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  • ribosomal
  • Using fecal samples from the LifeLines DEEP cohort, they have profiled the gut microbiome of 893 participants by 16s ribosomal RNA sequencing and identified novel cross-sectional associations between several bacterial taxa and cardiometabolic phenotypes such as the body mass index and blood lipid levels. (ahajournals.org)
  • genomic
  • Satellite and minisatellite DNAs constitute a considerable part of the genomic DNA and are often found as runs of thousands or more copies of unit sequences (100-300 bp and 3-15 bp, respectively) predominantly localized in heterochromatic regions. (biomedcentral.com)
  • taxa
  • We postulate that extensive restructuring and remodeling of Hox cis-regulatory regions occurring in different taxa lead to relatively different Hox expression patterns, which in turn may act as a driving force in generating diverse axial morphologies. (zfin.org)
  • repeats
  • Two repeats containing TA sequence binding sites were found in the 2.7 kb EAE and two were found in the 600 bp NAE. (sdbonline.org)
  • Using in silico digestion in combination with conventional restriction analysis and sequencing of repeated DNA fragments enabled us to isolate and characterize three highly abundant families of medium-sized repeats present in the D. virilis genome. (biomedcentral.com)
  • comparisons
  • Our results suggest that gene regulatory networks are broadly conserved in the phylum Nematoda, but this conservation persists despite substantial reorganization of regulatory elements and could not be detected using naïve comparisons of sequence similarity. (prolekare.cz)
  • similarity
  • In fact, sequence similarity between C. elegans and the distantly related nematodes was no greater than would be expected by chance. (prolekare.cz)
  • genetic
  • Largely based on these and similar findings, a current view of evolution of development emerged that emphasizes the conservation of the genetic "toolkit" within animals and the relative importance of regulatory changes in driving morphological change [ 6 ]. (prolekare.cz)
  • conservation
  • The resulting pattern of gene expression can be compared to the pattern driven by the endogenous regulatory element, with the similarities and differences giving evidence of conservation and divergence in the gene regulatory network. (prolekare.cz)
  • We wanted to assess the conservation of gene regulatory programs among distantly-related members of the phylum Nematoda, a group of morphologically similar worms with mostly small, vermiform bodies. (prolekare.cz)
  • recognition
  • Selective recognition of the b1-ARE is mediated by the N-terminal region of the HOX homeodomain. (sdbonline.org)
  • Hairpin polyamides are typically composed of pyrrole and imidazole rings and can be engineered, using simple recognition rules ( 16 ), to target specific 6-12 base pair (bp) sequences ( Fig. 1 A and Fig. S1 A and B ) ( 15 , 16 ). (pnas.org)
  • abstract
  • In his honor, we provide here an update of this review, although we will barely be able to scratch the surface, given that over 17,000 publications containing "homeobox," "homeodomain," or "Hox" in the title or abstract have appeared since the first publications. (springer.com)
  • significantly
  • Importantly, the sequence context of a binding site significantly influences binding energetics, and utilizing the full contextual information permits greater accuracy in annotating regulatory elements within a given genome. (pnas.org)
  • molecules
  • An approach toward this goal has been to engineer natural DNA binding molecules to target desired DNA sequences. (pnas.org)
  • elements
  • For the third year in a row, our list of top discoveries includes micro-RNAs (mi-RNAs), short regulatory elements that have emerged as key players in cardiometabolic disease pathogenesis. (ahajournals.org)