that treatment of mice with a dominant negative form of cJun (dn-cJun) increased the expression of genes involved in lipid metabolism and modulated the expression of nine microRNAs (miR). (nih.gov)
MicroRNAs are non-coding, regulatory elements approximately 22 nucleotides long, with the ability to control post-transcriptional expression of genes(3). (pharmaceuticalintelligence.com)
Here, we identified a PPARγ/microRNA-223 (miR-223) regulatory axis that controls macrophage polarization by targeting distinct downstream genes to shift the cellular response to various stimuli. (jci.org)
In summary, this study provides evidence to support the crucial role of a PPARγ/miR-223 regulatory axis in controlling macrophage polarization via distinct downstream target genes. (jci.org)
We devised a novel bioinformatics method to uncover interactive relationships between transcription factors or microRNAs and genes. (houstonmethodist.org)
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. (nature.com)
In this article the researchers describe their identification of important individual microRNAs and relevant genes they regulate to control regulatory T cell development. (rvc.ac.uk)
One or more transcription factors activate transcription by binding to cis-regulatory sites, which are commonly situated upstream of protein-coding genes. (nationaljewish.org)

Our results elucidating the cross-regulations among NF-κB, p53, and microRNAs provide insights into the complex regulatory mechanisms underlying HNSCC, and shows an efficient approach to inferring gene regulatory programs in biological complex systems. (houstonmethodist.org)
In future studies, it will be interesting to determine if similar microRNA-based regulatory mechanisms influence alcohol problems in human populations. (nih.gov)
however, the underlying regulatory mechanisms remain largely unknown. (researchgate.net)
Ncad expression level is precisely and dynamically controlled throughout development, however the underlying regulatory mechanisms remain largely unknown. (researchgate.net)
The analysis of epigenetics patterns or regulatory elements have been an increasing focus of research in many contexts, such as development biology or characterization of molecular mechanisms in complex diseases ( Schübeler, 2015 ). (biorxiv.org)

In this work, RVC researchers set about to understand microRNA regulation of helper T cells development. (rvc.ac.uk)
C) Gene regulation by transcription factors and microRNAs. (nationaljewish.org)
There are many different types of microRNAs involved in the regulation of different proteins and of other RNA molecules. (lu.se)
MicroRNAs participate in the regulation of asthma, the goal of this study is to summarize recent researches on the roles of microRNAs in the pathogenesis of asthma. (cdc.gov)
MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
Zhang et al cytokines, mediators and signals and closely related to demonstrated that microRNA let-7i was upregulated immune regulation. (cdc.gov)

This study demonstrates for the first time that alcohol exposure can cause rapid changes in microRNA levels, altering gene expression, and perhaps behavior," added Antonio Noronha, Ph.D., director of NIAAA's Division of Neuroscience and Behavior. (nih.gov)

Choose shMIMIC Lentiviral microRNA Pooled Libraries for constitutive expression of mature microRNAs. (horizondiscovery.com)

Here we describe how microRNA-regulated lentiviral vectors can be used to visualize specific cell populations by exploiting endogenous microRNA expression patterns. (lu.se)
Per Ludvik Brattås (Jakobsson group) " TRIM28 Controls a Gene Regulatory Network Based on Endogenous Retroviruses in Human Neural Progenitor Cells " (Cell 2017). (lu.se)

In humans with ALS, the analogous monocytes (CD14+CD16-) exhibited an ALS-specific microRNA inflammatory signature similar to that observed in the ALS mouse model, linking the animal model and the human disease. (nih.gov)
The researchers showed that the amount of a specific microRNA molecule known as miR-9 increases in brain cells within minutes of exposure to alcohol. (nih.gov)
It has proved difficult to develop drugs that act directly on epigenetic changes in DNA, but now it is possible instead to intervene later in the cell metabolism and regulate the level of specific microRNA molecules. (lu.se)

Transfection of HepG2 cells with sense or antisense miR-370 or miR-122 upregulated and downregulated, respectively, the transcription factor sterol-regulatory element binding protein 1c (SREBP-1c) and the enzymes diacylglycerol acyltransferase-2 (DGAT2), fatty acid synthase (FAS), and acyl-CoA carboxylase 1 (ACC1) that regulate fatty acid and triglyceride biosynthesis. (nih.gov)
The discovery of microRNAs that regulate gene expression has changed our view of cellular biochemistry. (spectrumnews.org)
Previously it was known that microRNAs were important for the development of a subset of helper T cells called regulatory T cells, which are required to regulate the immune response and prevent attacks against host tissue that lead to autoimmunity. (rvc.ac.uk)

Further examination of miR-148 established that Liver-X-Receptor (LXR) activation of the Sterol regulatory element-binding protein 1c (SREBP1c), the transcription factor responsible for controlling fatty acid production and glucose metabolism, also mediates the expression of miR-148a(4,5) That the promoter region of miR-148 contained binding sites for SREBP1c was shown by chromatin immunoprecipitation combined with massively parallel sequencing (ChIP-seq)(4). (pharmaceuticalintelligence.com)
In head and neck squamous cell carcinoma (HNSCC), mutations of p53 usually coexist with aberrant activation of NF-kappaB (NF-κB), other transcription factors and microRNAs, which promote tumor pathogenesis. (houstonmethodist.org)
We found that the majority of the predicted p53 targets overlapped with those for NF-κB, suggesting that the two transcription factors exert a concerted modulation on regulatory programs in tumor cells. (houstonmethodist.org)
We further investigated the interrelationships of p53 and NF-κB with five additional transcription factors, AP1, CEBPB, EGR1, SP1 and STAT3, and microRNAs mir21 and mir34ac. (houstonmethodist.org)
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (nih.gov)
After transcription, one or more microRNAs bind to cis-regulatory sites, usually in the 3' UTR of the mRNA, and repress protein translation 4 . (nationaljewish.org)

In recent years, a class of small molecules known as microRNAs have been found to play an important role in regulating gene products in most animal and plant species. (nih.gov)
Sofia Elmroth and her research team primarily study microRNAs, which are molecules that influence protein levels in the cells of the body indirectly by binding to messenger RNA. (lu.se)

The underlying processes are mediated by the regulatory microRNA molecule mir-71. (medindia.net)

MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR. (rvc.ac.uk)

Selectable promoters on optimized microRNA constructs with the Tet-On 3G tetracycline-inducible expression system for unsurpassed control of mature microRNA expression. (horizondiscovery.com)
A novel construct for inducible expression of a mature microRNA, shMIMIC Inducible Lentiviral microRNA pooled libraries are available to target every human and mouse microRNA within in the miRBase database ( www.mirbase.org ). (horizondiscovery.com)

Pooled lentiviral libraries offer an efficient and cost-effective method for screening large numbers of microRNAs without automation. (horizondiscovery.com)

This suggested that most might function in other types of regulatory pathways. (wikipedia.org)

NEAT1) sequester various regulatory proteins regulating gene expression including RNA modification (e.g. (bvsalud.org)

Du, T. & Zamore, P. D. microPrimer: the biogenesis and function of microRNA. (nature.com)

People with autism show differences from controls in the levels of microRNAs, small noncoding bits of RNA, in the social and sound-processing parts of the brain. (spectrumnews.org)

MicroRNA is categorized into tumor suppressor and oncomirs. (medrxiv.org)
Tumor suppressor microRNAs can repress the pathologically causative oncogenes of the hallmarks of Cancer. (medrxiv.org)
Numbers shown below represent number of publications held in OncomiRDB database for Oncogenic and Tumor-Suppressive MicroRNAs. (cancerindex.org)

Foxp3(+) T regulatory (Treg) cells prevent inflammatory disease but the mechanistic basis of suppression is not understood completely. (bvsalud.org)

The results of the present study indicate that microRNAs play important roles in regulating asthma immune responses. (cdc.gov)

David Baltimore discusses how microRNAs create regulatory tension in mammalian blood cells. (laskerfoundation.org)
Heart muscle cells die en masse after injury, yet the adult mammalian heart retains little capacity to regenerate them. (natureasia.com)

The expression patterns of microRNAs vary less by brain region and age in people with autism than in controls. (spectrumnews.org)

microRNA-103a-3p promotes inflammation and fibrosis in nonalcoholic fatty liver disease by targeting HBP1. (nih.gov)

MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells. (bvsalud.org)

We first construct a p21 regulatory network based on data from the literature and further expand it using algorithms that predict molecular interactions. (hindawi.com)
The collective findings indicate that miR-21 plays a regulatory role in host-pathogen interactions through IRAK4-mediated NF-κB signaling pathway. (frontiersin.org)

Ambros, V. The functions of animal microRNAs. (nature.com)

To investigate a gene regulatory network, an iterative process of four steps is needed. (hindawi.com)

Regulatory microRNA sequences may stimulate self-renewal of these muscle cells. (natureasia.com)
A major goal of this grant is to identify the key gene regulatory networks that underlie cell-intrinsic differences between neonatal and adult CD8+ T cells. (cornell.edu)
When a microRNA is present in the cell, it binds to the target sites and downregulates GFP expression, while in cells that do not express the microRNA GFP, it is expressed. (lu.se)

Recently, microRNAs have been widely used as a therapeutic approach for various types of Cancer. (medrxiv.org)
We are interested in microRNAs, which we think have a role in the development of cancer", says Sofi Elmroth. (lu.se)
The quantity of microRNAs in different types of cancer varies and each type of cancer appears to display a specific pattern. (lu.se)
27558 Mendelian disease regulatory variants from OMIM and ClinVar, 20963 complex disease regulatory variants from VarDi and NHGRI GWAS Catalog and 43364 recurrent cancer somatic variations. (lu.se)

Although this new type of regulatory mechanism is not well understood, it provides a fresh look at the relationship between food consumption and physiology. (biomedcentral.com)
Our findings may be useful for discovering cross-species regulatory mechanism in further study. (biomedcentral.com)
However, the integrated regulatory mechanism involving DEMs, mRNAs, and lncRNAs on OA progression is still unclear. (biomedcentral.com)
Dr. Treistman adds that the microRNA process observed in this study may represent a general mechanism of neuronal adaptation to alcohol, with miR-9 playing a pivotal role in a complex regulatory network. (nih.gov)

Earlier, the same researchers- Andres Naars and his team had found another microRNA called miR-33 to block HDL generation, and this blockage to reverse upon antisense targeting of miR-33(6). (pharmaceuticalintelligence.com)
In the current study, researchers led by Dr. Treistman, Professor of Psychiatry and Director of the Brudnick Neuropsychiatric Research Institute at the University of Massachusetts Medical School in Worcester , MA, examined whether microRNA might be involved in the alcohol tolerance observed in the BK channel. (nih.gov)

If these microRNAs are over or under expressed (increase or decrease in quantity) - for example owing to epigenetic changes to the DNA - this will have an impact on many other regulatory processes. (lu.se)

A new study now indicates that microRNA may influence the development of alcohol tolerance, a hallmark of alcohol abuse and dependence. (nih.gov)

However, how these factors and microRNAs interact to globally modulate gene expression and mediate oncogenesis is not fully understood. (houstonmethodist.org)

A Whole-Genome Analysis Framework for Effective Identification of Pathogenic Regulatory Variants in Mendelian Disease. (lu.se)

In situ hybridization-based detection of microRNAs in human diseases. (mdanderson.org)
A cis-acting structural variation at the ZNF558 locus controls a gene regulatory network in human brain development", Cell Stem Cell, 2022. (lu.se)

A resource for the conditional ablation of microRNAs in the mouse. (nature.com)

Take control of microRNA expression for powerful functional screening of hundreds or thousands of microRNAs. (horizondiscovery.com)
Mendelian regulatory variations including 42 enhancer, 142 promoter, 153 5' UTR, 43 3' UTR, 65 RNA gene, 3 imprinting control region, and 5 microRNA gene variations. (lu.se)
225 Functional regulatory SNVs in monogenic and complex diseases and 241910 SNVs from dbSNP as a negative control dataset. (lu.se)

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