• Bipartite and tripartite chimeras of the WPRE and HBVPRE possess activities which suggest that elements containing three subelements are posttranscriptionally stronger than those containing two. (asm.org)
  • Studies of genome wide transcriptional networks of human genomes currently lag behind those of yeast. (biomedcentral.com)
  • Although the knowledge of CREs and CRMs in a genome is crucial to elucidate gene regulatory networks and understand many important biological phenomena, little is known about the CREs and CRMs in most eukaryotic genomes due to the difficulty to characterize them by either computational or traditional experimental methods. (biomedcentral.com)
  • The ATCOECIS resource ( http://bioinformatics.psb.ugent.be/ATCOECIS/ ) makes it possible to query coexpression data and GO and cis - regulatory element annotations and to submit user-defined gene sets for motif analysis, providing an access point to unravel the regulatory code underlying transcriptional control in Arabidopsis ( Arabidopsis thaliana ). (plantphysiol.org)
  • A significant correlation between the Z scores of gene sets of TFBSs and individual genes across multiple conditions permitted successful identification of many known human transcriptional regulatory elements of genes as well as the prediction of numerous putative TFBSs of many genes which will constitute a good starting point for further experiments. (biomedcentral.com)
  • The results will be particularly relevant to interpretation of regulatory genetic variations. (europa.eu)
  • Diverse high-throughput technologies are providing information useful for understanding evolutionary processes, mapping regulatory networks, and developing new disease diagnostics and therapeutics. (keystonesymposia.org)
  • Several factors may confound the inference and interpretation of regulatory enhancer activity. (europa.eu)
  • There are likely many kinds of regulatory architectures with distinct levels of output and flexibility. (europa.eu)