• RPN1a (26S proteasome regulatory subunit RPN1a) Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins (By similarity). (agrisera.com)
  • Alternative names: 26S proteasome non-ATPase regulatory subunit 2 homolog A, AtRPN1a, 26S proteasome regulatory subunit S2 homolog A. (agrisera.com)
  • Domains Necessary for Gα12 Binding and Stimulation of Protein Phosphatase-2A (PP2A): Is Gα12 a Novel Regulatory Subunit of PP2A? (aspetjournals.org)
  • The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1. (bvsalud.org)
  • This gene encodes a member of the proteasome subunit S3 family that functions as one of the non-ATPase subunits of the 19S regulator lid. (nih.gov)
  • This gene encodes one of the regulatory subunits. (nih.gov)
  • This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. (nih.gov)
  • This gene encodes one of the non-ATPase subunits of the 19S regulator lid. (novusbio.com)
  • MicroRNA-182 targets protein phosphatase 1 regulatory inhibitor subunit 1C in glioblastoma. (nih.gov)
  • The predicted HupL polypeptide is homologous to the large subunit of [NiFe] uptake hydrogenases. (wikigenes.org)
  • The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. (nih.gov)
  • cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. (nih.gov)
  • Four different regulatory subunits and three catalytic subunits have been identified in humans. (nih.gov)
  • Description: A sandwich ELISA kit for detection of Protein Phosphatase 1, Regulatory Subunit 15A from Rat in samples from blood, serum, plasma, cell culture fluid and other biological fluids. (hiv-pharmacogenomics.org)
  • The product Assay kit for Goat Cyclin-dependent kinases regulatory subunit 2(CKS2) (ELISA) should be kept between two and eight degrees Celsius to ensure the retention of the stability and reactivity of the reagents included in the kit. (creatinekinases.com)
  • The product Assay kit for Goat Cyclin-dependent kinases regulatory subunit 2(CKS2) (ELISA) is intended to be used for research purposes only. (creatinekinases.com)
  • Heymut Omran, Mary Porter and colleagues identify the nexin link-dynein regulatory complex subunit DRC1 from Chlamydomonas and show that mutations in the human DRC1 homolog CCDC164 cause primary ciliary dyskinesia. (nature.com)
  • Most of these mutations change single amino acids in the PAFAH1B1 protein subunit. (medlineplus.gov)
  • Autosomal dominant mutations in one of the most ubiquitous isoforms of the inhibitory subunit (R1α) of protein kinase A (PKA) are linked to a generalized tumor predisposition, referred to as Carney complex (CNC). (mcmaster.ca)
  • Finally, it seems appropriate to consider the "sodium channel syndrome" (mutations in the gene of the α subunit of the sodium channel, SCN5A gene) as a single clinical entity that may manifest in a wide range of phenotypes, to thus have a better insight on these cardiac syndromes and potential outcomes for their clinical treatment. (bvsalud.org)
  • Proteasomes consist of a 19-subunit regulatory particle (RP) and 28-subunit core particle (CP) an α7β7β7α7 structure. (crispr-reagents.com)
  • J. Liu, D. L. Brautigan, Glycogen synthase association with the striated muscle glycogen targeting subunit of protein phosphatase- 1. (biosensingusa.com)
  • Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. (expasy.org)
  • Synthetic peptide corresponding to aa 281-294 (M 281 HRQET(PSO 3 )VDCLKKFN 294 ) of the α-subunit of mouse and rat CaM kinase II (Ca 2+ /Calmodulin-dependent Protein Kinase II) thiophosphorylated at (Thr 286 ). (enzolifesciences.com)
  • Recognizes the phosphorylated α-subunit of CaM kinase II. (enzolifesciences.com)
  • This antibody does not detect the non-phosphorylated α-subunit of rat CaM kinase II nor the ~60kDa β-subunit in either phosphorylation state. (enzolifesciences.com)
  • To identify subunits of the DRC, we characterized a Chlamydomonas motility mutant obtained by insertional mutagenesis. (umn.edu)
  • Rupp, G & Porter, ME 2003, ' A subunit of the dynein regulatory complex in Chlamydomonas is a homologue of a growth arrest-specific gene product ', Journal of Cell Biology , vol. 162, no. 1, pp. 47-57. (umn.edu)
  • A gene regulatory network has been formed with the top ranked coding genes to identify their role in causing diabetes. (researchgate.net)
  • Phosphatase 1 Nuclear Targeting Subunit (PNUTS) Regulates Aurora Kinases and Mitotic Progression. (nih.gov)
  • The dynein regulatory complex (DRC) is an important intermediate in the pathway that regulates flagellar motility. (umn.edu)
  • We show here that an interaction of EB1 with the SXIP-containing +TIP CDK5 regulatory subunit-associated protein 2 (CDK5RAP2) regulates several EB1 activities, including microtubule plus-end tracking, dynamics at microtubule plus ends, microtubule and α/β-tubulin binding, and microtubule polymerization. (uky.edu)
  • These hormones consist of two subunits, the common alpha- and specific beta-subunits, which associate noncovalently to form a heterodimer. (biovendor.com)
  • Receptor-stimulated guanine-nucleotide-triphosphate binding to guanine-nucleotide-binding regulatory proteins. (eurekamag.com)
  • The data thus provide evidence for an essential difference between GTP[S] and p[NH]ppG binding to guanine-nucleotide-binding regulatory proteins and suggest that, in addition to the nucleotide-exchange reaction, a (thio)phosphate-group-transfer process via guanine-nucleotide-binding regulatory protein beta subunits is involved in the receptor-stimulated binding of guanine nucleotide triphosphates to guanine-nucleotide-binding regulatory proteins. (eurekamag.com)
  • Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Rat Protein Phosphatase 1, Regulatory Subunit 15A (PPP1R15A) in samples from Tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species. (hiv-pharmacogenomics.org)
  • 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. (nih.gov)
  • The antibody was raised in rabbits by immunization with the recombinant Human Thyrostimulin beta subunit. (biovendor.com)
  • The immunization antigen (13.34 kDa) is a protein containing 120 AA of recombinant Human Thyrostimulin beta subunit. (biovendor.com)
  • Immunoaffinity chromatography on a column with immobilized recombinant Human Thyrostimulin beta subunit. (biovendor.com)
  • The alpha-subunit combines with four distinct beta-subunits giving rise to four biologically active hormones in human: FSH, LH, TSH, and CG. (biovendor.com)
  • It remains elusive how conformational changes of the AAA-ATPase unfoldase in the regulatory particle (RP) control the gating of the substrate-translocation channel leading to the proteolytic chamber of the core particle (CP). (rcsb.org)
  • The domains can occur within a single peptide chain or on distinct subunits. (bvsalud.org)
  • KAT8 regulatory NSL complex subunit 2 (KANSL2) also known as non-specific lethal 2 homolog (NSL2) is a protein that in humans is encoded by the KANSL2 gene. (wikipedia.org)
  • Structure of a CBS-domain pair from the regulatory γ1 subunit of human AMPK in complex with AMP and ZMP. (astx.com)
  • The PAFAH1B1 gene (also known as LIS1 ) provides instructions for making a protein that is one part (subunit) of a complex called platelet activating factor acetyl hydrolase 1B (PAFAH1B). (medlineplus.gov)
  • The abnormal PAFAH1B1 protein is less able to interact with microtubules and to attach (bind) to other subunits to form the PAFAH1B complex, both of which are needed for neuronal migration. (medlineplus.gov)
  • Thyrostimulin, a heterodimer of two new human glycoprotein hormone subunits, activates the thyroid-stimulating hormone receptor. (biovendor.com)
  • Aim: To evaluate the involvement of Th2 cells in different periods of the active phase of experimental periodontal disease and expression of the R1 subunit of the receptor for IFN-γ during the early and advanced progression of the disease. (bvsalud.org)
  • Proteasome subunit S5a contains two ubiquitin-interacting motifs (UIMs) through which it recruits ubiquitylated substrates to the proteasome for their degradation. (rcsb.org)
  • Kask L., Hillarp A., Ramesh B., Dahlbäck B., and Blom A. M. (2002) Structural requirements for the intra-cellular subunit polymerization of the complement inhibitor C4b-binding protein. (lu.se)
  • Ubiquitin is a key regulatory molecule in diverse cellular events. (rcsb.org)
  • Conclusions: These results indicate that the Th2 response may have a protective role during the pathogenesis of experimental periodontal disease, and that the IFN-γ R1 subunit may not be associated with periodontal disease progression. (bvsalud.org)
  • Biophysical Analysis of the N-Terminal Domain from the Human Protein Phosphatase 1 Nuclear Targeting Subunit PNUTS Suggests an Extended Transcription Factor TFIIS-Like Fold. (nih.gov)
  • Hsu SY, Nakabayashi K, Bhalla A. Evolution of glycoprotein hormone subunit genes in bilateral metazoa: identification of two novel human glycoprotein hormone subunit family genes, GPA2 and GPB5. (biovendor.com)
  • GATA-3 and IFN-γ R1 subunit expressions were evaluated during different stages of induced periodontal disease (early and advanced) and these data were correlated with the severity of periodontal destruction, which was determined clinically and histologically. (bvsalud.org)
  • Upregulation of Phosphatase 1 Nuclear-Targeting Subunit (PNUTS) Is an Independent Predictor of Poor Prognosis in Prostate Cancer. (nih.gov)
  • A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). (nih.gov)
  • Coronavirus RNA-dependent RNA polymerase interacts with the p50 regulatory subunit of host DNA polymerase delta and plays a synergistic role with RNA helicase in the induction of DNA damage response and cell cycle arrest in S phase. (cdc.gov)
  • In the new guidelines, the general principles of evaluating a vaccine after the elimination, reduction in content, removal or replacement of thiomersal from an already-licensed vaccine are discussed, with particular attention being given to the regulatory expectations for each of the above possibilities. (who.int)
  • Proteases that contain proteolytic core domains and ATPase-containing regulatory domains. (bvsalud.org)
  • They are usually comprised of large multi-subunit assemblies. (bvsalud.org)
  • β subunits incorporate on the complete α ring stepwise in the order β2 β3 β4 β5 β6 β1 to form the half-mer species α1-7β1-6 (47). (crispr-reagents.com)
  • Resumption of smallpox vaccine production would benefit from modern concepts of production and control, and modern regulatory expectations should be adhered to in the licensing process. (who.int)
  • Molecular cloning and expression of subunit 9 of the 26S proteasome.Hoffman L., Rechsteiner M.FEBS Lett. (joplink.net)